The Effects of Intermittent Hypoxic–Hyperoxic Exposures on Lipid Profile and Inflammation in Patients With Metabolic Syndrome

Background: Patients with metabolic syndrome (MS) tend to suffer from comorbidities, and are often simultaneously affected by obesity, dysglycemia, hypertension, and dyslipidemia. This syndrome can be reversed if it is timely diagnosed and treated with a combination of risk factors-reducing lifestyle changes and a tailored pharmacological plan. Interval hypoxic-hyperoxic training (IHHT) has been shown as an effective program in reducing cardiovascular risk factors in patients with MS even in the absence of exercise. However, the influence of IHHT on the lipid profile and inflammation in this clinical population remains relatively unknown.Methods: A prospective, single-center, randomized controlled trial was conducted on 65 (33 men) patients with MS aged 29–74 years, who were randomly allocated to the IHHT or control (sham) experimental groups. The IHHT group completed a 3-week, 5 days/week intermittent exposure to hypoxia and hyperoxia. The control (sham) group followed the same protocol but was breathing room air instead. The primary endpoints were the lipid profile (concentrations of total cholesterol [TC], low-density lipoprotein [LDL], high-density lipoprotein [HDL], and triglycerides [TG]) and the inflammatory factors such as high-sensitivity C-reactive protein (hs-CRP), galectin-3, heat shock proteins (Hsp70). The secondary endpoints were alanine aminotransferase (ALT), aspartate aminotransferase (AST), N-terminal pro-hormone of brain natriuretic peptide level (NTproBNP), transforming growth factor beta-1 (TGF-beta1), heart-type fatty acid-binding protein (H-FABP), and nitric oxide synthase 2 (NOS2).Results: There were no differences between the two groups but the different baseline values have affected these results. The IHHT group demonstrated pre-post decrease in total cholesterol (p = 0.001), LDL (p = 0.001), and TG levels (p = 0.001). We have also found a decrease in the CRP-hs (p = 0.015) and Hsp70 (p = 0.006) in IHHT-group after intervention, and a significant decrease in pre-post (delta) differences of NTproBNP (p < 0.0001) in the IHHT group compared to the control group. In addition, the patients of the IHHT group showed a statistically significant decrease in pre-post differences of ALT and AST levels in comparison with the control group (p = 0.001). No significant IHHT complications or serious adverse events were observed.Conclusions: The IHHT appears to improve lipid profile and anti-inflammatory status. It is a safe, well-tolerated procedure, and could be recommended as an auxiliary treatment in patients suffering from MS, however, the experiment results were limited by the baseline group differences.Clinical Trial Registration:ClinicalTrials.gov, identifier [NCT04791397]. Evaluation of the effect of IHHT on vascular stiffness and elasticity of the liver tissue in patients with MS.

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The Relationship Between Hematological Neoplasms and Lipid Profile

Medeniyet Medical Journal ◽

10.5222/mmj.2021.91145 ◽

2021 ◽

Author(s):

Erman Öztürk

Keyword(s):

Lipid Profile ◽

Total Cholesterol ◽

Chronic Diseases ◽

Hematological Malignancies ◽

Hematologic Malignancy ◽

International Prognostic Index ◽

Prognostic Index ◽

Density Lipoprotein ◽

Group Method ◽

Control Group

Objective: Hypocholesterolemia is a metabolism disorder that may be seen in chronic diseases and malignancies. Various dyslipidemia profiles have been shown in adult and pediatric hematological malignancies. We aimed to evaluate the lipid profile properties in patients diagnosed with a hematological malignancy compared to a healthy control group. Method: Out of 1213 patients diagnosed with hematologic malignancy, the data of 98 patients whose pretreatment lipid profiles had already been studied, were reviewed. Forty healthy individuals were selected as the control group. The levels of total cholesterol, triglycerides (TG), low-density lipoprotein (LDL), and high-density lipoprotein (HDL) were compared. Results: Triglyceride values were significantly higher (p=0.02), and the total cholesterol, LDL and HDL levels were lower in the study group compared to the control group. Triglyceride values were higher (p=0.013), and HDL levels were lower (p=0.022) in parallel with increases in uric acid levels. There was a significant correlation between the International Prognostic Index (IPI) score and TG (p=0.003) in those diagnosed with non-Hodgkin lymphoma (NHL). Whereas no significant correlation was found between TG, total cholesterol, and LDL values in the limited (early) and advanced stage NHL, while a significant negative correlation was found with HDL (p=0.027). Conclusion: Hypertriglyceridemia, as well as low LDL and HDL values may be seen in hematological malignancies. It should be kept in mind that there may be chronic diseases and malignancies in the etiology of incidental hypocholesterolemia and hypertriglyceridemia. Further studies are needed on this subject to determine the effects of dyslipidemia on the pathogenesis and prognosis of the disease in hematological malignancies.

