scholarly journals Assessment of Metformin as an Additional Treatment to Therapeutic Lifestyle Changes in Pediatric Patients with Metabolic Syndrome

Cholesterol ◽  
2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Rebecca M. Raub ◽  
Stanley J. Goldberg
Keyword(s):  
Metabolic Syndrome ◽  
Pediatric Population ◽  
Additional Treatment ◽  
Lifestyle Changes ◽  
Control Group ◽  
Average Dose ◽  
Z Score ◽  
Positive Direction ◽  
Metformin Group ◽  
Therapeutic Lifestyle Changes

Objective. To assess the effectiveness of metformin and therapeutic lifestyle changes (TLCs) in a clinical setting, compared to TLC alone in adolescents with metabolic syndrome (MS). Methodology. This study was a retrospective trial consisting of 60 patients, aged 8–18 years, who were treated for MS at an outpatient clinic. Two groups were formed: the metformin group (M group) and the control group (C group). The M group had been given metformin along with TLC, and the C group had been given TLC alone. Several outcome measures were obtained; the main outcome measure was measuring the change in percentile and z-score of weight and BMI. Results. There were no significant differences between the two groups at the conclusion of the study, except for height percentile (P=0.02) and z-score (P=0.03). Both groups showed promising significant intragroup decreases in weight z-score but BMI percentile and z-score were only significantly decreased in the M group. Conclusion. Metformin at an average dose of 1033 mg, when added to TLC, did not show any clinically important efficacy compared to TLC alone in a pediatric population with MS. However, both groups made significant changes in a positive direction, which may be solely due to TLC.

Physical activity and the metabolic syndrome in Canada

2006 ◽  
Vol 31 (1) ◽  
pp. 40-47 ◽  
Author(s):  
Susan E Brien ◽  
Peter T Katzmarzyk
Keyword(s):  
Physical Activity ◽  
Metabolic Syndrome ◽  
Health Surveys ◽  
Lifestyle Changes ◽  
Heart Health ◽  
Physically Active ◽  
The Metabolic Syndrome ◽  
Strenuous Activity ◽  
Therapeutic Lifestyle Changes ◽  
The Relationship

The metabolic syndrome (MetS) is a cluster of risk factors that predispose individuals to cardiovascular disease. Therapeutic lifestyle changes, including increased physical activity, are recommended for the prevention and treatment of MetS. The purpose of this study was to examine the relationship between physical activity and MetS in Canada. The sample included 6406 men and 6475 women aged 18-64 y who were participants in the Canadian Heart Health Surveys (1986-1992). MetS was classified using criteria modified from the US National Cholesterol Education Program. Participants were deemed physically active if they were active at least once each week for at least 30 min, engaging in strenuous activity some of the time. The relationship between physical activity and MetS was assessed using logistic regression, with age, smoking, alcohol consumption, and income adequacy as covariates. A total of 14.4% of Canadians had MetS and 33.6% were physically active. The odds ratio for MetS was 0.73 (95% confidence interval (CI): 0.54-0.98; p < 0.05) for physically active vs. physically inactive participants. The corresponding odds ratios were 0.45 (95% CI: 0.29-0.69; p < 0.001) and 0.67 (95% CI: 0.44-1.02; p = 0.06) for men and women, respectively. In summary, physical activity was associated with lower odds of MetS, particularly in men. Further research is required to determine the effectiveness of physical activity in the treatment of MetS.Key words: metabolic syndrome, physical activity, Canadian Heart Health Surveys.

scholarly journals Effects of antioxidant diet on the RBC indices in fructose-induced obesity rat model

2021 ◽  
Vol 8 (3) ◽  
pp. 21-28
Author(s):  
Dimitar Bakalov ◽  
Zafer Sabit ◽  
Radka Tafradjiiska ◽  
Pavlina Andreeva-Gateva
Keyword(s):  
Metabolic Syndrome ◽  
Rat Model ◽  
Molecular Mechanisms ◽  
Hemoglobin Concentration ◽  
Additional Treatment ◽  
Control Group ◽  
Male Wistar Rats ◽  
Rbc Indices ◽  
Antioxidant Diet

