Comparison of Different Anthropometric Measurements and Inflammatory Biomarkers

Introduction.Different anthropometric variables have been shown to be related to cardiovascular morbidity and mortality. Our aim was to compare the association between different anthropometric measurements and inflammatory status.Methods and results.A cross-sectional study design in which we analyzed the data collected during a five-year period in the Tel Aviv Medical Center Inflammation Survey (TAMCIS). Included in the study were 13,033 apparently healthy individuals at a mean (SD) age of 43. Of these, 8,292 were male and 4,741 female. A significant age-adjusted and multiple-adjusted partial correlation was noted between all anthropometric measurements and all inflammatory biomarkers. There was no significant difference in the correlation coefficients between different biomarkers and anthropometric variables.Conclusion.Most of the common used anthropometric variables are similarly correlated with inflammatory variables. The clinician can choose the variable that he/she finds easiest to use.

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Polymorphism in Vitamin D-Binding Protein as a Genetic Risk Factor in the Pathogenesis of Endometriosis

Endocrine Reviews ◽

10.1210/edrv.31.6.9988 ◽

2010 ◽

Vol 31 (6) ◽

pp. 943-944

Author(s):

Klaus Faserl ◽

Georg Golderer ◽

Leopold Kremser ◽

Herbert Lindner ◽

Bettina Sarg ◽

...

Keyword(s):

Vitamin D ◽

Risk Factor ◽

Acute Phase Proteins ◽

Binding Protein ◽

Medical Center ◽

Cross Sectional Study ◽

Vitamin D Binding Protein ◽

Complement Components ◽

Cross Sectional ◽

Significant Difference

Context Previous studies have implicated a deficiency in the inflammatory response in women who develop endometriosis. The specific immunological deficits have not been completely elucidated. Objective Our objective was to identify differences in protein expression in serum that might shed light on the pathophysiology of endometriosis. Design and Setting This cross-sectional study of women undergoing laparoscopy between 2003 and 2005 took place at a university medical center. Patients Patients included consenting women age 18-49 yr undergoing surgery for pain and/or infertility or elective tubal ligation. Women with acute or chronic medical conditions were excluded. Intervention Blood was collected preoperatively. Main Outcome Measure Proteomic analysis of serum was done using two-dimensional difference gel electrophoresis. Results We found 25 protein spots with a significant difference in abundance between women with endometriosis and controls, including acute-phase proteins and complement components. The abundance of vitamin D-binding protein was higher in all endometriosis pools by a factor of approximately 3 compared with the control pool (P < 0.02). Analysis of specific allele products using nano-LC-ESI-MS indicated that it was the GC*2 allele product that was in greater concentration in serum pools, as well as in single validation samples, in women with endometriosis (P = 0.006). In contrast to the GC*1 allele product, which is readily converted to a potent macrophage factor (Gc protein-derived macrophage-activating factor), the GC*2 allele product undergoes practically no such conversion. Conclusions We speculate that the inability to sufficiently activate macrophages’ phagocytotic function in those carrying the GC*2 polymorphism (more prevalent in endometriosis) may allow endometriotic tissues to implant in the peritoneal cavity. Future studies evaluating specific vitamin D-binding protein polymorphisms as a risk factor for endometriosis in larger populations of women are warranted.

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Frequency and Causes of Consuming Sports Supplements and Understanding their Side Effects Among Bodybuilders in Fitness Gyms of Kermanshah City

Current Nutrition & Food Science ◽

10.2174/1573401315666181218150450 ◽

2019 ◽

Vol 15 (7) ◽

pp. 735-744

Author(s):

Nadya Baharirad ◽

Saeid Komasi ◽

Alireza Khatooni ◽

Farideh Moradi ◽

Ali Soroush

Keyword(s):

