Biomedical Applications of Metal 3D Printing

Additive manufacturing's attributes include print customization, low per-unit cost for small- to mid-batch production, seamless interfacing with mainstream medical 3D imaging techniques, and feasibility to create free-form objects in materials that are biocompatible and biodegradable. Consequently, additive manufacturing is apposite for a wide range of biomedical applications including custom biocompatible implants that mimic the mechanical response of bone, biodegradable scaffolds with engineered degradation rate, medical surgical tools, and biomedical instrumentation. This review surveys the materials, 3D printing methods and technologies, and biomedical applications of metal 3D printing, providing a historical perspective while focusing on the state of the art. It then identifies a number of exciting directions of future growth: ( a) the improvement of mainstream additive manufacturing methods and associated feedstock; ( b) the exploration of mature, less utilized metal 3D printing techniques; ( c) the optimization of additively manufactured load-bearing structures via artificial intelligence; and ( d) the creation of monolithic, multimaterial, finely featured, multifunctional implants.

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3D Technology – Additive Manufacturing Applications and Prospects (Vol. 24, No. 9, Full Issue)

Asia-Pacific Biotech News ◽

10.1142/s0219030320001093 ◽

2020 ◽

Vol 24 (09) ◽

Keyword(s):

Additive Manufacturing ◽

3D Printing ◽

Environmental Impact ◽

Real World ◽

Vaccine Development ◽

Health Screening ◽

Wide Range ◽

The World ◽

Real World Applications ◽

Manufacturing Applications

For the month of September 2020, APBN dives into the world of 3D printing and its wide range of real-world applications. Keeping our focus on the topic of the year, the COVID-19 pandemic, we explore the environmental impact of the global outbreak as well as gain insight to the top 5 vaccine platforms used in vaccine development. Discover more about technological advancements and how it is assisting innovation in geriatric health screening.

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Additive Manufacturing of Biopolymers for Tissue Engineering and Regenerative Medicine: An Overview, Potential Applications, Advancements, and Trends

International Journal of Polymer Science ◽

10.1155/2021/4907027 ◽

2021 ◽

Vol 2021 ◽

pp. 1-20 ◽

Cited By ~ 2

Author(s):

Dhinakaran Veeman ◽

M. Swapna Sai ◽

P. Sureshkumar ◽

T. Jagadeesha ◽

L. Natrayan ◽

...

Keyword(s):

Tissue Engineering ◽

Additive Manufacturing ◽

3D Printing ◽

Regenerative Medicine ◽

Tissue Regeneration ◽

Three Dimensional ◽

Porous Scaffolds ◽

Wide Range ◽

Potential Applications ◽

Pharmaceutical Industries

As a technique of producing fabric engineering scaffolds, three-dimensional (3D) printing has tremendous possibilities. 3D printing applications are restricted to a wide range of biomaterials in the field of regenerative medicine and tissue engineering. Due to their biocompatibility, bioactiveness, and biodegradability, biopolymers such as collagen, alginate, silk fibroin, chitosan, alginate, cellulose, and starch are used in a variety of fields, including the food, biomedical, regeneration, agriculture, packaging, and pharmaceutical industries. The benefits of producing 3D-printed scaffolds are many, including the capacity to produce complicated geometries, porosity, and multicell coculture and to take growth factors into account. In particular, the additional production of biopolymers offers new options to produce 3D structures and materials with specialised patterns and properties. In the realm of tissue engineering and regenerative medicine (TERM), important progress has been accomplished; now, several state-of-the-art techniques are used to produce porous scaffolds for organ or tissue regeneration to be suited for tissue technology. Natural biopolymeric materials are often better suited for designing and manufacturing healing equipment than temporary implants and tissue regeneration materials owing to its appropriate properties and biocompatibility. The review focuses on the additive manufacturing of biopolymers with significant changes, advancements, trends, and developments in regenerative medicine and tissue engineering with potential applications.

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ADDITIVE MANUFACTURING - APPLICATION OPPORTUNITIES FOR THE AVIATION INDUSTRY

Journal of Air Transport Studies ◽

10.38008/jats.v6i2.59 ◽

2015 ◽

Vol 6 (2) ◽

pp. 63-86

Author(s):

Dipesh Dhital ◽

Yvonne Ziegler

Keyword(s):

Additive Manufacturing ◽

3D Printing ◽

Computer Aided Design ◽

Free Form ◽

Aviation Industry ◽

Layer By Layer ◽

Printing Technology ◽

3D Printing Technology ◽

Subtractive Manufacturing ◽

Aided Design

Additive Manufacturing also known as 3D Printing is a process whereby a real object of virtually any shape can be created layer by layer from a Computer Aided Design (CAD) model. As opposed to the conventional Subtractive Manufacturing that uses cutting, drilling, milling, welding etc., 3D printing is a free-form fabrication process and does not require any of these processes. The 3D printed parts are lighter, require short lead times, less material and reduce environmental footprint of the manufacturing process; and is thus beneficial to the aerospace industry that pursues improvement in aircraft efficiency, fuel saving and reduction in air pollution. Additionally, 3D printing technology allows for creating geometries that would be impossible to make using moulds and the Subtractive Manufacturing of drilling/milling. 3D printing technology also has the potential to re-localize manufacturing as it allows for the production of products at the particular location, as and when required; and eliminates the need for shipping and warehousing of final products.