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Influence of Apolipoprotein E on the Lipid Profile and Postprandial Triglyceride Levels in Brazilian Postmenopausal Women With Artery Disease

Clinical Medicine Insights Cardiology ◽

10.1177/1179546817731110 ◽

2017 ◽

Vol 11 ◽

pp. 117954681773111 ◽

Cited By ~ 1

Author(s):

Lúcia Helena Bonalume Tácito ◽

Lilian Nakachima Yamada ◽

Marcela Augusta de Souza Pinhel ◽

Juan Carlos Yugar-Toledo ◽

Dorotéia Rossi Silva Souza

Keyword(s):

Risk Factors ◽

Coronary Artery Disease ◽

Lipid Profile ◽

Postmenopausal Women ◽

Density Lipoprotein ◽

Control Group ◽

Metabolic Kinetics ◽

Postprandial Triglyceride ◽

Artery Disease ◽

Kinetics Of

This study confirms the association of risk factors for coronary artery disease (CAD) and the apoE polymorphisms, specifically related to the APOE*4 allele, with coronary disease in postmenopausal women. Significantly altered values of the lipid profile were found in patients when compared with controls, independent of the presence of the APOE*4 allele. However, the controls showed higher high-density lipoprotein cholesterol (HDL-C) levels and reduced triglyceride (TG) levels, differing significantly from patients. In this case, the study of subgroups, considering the APOE*3/3 and APOE*3/4 genotypes, suggests that the APOE*4 allele is not implicated in the variations of the lipid profile of patients and determined an increase in the production levels of HDL-C and a reduction in TG highly benefiting the control group compared with APOE*3/3 genotype. The metabolic kinetics of TG, although with the same pattern between groups, and the presence of the APOE*4 allele are suggested to be associated with accelerated clearance compared with APOE*3 allele in non-CAD group.

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Urinary Resveratrol Metabolites Output: Differential Associations with Cardiometabolic Markers and Liver Enzymes in House-Dwelling Subjects Featuring Metabolic Syndrome

Molecules ◽

10.3390/molecules25184340 ◽

2020 ◽

Vol 25 (18) ◽

pp. 4340

Author(s):

Vanessa Bullón-Vela ◽

Itziar Abete ◽

Maria Angeles Zulet ◽

Yifan Xu ◽

Miguel A. Martínez-González ◽

...

Keyword(s):

