Non-invasive and long-term core temperature measurement

Author(s):  
Molly Blank ◽  
Mike Sinclair
Author(s):  
Garrett Augustine ◽  
Scott Augustine

Core temperature is one of the most tightly auto-regulated physiological processes. Anesthetic drugs compromise the body’s ability to thermoregulate. When core temperature is outside of the normothermia range, patients are at increased risk of myriad complications. Hypothermic patients are at higher risk of, among other things, increased wound infections2, increased blood loss3, increased ICU times and hospital stays2, higher mortality rates4, increased transfusion requirements3. “Even mildly hypothermic patients could suffer an increase in adverse outcomes that can add costs of as much as $2,500–$7,000 per patient.”5 These risks are great such that clinicians actively warm hypothermic patients to achieve normothermia. Given the importance of the core temperature on outcomes, there is a clear necessity for accurate core temperature measurement. Core temperature measurement is often misunderstood. Perhaps due to the pervasive home use of oral mercury thermometers to “take your temperature,” many wrongly assume that non-invasive core temperature is measured easily and accurately. Oral, axilla, nasal are all unreliable. Temporal/forehead and ear are particularly inaccurate. “Global authorities in anesthesiology and medicine have cited inadequacies with virtually all thermometry”6 False assurance or false alarm are both dangerous. There is currently no non-invasive way to reliably and accurately measure core temperature. Why is this? The peripheral compartment is not in equilibrium with core. Fat and other layers further complicate the matter. Fat has the thermal conductivity of oak, and thus non-invasive methods to measure core are as Abreu puts it “taking measurements on the outside surface of an oak cask to determine the temperature of its contents.”6 Laws of Thermodynamics notwithstanding, many still try. Invasive esophageal or rectal and to a lesser extent bladder, are the only way to accurately measure core. The fact is, in order to measure their patients’ core temperature vital sign accurately, clinicians have only available to them the medical equivalent of a meat thermometer. Intubated patients under general anesthesia are perfectly suited for invasive core temperature monitoring. They are not going to gag the esophageal stethoscope, nor would they find rectal or bladder probing uncomfortable in their unconsciousness. Clinicians may find probing mildly unpleasant and a minor time consumption, but once again, given the lack of alternatives, the only real option is to grin and bear it. General anesthesia is not without risks, especially with increasingly increasing patients, and as sedation or blocks become more popular, invasive core temperature monitoring is unpractical. This highlights the stark question: Is it possible to accurately and reliably ascertain core temperature non-invasively?


2015 ◽  
Vol 60 (1) ◽  
pp. 1-9 ◽  
Author(s):  
Ivo F. Brandes ◽  
Thorsten Perl ◽  
Martin Bauer ◽  
Anselm Bräuer

AbstractReliable continuous perioperative core temperature measurement is of major importance. The pulmonary artery catheter is currently the gold standard for measuring core temperature but is invasive and expensive. Using a manikin, we evaluated the new, noninvasive SpotOn™ temperature monitoring system (SOT). With a sensor placed on the lateral forehead, SOT uses zero heat flux technology to noninvasively measure core temperature; and because the forehead is devoid of thermoregulatory arteriovenous shunts, a piece of bone cement served as a model of the frontal bone in this study. Bias, limits of agreements, long-term measurement stability, and the lowest measurable temperature of the device were investigated. Bias and limits of agreement of the temperature data of two SOTs and of the thermistor placed on the manikin’s surface were calculated. Measurements obtained from SOTs were similar to thermistor values. The bias and limits of agreement lay within a predefined clinically acceptable range. Repeat measurements differed only slightly, and stayed stable for hours. Because of its temperature range, the SOT cannot be used to monitor temperatures below 28°C. In conclusion, the new SOT could provide a reliable, less invasive and cheaper alternative for measuring perioperative core temperature in routine clinical practice. Further clinical trials are needed to evaluate these results.


