Hemodynamic responses during graded and constant-load plantar flexion exercise in middle-aged men and women with type 2 diabetes

We tested the hypotheses that type 2 diabetes (T2D) impairs the 1) leg hemodynamic responses to an incremental intermittent plantar-flexion exercise and 2) dynamic responses of leg vascular conductance (LVC) during low-intensity (30% maximal voluntary contraction, MVC) and high-intensity (70% MVC) constant-load plantar-flexion exercise in the supine posture. Forty-four middle-aged individuals with T2D (14 women), and 35 healthy nondiabetic (ND) individuals (18 women) were tested. Leg blood flow (LBF) was measured between each contraction using venous occlusion plethysmography. During the incremental test peak force (Fpeak) relative to MVC was significantly reduced ( P < 0.05) in men and women with T2D compared with their respective nondiabetic counterparts. Peak LBF and the slope of LBF relative to percentage Fpeak were also reduced ( P < 0.05) in women with T2D compared with healthy women (peak blood flow, 460.6 ± 126.8 vs. 628.3 ± 347.7 ml/min; slope, 3.78 ± 1.74 vs. 5.85 ± 3.14 ml·min−1·%Fpeak−1) and in men with T2D compared with nondiabetic men (peak blood flow, 621.7 ± 241.3 vs. 721.2 ± 359.7 ml/min; slope, 5.75 ± 2.66 vs. 6.33 ± 3.63 ml·min−1·%Fpeak−1). During constant-load contractions at 30% MVC T2D did not affect the dynamic responses of LVC (LBF/MAP). However, at 70% MVC [completed by a subgroup of participants (20 with T2D, 6 women; 13 ND, 6 women)] the time constant of the second growth phase of LVC was longer and the amplitude of the first growth phase was lower ( P < 0.05 for both) in men and women with T2D. The results suggest that the T2D-induced impairments in performance of the leg muscles are related to reductions in blood flow in both men and women.

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Similar level of impairment in exercise performance and oxygen uptake kinetics in middle-aged men and women with type 2 diabetes

AJP Regulatory Integrative and Comparative Physiology ◽

10.1152/ajpregu.00012.2012 ◽

2012 ◽

Vol 303 (1) ◽

pp. R70-R76 ◽

Cited By ~ 29

Author(s):

Eamonn O'Connor ◽

Catherine Kiely ◽

Donal O'Shea ◽

Simon Green ◽

Mikel Egaña

Keyword(s):

Type 2 Diabetes ◽

Oxygen Uptake ◽

Ventilatory Threshold ◽

Constant Load ◽

Peak Oxygen Uptake ◽

Oxygen Uptake Kinetics ◽

Dynamic Responses ◽

Middle Aged ◽

Men And Women

The present study tested the hypothesis that the magnitude of the type 2 diabetes-induced impairments in peak oxygen uptake (V̇o2) and V̇o2 kinetics would be greater in females than males in middle-aged participants. Thirty-two individuals with type 2 diabetes (16 male, 16 female), and 32 age- and body mass index (BMI)-matched healthy individuals (16 male, 16 female) were recruited. Initially, the ventilatory threshold (VT) and peak V̇o2 were determined. On a separate day, subjects completed four 6-min bouts of constant-load cycling at 80% VT for the determination of V̇o2 kinetics using standard procedures. Cardiac output (CO) (inert gas rebreathing) was recorded at rest, 30, and 240 s during two additional bouts. Peak V̇o2 (ml·kg−1·min−1) was significantly reduced in men and women with type 2 diabetes compared with their respective nondiabetic counterparts (men, 27.8 ± 4.4 vs. 31.1 ± 6.2 ml·kg−1·min−1; women, 19.4 ± 4.1 vs. 21.4 ± 2.9 ml·kg−1·min−1). The time constant (s) of phase 2 (τ2) and mean response time (s) of the V̇o2 response (MRT) were slowed in women with type 2 diabetes compared with healthy women (τ2, 43.3 ± 9.8 vs. 33.6 ± 10.0 s; MRT, 51.7 ± 9.4 vs. 43.5 ± 11.4s) and in men with type 2 diabetes compared with nondiabetic men (τ2, 43.8 ± 12.0 vs. 35.3 ± 9.5 s; MRT, 57.6 ± 8.3 vs. 47.3 ± 9.3 s). The magnitude of these impairments was not different between males and females. The steady-state CO responses or the dynamic responses of CO were not affected by type 2 diabetes among men or women. The results suggest that the type 2 diabetes-induced impairments in peak V̇o2 and V̇o2 kinetics are not affected by sex in middle aged participants.