Metabolic Syndrome ◽

Lipid Profile ◽

Total Cholesterol ◽

Phase Ii ◽

Liver Enzymes ◽

Density Lipoprotein ◽

Total Urine ◽

Liver Markers ◽

Glutamyl Transferase ◽

Phase Ii Metabolites

Metabolic syndrome (MetS) components are strongly associated with increased risk of non-alcoholic fatty liver disease (NAFLD) development. Several studies have supported that resveratrol is associated with anti-inflammatory and antioxidant effects on health status. The main objective of this study was to assess the putative associations between some urinary resveratrol phase II metabolites, cardiometabolic, and liver markers in individuals diagnosed with MetS. In this cross-sectional study, 266 participants from PREDIMED Plus study (PREvención con DIeta MEDiterránea) were divided into tertiles of total urinary resveratrol phase II metabolites (sum of five resveratrol conjugation metabolites). Urinary resveratrol metabolites were analyzed by ultra- performance liquid chromatography coupled to triple quadrupole mass spectrometry (UPLC-Q-q-Q MS), followed by micro-solid phase extraction (µ-SPE) method. Liver function markers were assessed using serum levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and gamma-glutamyl transferase (GGT). Moreover, lipid profile was measured by triglycerides, very-low-density lipoprotein cholesterol (VLDL-c), and total cholesterol/high-density lipoprotein ratio (total cholesterol/HDL). Linear regression adjusted models showed that participants with higher total urine resveratrol concentrations exhibited improved lipid and liver markers compared to the lowest tertile. For lipid determinations: log triglycerides (βT3= −0.15, 95% CI; −0.28, −0.02, p-trend = 0.030), VLDL-c, (βT3= −4.21, 95% CI; −7.97, −0.46, p-trend = 0.039), total cholesterol/HDL ratio Moreover, (βT3= −0.35, 95% CI; −0.66, −0.03, p-trend = 0.241). For liver enzymes: log AST (βT3= −0.12, 95% CI; −0.22, −0.02, p-trend = 0.011, and log GGT (βT3= −0.24, 95% CI; −0.42, −0.06, p-trend = 0.002). However, there is no difference found on glucose variables between groups. To investigate the risk of elevated serum liver markers, flexible regression models indicated that total urine resveratrol metabolites were associated with a lower risk of higher ALT (169.2 to 1314.3 nmol/g creatinine), AST (599.9 to 893.8 nmol/g creatinine), and GGT levels (169.2 to 893.8 nmol/g creatinine). These results suggested that higher urinary concentrations of some resveratrol metabolites might be associated with better lipid profile and hepatic serum enzymes. Moreover, urinary resveratrol excreted showed a reduced odds ratio for higher liver enzymes, which are linked to NAFLD.

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Effect of green tea consumption on the metabolic syndrome indices in women: a clinical trial study

Nutrition & Food Science ◽

10.1108/nfs-03-2018-0091 ◽

2019 ◽

Vol 49 (1) ◽

pp. 32-46 ◽

Cited By ~ 3

Author(s):

Fatemehbanoo Mortazavi ◽

Zamzam Paknahad ◽

Akbar Hasanzadeh

Keyword(s):

Blood Pressure ◽

Metabolic Syndrome ◽

Clinical Trial ◽

Lipid Profile ◽

Blood Sugar ◽

Green Tea ◽

Density Lipoprotein ◽

Control Group ◽

Tea Consumption ◽

Content Type

PurposeMetabolic syndrome (MetS) is a complex disorder that exacerbates the risk of cardiovascular disease and diabetes mellitus; some studies have indicated the beneficial effects of green tea on human health. The purpose of this study is to investigate the effects of green tea consumption on the MetS indicators in women.Design/methodology/approachA randomized clinical trial was carried out on 70 eligible women with confirmed diagnosis of MetS who visited Shabani Diabetes Clinic (Isfahan, Iran). Participants were randomly divided into two groups. Participants in the Green Tea Group were asked to consume three 200 cc of green tea in the morning, at noon and at night for eight weeks, while people in the control group were asked to take identical amount of lukewarm water at the same schedule. Anthropometric indicators, blood pressure, blood sugar, lipid profile, diet and physical activity were assessed at the beginning and the end of the study.FindingsAn independentt-test showed that weight (p =0.001), body mass index (p =0.001), waist circumference (p< 0.001) and waist–hip ratio (p =0.02), systolic blood pressure (p =0.04), fasting blood glucose (p =0.01) and low density lipoprotein (p =0.03) changed significantly more in the Green Tea Group than in the control group; but no such inter-group difference was observed in diastolic blood pressure, triglyceride, total cholesterol and high density lipoprotein (HDL) values (p> 0.05).Originality/valueRegular consumption of green tea for eight weeks significantly improved anthropometric indices, blood pressure, blood sugar and lipid profile in women with MetS. Therefore, this beverage can serve as part of an effective dietary strategy to control MetS.

