scholarly journals Vaxjo: A Web-Based Vaccine Adjuvant Database and Its Application for Analysis of Vaccine Adjuvants and Their Uses in Vaccine Development

2012 ◽  
Vol 2012 ◽  
pp. 1-13 ◽  
Author(s):  
Samantha Sayers ◽  
Guerlain Ulysse ◽  
Zuoshuang Xiang ◽  
Yongqun He
Keyword(s):  
Data Exchange ◽  
Vaccine Development ◽  
Vaccine Adjuvant ◽  
Vaccine Adjuvants ◽  
Web Based ◽  
Host Immune Responses ◽  
Ontology Language ◽  
Analysis System ◽  
User Friendly

Vaccine adjuvants are compounds that enhance host immune responses to co-administered antigens in vaccines. Vaxjo is a web-based central database and analysis system that curates, stores, and analyzes vaccine adjuvants and their usages in vaccine development. Basic information of a vaccine adjuvant stored in Vaxjo includes adjuvant name, components, structure, appearance, storage, preparation, function, safety, and vaccines that use this adjuvant. Reliable references are curated and cited. Bioinformatics scripts are developed and used to link vaccine adjuvants to different adjuvanted vaccines stored in the general VIOLIN vaccine database. Presently, 103 vaccine adjuvants have been curated in Vaxjo. Among these adjuvants, 98 have been used in 384 vaccines stored in VIOLIN against over 81 pathogens, cancers, or allergies. All these vaccine adjuvants are categorized and analyzed based on adjuvant types, pathogens used, and vaccine types. As a use case study of vaccine adjuvants in infectious disease vaccines, the adjuvants used inBrucellavaccines are specifically analyzed. A user-friendly web query and visualization interface is developed for interactive vaccine adjuvant search. To support data exchange, the information of vaccine adjuvants is stored in the Vaccine Ontology (VO) in the Web Ontology Language (OWL) format.

Classification as Evaluation

2011 ◽  
pp. 41-62 ◽  
Author(s):  
Sari Hakkarainen ◽  
Darijus Strasunskas ◽  
Lillian Hella ◽  
Stine Tuxen
Keyword(s):  
Web Applications ◽  
Evaluation Criteria ◽  
Web Based ◽  
Classification Approach ◽  
The Core ◽  
Ontology Language ◽  
Ontology Building ◽  
Using Data

Ontology is the core component in Semantic Web applications. The employment of an ontology building method affects the quality of ontology and the applicability of ontology language. A weighted classification approach for ontology building guidelines is presented in this chapter. The evaluation criteria are based on an existing classification scheme of a semiotic framework for evaluating the quality of conceptual models. A sample of Web-based ontology building method guidelines is evaluated in general and experimented with using data from a case study in particular. Directions for further refinement of ontology building methods are discussed.

scholarly journals Bioinformatic Teaching Resources – For Educators, by Educators – Using KBase, a Free, User-Friendly, Open Source Platform

2021 ◽  
Vol 6 ◽  
Author(s):  
Ellen G. Dow ◽  
Elisha M. Wood-Charlson ◽  
Steven J. Biller ◽  
Timothy Paustian ◽  
Aaron Schirmer ◽  
...  
Keyword(s):  
Energy Systems ◽  
Department Of Energy ◽  
Student Survey ◽  
Teaching Resources ◽  
Web Based ◽  
The Past ◽  
Instructional Units ◽  
Bioinformatics Education ◽  
User Friendly

Over the past year, biology educators and staff at the U.S. Department of Energy Systems Biology Knowledgebase (KBase) initiated a collaborative effort to develop a curriculum for bioinformatics education. KBase is a free web-based platform where anyone can conduct sophisticated and reproducible bioinformatic analyses via a graphical user interface. Here, we demonstrate the utility of KBase as a platform for bioinformatics education, and present a set of modular, adaptable, and customizable instructional units for teaching concepts in Genomics, Metagenomics, Pangenomics, and Phylogenetics. Each module contains teaching resources, publicly available data, analysis tools, and Markdown capability, enabling instructors to modify the lesson as appropriate for their specific course. We present initial student survey data on the effectiveness of using KBase for teaching bioinformatic concepts, provide an example case study, and detail the utility of the platform from an instructor’s perspective. Even as in-person teaching returns, KBase will continue to work with instructors, supporting the development of new active learning curriculum modules. For anyone utilizing the platform, the growing KBase Educators Organization provides an educators network, accompanied by community-sourced guidelines, instructional templates, and peer support, for instructors wishing to use KBase within a classroom at any educational level–whether virtual or in-person.