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Lack of age-specific influence on leg blood flow during incremental calf plantar-flexion exercise in men and women

European Journal of Applied Physiology ◽

10.1007/s00421-018-3833-z ◽

2018 ◽

Vol 118 (5) ◽

pp. 989-1001 ◽

Cited By ~ 2

Author(s):

Heather Reilly ◽

Louise M. Lane ◽

Mikel Egaña

Keyword(s):

Blood Flow ◽

Plantar Flexion ◽

Men And Women ◽

Leg Blood Flow ◽

Specific Influence ◽

Plantar Flexion Exercise

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159-OR: Changes in Dairy Product Consumption and Risk of Type 2 Diabetes among U.S. Men and Women

Diabetes ◽

10.2337/db19-159-or ◽

2019 ◽

Vol 68 (Supplement 1) ◽

pp. 159-OR

Author(s):

JEAN-PHILIPPE DROUIN-CHARTIER ◽

YANPING LI ◽

ANDRES V. ARDISSON KORAT ◽

MING DING ◽

BENOÎT LAMARCHE ◽

...

Keyword(s):

Type 2 Diabetes ◽

Dairy Product ◽

Men And Women ◽

Product Consumption ◽

Dairy Product Consumption

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1645-P: Polygenic Risk Score for Prediction of Complications in Men and Women with Type 2 Diabetes

Diabetes ◽

10.2337/db20-1645-p ◽

2020 ◽

Vol 69 (Supplement 1) ◽

pp. 1645-P

Author(s):

JOHANNE TREMBLAY ◽

REDHA ATTAOUA ◽

MOUNSIF HALOUI ◽

RAMZAN TAHIR ◽

CAROLE LONG ◽

...

Keyword(s):

Type 2 Diabetes ◽

Risk Score ◽

Polygenic Risk Score ◽

Men And Women ◽

Polygenic Risk ◽

Prediction Of Complications

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1715-P: Impaired Postprandial Adipose Tissue Microvascular Blood Flow in Healthy People with a Family History of Type 2 Diabetes

Diabetes ◽

10.2337/db20-1715-p ◽

2020 ◽

Vol 69 (Supplement 1) ◽

pp. 1715-P

Author(s):

KATHERINE ROBERTS-THOMSON ◽

RYAN D. RUSSELL ◽

DONGHUA HU ◽

TIMOTHY M. GREENAWAY ◽

ANDREW C. BETIK ◽

...

Keyword(s):

Type 2 Diabetes ◽

Blood Flow ◽

Adipose Tissue ◽

Family History ◽

Healthy People ◽

Microvascular Blood Flow ◽

History Of

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Trabecular Bone Score in Thais with or without Type 2 Diabetes

Journal of the Medical Association of Thailand ◽

10.35755/jmedassocthai.2020.11.11245 ◽

2020 ◽

Vol 103 (11) ◽

pp. 1131-1137

Keyword(s):

Diabetes Mellitus ◽

Bone Mineral Density ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Fracture Risk ◽