Side Effects ◽

Female Athletes ◽

Correlation Coefficients ◽

Simple Random Sampling ◽

Cross Sectional Study ◽

Sufficient Information ◽

Chi Square ◽

Cross Sectional ◽

Sports Supplements ◽

Significant Difference

Background: Nowadays, paying attention to sports nutrition, particularly focus on using supplements among athletes is increasing rapidly. Objective: This study has been carried out in order to investigate the frequency and causes of consuming supplements and understanding the side effects related to their consumption among bodybuilders in Kermanshah City. Methods: The samples of this cross-sectional study include teenagers and young adults who are the members of fitness gyms around Kermanshah City. 244 individuals were selected as samples using simple random sampling. In order to gather the required data, a four-sectioned questionnaire designed by the research team was used. The data analysis was done using chi-square, independent ttest, and Pearson's and Spearman's correlation coefficients by SPSS-20. Results: The majority of bodybuilders participating in the study (95.3%) have used supplements. The sources suggesting the consumption of supplements included other athletes, the coach, the media, nutrition specialists, and medical doctors, respectively. Generally, 37 types of sports supplements are used by the bodybuilders. Based on their rank, the supplements include vitamin C, Creatine, vitamin E, multivitamin, and iron. The most frequent reasons for consuming sports supplements included muscle building, increasing energy, and improving athletic performance. There is a significant difference between male and female athletes with regards to knowing the psychological and sexual side effects of consuming sports supplements (P<0.05). In general, the level of understanding and knowing the side effects of consuming sports supplements among athletes is not desirable. Conclusion: Since a significant percentage of athletes, particularly male athletes, have a history of consuming sports supplements, it is necessary that the people related to this issue including athletes, coaches, doctors, and nutrition specialists, get sufficient information about the ingredients, side effects, benefits, and applications of various nutritional supplements. Dysfunctional beliefs about the supplements consumption or non-consumption should be discussed.

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Urinary pentosidine level is associated with grip strength and gait speed in community-dwelling adults: a cross-sectional study

BMC Musculoskeletal Disorders ◽

10.1186/s12891-021-04279-5 ◽

2021 ◽

Vol 22 (1) ◽

Author(s):

Kenta Moriwaki ◽

Hiromi Matsumoto ◽

Chika Tanimura ◽

Mari Osaki ◽

Hideki Nagashima ◽

...

Keyword(s):

Grip Strength ◽

Muscle Mass ◽

Gait Speed ◽

Correlation Coefficients ◽

Cross Sectional Study ◽

Community Dwelling ◽

Cross Sectional ◽

Significant Difference ◽

Student’S T ◽

Age And Sex

Abstract Background Muscle and bone interactions might be associated with osteoporosis and sarcopenia. Urinary pentosidine and serum 25-hydroxyvitamin D (25(OH)D) might affect muscle and bone interactions. It is unclear whether these biomarkers are affected by age and sex or play a role in muscle and physical functions. We aimed to investigate the association between urinary pentosidine and serum 25(OH)D levels with muscle mass, muscle strength, and physical performance in community-dwelling adults. Methods Two-hundred and fifty-four middle-aged and elderly adults were enrolled. There was no significant difference in age between 97 men (75.0 ± 8.9 years) and 157 women (73.6 ± 8.1 years). The skeletal muscle mass index (SMI), grip strength, and gait speed were assessed. The urinary pentosidine level was measured. We evaluated the association of urinary pentosidine and serum 25(OH)D levels with age and sex (student’s t-test) and correlations between biomarker and each variable (Pearson’s correlation coefficients). Multiple regression analysis was performed with grip strength and gait speed as dependent variables and with age, height, weight, body mass index (BMI), speed of sound (SOS), SMI, glycated hemoglobin (HbA1c), estimated glomerular filtration rate (eGFR), 25(OH)D, and pentosidine as independent variables using the stepwise method. Results The urinary pentosidine level was negatively correlated with grip strength, gait speed, eGFR, and insulin-like growth factor-1 (IGF-1) in men and with SOS, grip strength, and gait speed in women. The serum 25(OH)D level was positively correlated with IGF-1 in women and grip strength in men. Grip strength was associated with age, height, and pentosidine in men and height and pentosidine in women. Gait speed was associated with age, BMI, and pentosidine in men and age, height, and pentosidine in women. Conclusion Urinary pentosidine levels are significantly associated with grip strength and gait speed and may serve as a biomarker of muscle and bone interactions.

