scholarly journals High-protein diet selectively reduces fat mass and improves glucose tolerance in Western-type diet-induced obese rats

2013 ◽  
Vol 305 (6) ◽  
pp. R582-R591 ◽  
Author(s):  
Andreas Stengel ◽  
Miriam Goebel-Stengel ◽  
Lixin Wang ◽  
Eugenia Hu ◽  
Hiroshi Karasawa ◽  
...  
Keyword(s):  
Glucose Tolerance ◽  
Fat Mass ◽  
Peptide Yy ◽  
Selective Reduction ◽  
High Protein Diet ◽  
High Protein ◽  
Male Rats ◽  
Dark Phase ◽  
Obese Rats ◽  
Treatment Of Obesity

Obesity is an increasing health problem. Because drug treatments are limited, diets remain popular. High-protein diets (HPD) reduce body weight (BW), although the mechanisms are unclear. We investigated physiological mechanisms altered by switching diet induced obesity (DIO) rats from Western-type diet (WTD) to HPD. Male rats were fed standard (SD) or WTD (45% calories from fat). After developing DIO (50% of rats), they were switched to SD (15% calories from protein) or HPD (52% calories from protein) for up to 4 weeks. Food intake (FI), BW, body composition, glucose tolerance, insulin sensitivity, and intestinal hormone plasma levels were monitored. Rats fed WTD showed an increased FI and had a 25% greater BW gain after 9 wk compared with SD ( P < 0.05). Diet-induced obese rats switched from WTD to HPD reduced daily FI by 30% on day 1, which lasted to day 9 (−9%) and decreased BW during the 2-wk period compared with SD/SD ( P < 0.05). During these 2 wk, WTD/HPD rats lost 72% more fat mass than WTD/SD ( P < 0.05), whereas lean mass was unaltered. WTD/HPD rats had lower blood glucose than WTD/SD at 30 min postglucose gavage ( P < 0.05). The increase of pancreatic polypeptide and peptide YY during the 2-h dark-phase feeding was higher in WTD/HPD compared with WTD/SD ( P < 0.05). These data indicate that HPD reduces BW in WTD rats, which may be related to decreased FI and the selective reduction of fat mass accompanied by improved glucose tolerance, suggesting relevant benefits of HPD in the treatment of obesity.

scholarly journals High Protein Diet Selectively Reduces Fat Mass and Improves Glucose Tolerance in Diet-Induced Obese (DIO) Rats

2011 ◽  
Vol 140 (5) ◽  
pp. S-333
Author(s):  
Andreas Stengel ◽  
Miriam Goebel ◽  
Lixin Wang ◽  
Eugenia Hu ◽  
Joseph R. Pisegna ◽  
...  
Keyword(s):  
Glucose Tolerance ◽  
Fat Mass ◽  
High Protein Diet ◽  
High Protein ◽  
Protein Diet

Ingestive patterns of liver-denervated rats presented with several diets

1994 ◽  
Vol 267 (1) ◽  
pp. R44-R52
Author(s):  
L. L. Bellinger ◽  
G. Dula ◽  
F. E. Williams
Keyword(s):  
Food Intake ◽  
High Protein Diet ◽  
Male Rats ◽  
Sham Operation ◽  
Dark Phase ◽  
Sweetened Condensed Milk ◽  
Afferent Nerves ◽  
Condensed Milk ◽  
Body Weights ◽  
Diet Exposure

The liver by way of afferent nerves is suggested to be a controller of food intake. In experiment 1, male rats were given a 15% fructose solution during the first 4 h of the dark phase, while chow was available the rest of the time, for 10 days, before total liver denervation (TLD) or sham operation. Postsurgery ingestion patterns (15-min measurements for 4 h) of fructose were similar in the two groups. However, chow intake in the TLD group was slightly attenuated the first 2 days after surgery. In experiment 2, rats were given chow in cups and vegetable oil in bottles for 8 days before TLD or sham operation. After surgery, hourly ingestion of chow and oil did not differ between the groups; however, there was a trend for the TLD group to take more oil in the dark phase on the first-day diet exposure. In experiment 3, rats were fed a high-protein diet for 21 days before TLD or sham operation. With the use of a computer-operated system, postsurgery meal size, meal duration, and frequency patterns were found to be comparable between the groups. In experiment 4, rats were given a diet of sweetened condensed milk mixed with water (3:1 vol/vol) and vitamins for 14 days before hepatic vagal branch transection (HVBX) or sham operation. After surgery the first-day milk intake of both groups was similar up to 3.5 h and then depressed at 4 and 24 h in the HVBX rats, but was again comparable over the next 13 days; body weights were similar throughout the study.(ABSTRACT TRUNCATED AT 250 WORDS)

