scholarly journals When energy balance is maintained, exercise does not induce negative fat balance in lean sedentary, obese sedentary, or lean endurance-trained individuals

2009 ◽  
Vol 107 (6) ◽  
pp. 1847-1856 ◽  
Author(s):  
Edward L. Melanson ◽  
Wendolyn S. Gozansky ◽  
Daniel W. Barry ◽  
Paul S. MacLean ◽  
Gary K. Grunwald ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Fatty Acid ◽  
Energy Balance ◽  
Fat Oxidation ◽  
Substrate Oxidation ◽  
Acute Effects ◽  
Sedentary Control ◽  
Men And Women ◽  
Energy Replacement ◽  
The Impact

Fat oxidation during exercise is increased by endurance training, and evidence suggests that fat oxidation during exercise is impaired in obesity. Thus the primary aim of this study was to compare the acute effects of exercise on 24-h fat oxidation and fat balance in lean sedentary [LS, n = 10, body mass index (BMI) = 22.5 ± 6.5 kg/m2], lean endurance-trained (LT, n = 10, BMI = 21.2 ± 1.2 kg/m2), and obese sedentary (OS, n = 7, BMI = 35.5 ± 4.4 kg/m2) men and women. Twenty-four-hour energy expenditure and substrate oxidation were measured under sedentary (control; CON) and exercise (EX) conditions while maintaining energy balance. During EX, subjects performed 1 h of stationary cycling at 55% of aerobic capacity. Twenty-four-hour fat oxidation did not differ on the CON or EX day in LS (43 ± 9 vs. 29 ± 7 g/day, respectively), LT (53 ± 8 vs. 42 ± 5 g/day), or OS (58 ± 7 vs. 80 ± 9 g/day). However, 24-h fat balance was significantly more positive on EX compared with CON ( P < 0.01). Twenty-four-hour glucose, insulin, and free fatty acid (FFA) profiles were similar on the EX and CON days, but after consumption of the first meal, FFA concentrations remained below fasting levels for the remainder of the day. These data suggest that when exercise is performed with energy replacement (i.e., energy balance is maintained), 24-h fat oxidation does not increase and in fact, may be slightly decreased. It appears that the state of energy balance is an underappreciated factor determining the impact of exercise on fat oxidation.

scholarly journals Changes in Energy Expenditure and Substrate Oxidation Resulting from Weight Loss in Obese Men and Women: Is There an Important Contribution of Leptin?1

2000 ◽  
Vol 85 (4) ◽  
pp. 1550-1556 ◽  
Author(s):  
Eric Doucet ◽  
Sylvie St. Pierre ◽  
Natalie Alméras ◽  
Pascale Mauriège ◽  
Denis Richard ◽  
...  
Keyword(s):  
Weight Loss ◽  
Energy Expenditure ◽  
Resting Energy Expenditure ◽  
Fat Oxidation ◽  
Substrate Oxidation ◽  
Energy Restriction ◽  
Fat Free Mass ◽  
Hormonal Changes ◽  
Men And Women ◽  
The Impact

The aim of the present study was to determine the impact of weight loss and its related metabolic and hormonal changes on resting energy expenditure (REE) and substrate oxidation. Forty subjects (16 men and 24 women) took part in a 15-week weight loss program that consisted of drug therapy (fenfluramine, 60 mg/day) or placebo coupled to an energy restriction (−700 Cal/day). Subjects were asked to come to the laboratory after an overnight fast for an indirect calorimetry measurement before and after weight loss. Fasting blood samples were also drawn and were analyzed for plasma glucose, insulin, leptin, and free fatty acid determinations. This program reduced body weight by 11% and 9% (P &lt; 0.01) in men and women, respectively. Fat mass (FM) and fat-free mass (FFM) were also significantly reduced in both sexes. A significant decrease in REE (13%; P &lt; 0.01) and fat oxidation (11%; P = 0.08) was observed in men in response to this program, whereas no significant differences were noted for these variables in women. In men, positive correlations were found between changes in FFM and energy-related variables, whereas the best predictor of changes in REE and substrate oxidation was the change in FM in women. The most important finding of this study is that in men, the association between changes in fasting plasma leptin and changes in REE (r = 0.50; P &lt; 0.01) and fat oxidation (r = 0.63; P &lt; 0.01) persist after correction for changes in body composition. These results suggest that a comparable weight loss is accompanied by a greater decrease in REE and substrate oxidation in men than in women, and that these changes are better explained by changes in leptinemia in men and by changes in FM in women.