2021 ◽  
Vol 3 (3) ◽  
pp. 209-223
Author(s):  
Nayana Shetty

Many sports have a high risk of climatic ailments, such as hypothermia, hyperthermia, and heatstroke. The measurement of a sportsperson's body core temperature (Tc) may have an impact on their performances and it assists them to avoid injuries as well. To avoid complications like electrolyte imbalances or infections, it's essential to precisely measure the core body temperature during targeted temperature control when spontaneous circulation has returned. Previous approaches on the other hand, are intrusive and difficult to use. The usual technique, an oesophageal thermometer, was compared to a disposable non-invasive temperature sensor that used the heat flux methodology. This research indicates that, non-invasive disposable sensors used to measure core body temperature are very reliable when used for targeted temperature control after overcoming a cardiac arrest successfully. The non-invasive method of temperature measurement has somewhat greater accuracy than the invasive approach. The results of this study must be confirmed by more clinical research with various sensor types to figure out if the bounds of agreement could be increased. This will ensure that the findings are accurate based on core temperature.


2011 ◽  
Vol 32 (5) ◽  
pp. 559-570 ◽  
Author(s):  
L P J Teunissen ◽  
J Klewer ◽  
A de Haan ◽  
J J de Koning ◽  
H A M Daanen

2021 ◽  
Vol 23 (3) ◽  
pp. 346-353
Author(s):  
Salvatore L Cutuli ◽  
◽  
Eduardo A Osawa ◽  
Christopher T Eyeington ◽  
Helena Proimos ◽  
...  

Objective: The accuracy of different non-invasive body temperature measurement methods in intensive care unit (ICU) patients is uncertain. We aimed to study the accuracy of three commonly used methods. Design: Prospective observational study. Setting: ICUs of two tertiary Australian hospitals. Participants: Critically ill patients admitted to the ICU. Interventions: Invasive (intravascular and intra-urinary bladder catheter) and non-invasive (axillary chemical dot, tympanic infrared, and temporal scanner) body temperature measurements were taken at study inclusion and every 4 hours for the following 72 hours. Main outcome measures: Accuracy of non-invasive body temperature measurement methods was assessed by the Bland–Altman approach, accounting for repeated measurements and significant explanatory variables that were identified by regression analysis. Clinical adequacy was set at limits of agreement (LoA) of 1C compared with core temperature. Results: We studied 50 consecutive critically ill patients who were mainly admitted to the ICU after cardiac surgery. From over 375 observations, invasive core temperature (mostly pulmonary artery catheter) ranged from 33.9C to 39C. On average, the LoA between invasive and non-invasive measurements methods were about 3C. The temporal scanner showed the worst performance in estimating core temperature (bias, 0.66C; LoA, 1.23C, +2.55C), followed by tympanic infrared (bias, 0.44C; LoA, 1.73C, +2.61C) and axillary chemical dot methods (bias, 0.32°C; LoA, 1.64C, +2.28C). No methods achieved clinical adequacy even accounting for significant explanatory variables. Conclusions: The axillary chemical dot, tympanic infrared and temporal scanner methods are inaccurate measures of core temperature in ICU patients. These non-invasive methods appeared unreliable for use in ICU patients.


2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Aaro Salosensaari ◽  
Ville Laitinen ◽  
Aki S. Havulinna ◽  
Guillaume Meric ◽  
Susan Cheng ◽  
...  

AbstractThe collection of fecal material and developments in sequencing technologies have enabled standardised and non-invasive gut microbiome profiling. Microbiome composition from several large cohorts have been cross-sectionally linked to various lifestyle factors and diseases. In spite of these advances, prospective associations between microbiome composition and health have remained uncharacterised due to the lack of sufficiently large and representative population cohorts with comprehensive follow-up data. Here, we analyse the long-term association between gut microbiome variation and mortality in a well-phenotyped and representative population cohort from Finland (n = 7211). We report robust taxonomic and functional microbiome signatures related to the Enterobacteriaceae family that are associated with mortality risk during a 15-year follow-up. Our results extend previous cross-sectional studies, and help to establish the basis for examining long-term associations between human gut microbiome composition, incident outcomes, and general health status.