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ADIPONUTRIN LEVELS IN HYPERTENSIVE PATIENTS DEPENDING ON THE DEGREE OF OBESITY

Inter Collegas ◽

10.35339/ic.8.1.10-17 ◽

2021 ◽

Vol 8 (1) ◽

pp. 10-17

Author(s):

P. Kravchun ◽

O. Kadykova ◽

U. Herasymchuk

Keyword(s):

Risk Factors ◽

Metabolic Syndrome ◽

Body Mass Index ◽

Lipid Profile ◽

Linear Relationship ◽

Carbohydrate Metabolism ◽

Overweight And Obesity ◽

Control Group ◽

Hypertensive Patients ◽

Grade 3

Introduction. Well-known the fact that obesity, especially its abdominal (visceral) form, is one of the most important risk factors for hypertension. The purpose: to determine the level of adiponutrin in patients with hypertension and obesity. Assess how the degree of hypertension and obesity affects the level of adiponutrin in our patients with this comorbid pathology. Materials and methods. The study included 58 patients with hypertension. Grade 1 was diagnosed in 12 (20.69%), grade 2 - in 16 (27.59%), grade 3 - in 30 (51.72%) examined patients. Of these, 32 women and 26 men aged 32 to 79 years (mean age 57.5 ± 10.11 years). Patients underwent anthropometric measurements, assessed lipid profile and changes in carbohydrate metabolism, adiponutrin levels. Results. The level of adiponutrin in all groups of hypertensive patients with overweight and obesity was significantly increased compared to the control group, but the degree of hypertension did not affect the level of adiponutrin. However, the concentration of the latter in the serum gradually increases according to the duration of hypertension. In addition, the level of adiponutrin increased depending on the degree of obesity, which, in turn, was confirmed by a reliable direct linear relationship between adiponutrin and body mass index. Conclusions. Based on the data obtained, adiponutrin can be considered as a marker of metabolic syndrome.

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Association of VEGF +405 C > G (rs2010963) polymorphism with susceptibility of metabolic syndrome: Cardio-metabolic risk factors and serum Matrix Metaloproteinase-3 concentrations

Ecological genetics ◽

10.17816/ecogen70303 ◽

2021 ◽

Vol 19 (3) ◽

pp. 263-271

Author(s):

Leila Nikniaz ◽

Mahdieh Abbasalizad-Farhangi

Keyword(s):

Risk Factors ◽

Metabolic Syndrome ◽

Gene Polymorphism ◽

Density Lipoprotein ◽

Serum Levels ◽

Control Group ◽

Vegf Gene ◽

Pcr Rflp ◽

Elisa Technique ◽

Vegf Gene Polymorphism

BACKGROUND: In the present study we investigated the role of +405 VEGF gene polymorphism in the pathogenesis of metabolic syndrome and to explore its association with several biochemical risk factors. MATERIALS AND METHODS: VEGF +405 single nucleotide polymorphism were genotyped in 150 patients with metabolic syndrome and 50 healthy individuals using the PCR-RFLP method. Serum levels of biochemical variables were assessed by commercial ELISA technique. RESULTS: GC genotype was more prevalent among patients with metabolic syndrome. In GC genotype, patients with metabolic syndrome had higher waist to hip ratio, WHR, triglyceride, and lower high density lipoprotein and alanine aminotransferase concentrations compared with the control group. CONCLUSIONS: The current study demonstrated that +405 VEGF gene polymorphism was a potent predictor of metabolic abnormalities in patients with metabolic syndrome. Further studies with larger sample size are needed to clarify these associations properly.

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Metabolic Syndrome and Cardiovascular Risk Factors in Obese Adolescent

Open Access Macedonian Journal of Medical Sciences ◽

10.3889/oamjms.2016.037 ◽

2016 ◽

Vol 4 (1) ◽

pp. 118-121 ◽

Cited By ~ 11

Author(s):

Manal Mansour ◽

Yasser E. Nassef ◽

Mones Abu Shady ◽

Ali Abdel Aziz ◽

Heba A. El Malt

Keyword(s):