scholarly journals Determinants of plasma dihydrophylloquinone in men and women

2005 ◽  
Vol 93 (5) ◽  
pp. 701-708 ◽  
Author(s):  
Arja T. Erkkilä ◽  
Alice H. Lichtenstein ◽  
Paul F. Jacques ◽  
Frank B. Hu ◽  
Peter W. F. Wilson ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Fatty Acid ◽  
Odds Ratio ◽  
Geometric Mean ◽  
Population Based ◽  
Unintended Consequence ◽  
Fatty Acid Intake ◽  
Food Frequency ◽  
Men And Women ◽  
Acid Intake

Commercial hydrogenation results in the formation of trans fatty acids. An unintended consequence of the hydrogenation process is conversion of phylloquinone (vitamin K1) to dihydrophylloquinone. Plasma dihydrophylloquinone concentrations have yet to be characterized in population-based studies. Dietary determinants of plasma dihydrophylloquinone were estimated using a semi-quantitative food frequency questionnaire in 803 men and 913 women in the Framingham Offspring Study. Geometric mean dihydrophylloquinone intake was 21·3 (95 % CI 20·4, 22·3) μg/d in men and 19·4 (95 % CI 18·5, 20·2) μg/d in women. Detectable (>0·05 nmol/l) plasma dihydrophylloquinone concentrations were measured in 41 % and 30 % of men and women, respectively. The multivariate odds ratio (OR) of detectable plasma dihydrophylloquinone from the lowest to the highest quartile category of dihydrophylloquinone intake were 1 (referent), 1·13 (95 % CI 0·83, 1·53), 1·66 (95 % CI 1·21, 2·26) and 1·84 (95 % CI 1·31, 2·58), P for trend <0·001, adjusted for sex, age, body mass index, triacylglycerols, season and energy intake. Higher trans fatty acid intake was associated with higher multivariate OR for detectable plasma dihydrophylloquinone (OR comparing extreme quartiles 2·41 (95 % CI 1·59, 3·64), P for trend <0·001). There were limitations in the use of plasma dihydrophylloquinone, evident in the high proportion of the population that had non-detectable dihydrophylloquinone concentrations. Despite this caveat, higher plasma dihydrophylloquinone was associated with higher dihydrophylloquinone intake and higher trans fatty acid intake.

scholarly journals Peak Fat Oxidation Rate Is Closely Associated With Plasma Free Fatty Acid Concentrations in Women; Similar to Men

2021 ◽  
Vol 12 ◽  
Author(s):  
Jacob Frandsen ◽  
Axel Illeris Poggi ◽  
Christian Ritz ◽  
Steen Larsen ◽  
Flemming Dela ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Free Fatty Acid ◽  
Plasma Free Fatty Acid ◽  
Fat Oxidation ◽  
Whole Body ◽  
Men And Women ◽  
Fed State ◽  
Repeated Exercise ◽  
Graded Exercise ◽  
Plasma Ffa

Introduction: In men, whole body peak fat oxidation (PFO) determined by a graded exercise test is closely tied to plasma free fatty acid (FFA) availability. Men and women exhibit divergent metabolic responses to fasting and exercise, and it remains unknown how the combined fasting and exercise affect substrate utilization in women. We aimed to investigate this, hypothesizing that increased plasma FFA concentrations in women caused by fasting and repeated exercise will increase PFO during exercise. Then, that PFO would be higher in women compared with men (data from a previous study).Methods: On two separate days, 11 young endurance-trained women were investigated, either after an overnight fast (Fast) or 3.5 h after a standardized meal (Fed). On each day, a validated graded exercise protocol (GXT), used to establish PFO by indirect calorimetry, was performed four times separated by 3.5 h of bed rest both in the fasted (Fast) or fed (Fed) state.Results: Peak fat oxidation increased in the fasted state from 11 ± 3 (after an overnight fast, Fast 1) to 16 ± 3 (mean ± SD) mg/min/kg lean body mass (LBM) (after ~22 h fast, Fast 4), and this was highly associated with plasma FFA concentrations, which increased from 404 ± 203 (Fast 1) to 865 ± 210 μmol/L (Fast 4). No increase in PFO was found during the fed condition with repeated exercise. Compared with trained men from a former identical study, we found no sex differences in relative PFO (mg/min/kg LBM) between men and women, in spite of significant differences in plasma FFA concentrations during exercise after fasting.Conclusion: Peak fat oxidation increased with fasting and repeated exercise in trained women, but the relative PFO was similar in young trained men and women, despite major differences in plasma lipid concentrations during graded exercise.

scholarly journals Acute Effects of Capsaicin on Energy Expenditure and Fat Oxidation in Negative Energy Balance

PLoS ONE ◽  
2013 ◽  
Vol 8 (7) ◽  
pp. e67786 ◽  
Author(s):  
Pilou L. H. R. Janssens ◽  
Rick Hursel ◽  
Eveline A. P. Martens ◽  
Margriet S. Westerterp-Plantenga
Keyword(s):  
Energy Balance ◽  
Energy Expenditure ◽  
Fat Oxidation ◽  
Negative Energy ◽  
Negative Energy Balance ◽  
Acute Effects

scholarly journals Effect of frequent interruptions of sedentary time on nutrient metabolism in sedentary overweight male and female adults