Daytime increase in caloric intake without change in total 24-h caloric intake can increase adiposity but not total bodyweight in rats with inverted feeding pattern

2017 ◽  
Vol 42 (9) ◽  
pp. 931-940 ◽  
Author(s):  
Lanni Sarmento da Rocha ◽  
Rhowena Jane Barbosa de Matos ◽  
Julliet Araújo de Souza ◽  
Ana Carolina Oliveira Costa ◽  
Sandra Lopes de Souza ◽  
...  
Keyword(s):  
Glucose Tolerance ◽  
Food Availability ◽  
Fasting Glucose ◽  
Caloric Intake ◽  
Male Rats ◽  
Feeding Pattern ◽  
Oral Glucose ◽  
Dark Phase ◽  
Self Selection ◽  
Selection Of

The goal of this study was to evaluate the effect of the food availability period on body weight, self-selection of macronutrients, adiposity, lipoprotein, and serum glucose profiles without changing energy intake. Young male rats were divided into 2 groups according to the availability of food during the light and dark phases of the cycle, forming 2 groups: control group (CG) and group with inverted feeding pattern (IFPG). Before inversion of food availability on the 80th day, circadian food intake was measured every 4 h over 24 h during 3 days. The glycemic curve, an oral test for glucose tolerance, and self-selection of macronutrients were evaluated. Blood samples were collected for analysis of fasting glucose, triglycerides, and total cholesterol fractions. The IFPG showed an increase in fasting glucose in the dark phase of the cycle, changes in the glycemic curve, and oral glucose tolerance test. It also showed increased abdominal and liver fat and distinct choice of macronutrients compared with the CG. A change in the availability of food according to the phase of the circadian cycle produces changes in glucose and feeding circadian rhythm culminating in increased abdominal and hepatic fat. These effects can increase the risk of metabolic disorders and installation of chronic diseases.

scholarly journals Glucose Tolerance in Response to a High-Fat Diet Is Improved by a High-Protein Diet

Obesity ◽  
2012 ◽  
Vol 20 (9) ◽  
pp. 1859-1865 ◽  
Author(s):  
Mary A. Honors ◽  
Sara L. Hargrave ◽  
Kimberly P. Kinzig
Keyword(s):  
Glucose Tolerance ◽  
High Fat Diet ◽  
High Protein Diet ◽  
High Protein ◽  
Protein Diet ◽  
High Fat

scholarly journals Renal hypertrophy and function in irradiated and nephrectomized rats fed a high protein diet

1962 ◽  
Vol 202 (1) ◽  
pp. 88-90 ◽  
Author(s):  
Frank Konishi ◽  
R. W. Brauer
Keyword(s):  
High Protein Diet ◽  
Compensatory Hypertrophy ◽  
High Protein ◽  
Protein Diet ◽  
Male Rats ◽  
Renal Neoplasm ◽  
Renal Hypertrophy ◽  
X Irradiation ◽  
Renal Clearances ◽  
And Function

Male rats exposed to a total of 740 rad X-irradiation were fed a high protein diet and unilaterally nephrectomized to investigate functional and compensatory regenerative capacity of the kidney as probable indices of residual radiation injury. The extent of compensatory hypertrophy after nephrectomy showed a significantly greater increase due to the high protein diet but no effect due to irradiation. Estimates of maximal tubular excretions of p-aminohippurate (PAH), however, were significantly greater in irradiated groups than in control groups when determined 3 weeks postnephrectomy. Renal clearances of CIn and CPAH were significantly depressed after nephrectomy but not after radiation. Histological studies of the kidneys did not indicate renal damage by radiation except for an isolated instance of a renal neoplasm in an irradiated, nephrectomized rat fed a high protein diet. The results indicate that radiation does not modify compensatory hypertrophy after unilateral nephrectomy but appears to increase the apparent functional capacity of the tubules.