Risk Factors ◽

Metabolic Syndrome ◽

Cardiovascular Risk ◽

Blood Glucose ◽

Total Cholesterol ◽

Blood Lipids ◽

Density Lipoprotein ◽

P Value ◽

Lipid Levels ◽

Obese Adolescent

BACKGROUND: Childhood and adolescent obesity is associated with insulin resistance, abnormal glucose metabolism, hypertension, dyslipidemia, inflammation, liver disease, and compromised vascular function. The purpose of this study was to determine the prevalence of cardiovascular risk factor abnormalities and metabolic syndrome in a sample of obese adolescent as prevalence data might be helpful in improving engagement with obesity treatment in future. The high blood lipid levels and obesity are the main risk factors for cardio vascular diseases. Atherosclerotic process begins in childhood.AIM: This study aimed to investigate the relationship between obesity in adolescent and their blood lipids levels and blood glucose level.METHODS: This study was conducted with 100 adolescents of both gender age 12-17 years and body mass index (BMI) greater than 95th percentiles and 100 normal adolescents as control group. The blood samples were collected from all adolescents after overnight fasting (10 hours) to analyze blood lipids (Total cholesterol, high density lipoprotein, low density lipoprotein) and hematological profile (Hemoglobin, platelets and red blood cell, C reactive protein and fasting blood glucose.RESULTS: There were statistical difference between the two groups for red blood cells (P<0.001), Hemoglobin (P < 0.001) and platelets (P = 0.002), CRP (P = 0.02). Positive correlation was found between the two groups as regards total cholesterol (P = 0.0001), P value was positive for HDL (P = 0.005 and Atherogenic index P value was positive (P = 0.002). Positive correlation was found between the two group as regards fasting blood glucose (P = 0.001).CONCLUSION: Saturated fat was associated with elevated lipid levels in obese children. These results reinforce the importance of healthy dietary habits since child-hood in order to reduce the risks of cardiovascular diseases in adulthood.

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Prevalence of Metabolic Syndrome and its Related Risk Factors in the City of Oran, Algeria: the ISOR Study

Ethnicity & Disease ◽

10.18865/ed.26.1.99 ◽

2016 ◽

Vol 26 (1) ◽

pp. 99 ◽

Cited By ~ 9

Author(s):

Leila Houti ◽

Imane Hamani-Medjaoui ◽

Sarah A. Lardjam-Hetraf ◽

Hadjira Ouhaibi-Djellouli ◽

Saada Chougrani ◽

...

Keyword(s):

Physical Activity ◽

Risk Factors ◽

Metabolic Syndrome ◽

Abdominal Obesity ◽

Urban Population ◽

Density Lipoprotein ◽

Hdl Cholesterol ◽

Lifestyle Changes ◽

Cholesterol Concentration ◽

The City

Background: Aging and lifestyle changes had led to an epidemiological transition, with a significant impact on the incidence of cardiovascular diseases in North Africa. Objective: The aim of this study was to determine the prevalence of metabolic syndrome and its associated factors, which were unknown, among an urban population in Algeria.Methods: During 2007-2009, 787 individuals aged 30-64 years, randomly selected from the list of insured persons residing in the city of Oran, participated in a clinical, anthropometric and biological survey. Participants were classified according to the National Cholesterol Education Program - Adult Treatment Panel (NCEP-ATP) III definition of metabolic syndrome. Results: The prevalence of metabolic syndrome was 20%, higher in women than men (25.9 vs 13.7%; P<.0001). Among the components of the syndrome, the most common risk factors observed in women were a low high-density lipoprotein (HDL) cholesterol concentration (60.4% vs 44.2% in men) and abdominal obesity (46.8% vs 30.1% in men) whereas men displayed more high blood pressure (42.5% vs 34.8% in women). In men, metabolic syndrome was more frequent in married and highly educated participants. In contrast, women with a high level of education and who had an intermediate level of physical activity seemed to be protected. Conclusions: Metabolic syndrome, prevalent in the urban population of North Algeria, is associated with a high proportion of low HDL-cholesterol and abdominal obesity, especially among women. There is a need for prevention strategies involving promotion of physical activity for the whole population and screening for hypertension among men. Ethn Dis. 2016;26(1):99-106; doi:10.18865/ed.26.1.99

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Gender based differences in lipid profile and other novel atherogenic risk factors in type-2 diabetes mellitus patients

International Journal of Research in Medical Sciences ◽

10.18203/2320-6012.ijrms20213940 ◽

2021 ◽

Vol 9 (10) ◽

pp. 3099

Author(s):

Arpita Jaidev ◽

Hitesh Shah ◽

Mayank K. Chaturvedi

Keyword(s):