2019 ◽  
Vol 126 (4) ◽  
pp. 984-992 ◽  
Author(s):  
Nathan P. De Jong ◽  
Corey A. Rynders ◽  
David A. Goldstrohm ◽  
Zhaoxing Pan ◽  
Andrew H. Lange ◽  
...  
Keyword(s):  
Physical Activity ◽  
Energy Balance ◽  
Energy Expenditure ◽  
Dietary Fat ◽  
Sedentary Time ◽  
Fat Oxidation ◽  
Substrate Oxidation ◽  
Carbohydrate Oxidation ◽  
Moderate Intensity ◽  
Dietary Fat Oxidation

This study compared 24-h nutrient oxidation responses between a sedentary condition (SED) and a condition in which short 5-min bouts of moderate-intensity physical activity were performed hourly for nine consecutive hours over 4 days (MICRO). To determine whether any shifts in fuel use were due solely to increases in energy expenditure, we also studied a condition consisting of a single isoenergetic 45-min bout of moderate-intensity exercise (ONE). Twenty sedentary overweight or obese adults (10 men/10 women; 32.4 ± 6.3 yr; BMI, 30.6 ± 2.9 kg/m2) completed all three conditions (MICRO, SED, and ONE) in a randomized order. Each condition consisted of a 3-day free-living run-in followed by a 24-h stay in a whole-room calorimeter to measure total energy expenditure (TEE) and substrate utilization. Dietary fat oxidation was also assessed during the chamber stay by administering a [1-13C] oleic acid tracer at breakfast. Energy intake was matched across conditions. Both MICRO and ONE increased TEE relative to SED, resulting in a negative energy balance. HOMA-IR improved in both activity conditions. MICRO increased 24-h carbohydrate oxidation compared with both ONE and SED ( P < 0.01 for both). ONE was associated with higher 24-h total fat oxidation compared with SED, and higher 24-h dietary fat oxidation compared with both SED and MICRO. Differences in substrate oxidation remained significant after adjusting for energy balance. In overweight and obese men and women, breaking up sitting time increased reliance upon carbohydrate as fuel over 24 h, while a single energy-matched continuous bout of exercise preferentially relies upon fat over 24 h. NEW & NOTEWORTHY Insulin sensitivity, as assessed by HOMA-IR, was improved after 4 days of physical activity, independent of frequency and duration of activity bouts. Temporal patterns of activity across the day differentially affect substrate oxidation. Frequent interruptions of sedentary time with short bouts of walking primarily increase 24-h carbohydrate oxidation, whereas an energy-matched single continuous bout of moderate intensity walking primarily increased 24-h fat oxidation.

scholarly journals Cross talk between physical activity and appetite control: does physical activity stimulate appetite?

2003 ◽  
Vol 62 (3) ◽  
pp. 651-661 ◽  
Author(s):  
J. E. Blundell ◽  
R. J. Stubbs ◽  
D. A. Hughes ◽  
S. Whybrow ◽  
N. A. King
Keyword(s):  
Physical Activity ◽  
Energy Balance ◽  
Food Intake ◽  
Weight Control ◽  
Negative Energy ◽  
Positive Energy ◽  
Exact Nature ◽  
Appetite Control ◽  
Men And Women ◽  
The Impact

Physical activity has the potential to modulate appetite control by improving the sensitivity of the physiological satiety signalling system, by adjusting macronutrient preferences or food choices and by altering the hedonic response to food. There is evidence for all these actions. Concerning the impact of physical activity on energy balance, there exists a belief that physical activity drives up hunger and increases food intake, thereby rendering it futile as a method of weight control. There is, however, no evidence for such an immediate or automatic effect. Short (1–2 d)-term and medium (7–16 d)-term studies demonstrate that men and women can tolerate substantial negative energy balances of ≤4MJ energy cost/d when performing physical activity programmes. Consequently, the immediate effect of taking up exercise is weight loss (although this outcome is sometimes difficult to assess due to changes in body composition or fluid compartmentalization). However, subsequently food intake begins to increase in order to provide compensation for about 30% of the energy expended in activity. This compensation (up to 16 d) is partial and incomplete. Moreover, subjects separate into compensators and non-compensators. The exact nature of these differences in compensation and whether it is actually reflective of non-compliance with protocols is yet to be determined. Some subjects (men and women) performing activity with a cost of ≤4 MJ/d for 14 d, show no change in daily energy intake. Conversely, it can be demonstrated that when active individuals are forced into a sedentary routine food intake does not decrease to a lower level to match the reduced energy expenditure. Consequently, this situation creates a substantial positive energy balance accompanied by weight gain. The next stage is to further characterize the compensators and non-compensators, and to identify the mechanisms (physiological or behavioural) that are responsible for the rate of compensation and its limits.