Geo-Sentiment Analysis as a Location-Based Opinion Analysis System on Public Opinion Data about Governor Candidates

2018 ◽  
Vol 7 (4.44) ◽  
pp. 110
Author(s):  
Imam Fahrur Rozi ◽  
Dika Rizky Yunianto ◽  
Mustika Mentari ◽  
Awan Setiawan ◽  
Rudy Ariyanto ◽  
...  
Keyword(s):  
Social Media ◽  
Text Classification ◽  
Classification System ◽  
Classification Method ◽  
Bayes Classifier ◽  
Opinion Analysis ◽  
Analysis System ◽  
User Friendly ◽  
Pie Chart

Ahead of governor elections, there were a lot of news and opinions related to the candidates through social media. The candidates could map the positive public opinions as their political supports that need to be strengthened, and the negative opinions that need for correction. To map those opinions, it is necessary for an opinion classification system from textual opinions. It became the focus of this research. The system was designed to work on textual opinions in Bahasa since the proposed case study was the opinion of East Java governor candidates mainly written in Bahasa. Classification method that was used to classify the opinions in this system, is Naive Bayes Classifier (NBC). The opinions would be classified into 2 classes, negative and positive opinion. The classified opinions then grouped by region. It would make users easier to map the opinion in each region. The visualization became more user-friendly since the count of classified opinion displayed as a pie chart on a geographical mode or a map. After testing on the classification results, the accuracy value that we got was 78%. It indicated that NBC could perform very well as a simple text classification method with a good result. 

scholarly journals How suitable is Yahoo! Groups for school librarians’ professional networking? A case study from Hong Kong

2016 ◽  
Author(s):  
Samson Choi ◽  
Zvjezdana Dukic
Keyword(s):  
Hong Kong ◽  
Qualitative Data ◽  
Case Study Research ◽  
School Librarians ◽  
Web Based ◽  
Professional Needs ◽  
Professional Networking ◽  
Group Members ◽  
User Friendly

This paper explores how members of Hong Kong based professional association of school librarians (ALESS) use Yahoo! Groups platform for their professional networking and how the platform satisfies the group’s professional needs. The case study research method is applied and both quantitative and qualitative data are collected. It is revealed that ALESS members effectively use Yahoo! Groups platform even though they do not exploit all available features. ALESS members regularly use web-based mail and occasionally Files and Polls. Although some group members think that Yahoo! Groups need to be replaced with a more user- friendly tool, most respondents agree that for the time being Yahoo! Groups platform fairly fulfils ALESS group’s needs. Further analysis of existing social networking software and ALESS group’s needs and preferences are recommended.

scholarly journals Immunization with short peptide particles reveals a functional CD8+ T-cell neoepitope in a murine renal carcinoma model

2021 ◽  
Vol 9 (12) ◽  
pp. e003101
Author(s):  
Xuedan He ◽  
Shiqi Zhou ◽  
Melissa Dolan ◽  
Yuhao Shi ◽  
Jianxin Wang ◽  
...  
Keyword(s):  
T Cells ◽  
Cancer Vaccine ◽  
Vaccine Development ◽  
Immune Checkpoint Blockade ◽  
Vaccine Adjuvant ◽  
Vaccine Adjuvants ◽  
Functional Responses ◽  
Class I Mhc ◽  
Mhc I ◽  
Multiple Orders