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Ischemic Index and Distribution of Retinal Capillary Non-perfusion in Neovascular Glaucoma: a Retrospective Study

10.21203/rs.3.rs-165576/v1 ◽

2021 ◽

Author(s):

Charles DeBoer ◽

Brandon J. Wong ◽

Hossein Ameri

Keyword(s):

Medical Center ◽

Neovascular Glaucoma ◽

Cross Sectional Study ◽

Retinal Ischemia ◽

Posterior Pole ◽

Panretinal Photocoagulation ◽

Newly Diagnosed ◽

Cross Sectional ◽

Significant Difference ◽

Retinal Capillary

Abstract Purpose: To evaluate the pattern of retinal ischemia in newly diagnosed neovascular glaucoma (NVG).Methods: This is a retrospective single-center cross-sectional study of patients seen at LAC+USC Medical Center from January 2015 to April 2020. Patients with newly diagnosed NVG and ultra-widefield fluorescein angiography (UWFA) without prior panretinal photocoagulation were included. A total of 11 eyes from 10 patients met inclusion criteria. Three zones centered on the fovea were defined: posterior pole (within 2 disc-fovea lengths), mid periphery (between 2 and 3 disc-fovea lengths), and far periphery (>3 disc-fovea lengths). Ischemic index was calculated in these zones using ImageJ software.Results: The etiology of NVG was from proliferative diabetic retinopathy (n=9) and central retinal vein occlusion (n=2). Patients were aged between 48-74 years old. Ischemic index was found to be 91% in the far periphery, 77% in the mid periphery, and 42% at the posterior pole. The total average ischemic index was 76%. There was a statistically significant difference between the far periphery and posterior pole and mid periphery and posterior pole.Conclusions: High levels of retinal ischemia were found with newly diagnosed NVG. The pattern of ischemia was more pronounced in the far periphery than posterior pole.

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Arrhythmias in Children with Normal Heart in Albaha, Saudi Arabia

Journal of Health and Medical Sciences ◽

10.31014/aior.1994.04.01.154 ◽

2021 ◽

Vol 4 (1) ◽

Author(s):

Abdulmajid Almawazini ◽

◽

Saleh Jamaan Al Ghamdi ◽

Chafik Ibrahim Hassan ◽

Sami Ahmed Taha ◽

...

Keyword(s):

Saudi Arabia ◽

Hospital Admissions ◽

Cross Sectional Study ◽

Supraventricular Arrhythmias ◽

Normal Heart ◽

Cross Sectional ◽

Risk Of Death ◽

Clinical Presentations ◽

Significant Difference ◽

The Common

Introduction: Arrhythmias in children with structurally normal hearts are common and reported as the causes of many hospital admissions. Generally, the risk of death is low. Physical examination is important in children with arrhythmias. Objectives: This study aimed to review the common types and clinical presentations of arrhythmias in children with normal heart structures in Albaha, Saudi Arabia. Methodology: In this hospital-based retrospective cross-sectional study, the medical records of children were reviewed from January 2010 to December 2020. Results: Overall, 214 children were included in this study. The prevalence of arrhythmias was 27.10% in children aged 5-8 years; 18.7%, 8-12 years; 16.82%, 3-5 years; 16.35%, 1-3 years; 13.55%, 12-14 years; and 7.48%, <1 year. Arrhythmias were more frequent in females aged <5 years and in males aged >5 years; however, overall, there was no significant difference between females (47.20%) and males (52.80%). Supraventricular arrhythmias were the commonest and found in 85% of the children and ventricular arrhythmias were found in 15%. Sinus tachycardia was the most common type of arrhythmia, reported in 25% of the children. Conclusion: In general, arrhythmias in the children are asymptomatic. History, clinical examination, and electrocardiography are important for the diagnosis. Supraventricular arrhythmias are the most common. There is no significant difference between females and males with respect to the prevalence of arrhythmias.