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Hybrid Metal 3D Printing for Selective Polished Surface

Materials Science Forum ◽

10.4028/www.scientific.net/msf.1027.136 ◽

2021 ◽

Vol 1027 ◽

pp. 136-140

Author(s):

Sze Yi Mak ◽

Kwong Leong Tam ◽

Ching Hang Bob Yung ◽

Wing Fung Edmond Yau

Keyword(s):

Additive Manufacturing ◽

3D Printing ◽

Surface Finishing ◽

Polished Surface ◽

Post Processing ◽

One Stop ◽

Metal 3D Printing ◽

Critical Challenge ◽

Metal Additive

Metal additive manufacturing has found broad applications in diverse disciplines. Post processing to homogenize and improve surface finishing remains a critical challenge to additive manufacturing. We propose a novel one-stop solution of adopting hybrid metal 3D printing to streamlining the additive manufacturing workflow as well as to improve surface roughness quality of selective interior surface of the printed parts. This work has great potential in medical and aerospace industries where complicated and high-precision additive manufacturing is anticipated.

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Physico-Chemical Challenges in 3D Printing of Polymeric Nanocomposites and Hydrogels for Biomedical Applications

Journal of Nanoscience and Nanotechnology ◽

10.1166/jnn.2021.19063 ◽

2021 ◽

Vol 21 (5) ◽

pp. 2778-2792

Author(s):

Massimo Bonini

Keyword(s):

Additive Manufacturing ◽

3D Printing ◽

Biomedical Applications ◽

Nanocomposite Materials ◽

Manufacturing Processes ◽

Polymeric Nanocomposites ◽

Physico Chemical ◽

Polymeric Hydrogels ◽

Manufacturing Techniques

Additive manufacturing techniques (i.e., 3D printing) are rapidly becoming one of the most popular methods for the preparation of materials to be employed in many different fields, including biomedical applications. The main reason is the unique flexibility resulting from both the method itself and the variety of starting materials, requiring the combination of multidisciplinary competencies for the optimization of the process. In particular, this is the case of additive manufacturing processes based on the extrusion or jetting of nanocomposite materials, where the unique properties of nanomaterials are combined with those of a flowing matrix. This contribution focuses on the physico-chemical challenges typically faced in the 3D printing of polymeric nanocomposites and polymeric hydrogels intended for biomedical applications. The strategies to overcome those challenges are outlined, together with the characterization approaches that could help the advance of the field.

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What Is Design for Additive Manufacturing (DfAM)?

Advances in Civil and Industrial Engineering - Additive Manufacturing Applications for Metals and Composites ◽

10.4018/978-1-7998-4054-1.ch009 ◽

2020 ◽

pp. 164-186

Author(s):

Seung Hwan Joo ◽

Sung Mo Lee ◽

Jin Ho Yoo ◽

Hyeon Jin Son ◽

Seung Ho Lee

Keyword(s):

Additive Manufacturing ◽

3D Printing ◽

Design Optimization ◽

Advanced Manufacturing ◽

Design For Additive Manufacturing ◽

Printing Technology ◽

Actual Production ◽

Manufacturing Design ◽

Metal 3D Printing ◽

Is Design

In order to use 3D printing technology as a sanction, it is necessary to optimize topology, component unification, and reduce weight need for advanced manufacturing design. In the case of metal 3D printing, it is necessary to manage deformation and defects in the process cause of using laser, and support generation and design optimization must be accompanied for efficiency. Currently, design progresses through simulation before actual production in AM field. This chapter explores design in additive manufacturing.

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DLP 3D Printing Meets Lignocellulosic Biopolymers: Carboxymethyl Cellulose Inks for 3D Biocompatible Hydrogels

Polymers ◽

10.3390/polym12081655 ◽

2020 ◽

Vol 12 (8) ◽

pp. 1655 ◽

Cited By ~ 4

Author(s):

Giuseppe Melilli ◽

Irene Carmagnola ◽

Chiara Tonda-Turo ◽

Fabrizio Pirri ◽

Gianluca Ciardelli ◽

...