Diabetes Mellitus ◽

Risk Factors ◽

Lipid Profile ◽

Total Cholesterol ◽

Demographic Data ◽

Density Lipoprotein ◽

Atherogenic Index ◽

Atherogenic Dyslipidemia ◽

Diabetic Patients ◽

Men And Women

Background: Utilization of lipids and lipoproteins gets altered in diabetes mellitus (DM) leading to atherogenic dyslipidemia. This study evaluates cardiovascular risk profile of diabetic men and women, including conventional lipid profile and novel risk factors namely lipid ratios, atherogenic coefficient and atherogenic index.Methods: In all 200 diabetic patients (100 males and 100 females) aged 18-65 years who were under treatment were randomly sampled for the study. Socio-demographic data were collected. Glycated hemoglobin levels, lipid profile, fasting blood sugar, were estimated using standard procedures. Anthropometric variables such body mass index (BMI) was measured, systolic and diastolic blood pressures were also taken. There was no difference between men and women with respect to duration of DM and type of treatment.Results: Lipid profile estimates showed that diabetic females had higher level of total cholesterol (TC) (198.07 vs 169.5 mg/dl) and higher level of high-density lipoprotein (HDL)-C (43.99 vs. 41 mg/dl) as compared to males. All the parameters that are raised total cholesterol, triglyceride levels and low-density lipoprotein (LDL) levels were observed in significantly higher proportion of females as compared to males. The values of atherogenic indices [CR1, CR2, AC and atherogenic index of plasma (AIP)] for both genders were higher than the baseline value. In this study females had higher mean non-HDL 154 mg/dl as compared to males mean non-HDL 129 mg/dl and this study showed that female participants held on in high-risk AIP category and so they were at a higher risk of developing coronary heart condition.Conclusions: Dyslipidemia was observed in a greater proportion of female diabetic patients than male diabetic patients.

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Dyslipidemia in Psoriasis: A Case - Controlled Study

Nepal Journal of Dermatology Venereology & Leprology ◽

10.3126/njdvl.v19i2.38556 ◽

2021 ◽

Vol 19 (2) ◽

pp. 39-43

Author(s):

Monique Kafle ◽

Madhu Gyawlee ◽

Amit Amatya ◽

Bhaskar Mohan Meher Kayastha ◽

Smarika Upadhyaya

Keyword(s):

High Density Lipoprotein ◽

Lipid Profile ◽

Total Cholesterol ◽

Low Density Lipoprotein ◽

Density Lipoprotein ◽

High Density ◽

Controlled Study ◽

Control Group ◽

Low Density ◽

Chronic Inflammatory Condition

INTRODUCTION: Psoriasis is a chronic inflammatory condition of skin which can be associated with other ailments including dyslipidemia which is an abnormal serum lipid profile. OBJECTIVE: The aim of present study was to determine correlation between dyslipidemia and Psoriasis of patients visiting the Out-patient Department of Patan Hospital METHODS: Ninety patients were selected for study. Among them 30 patients with psoriasis were taken as cases and 60 patients that matched for age and sex with Psoriasis patients were taken as controls. The lipid profile that comprised four parameters: serum High-density Lipoprotein, Low-density Lipoprotein, Total Cholesterol and Triglyceride were determined and compared for both case and control groups. RESULTS: More than 95% of the psoriatic patients had dyslipidemia. The odds of dyslipidemia among Psoriatic patients were 1.709 times higher compared to control group (p <0.001). Among the parameters, results showed High-density lipoprotein was significantly lower while Triglyceride was significantly higher among the cases compared to controls with p value of 0.012 and 0.001 respectively. The risk factors like smoking and alcohol were present in higher proportions among the patients with dyslipidemia but it failed to reach statistical significance. With increase in duration of Psoriasis and PASI scores, lipid parameters i.e., Total cholesterol, triglyceride and Low-density lipoprotein increased while High density lipoprotein decreased but this correlation was insignificant. CONCLUSION: This study showed Dyslipidemia is significantly higher among patients with Psoriasis especially lipid profile parameters Triglyceride and total cholesterol. Thus, timely screening and management of dyslipidemia among Psoriatic patients might be helpful in prevention of future cardiovascular events.

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