2020 ◽  
Vol 87 (9) ◽  
pp. 553-563
Author(s):  
Jörg Gebhardt ◽  
Guruprasad Sosale ◽  
Subhashish Dasgupta

AbstractAccurate and responsive non-invasive temperature measurements are enablers for process monitoring and plant optimization use cases in the context of Industry 4.0. If their performance is proven for large classes of applications, such measurement principles can replace traditional invasive measurements. In this paper we describe a two-step model to estimate the process temperature from a pipe surface temperature measurement. This static case model is compared to and enhanced by computational fluid dynamic (CFD) calculations to predict transient situations. The predictions of the approach are validated by means of controlled experiments in a laboratory environment. The experimental results demonstrate the efficacy of the model, the responsiveness of the pipe surface temperature, and that state of the art industrial non-invasive sensors can achieve the performance of invasive thermowells. The non-invasive sensors are then used to demonstrate the performance of the model in industrial applications for cooling fluids and steam.


Diagnostics ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 900
Author(s):  
Krasimir Kostov ◽  
Alexander Blazhev

Thickening of the vascular basement membrane (BM) is a fundamental structural change in the small blood vessels in diabetes. Collagen type IV (CIV) is a major component of the BMs, and monitoring the turnover of this protein in type 2 diabetes (T2D) can provide important information about the mechanisms of vascular damage. The aim of the study was through the use of non-invasive biomarkers of CIV (autoantibodies, derivative peptides, and immune complexes) to investigate vascular turnover of CIV in patients with long-term complications of T2D. We measured serum levels of these biomarkers in 59 T2D patients with micro- and/or macrovascular complications and 20 healthy controls using an ELISA. Matrix metalloproteinases-2 and -9 (MMP-2 and MMP-9) were also tested. In the T2D group, significantly lower levels of CIV markers and significantly higher levels of MMP-2 and MMP-9 were found compared to controls. A significant positive correlation was found between IgM antibody levels against CIV and MMP-2. These findings suggest that vascular metabolism of CIV is decreased in T2D with long-term complications and show that a positive linear relationship exists between MMP-2 levels and CIV turnover in the vascular wall.


2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Julia García Mancebo ◽  
Sara de la Mata Navazo ◽  
Estíbaliz López-Herce Arteta ◽  
Rosario Montero Mateo ◽  
Isabel María López Esteban ◽  
...  

AbstractDuring the last decades, the number of patients with long stay admissions (LSA) in PICU has increased. The purpose of this study was to identify factors associated with PICU LSA, assessing healthcare resources use and changes in the profile of these patients. A retrospective, observational, single-center study was carried out. Characteristics of LSA were compared between two periods (2006–2010 and 2011–2015). During the earlier period there were 2,118 admissions (3.9% of them LSA), whereas during the second period, there were 1,763 (5.4% of them LSA) (p = 0.025). LSA accounted for 33.7% PICU stay days during the first period and 46.7% during the second (p < 0.001). Higher use of non-invasive ventilation (80.2% vs. 37.8%, p = 0.001) and high-flow oxygen therapy (68.8% vs. 37.8%, p = 0.005) was observed in the 2011–2015 cohort, whereas the use of arterial catheter (77.1% vs. 92.6%, p = 0.005), continuous infusion of adrenaline (55.2% vs. 75.9%, p = 0.004), and hemoderivative transfusion (74% vs. 89.2%, p = 0.010) was less frequent. In the 2006–2010 cohort, hospital-acquired infections were more common (95.2% vs. 68.8%, p < 0.001) and mortality was higher (26.8% vs. 13.8%, p = 0.026). The number of long-stay PICU admissions have increased entailing an intensive use of healthcare resources. These patients have a high risk for complications and mortality.


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