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The Relationship between Resilience and Academic Burnout among Nursing and Midwifery Students in Kermanshah, Iran

Education Research International ◽

10.1155/2021/6647012 ◽

2021 ◽

Vol 2021 ◽

pp. 1-7

Author(s):

Maryam Janatolmakan ◽

Yousef Torabi ◽

Shahab Rezaeian ◽

Bahare Andayeshgar ◽

Amirabbas Dabiry ◽

...

Keyword(s):

Linear Regression Analysis ◽

Correlation Coefficients ◽

Maslach Burnout Inventory ◽

Cross Sectional Study ◽

Student Survey ◽

Cross Sectional ◽

Academic Burnout ◽

Significant Difference ◽

The Mean ◽

The Difference

Background. Nursing and midwifery students have relatively high levels of academic burnout. One of the mechanisms to combat this issue is resilience. The results related to the association between academic burnout and resilience indicate a negative association, but various studies have reported different correlation coefficients. Therefore, the current study was aimed to investigate the association between resilience and academic burnout among nursing and midwifery students. Methods. A total of 240 nursing and midwifery students were recruited in this cross-sectional study using stratified random sampling. Data were collected by a demographic information questionnaire, the Connor–Davidson Resilience Scale (CD-RISC), and the Maslach Burnout Inventory-Student Survey (MBI-SS). Data were analyzed by SPSS-16 using t-test, ANOVA, Spearman’s correlation coefficient, and linear regression analysis. Results. The mean scores of academic burnout for nursing and midwifery students were 41.4 ± 14.8 and 41.2 ± 12.3, respectively, but the difference was not statistically significant ( p = 0.368). The mean scores of resilience for nursing and midwifery students were 58.1 ± 13.3 and 52.9 ± 13.9, respectively, which showed a statistically significant difference ( p = 0.004). Resilience was significantly inversely correlated with academic burnout in nursing and midwifery students (r = −0.04, p < 0.001; r = −0.39, p < 0.001). Increased resilience in students decreased academic burnout ( p < 0.001). Conclusion. Academic burnout was moderate in nursing and midwifery students, but resilience was relatively high. Given the negative correlation between resilience and academic burnout, it is necessary to strengthen resilience skills and reduce factors that cause academic burnout.

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Arrhythmias in Children with Normal Heart in Albaha, Saudi Arabia

10.31219/osf.io/dn5x6 ◽

2021 ◽

Author(s):

Abdulmajid Almawazini ◽

Saleh Jamaan Al Ghamdi ◽

Chafik Ibrahim Hassan ◽

Sami Ahmed Taha ◽

Ramzi Ahmed Mohammed Alzahrani ◽

...

Keyword(s):

