scholarly journals Pleural Mesothelioma Surveillance: Validity of Cases from a Tumour Registry

2012 ◽  
Vol 19 (2) ◽  
pp. 103-107 ◽  
Author(s):  
France Labrèche ◽  
Bruce W Case ◽  
Gaston Ostiguy ◽  
Jean Chalaoui ◽  
Michel Camus ◽  
...  

BACKGROUND: Pleural mesothelioma is a rare tumour associated with exposure to asbestos fibres. Fewer than than one-quarter of cases registered in the Quebec Tumour Registry (QTR) have been compensated as work-related. While establishing a surveillance system, this led to questioning as to whether there has been over-registration of cases that are not authentic pleural mesotheliomas in the QTR.OBJECTIVE: To assess whether registered cases of pleural mesothelioma could be confirmed.METHODS: A medical chart review was designed to assess the proportion of mesothelioma cases newly registered in the QTR in 2001/2002 that could be confirmed. For each registered case, clinical, medical imaging and pathology information were sought and, occasionally, additional immunohistochemistry staining was obtained. Three specialists – a chest physician, a radiologist and a pathologist – reviewed the available information and material, coding each mesothelioma case as to degree of certainty of the mesothelioma diagnosis.RESULTS: The QTR reported 190 incident cases of mesothelioma (81% males) for the period. The specialists classified 81% of charts as ‘certain/probable’or ‘possible’ mesotheliomas, 8% as ‘unlikely to be a mesothelioma’ and 11% as ‘not a mesothelioma’. After excluding chart summaries of unsatisfactory quality, 87% to 88% of the charts were classified as ‘certain/probable’ or ‘possible’ mesotheliomas, and 9% to 11% were still considered ‘not a mesothelioma’.CONCLUSION: Tumour registry data are a valid source of information for mesothelioma surveillance. While there is some over-registration of mesothelioma cases in the QTR, a significant majority of registered cases appeared to be authentic. Over-registration cannot explain the greater proportion of cases that were not compensated.

1907 ◽  
Vol 4 (6) ◽  
pp. 253-257 ◽  
Author(s):  
A. C. Seward

The following notes on three fossil plants handed to me by Dr. Hume have been written at the request of Capt. Lyons, Director-General of the Survey Department of Egypt. The material is unfortunately too fragmentary to admit of satisfactory determination; but in view of our ignorance in regard to the former vegetation of Egypt, it is desirable to put on record all available information. Of the three fossils only one is sufficiently well preserved to be referred with any degree of certainty to a genus.


2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Cheng-Kuan Lin ◽  
Yu-Ying Chang ◽  
Jung-Der Wang ◽  
Lukas Jyuhn-Hsiarn Lee

Objective. This paper aimed to determine the standardised incidence ratio (SIR) of malignant pleural mesothelioma (MPM) in workers exposed to asbestos in Taiwan.Methods. All workers employed in asbestos-related factories and registered by the Bureau of Labour Insurance between 1 March, 1950, and 31 December, 1989, were included in the study and were followed from 1 January, 1980, through 31 December, 2009. Incident cases of all cancers, including MPM (ICD-9 code: 163), were obtained from the Taiwan Cancer Registry. SIRs were calculated based on comparison with the incidence rate of the general population of Taiwan and adjusted for age, calendar period, sex, and duration of employment.Results. The highest SIR of MPM was found for male workers first employed before 1979, with a time since first employment more than 30 years (SIR 4.52, 95% CI: 2.25–8.09). After consideration of duration of employment, the SIR for male MPM was 5.78 (95% CI: 1.19–16.89) for the workers employed for more than 20 years in asbestos-related factories.Conclusions. This study corroborates the association between occupational asbestos exposure and MPM. The highest risk of MPM was found among male asbestos workers employed before 1979 and working for more than 20 years in asbestos-related factories.


2019 ◽  
Vol 180 (4) ◽  
pp. 257-263
Author(s):  
Guy Fagherazzi ◽  
Gaelle Gusto ◽  
Douae El Fatouhi ◽  
Francesca Romana Mancini ◽  
Beverley Balkau ◽  
...  