Abstract The oxidative stress is one of the known and discussed culprits for development and progression of the disturbances in Metabolic syndrome (MetS). In our study, we are investigating the effects of antioxidant additives as additional treatment and prophylaxis in a model of MetS. We are using a fructose-induced metabolic syndrome rat model to examine the effects of antioxidant preparation ZellSchutz. Four experimental groups were formed using male Wistar rats (n = 60). The control group received standard rat chow, the other groups received either ZellSchutz (Z), fructose (F), or fructose and ZellSchutz (ZF). Our results showed an unexpected increase in the RBC indices in rats with dual treatment. There was a significant increase in hemoglobin concentration, MCHC, and MCV in those animals (p<0.001). The preliminary data shows the important role of antioxidants as supplementary therapy in metabolic syndrome. Further investigations will be carried on to reveal the molecular mechanisms of the observed changes.

scholarly journals The Effects of Intermittent Hypoxic–Hyperoxic Exposures on Lipid Profile and Inflammation in Patients With Metabolic Syndrome

2021 ◽  
Vol 8 ◽  
Author(s):  
A. Bestavashvili Afina ◽  
S. Glazachev Oleg ◽  
A. Bestavashvili Alexander ◽  
Dhif Ines ◽  
Suvorov Alexander Yu ◽  
...  
Keyword(s):  
Risk Factors ◽  
Metabolic Syndrome ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Density Lipoprotein ◽  
Lifestyle Changes ◽  
Control Group ◽  
Fatty Acid Binding ◽  
Inflammatory Status ◽  
Control Sham

Background: Patients with metabolic syndrome (MS) tend to suffer from comorbidities, and are often simultaneously affected by obesity, dysglycemia, hypertension, and dyslipidemia. This syndrome can be reversed if it is timely diagnosed and treated with a combination of risk factors-reducing lifestyle changes and a tailored pharmacological plan. Interval hypoxic-hyperoxic training (IHHT) has been shown as an effective program in reducing cardiovascular risk factors in patients with MS even in the absence of exercise. However, the influence of IHHT on the lipid profile and inflammation in this clinical population remains relatively unknown.Methods: A prospective, single-center, randomized controlled trial was conducted on 65 (33 men) patients with MS aged 29–74 years, who were randomly allocated to the IHHT or control (sham) experimental groups. The IHHT group completed a 3-week, 5 days/week intermittent exposure to hypoxia and hyperoxia. The control (sham) group followed the same protocol but was breathing room air instead. The primary endpoints were the lipid profile (concentrations of total cholesterol [TC], low-density lipoprotein [LDL], high-density lipoprotein [HDL], and triglycerides [TG]) and the inflammatory factors such as high-sensitivity C-reactive protein (hs-CRP), galectin-3, heat shock proteins (Hsp70). The secondary endpoints were alanine aminotransferase (ALT), aspartate aminotransferase (AST), N-terminal pro-hormone of brain natriuretic peptide level (NTproBNP), transforming growth factor beta-1 (TGF-beta1), heart-type fatty acid-binding protein (H-FABP), and nitric oxide synthase 2 (NOS2).Results: There were no differences between the two groups but the different baseline values have affected these results. The IHHT group demonstrated pre-post decrease in total cholesterol (p = 0.001), LDL (p = 0.001), and TG levels (p = 0.001). We have also found a decrease in the CRP-hs (p = 0.015) and Hsp70 (p = 0.006) in IHHT-group after intervention, and a significant decrease in pre-post (delta) differences of NTproBNP (p &lt; 0.0001) in the IHHT group compared to the control group. In addition, the patients of the IHHT group showed a statistically significant decrease in pre-post differences of ALT and AST levels in comparison with the control group (p = 0.001). No significant IHHT complications or serious adverse events were observed.Conclusions: The IHHT appears to improve lipid profile and anti-inflammatory status. It is a safe, well-tolerated procedure, and could be recommended as an auxiliary treatment in patients suffering from MS, however, the experiment results were limited by the baseline group differences.Clinical Trial Registration:ClinicalTrials.gov, identifier [NCT04791397]. Evaluation of the effect of IHHT on vascular stiffness and elasticity of the liver tissue in patients with MS.