Trabecular Bone ◽

Trabecular Bone Score ◽

Mineral Density ◽

Men And Women

Background: When compared to people without type 2 diabetes mellitus (T2DM), people with T2DM have an increase in fracture risk despite having higher bone mineral density (BMD). Many studies in Caucasians demonstrated that trabecular bone score (TBS) is lower in people with T2DM than those without. The utility of TBS as a fracture risk assessment tool in Asians with T2DM is currently unclear. Objective: To compared lumbar spine (LS) BMD and TBS in Thais with or without T2DM and investigate the correlation between TBS and hemoglobin A1c (HbA1c) and diabetes duration in participants with T2DM. Materials and Methods: The present study was a cross-sectional study that included 97 participants with T2DM (37 men and 60 women) and 342 participants without T2DM (174 men and 168 women). LS-BMD and TBS were obtained. Results: Men and women with T2DM were older and had higher body mass index (BMI). Men with T2DM had significant higher LS-BMD (1.051±0.166 versus 0.972±0.125, p=0.009) and non-significant lower TBS (1.333±0.084 versus 1.365±0.096, p=0.055) than those without. Similarly, women with T2DM had significant higher LS-BMD (0.995±0.155 versus 0.949±0.124, p=0.021) and lower TBS (1.292±0.105 versus 1.382±0.096, p<0.001). After adjusting for age and BMI, T2DM predicted higher BMD in men (p<0.001), but not in women (p=0.143). T2DM was not associated with TBS after adjusting for age and BMI in both genders (p=0.403 and p=0.151 in men and women, respectively). TBS did not correlate with HbA1c in both genders. However, TBS was non-significantly associated with diabetes duration in women (p=0.073), but not in men (p=0.639). Conclusion: T2DM significantly predicted higher LS-BMD only in men and was not independently associated with TBS in both genders. These data highlighted that, in T2DM, there was some variation in the clinical usefulness of BMD and TBS in predicting osteoporotic fractures with regard to clinical characteristic of participants. Keywords: Bone mineral density, Type 2 diabetes mellitus, Trabecular bone score

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Are there sex differences in the effect of type 2 diabetes in the incidence and outcomes of myocardial infarction? A matched-pair analysis using hospital discharge data

Cardiovascular Diabetology ◽

10.1186/s12933-021-01273-y ◽

2021 ◽

Vol 20 (1) ◽

Author(s):

Ana Lopez-de-Andres ◽

Rodrigo Jimenez-Garcia ◽

Valentin Hernández-Barrera ◽

Jose M. de Miguel-Yanes ◽

Romana Albaladejo-Vicente ◽

...

Keyword(s):

Myocardial Infarction ◽

Type 2 Diabetes ◽

Sex Differences ◽

Propensity Score ◽

Propensity Score Matching ◽

Hospital Discharge ◽

St Elevation Myocardial Infarction ◽

Men And Women ◽

St Elevation

Abstract Background To analyze incidence, use of therapeutic procedures, and in-hospital outcomes in patients with ST elevation myocardial infarction (STEMI) and non-ST elevation myocardial infarction (NSTEMI) according to the presence of type 2 diabetes (T2DM) in Spain (2016–2018) and to investigate sex differences. Methods Using the Spanish National Hospital Discharge Database, we estimated the incidence of myocardial infarctions (MI) in men and women with and without T2DM aged ≥ 40 years. We analyzed comorbidity, procedures, and outcomes. We matched each man and woman with T2DM with a non-T2DM man and woman of identical age, MI code, and year of hospitalization. Propensity score matching was used to compare men and women with T2DM. Results MI was coded in 109,759 men and 44,589 women (30.47% with T2DM). The adjusted incidence of STEMI (IRR 2.32; 95% CI 2.28–2.36) and NSTEMI (IRR 2.91; 95% CI 2.88–2.94) was higher in T2DM than non-T2DM patients, with higher IRRs for NSTEMI in both sexes. The incidence of STEMI and NSTEMI was higher in men with T2DM than in women with T2DM. After matching, percutaneous coronary intervention (PCI) was less frequent among T2DM men than non-T2DM men who had STEMI and NSTEMI. Women with T2DM and STEMI less frequently had a code for PCI that matched that of non-T2DM women. In-hospital mortality (IHM) was higher among T2DM women with STEMI and NSTEMI than in matched non-T2DM women. In men, IHM was higher only for NSTEMI. Propensity score matching showed higher use of PCI and coronary artery bypass graft and lower IHM among men with T2DM than women with T2DM for both STEMI and NSTEMI. Conclusions T2DM is associated with a higher incidence of STEMI and NSTEMI in both sexes. Men with T2DM had higher incidence rates of STEMI and NSTEMI than women with T2DM. Having T2DM increased the risk of IHM after STEMI and NSTEMI among women and among men only for NSTEMI. PCI appears to be less frequently used in T2DM patients After STEMI and NSTEMI, women with T2DM less frequently undergo revascularization procedures and have a higher mortality risk than T2DM men.