A long-term high-protein diet markedly reduces adipose tissue without major side effects in Wistar male rats

2004 ◽  
Vol 287 (4) ◽  
pp. R934-R942 ◽  
Author(s):  
Magali Lacroix ◽  
Claire Gaudichon ◽  
Antoine Martin ◽  
Céline Morens ◽  
Véronique Mathé ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Weight Control ◽  
High Protein Diet ◽  
High Protein ◽  
Protein Diet ◽  
Male Rats ◽  
Calcium Balance ◽  
Long Term Effects ◽  
Wistar Male Rats

Although there is a considerable interest of high-protein, low-carbohydrate diets to manage weight control, their safety is still the subject of considerable debate. They are suspected to be detrimental to the renal and hepatic functions, calcium balance, and insulin sensitivity. However, the long-term effects of a high-protein diet on a broad range of parameters have not been investigated. We studied the effects of a high-protein diet in rats over a period of 6 mo. Forty-eight Wistar male rats received either a normal-protein (NP: 14% protein) or high-protein (HP: 50% protein) diet. Detailed body composition, plasma hormones and nutrients, liver and kidney histopathology, hepatic markers of oxidative stress and detoxification, and the calcium balance were investigated. No major alterations of the liver and kidneys were found in HP rats, whereas NP rats exhibited massive hepatic steatosis. The calcium balance was unchanged, and detoxification markers (GSH and GST) were enhanced moderately in the HP group. In contrast, HP rats showed a sharp reduction in white adipose tissue and lower basal concentrations of triglycerides, glucose, leptin, and insulin. Our study suggests that the long-term consumption of an HP diet in male rats has no deleterious effects and could prevent metabolic syndrome.

scholarly journals Comparison of body composition changes between low calorie high protein diet to standard protein in obese individuals with weight cycling – a randomised trial

F1000Research ◽  
2018 ◽  
Vol 7 ◽  
pp. 445 ◽  
Author(s):  
Joan Jutamulia ◽  
Adventia Natali Paranoan ◽  
Septian Ika Prasetya ◽  
Ninik Mudjihartini ◽  
Fiastuti Witjaksono
Keyword(s):  
Body Composition ◽  
Fat Mass ◽  
High Protein Diet ◽  
High Protein ◽  
Protein Diet ◽  
Weight Cycling ◽  
Low Calorie ◽  
Protein Group ◽  
History Of ◽  
Standard Protein

Background: The world prevalence of obesity in adult population in 2014 was nearly 13% while in Indonesia, it has reached 32.9% in the same year. Obesity is an established risk factors for cardiovascular diseases. A large proportion of people who had succeeded to reduce body weight failed to maintain it (weight cycling). Studies were inconclusive about the best composition in the diet for such people. The purpose of this research was to evaluate the body composition changes resulted from low calorie high protein and standard protein diet programme in obese people with history of weight cycling. Methods: This is an open-randomized clinical trial of weight loss program as a part of a larger study researching the effect of low calorie high protein diet to body composition, oxidative stress, inflammation marker and metabolic syndrome in obese with weight cycling. A total of 61 adult obese men and women with history of weight cycling were recruited. Subjects were assigned to low calorie diet and were randomly distributed into two intervention groups, namely high protein group (22-30 % of total calories intake) and standard protein group (12-20%). Anthropometry and body composition data were taken at baseline and at the end of the study. Subjects were followed up to 8 weeks with daily reminder and weekly counselling. Results: Fourty five participants completed the study. There were significant reductions in in body weight and body mass index (BMI), fat mass, fat mass percentage, muscle mass, and gain in muscle mass percentage occurred in both groups (Standard protein: P<0.001; High protein: P<0.001 for all variables except for fat mass P= 0,001) with no difference between group (P>0.05). Conclusion: Calories deficit with either high protein or standard protein for 8 weeks brought about significant reduction in body composition

554 A High Protein Diet Reduces Body Fat Mass and Alters the Gut Microbiome, With Expansion of Akkermansia, in a Rat Model of Diet-Induced Obesity

2016 ◽  
Vol 150 (4) ◽  
pp. S117
Author(s):  
Jonathan Jacobs ◽  
Lixin Wang ◽  
Mulugeta Million ◽  
Joseph R. Pisegna ◽  
Yvette Tache
Keyword(s):  
Body Fat ◽  
Fat Mass ◽  
Rat Model ◽  
Gut Microbiome ◽  
High Protein Diet ◽  
High Protein ◽  
Protein Diet ◽  
Body Fat Mass ◽  
Diet Induced Obesity

scholarly journals Long-Term Intake of a High-Protein Diet with or without Potassium Citrate Modulates Acid-Base Metabolism, but Not Bone Status, in Male Rats

2008 ◽  
Vol 138 (4) ◽  
pp. 718-724 ◽  
Author(s):  
Julie Mardon ◽  
Véronique Habauzit ◽  
Anna Trzeciakiewicz ◽  
Marie-Jeanne Davicco ◽  
Patrice Lebecque ◽  
...  
Keyword(s):  
High Protein Diet ◽  
Potassium Citrate ◽  
High Protein ◽  
Protein Diet ◽  
Male Rats ◽  
Acid Base ◽  
Bone Status
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