Saudi Arabia ◽

Hospital Admissions ◽

Cross Sectional Study ◽

Supraventricular Arrhythmias ◽

Normal Heart ◽

Cross Sectional ◽

Risk Of Death ◽

Clinical Presentations ◽

Significant Difference ◽

The Common

Arrhythmias in children with structurally normal hearts are common and reported as the causes of many hospital admissions. Generally, the risk of death is low. Physical examination is important in children with arrhythmias. Objectives: This study aimed to review the common types and clinical presentations of arrhythmias in children with normal heart structures in Albaha, Saudi Arabia. Methodology: In this hospital-based retrospective cross-sectional study, the medical records of children were reviewed from January 2010 to December 2020. Results: Overall, 214 children were included in this study. The prevalence of arrhythmias was 27.10% in children aged 5-8 years; 18.7%, 8-12 years; 16.82%, 3-5 years; 16.35%, 1-3 years; 13.55%, 12-14 years; and 7.48%, <1 year. Arrhythmias were more frequent in females aged <5 years and in males aged >5 years; however, overall, there was no significant difference between females (47.20%) and males (52.80%). Supraventricular arrhythmias were the commonest and found in 85% of the children and ventricular arrhythmias were found in 15%. Sinus tachycardia was the most common type of arrhythmia, reported in 25% of the children. Conclusion: In general, arrhythmias in the children are asymptomatic. History, clinical examination, and electrocardiography are important for the diagnosis. Supraventricular arrhythmias are the most common. There is no significant difference between females and males with respect to the prevalence of arrhythmias.

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Hiperglikemia dan Status Inflamasi pada Pasien Sindroma Koroner Akut

MEDULA ◽

10.46496/medula.v6i2.6724 ◽

2019 ◽

Vol 6 (2) ◽

Author(s):

Jamaluddin Jamaluddin

Keyword(s):

Leukocyte Count ◽

Cross Sectional Study ◽

Cross Sectional ◽

Coronary Syndrome ◽

Inflammatory Status ◽

Mediators Of Inflammation ◽

Significant Difference ◽

Coronary Syndromes ◽

Cellular Mediators ◽

The Relationship

ABSTRACTBackground: Hyperglycaemia in patients with acute coronary syndromes (ACS) is associated with increased cardiovascular (CV) risk. Hyperglycaemia in patients with ACS may be associated with increased systemic inflammation. Leukocytes are the major cellular mediators of inflammation and their elevated count is associated with higher CV event rate in ACS patients. Thus, it is possible that there is a relationship between hyperglycaemia and high leukocyte count among patients with ACS. Research Purpose: Aim of study is to investigate the relationship between hyperglycaemia and leukocyte count in ACS patients. Research Methods: This is a cross sectional study, which was held on January to April 2014 among 60 ACS patients in CVCU Wahidin Sudorohusodo Hospital. Glucose level and leukocyte count on admission were measured in 60 ACS patients. Patients was grouped into two groups, hyperglycemic ACS group (glycaemia on admission ≥ 140 mg/dL) and normoglycemic one (glycaemia on admission < 140mg/dL). Leukocyte count was compared to hyperglycemia and normoglycemia patients. Reseaerch Result: Mean of leucocytes count was significantly different between normoglycaemia and hyperglycaemia ACS patients, both in all patients (9.34 ± 2.58 x 103 vs 13.63 ± 3.10 x 103 , P<0.0001) and in non DM patients (9.34 ± 2.58 x 103 vs 14.08 ± 3.20 x 103 , P<0.0001). There was no significant difference of mean leucocytes count between DM and non DM ACS patients admitted with hyperglicaemia (12.38 ± 2.54 x 103 vs 14.08 ± 3.20 x 103 , P=0.121). Conclusion: The conclusion of this study was hyperglycaemia is assocciated with inflammatory status in ACS patients. Keywords :Acute coronary syndrome, hyperglycemia, and inflammation status

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Polymorphism in Vitamin D-Binding Protein as a Genetic Risk Factor in the Pathogenesis of Endometriosis

Endocrinology ◽

10.1210/endo.151.12.9990 ◽

2010 ◽

Vol 151 (12) ◽

pp. 5971-5972

Author(s):

Klaus Faserl ◽

Georg Golderer ◽

Leopold Kremser ◽

Herbert Lindner ◽

Bettina Sarg ◽

...