Substitution of parts of aerobic training by resistance training lowers fasting hyperglycemia in individuals with metabolic syndrome

2021 ◽  
Vol 46 (1) ◽  
pp. 69-76
Author(s):  
Alfonso Moreno-Cabañas ◽  
Juan Fernando Ortega ◽  
Felix Morales-Palomo ◽  
Miguel Ramirez-Jimenez ◽  
Laura Alvarez-Jimenez ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Resistance Training ◽  
Oxygen Uptake ◽  
Maximal Oxygen Uptake ◽  
Aerobic Training ◽  
Control Group ◽  
Maximal Heart Rate ◽  
Model Assessment ◽  
Z Score ◽  
Leg Press

We sought to determine the effects of substituting parts of aerobic training (AT) by resistance training (RT) on metabolic syndrome (MetS) factors. MetS patients (aged 56 ± 7 years; body mass index 33 ± 5 kg·m−2 and 3.9 ± 0.8 MetS factors) were randomized to undergo 1 of the following isocaloric, 16-week long exercise programs: (i) cycling 4 bouts of 4-min at 90% of maximal heart rate (HRmax) followed by 3 sets of 12 repetitions of 3 lower limb free-weight exercises (high-intensity interval training (HIIT)+RT group; n = 33), (ii) cycling 5 bouts of 4 min at 90% of HRmax (HIIT+HIIT group; n = 33), or (iii) no exercise control group (n = 21). We measured the evolution of all 5 MetS components (z score), cardiorespiratory fitness (maximal oxygen uptake), leg strength and power (leg press 1-repetition maximum (1RM) and countermovement jump (CMJ)), fasting blood glucose (FG), fasting insulin, and insulin resistance (homeostasis model assessment 2). Both training groups improved maximal oxygen uptake similarly (170 ± 310 and 190 ± 210 mL O2·min−1; P < 0.001) and z score (−0.12 ± 0.29 and −0.12 ± 0.31 for HIIT+RT and HIIT+HIIT, respectively; P < 0.02). However, only HIIT+RT improved CMJ (P = 0.002) and leg press 1RM above the HIIT+HIIT group (21% vs 6%; P < 0.001). Furthermore, FG only decreased in the HIIT+RT group (5%; P = 0.026, time × group). Our findings suggest that substitution of part of HIIT by leg RT improves glucose control in MetS individuals. Novelty Most studies addressing the efficacy of endurance versus resistance training are not matched by energy expenditure. We found that substituting 20% of AT with RT reduces hyperglycemia in MetS individuals. Training recommendations to regain glycemic control in MetS individuals should include resistance training.

Disorders of the autonomic nervous system in patients with leiomyoma associated with metabolic syndrome

2017 ◽  
pp. 98-100
Author(s):  
M. Pavlovska ◽  
Keyword(s):  
Metabolic Syndrome ◽  
Nervous System ◽  
Autonomic Nervous System ◽  
Uterine Leiomyoma ◽  
Sleep Disturbances ◽  
Parasympathetic Nervous System ◽  
Control Group ◽  
Positive Direction ◽  
Autonomic Nervous ◽  
The Metabolic Syndrome