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P-174: Type 2 diabetes and cognitive decline in a large sample of community-dwelling older men and women

Alzheimer s & Dementia ◽

10.1016/j.jalz.2007.04.137 ◽

2007 ◽

Vol 3 (3S_Part_2) ◽

pp. S154-S154

Author(s):

Olivia I. Okereke ◽

Jae H. Kang ◽

Nancy R. Cook ◽

J. Michael Gaziano ◽

JoAnn E. Manson ◽

...

Keyword(s):

Type 2 Diabetes ◽

Cognitive Decline ◽

Older Men ◽

Community Dwelling ◽

Men And Women ◽

Large Sample ◽

Older Men And Women

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Lipoprotein(a) and Risk of Type 2 Diabetes

Clinical Chemistry ◽

10.1373/clinchem.2010.146779 ◽

2010 ◽

Vol 56 (8) ◽

pp. 1252-1260 ◽

Cited By ~ 99

Author(s):

Samia Mora ◽

Pia R Kamstrup ◽

Nader Rifai ◽

Børge G Nordestgaard ◽

Julie E Buring ◽

...

Keyword(s):

Risk Factors ◽

Type 2 Diabetes ◽

Cardiovascular Risk ◽

Men And Women ◽

Lipoprotein A ◽

Incident Type ◽

Reactive Protein ◽

Hb A1c ◽

Hormone Use

BACKGROUND Previous studies have demonstrated that cardiovascular risk is higher with increased lipoprotein(a) [Lp(a)]. Whether Lp(a) concentration is related to type 2 diabetes is unclear. METHODS In 26 746 healthy US women (mean age 54.6 years), we prospectively examined baseline Lp(a) concentrations and incident type 2 diabetes (n = 1670) for a follow-up period of 13 years. We confirmed our findings in 9652 Danish men and women with prevalent diabetes (n = 419). Analyses were adjusted for risk factors that included age, race, smoking, hormone use, family history, blood pressure, body mass index, hemoglobin A1c (Hb A1c), C-reactive protein, and lipids. RESULTS Lp(a) was inversely associated with incident diabetes, with fully adjusted hazard ratios (HRs) and 95% CIs for quintiles 2–5 vs quintile 1 of 0.87 (0.75–1.01), 0.80 (0.68–0.93), 0.88 (0.76–1.02), and 0.78 (0.67–0.91); P for trend 0.002. The association was stronger in nonfasting women, for whom respective HRs were 0.79 (0.58–1.09), 0.78 (0.57–1.08), 0.66 (0.46–0.93), and 0.56 (0.40–0.80); P for trend 0.001; P for interaction with fasting status 0.002. When we used Lp(a) ≥10 mg/L and Hb A1c <5% as reference values, the adjusted HRs were 1.62 (0.91–2.89) for Lp(a) <10 mg/L and Hb A1c <5%, 3.50 (3.06–4.01) for Lp(a)≥10 mg/L and Hb A1c 5%–<6.5%, and 5.36 (4.00–7.19) for Lp(a) <10 mg/L and Hb A1c 5%–<6.5%. Results were similar in nonfasting Danish men and women, for whom adjusted odds ratios were 0.75 (0.55–1.03), 0.64 (0.46–0.88), 0.74 (0.54–1.01), and 0.58 (0.42–0.79) for Lp(a) quintiles 2–5 vs quintile 1; P for trend 0.002. CONCLUSIONS Our results indicated that Lp(a) was associated inversely with risk of type 2 diabetes independently of risk factors, in contrast to prior findings of positive associations of Lp(a) with cardiovascular risk.

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