BackgroundInduction of CD8+ T cells that recognize immunogenic, mutated protein fragments in the context of major histocompatibility class I (MHC-I) is a pressing challenge for cancer vaccine development.MethodsUsing the commonly used murine renal adenocarcinoma RENCA cancer model, MHC-I restricted neoepitopes are predicted following next-generation sequencing. Candidate neoepitopes are screened in mice using a potent cancer vaccine adjuvant system that converts short peptides into immunogenic nanoparticles. An identified functional neoepitope vaccine is then tested in various therapeutic experimental tumor settings.ResultsConversion of 20 short MHC-I restricted neoepitope candidates into immunogenic nanoparticles results in antitumor responses with multivalent vaccination. Only a single neoepitope candidate, Nesprin-2 L4492R (Nes2LR), induced functional responses but still did so when included within 20-plex or 60-plex particles. Immunization with the short Nes2LR neoepitope with the immunogenic particle-inducing vaccine adjuvant prevented tumor growth at doses multiple orders of magnitude less than with other vaccine adjuvants, which were ineffective. Nes2LR vaccination inhibited or eradicated disease in subcutaneous, experimental lung metastasis and orthotopic tumor models, synergizing with immune checkpoint blockade.ConclusionThese findings establish the feasibility of using short, MHC-I-restricted neoepitopes for straightforward immunization with multivalent or validated neoepitopes to induce cytotoxic CD8+ T cells. Furthermore, the Nes2LR neoepitope could be useful for preclinical studies involving renal cell carcinoma immunotherapy.

scholarly journals Referencing@Portsmouth: a web-based, interactive referencing tool

2010 ◽  
Author(s):  
Roisin Gwyer ◽  
Linda Jones ◽  
James Stewart Matthews ◽  
Anne Worden
Keyword(s):  
Undergraduate Students ◽  
Web Based ◽  
Selection Tool ◽  
Hierarchical Selection ◽  
Search Facility ◽  
The University ◽  
User Friendly ◽  
Web Designers

This case study describes a project at the University of Portsmouth library to create a sustainable web-based tool to help undergraduate students with the thorny issue of academic referencing of their sources for written work, using a hierarchical selection tool, backed up by an optional search facility. It is intended to encourage them to think analytically about their sources. The selection tool needed to be user-friendly and easy to manage by librarians who are not also web designers. The project went live with APA style referencing and has been expanded to cover OSCOLA (law) referencing, with Vancouver style in the pipeline.. Although intended for Portsmouth students, among whom its use is growing rapidly, others have linked to it, including the Intute website. This case study describes a project at the University of Portsmouth library to create a sustainable web-based tool to help undergraduate students with the thorny issue of academic referencing of their sources for written work, using a hierarchical selection tool, backed up by an optional search facility. It is intended to encourage them to think analytically about their sources. The selection tool needed to be user-friendly and easy to manage by librarians who are not also web designers. The project went live with APA style referencing and has been expanded to cover OSCOLA (law) referencing, with Vancouver style in the pipeline.. Although intended for Portsmouth students, among whom its use is growing rapidly, others have linked to it, including the Intute website.

scholarly journals COVIDep platform for real-time reporting of vaccine target recommendations for SARS-CoV-2: Description and connections with COVID-19 immune responses and preclinical vaccine trials

2020 ◽  
Author(s):  
Syed Faraz Ahmed ◽  
Ahmed A. Quadeer ◽  
Matthew R. McKay
Keyword(s):  
Immune Responses ◽  
B Cell ◽  
Vaccine Development ◽  
Experimental Studies ◽  
Genetic Data ◽  
T Cell Epitopes ◽  
Web Based ◽  
Vaccine Trials ◽  
User Friendly ◽  
Immune Target

AbstractWe introduce COVIDep (https://COVIDep.ust.hk), a web-based platform that provides immune target recommendations for guiding SARS-CoV-2 vaccine development. COVIDep implements a protocol that pools together publicly-available genetic data for SARS-CoV-2 and epitope data for SARS-CoV to identify B cell and T cell epitopes that present potential immune targets for SARS-CoV-2. Correspondences between outputs of COVIDep and immune responses recorded in COVID-19 patients and preclinical vaccine trials are also indicated. The platform is user-friendly, flexible, and based on up-to-date data. It may help guide vaccine designs and associated experimental studies for SARS-CoV-2.

scholarly journals Case study of Argus in Togo: An SMS and web-based application to support public health surveillance, results from 2016 to 2019

PLoS ONE ◽  
2020 ◽  
Vol 15 (12) ◽  
pp. e0243131
Author(s):  
José Guerra ◽  
Kokou Mawule Davi ◽  
Florentina Chipuila Rafael ◽  
Hamadi Assane ◽  
Lucile Imboua ◽  
...  
Keyword(s):  
Public Health ◽  
Public Health Surveillance ◽  
Health Surveillance ◽  
Web Based ◽  
Healthcare Facilities ◽  
Report Data ◽  
Health Surveillance Data ◽  
Time Required ◽  
User Friendly