Energy deficit without reducing dietary carbohydrate alters resting carbohydrate oxidation and fatty acid availability

2005 ◽  
Vol 98 (5) ◽  
pp. 1612-1618 ◽  
Author(s):  
Jeffrey F. Horowitz ◽  
Amy E. Kaufman ◽  
Amanda K. Fox ◽  
Matthew P. Harber
Keyword(s):  
Fatty Acid ◽  
Energy Balance ◽  
Mrna Expression ◽  
Vastus Lateralis ◽  
Fold Increase ◽  
Peak Oxygen Uptake ◽  
Pyruvate Dehydrogenase Kinase ◽  
Energy Deficit ◽  
Low Fat Diet ◽  
The Impact

Reduced carbohydrate (CHO) availability after exercise has a potent influence on the regulation of substrate metabolism, but little is known about the impact of fat availability and/or energy deficit on fuel metabolism when dietary CHO availability is not reduced. The purpose of this study was to determine the influence of a postexercise energy deficit, independent of CHO availability, on plasma substrate concentrations and substrate oxidation. Seven moderately trained men (peak oxygen uptake: 56 ± 2 ml·kg−1·min−1) performed exhaustive cycling exercise on two separate occasions. The two trials differed only by the meals ingested after exercise: 1) a high-fat diet designed to maintain energy balance or 2) a low-fat diet designed to elicit energy deficit. The CHO and protein contents of the diets were identical. The next morning, we measured plasma substrate and insulin concentrations and CHO oxidation, and we obtained muscle biopsies from the vastus lateralis for measurement of pyruvate dehydrogenase kinase (PDK)-2 and PDK-4 mRNA expression by using RT-PCR. Despite identical blood glucose (5.0 ± 0.1 and 4.9 ± 0.1 mM) and insulin (7.9 ± 1.1 and 8.4 ± 0.9 μU/ml) concentrations, plasma fatty acid and glycerol concentrations were elevated three- to fourfold during energy deficit compared with energy balance and CHO oxidation was 40% lower ( P < 0.01) the morning after energy deficit compared with energy balance (328 ± 69 and 565 ± 89 μmol/min). The lower CHO oxidation was accompanied by a 7.3 ± 2.5-fold increase in PDK-4 mRNA expression after energy deficit ( P < 0.05), whereas PDK-2 mRNA was similar between the trials. In conclusion, energy deficit increases fatty acid availability, increases PDK-4 mRNA expression, and suppresses CHO oxidation even when dietary CHO content is not reduced.

scholarly journals Acute effects on metabolism and appetite profile of one meal difference in the lower range of meal frequency

2008 ◽  
Vol 99 (6) ◽  
pp. 1316-1321 ◽  
Author(s):  
Astrid J. Smeets ◽  
Margriet S. Westerterp-Plantenga
Keyword(s):  
Energy Balance ◽  
Energy Expenditure ◽  
Fat Oxidation ◽  
Substrate Oxidation ◽  
Normal Weight ◽  
Meal Frequency ◽  
Experimental Conditions ◽  
Respiration Chamber ◽  
Large Fluctuations ◽  
Diet Induced Thermogenesis

A gorging pattern of food intake has been shown to enhance lipogenesis and increase body weight, which may be due to large fluctuations in storage and mobilisation of nutrients. In a state of energy balance, increasing meal frequency, and thereby decreasing inter-meal interval, may prevent large metabolic fluctuations. Our aim was to study the effect of the inter-meal interval by dividing energy intake over two or three meals on energy expenditure, substrate oxidation and 24 h satiety, in healthy, normal-weight women in a state of energy balance. The study was a randomised crossover design with two experimental conditions. During the two experimental conditions subjects (fourteen normal-weight women, aged 24·4 (sd 7·1) years, underwent 36 h sessions in energy balance in a respiration chamber for measurements of energy expenditure and substrate oxidation. The subjects were given two (breakfast, dinner) or three (breakfast, lunch, dinner) meals per d. We chose to omit lunch in the two meals condition, because this resulted in a marked difference in inter-meal-interval after breakfast (8·5 h v. 4 h). Eating three meals compared with two meals had no effects on 24 h energy expenditure, diet-induced thermogenesis, activity-induced energy expenditure and sleeping metabolic rate. Eating three meals compared with two meals increased 24 h fat oxidation, but decreased the amount of fat oxidised from the breakfast. The same amount of energy divided over three meals compared with over two meals increased satiety feelings over 24 h. In healthy, normal-weight women, decreasing the inter-meal interval sustains satiety, particularly during the day, and sustains fat oxidation, particularly during the night.

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