Hypothesis Previous work suggested no or inconsistent associations between components of work-related stress and type 2 diabetes risk, but suggested sex-specific differences should be further investigated, as women potentially had higher risks. Methods We analyzed data from 73 517 women, mostly teachers, from the E3N cohort study followed for 22 years (1992–2014), to study the association between mentally tiring work, used as a proxy of job demands, and type 2 diabetes risk. Univariate and multivariable Cox regression models were used to estimate hazard ratios and 95% confidence intervals. Results A total of 4187 incident cases of type 2 diabetes cases were observed. There was a higher type 2 diabetes risk for women with a ‘Very mentally tiring work’ when compared to women with ‘Little or not mentally tiring work’ (HR = 1.21 (1.09–1.35)). This association was independent of unhealthy lifestyle and traditional metabolic factors. An interaction between mentally tiring work and BMI was detected (P < 0.0001), with a stronger association being observed in non-overweight women, HR = 1.26 (1.08–1.47) vs HR = 1.14 (0.98, 1.32), in overweight women. Conclusions We observed an increased risk of type 2 diabetes associated with mentally tiring work, used as a proxy of job demands. These observational results suggest the importance of taking into consideration the potential long-term metabolic impact of work-related stress for women working in a demanding environment. Increased support for such women should be investigated in intervention studies.


2014 ◽  
Vol 3 (3) ◽  
pp. 41
Author(s):  
Roman Vavrek ◽  
Ivana Kravčáková Vozárová ◽  
Martina Cehlárová ◽  
Ivana Ondrijová

The municipality as an entity of the local government and disposes defined rights and obligations, which are governed by the special regulations. In accordance with Act no. 211/2000 Coll. on free access to information, the municipality is mandatory publish and make available information that this Act also more specify. This paper focuses on availability of information from websites or other available sources. The basic set was represented by 91 municipalities of Prešov district, in which were surveyed a total of 75 data (6 identification and 69 financial). Within the implemented questioning, we can conclude especially the availability of identification data, for which there are multiple sources (eg. number of inhabitants). Overall, however, the municipalities did not provide the requested information, when up to 27 municipalities did not provide more than 5 data (including 3 identification). One of the outcomes is also a proving of small correlation between the volume of data obtained from the municipality and the number of its inhabitants, respectively the distance from the district town.


Author(s):  
Nikolay Kanev ◽  

ntroduction. The present article is a primary publication of a newly discovered sphragistic artefact from the area of the medieval fortress of Rusokastro, which was acquired by the Regional Historical Museum in Burgas in 2019. Methods. In their entirety, the Byzantine lead seals are an important primary and reliable source of information on various aspects of Byzantine history. Byzantine seals are especially important from the perspective of prosopography. First of all, they are invaluable evidence of individuals who, in one way or another, participated in the social and political life of the Byzantine Empire. Therefore, the discovery of each new sphragistic monument is of great importance and the available information must be carefully analyzed. Analysis. This interesting artefact is a lead seal of the brother of the Byzantine emperor Alexius I Komnenos (1081–1118), Adrian Komnenos as a protosebastos and megas domestikos of the entire West. The obverse depicts Saint George, nimbate, standing, facing forward, holding a spear in his right hand, and resting his left hand on a shield. Inscription in 7 lines within dotted border on the reverse: + Κ(ύρι)ε β(οή)θ(ει) τῷ σῷ δούλῳ Ἀδριανῷ (πρωτο)σεβαστῷ (καὶ) μ(ε)γ(άλῳ) δομ[ε]στίκῳ πάσης Δύσεως τῷ Κομνην(ῷ). The seal dates from the end of the 11th century. Results. This new Byzantine lead seal, described in this article, increases the number of medieval sphragistic finds in the Rusokastro area, which belong to an undeniably wide chronological range – from the second half of the 8th century to the beginning of the 12th century. Thus, the number of lead seals from the area of Rusokastro grow to six, five of which are Byzantine and one is a Bulgarian imperial seal.


Energies ◽  
2020 ◽  
Vol 13 (22) ◽  
pp. 5896
Author(s):  
Tadej Skrjanc ◽  
Rafael Mihalic ◽  
Urban Rudez

This research represents a conceptual shift in the process of introducing flexibility into power system frequency stability-related protection. The existing underfrequency load shedding (UFLS) solution, although robust and fast, has often proved to be incapable of adjusting to different operating conditions. It triggers upon detection of frequency threshold violations, and functions by interrupting the electricity supply to a certain number of consumers, both of which values are decided upon beforehand. Consequently, it often does not comply with its main purpose, i.e., bringing frequency decay to a halt. Instead, the power imbalance is often reversed, resulting in equally undesirable frequency overshoots. Researchers have sought a solution to this shortcoming either by increasing the amount of available information (by means of wide-area communication) or through complex changes to all involved protection relays. In this research, we retain the existing concept of UFLS that performs so well for fast-occurring frequency events. The flexible rebalancing of power is achieved by a small and specialized group of intelligent electronic devices (IEDs) with machine learning functionalities. These IEDs interrupt consumers only when the need to do so is detected with a high degree of certainty. Their small number assures the fine-tuning of power rebalancing and, at the same time, poses no serious threat to system stability in cases of malfunction.