Keyword(s):

Mechanical Properties ◽

Additive Manufacturing ◽

3D Printing ◽

Carboxymethyl Cellulose ◽

Biomedical Applications ◽

Digital Light Processing ◽

Chemically Modified ◽

Significant Step ◽

3D Printed ◽

Biomedical Field

The development of new bio-based inks is a stringent request for the expansion of additive manufacturing towards the development of 3D-printed biocompatible hydrogels. Herein, methacrylated carboxymethyl cellulose (M-CMC) is investigated as a bio-based photocurable ink for digital light processing (DLP) 3D printing. CMC is chemically modified using methacrylic anhydride. Successful methacrylation is confirmed by 1H NMR and FTIR spectroscopy. Aqueous formulations based on M-CMC/lithium phenyl-2,4,6-trimethylbenzoylphosphinate (LAP) photoinitiator and M-CMC/Dulbecco’s Modified Eagle Medium (DMEM)/LAP show high photoreactivity upon UV irradiation as confirmed by photorheology and FTIR. The same formulations can be easily 3D-printed through a DLP apparatus to produce 3D shaped hydrogels with excellent swelling ability and mechanical properties. Envisaging the application of the hydrogels in the biomedical field, cytotoxicity is also evaluated. The light-induced printing of cellulose-based hydrogels represents a significant step forward in the production of new DLP inks suitable for biomedical applications.

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On the verge of disruption: rethinking position and role – the case of additive manufacturing

Journal of Business and Industrial Marketing ◽

10.1108/jbim-10-2018-0293 ◽

2019 ◽

Vol 34 (5) ◽

pp. 1093-1105 ◽

Cited By ~ 3

Author(s):

Christina Öberg ◽

Tawfiq Shams

Keyword(s):

Supply Chain ◽

Additive Manufacturing ◽

3D Printing ◽

Design Methodology ◽

Secondary Data ◽

Point Of View ◽

Disruptive Technology ◽

Content Type ◽

Business Cases ◽

Metal 3D Printing

Purpose With the overarching idea of disruptive technology and its effects on business, this paper focuses on how companies strategically consider meeting the challenge of a disruptive technology such as additive manufacturing. The purpose of this paper is to describe and discuss changes in positions and roles related to the implementation of a disruptive technology. Design/methodology/approach Additive manufacturing could be expected to have different consequences for parties based on their current supply chain positions. The paper therefore investigates companies’ strategies related to various supply chain positions and does so by departing from a position and role point of view. Three business cases related to metal 3D printing - illustrating sub-suppliers, manufacturers and logistics firms - describe as many strategies. Data for the cases were collected through meetings, interviews, seminars and secondary data focusing on both current business activities related to additive manufacturing and scenarios for the future. Findings The companies attempted to defend their current positions, leading to new roles for them. This disconnects the change of roles from that of positions. The changed roles indicate that all parties, regardless of supply chain positions, would move into competing producing roles, thereby indicating how a disruptive technology may disrupt network structures based on companies’ attempts to defend their positions. Originality/value The paper contributes to previous research by reporting a disconnect between positions and roles among firms when disruption takes place. The paper further denotes how the investigated firms largely disregarded network consequences at the disruptive stage, caused by the introduction of additive manufacturing. The paper also contributes to research on additive manufacturing by including a business dimension and linking this to positions and roles.

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Investigation of a Short Carbon Fibre-Reinforced Polyamide and Comparison of Two Manufacturing Processes: Fused Deposition Modelling (FDM) and Polymer Injection Moulding (PIM)

Materials ◽

10.3390/ma13030672 ◽

2020 ◽

Vol 13 (3) ◽

pp. 672 ◽

Cited By ~ 7

Author(s):

Elena Verdejo de Toro ◽

Juana Coello Sobrino ◽

Alberto Martínez Martínez ◽

Valentín Miguel Eguía ◽

Jorge Ayllón Pérez

Keyword(s):

Mechanical Properties ◽

Additive Manufacturing ◽

3D Printing ◽

Injection Moulding ◽

New Technologies ◽

Mechanical Response ◽

Fused Deposition Modelling ◽

Layer By Layer ◽

Polymer Injection ◽

Fused Deposition

New technologies are offering progressively more effective alternatives to traditional ones. Additive Manufacturing (AM) is gaining importance in fields related to design, manufacturing, engineering and medicine, especially in applications which require complex geometries. Fused Deposition Modelling (FDM) is framed within AM as a technology in which, due to their layer-by-layer deposition, thermoplastic polymers are used for manufacturing parts with a high degree of accuracy and minimum material waste during the process. The traditional technology corresponding to FDM is Polymer Injection Moulding, in which polymeric pellets are injected by pressure into a mould using the required geometry. The increasing use of PA6 in Additive Manufacturing makes it necessary to study the possibility of replacing certain parts manufactured by injection moulding with those created using FDM. In this work, PA6 was selected due to its higher mechanical properties in comparison with PA12. Moreover, its higher melting point has been a limitation for 3D printing technology, and a further study of composites made of PA6 using 3D printing processes is needed. Nevertheless, analysis of the mechanical response of standardised samples and the influence of the manufacturing process on the polyamide’s mechanical properties needs to be carried out. In this work, a comparative study between the two processes was conducted, and conclusions were drawn from an engineering perspective.

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