The objective: to examine the manifestations of autonomic nervous system dysfunction in women with uterine leiomyoma against the background of metabolic syndrome. Patients and methods. The study included 64 women (30 patients with uterine leiomyoma associated with metabolic syndrome, a group 1, and 34 healthy women, the control group). To characterize the state of the autonomic nervous system applied of A.M. Wayne was determined, index Kerdo, evaluated the degree of sleep according to the questionnaire of A.M. Wayne. Results. Kerdo index inclined in a positive direction and rate was 20.04. Established light sleep disturbances on tables A.M. Wayne in 36.7% of patients in normal – 2.94%, that indicate the presence of somaticaly-vegetative signs and an indication of dysfunctional deviations of the autonomic nervous system tone. Сonclusion. On the basis of subjective and objective signs of dominance tone of the sympathetic and parasympathetic nervous system in patients with uterine leiomyoma, associated with metabolic syndrome, found vahotonic option dysfunction of the autonomic nervous system. Kerdo index showed a negative sign, which is -3.6; in healthy individuals Key words: autonomic tone, uterine leiomyoma, the metabolic syndrome.

scholarly journals Inter-Individual Variability in Metabolic Syndrome Severity Score and VO2max Changes Following Personalized, Community-Based Exercise Programming

2019 ◽  
Vol 16 (23) ◽  
pp. 4855
Author(s):  
Sophie Seward ◽  
Joyce Ramos ◽  
Claire Drummond ◽  
Angela Dalleck ◽  
Bryant Byrd ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Treatment Group ◽  
Exercise Intervention ◽  
Exercise Program ◽  
Community Setting ◽  
Individual Variability ◽  
Control Group ◽  
Z Score ◽  
Cvd Risk ◽  
Community Based

This study sought to examine the effectiveness of a personalized, community-based exercise program at reducing MetS severity and consequently Type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD) risk. One-hundred and fifty physically inactive participants (aged 18–83 years) were randomized to a non-exercise control group (n = 75; instructed to continue their usual lifestyle habits) or treatment group (n = 75). Participants randomized to the treatment group completed a 12 week personalized exercise training program based on the American Council on Exercise (ACE) Integrated Fitness Training (IFT) model guidelines. Z-scores were derived from levels of metabolic syndrome risk factors to determine the severity of MetS (MetS z-score). After 12 weeks, the treatment group showed a significant favorable change in MetS z-score, whereas the control group demonstrated increased severity of the syndrome (between-group difference, p < 0.05). The proportion of MetS z-score responders (Δ > −0.48) was greater following the exercise intervention (71%, 50/70) compared to control (10%, 7/72) (between group difference, p < 0.001). The inter-individual variability in VO2max change also showed a similar trend. These findings provide critical translational evidence demonstrating that personalized exercise programming based upon the ACE IFT model guidelines can be successfully implemented within the community setting to reduce T2DM and CVD risk.

scholarly journals PENGARUH THERAPEUTIC LIFESTYLE CHANGES (TLCs) TERHADAP KUALITAS HIDUP LANSIA HIPERTENSI

2020 ◽  
Vol 11 (1) ◽  
pp. 1444-1453
Author(s):  
Awaludin Jahid Abdillah
Keyword(s):  
Quality Of Life ◽  
Intervention Group ◽  
The Elderly ◽  
Lifestyle Changes ◽  
Control Group ◽  
P Value ◽  
Average Difference ◽  
Therapeutic Lifestyle Changes ◽  
Difference Test