2009 ◽  
Vol 11 (2) ◽  
Author(s):  
Hilde Langseth

<strong><span style="font-family: TimesNewRomanPS-BoldMT;"><span style="font-family: TimesNewRomanPS-BoldMT;"><p align="left"> </p></span></span><p align="left"><span style="font-size: x-small; font-family: TimesNewRomanPS-BoldMT;"><span style="font-size: x-small; font-family: TimesNewRomanPS-BoldMT;">ENGLISH SUMMARY</span></span></p></strong><span style="font-size: x-small; font-family: TimesNewRomanPSMT;"><span style="font-size: x-small; font-family: TimesNewRomanPSMT;"><span style="font-size: x-small; font-family: TimesNewRomanPSMT;"><span style="font-size: x-small; font-family: TimesNewRomanPSMT;"><p align="left">Langseth H.</p></span></span></span><span style="font-size: x-small; font-family: TimesNewRomanPSMT;"><p align="left"> </p></span></span><p align="left"><strong><span style="font-size: x-small; font-family: TimesNewRomanPS-BoldMT;"><span style="font-size: x-small; font-family: TimesNewRomanPS-BoldMT;">Cancer risk in Norwegian pulp and paper workers. </span></span></strong><em><span style="font-size: x-small; font-family: TimesNewRomanPS-ItalicMT;"><span style="font-size: x-small; font-family: TimesNewRomanPS-ItalicMT;">Nor J Epidemiol </span></span></em><span style="font-size: x-small; font-family: TimesNewRomanPSMT;"><span style="font-size: x-small; font-family: TimesNewRomanPSMT;">2001; </span></span><strong><span style="font-size: x-small; font-family: TimesNewRomanPS-BoldMT;"><span style="font-size: x-small; font-family: TimesNewRomanPS-BoldMT;">11 </span></span></strong><span style="font-size: x-small; font-family: TimesNewRomanPSMT;"><span style="font-size: x-small; font-family: TimesNewRomanPSMT;">(2): 187-192.<p align="left">Results from a historical prospective cohort study on Norwegian pulp and paper workers showed a significant</p><p align="left">increase in risk of lung cancer, pleural mesothelioma, colon cancer and malignant melanomas among</p><p align="left">men, compared to the Norwegian population. The risk of lung cancer was highest among sulphite mill</p><p align="left">workers. The risk of pleural mesothelioma was highest among maintenance workers with asbestos exposure.</p><p align="left">Most of the increased risk in lung cancer can be explained by a combination of smoking habits and</p><p align="left">asbestos use, although an effect of other work-related exposures (sulfur and chloride compounds, wood</p><p align="left">dust) cannot be excluded. Among the female part of the cohort we found a significant excess in risk of</p><p align="left">ovarian cancer. The risk was highest among those younger than 55 years, and mostly among those working</p><p align="left">in paper departments. Relatively little is known about the causes of ovarian cancer, but it is however</p><p align="left">known that 5-7% can be explained by hereditary factors. Furthermore, fertility pattern plays a role.</p><p align="left">Asbestos and talc, which both have been used in the pulp and paper industry, are occupational and environmental</p><p>agents, discussed as possible carcinogens for ovarian cancer.</p></span></span></p>


2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Putnam Barber ◽  
Steven Rathgeb Smith

AbstractTax-exempt organizations in the United States are, in general, required to file regular reports on their operations with the Internal Revenue Service (IRS). These filings represent a significant burden for the filing organizations, are a critical source of information for many observers, and are relied upon by regulators and donors as indicators of the organizations’ commitment to achieving the wide variety of purposes for which the exemptions are granted. This paper recommends that the resources of the IRS be refocused so that greater attention can be paid to complex organizations, while the burden of preparing annual filings by simpler organization is also reduced. More generally, this paper also recommends that new attention be paid to the information collected and to its publication. It argues that the needs of the public and other regulatory agencies are not well-served by the current information and that the limitations on currently available information contribute to misunderstanding of and cynicism about the role of charitable nonprofits in American life.


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