Keyword(s):

Vitamin D ◽

Risk Factor ◽

Acute Phase Proteins ◽

Binding Protein ◽

Medical Center ◽

Cross Sectional Study ◽

Vitamin D Binding Protein ◽

Complement Components ◽

Cross Sectional ◽

Significant Difference

Context: Previous studies have implicated a deficiency in the inflammatory response in women who develop endometriosis. The specific immunological deficits have not been completely elucidated. Objective: Our objective was to identify differences in protein expression in serum that might shed light on the pathophysiology of endometriosis. Design and Setting: This cross-sectional study of women undergoing laparoscopy between 2003 and 2005 took place at a university medical center. Patients: Patients included consenting women age 18-49 yr undergoing surgery for pain and/or infertility or elective tubal ligation. Women with acute or chronic medical conditions were excluded. Intervention: Blood was collected preoperatively. Main Outcome Measure: Proteomic analysis of serum was done using two-dimensional difference gel electrophoresis. Results: We found 25 protein spots with a significant difference in abundance between women with endometriosis and controls, including acute-phase proteins and complement components. The abundance of vitamin D-binding protein was higher in all endometriosis pools by a factor of approximately 3 compared with the control pool (P < 0.02). Analysis of specific allele products using nano-LC-ESI-MS indicated that it was the GC*2 allele product that was in greater concentration in serum pools, as well as in single validation samples, in women with endometriosis (P = 0.006). In contrast to the GC*1 allele product, which is readily converted to a potent macrophage factor (Gc protein-derived macrophage-activating factor), the GC*2 allele product undergoes practically no such conversion. Conclusions: We speculate that the inability to sufficiently activate macrophages’ phagocytotic function in those carrying the GC*2 polymorphism (more prevalent in endometriosis) may allow endometriotic tissues to implant in the peritoneal cavity. Future studies evaluating specific vitamin D-binding protein polymorphisms as a risk factor for endometriosis in larger populations of women are warranted.

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Effect of overweight on gastrointestinal microbiology and immunology: correlation with blood biomarkers

British Journal Of Nutrition ◽

10.1017/s0007114509992807 ◽

2009 ◽

Vol 103 (7) ◽

pp. 1070-1078 ◽

Cited By ~ 32

Author(s):

Kirsti Tiihonen ◽

Arthur C. Ouwehand ◽

Nina Rautonen

Keyword(s):

Lactic Acid ◽

Inverse Correlation ◽

Cross Sectional Study ◽

Normal Weight ◽

Inflammatory Biomarkers ◽

Microbial Composition ◽

Cross Sectional ◽

Inflammatory Status ◽

Obese Subjects ◽

Branched Chain

A cross-sectional study was carried out in order to compare intestinal microbiological and immunological biomarkers with blood glucose and lipids, satiety-related hormones and inflammatory biomarkers characterising differences between obese and normal weight subjects. Faecal and blood samples were obtained from twenty obese subjects with an average BMI of 32·9 kg/m2and twenty normal weight subjects with an average BMI of 23·3 kg/m2. Blood insulin, TAG and leptin were significantly elevated, whereas concentrations of HDL and ghrelin were significantly decreased in the obese subjects. Inflammatory status in the obese subjects was characterised by a trend for elevated blood C-reactive protein (CRP;P = 0·06) and IL-6 (P = 0·02). The faecal microbial composition differed between the groups; less sulphate-reducing bacteria (P = 0·05) and a trend for lessBacteroides(P = 0·07) were measured for overweight subjects. Furthermore, an inverse correlation was demonstrated between faecalBacteroideslevels and waist circumference (P = 0·05). The faecal microbial metabolites differed between the groups; increased concentrations of branched-chain fatty acids, phenolics, valeric acid, di- and hydroxy acids were described in the obese subjects. No differences between the measured intestinal inflammatory biomarkers were detected. However, systemic inflammation (CRP and IL-6) was correlated with the faecal concentrations of phenolics and lactic acid (P < 0·05 and 0·05, andP < 0·01 and 0·05, respectively). In summary, weight-related differences were observed both in the intestinal microbial composition and its activity. The role of intestinal signals, such as phenolics and lactic acid in the development of weight-related problems, needs to be studied further.

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