ABSTRAKKehadiran penyakit kronis salah satunya adalah hipertensi di kalangan lansia memberikan risiko penurunan fungsional pada populasi lansia dan dapat mempengaruhi kualitas hidup lansia. Salah satu penatalaksanaan hipertensi pada lansia adalah melakukan modifikasi perilaku atau gaya hidup lansia itu sendiri atau lebih dikenal denganTherapeutic Lifestyle Changes for hypertension (TLCs). Tujuan penelitian ini adalah pengaruh Therapeutic Lifestyle Changes (TLCs) terhadap kualitas hidup lansia dengan hipertensi.Desain penelitian yang digunakan adalah Pre Eksperimental Design (quasi experiment) dengan pretest-posttest with control group.  Jumlah sampel yang digunakan adalah 64 sampel terdiri dari 32 responden pada kelompok intervensi dan kelompok kontrol. Analisis data statistic menggunakan T test independen dan Mann-Whitney test.Uji beda rata-rata menunjukan terdapat pengaruh therapeutic lifestyle changes terhadap kualitas hidup lansia dengan hipertensi pada kelompok intervensi pada domain  Aktifitas pada masa lampau kini dan yang akan datang (p value 0.020), domain partisipasi sosial (p value 0.000) dan domain persahabatan dan cinta kasih (p value 0.020), sedangkan uji beda rata-rata pada kelompok intervensi dan kontrol didapatkan pengaruh kualitas lansia dengan hipertensi (p value 0.000).Kata Kunci :  Therapeutic Lifestyle Changes, Kualitas hidup  ABSTRACTThe presence of chronic diseases, one of which is hypertension among the elderly provides a risk of functional decline in the elderly population and can affect the quality of life of the elderly. One of the management of hypertension in the elderly is to modify the behavior or lifestyle of the elderly itself or better known as Therapeutic Lifestyle Changes for hypertension (TLCs). The purpose of this study is the effect of Therapeutic Lifestyle Changes (TLCs) on the quality of life of the elderly with hypertension.The research design used was Pre Experimental Design (quasi experiment) with pretest-posttest with control group. The number of samples used was 64 samples consisting of 32 respondents in the intervention group and the control group. Statistical data analysis using independent T test and Mann-Whitney test.The average difference test shows there is an effect of therapeutic lifestyle changes on the quality of life of the elderly with hypertension in the intervention group in the past and present domains of activity (p value 0.020), the domain of social participation (p value 0.000) and the domain of friendship and love you (p value 0.020). while the average difference test in the intervention and control group was influenced by the quality of the elderly with hypertension (p value 0.000).Keywords: Therapeutic Lifestyle Changes, Quality of  life

scholarly journals Sodium Alginate Supplementation Plus HIIT and MICT Can Induce CCK and PYY Increment in Men With Metabolic Syndrome

2021 ◽  
Author(s):  
Alireza Ebrahimi ◽  
Mohammad azizi ◽  
Worya Tahmasebi ◽  
Rastegar Hoseini
Keyword(s):  
Metabolic Syndrome ◽  
Sodium Alginate ◽  
Control Group ◽  
Z Score ◽  
Active Recovery ◽  
Sweet Water ◽  
The Usa ◽  
And Control ◽  
Main Meals ◽  
Made In

Abstract Background: Abdominal obesity is a common phenomenon in metabolic syndrome (MetS). Inducing satiety by weight management plays an important role in reducing the risk of obesity and consequently MetS. This study was investigated effect of sodium alginate supplementation plus HIIT and MICT on CCK and PYY increment in MetS men. Methods: For this purpose, 40 men with MetS volunteered and were randomly divided into five groups as follow: HIIT groups with supplement (n=8, 4*4 min bouts at 85-95% of HRpeak, with 3 min of active recovery at 50-70% HRpeak, 3 ses/week), HIIT (n=8, 4*4 min bouts at 85-95% of HRpeak, with 3 min of active recovery at 50-70% HRpeak, 3 ses/week), MICT with supplement (n=8, 30 min at 60-70% HRpeak, 3 ses/week), MICT (n=8, 30 min at 60-70% HRpeak, 3 ses/week) and control group (n = 8, no exercise). The HITT+S and MICT+S groups consumed 1.5 g of Sigma sodium alginate (made in the USA) solution in 100 mg of sweet water (7 g of fructose), 30 minutes before 3 main meals three days per week during 8 weeks. Results: After 8 weeks of interventions, CCK and PYY were markedly increased in the studied groups, this increase was significantly greater in the HIIT+S than other groups. Also, the MetS Z score was significantly decreased in all studied groups and this decrease was significantly higher in the HIIT+S than other groups (P <0.05). Conclusion: The results showed that HIIT and MICT led to an overall improvement in men with MetS. However, combining sodium alginate supplementation triggers these improvements.Trial registration: IRCT20190916044788N1. Registered 12 march 2020, https://www.irct.ir/

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