Introduction Argus is an open source electronic solution to facilitate the reporting and management of public health surveillance data. Its components include an Android-phone application, used by healthcare facilities to report results via SMS; and a central server located at the Ministry of Health, displaying aggregated results on a web platform for intermediate and central levels. This study describes the results of the use of Argus in two regions of Togo. Methods Argus was used in 148 healthcare facilities from May 2016 to July 2018, expanding to 185 healthcare facilities from July 2018. Data from week 21 of 2016 to week 12 of 2019 was extracted from the Argus database and analysed. An assessment mission took place in August 2016 to collect users’ satisfaction, to estimate the concordance of the received data with the collected data, and to estimate the time required to report data with Argus. Results Overall completeness of data reporting was 76%, with 80% of reports from a given week being received before Tuesday 9PM. Concordance of data received from Argus and standard paper forms was 99.7%. Median time needed to send a report using Argus was 4 minutes. Overall completeness of data review at district, regional, and central levels were 89%, 68%, and 35% respectively. Implementation cost of Argus was 23 760 USD for 148 facilities. Conclusions The use of Argus in Togo enabled healthcare facilities to send weekly reports and alerts through SMS in a user-friendly, reliable and timely manner. Reengagement of surveillance officers at all levels, especially at the central level, enabled a dramatic increase in completeness and timeliness of data report and data review.

The Role of Web Based Accounting Online System 2.0 as the Company's Income and Expense Management

2017 ◽  
Vol 1 (1) ◽  
pp. 44-49
Author(s):  
Nur Azizah ◽  
Dedeh Supriyanti ◽  
Siti Fairuz Aminah Mustapha ◽  
Holly Yang
Keyword(s):  
Financial Management ◽  
Accounting System ◽  
Bank Account ◽  
Web Based ◽  
Online System ◽  
Version 2.0 ◽  
User Friendly ◽  
The Impact ◽  
A Company

In a company, the process of income and expense of money must have a profit-generating goal base. The success of financial management within the company, can be monitored from the ability of the financial management in managing the finances and utilize all the opportunities that exist with as much as possible with the aim to control the company's cash (cash flow) and the impact of generating profits in accordance with expectations. With a web-based online accounting system version 2.0, companies can be given the ease to manage money in and out of the company's cash. It has a user friendly system with navigation that makes it easy for the financial management to use it. Starting from the creation of a company's cash account used as a cash account and corporate bank account on the system, deletion or filing of cash accounts, up to the transfer invoice creation feature, receive and send money. Thus, this system is very effective and efficient in the management of income and corporate cash disbursements.   Keywords:​Accounting Online System, Financial Management, Cash and Bank

A Case Study on Web-based Learning Environment Evaluation in Higher Education: Learner Perspectives in a Private University in Malaysia.

2020 ◽  
Vol 1 (2) ◽  
pp. 18-33
Author(s):  
Zarina Che Imbi ◽  
Tse-Kian Neo ◽  
Mai Neo
Keyword(s):  
Higher Education ◽  
Learning Environment ◽  
Private University ◽  
Systematic Evaluation ◽  
Digital Learning ◽  
Mixed Method Research ◽  
Web Based ◽  
Web Based Learning ◽  
Kirkpatrick’S Model

In the era of digital learning, multimedia-based classroom has been commonly used in higher education including Malaysian higher education institutions. A case study has been performed to evaluate web-based learning using Level 1 to 3 of Kirkpatrick's model in a multi-disciplinary course at Multimedia University, Malaysia. In this study, mixed method research was employed in which triangulation was performed from multiple sources of data collection to give deeper understanding. Students perceived that learning with multimedia was enjoyable. They were also motivated in learning and engaged through the use of web module as multimedia was perceived to motivate them and make learning fun. Students showed significant improvements in their knowledge based on the pre-test and post-test results on learning evaluation. Students were perceived to transfer the learning from web-based learning into the learning outcome. The systematic evaluation can provide the feedback that educators and institution as a whole need to improve the learning environment and programme quality. This study contributes to the research field by adding another perspective in evaluations of web-based learning. It also provides empirical evidence on student perspectives, learning and behaviour in a private university. It demonstrated that the Kirkpatrick's model is useful as an evaluation tool to be used in higher education.

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