scholarly journals Metabolic Risk Susceptibility in Men Is Partially Related to Adiponectin/Leptin Ratio

2013 ◽  
Vol 2013 ◽  
pp. 1-9 ◽  
Author(s):  
Gloria Lena Vega ◽  
Scott M. Grundy
Keyword(s):  
Insulin Sensitivity ◽  
Hdl Cholesterol ◽  
Cross Sectional Study ◽  
High Ratio ◽  
Cross Sectional ◽  
Cholesterol Ratio ◽  
Adult Men ◽  
Low Hdl ◽  
Adipose Tissue Triglyceride ◽  
High Triglyceride

Background. High adiponectin/leptin ratio may be protective from metabolic risks imparted by high triglyceride, low HDL, and insulin resistance.Methods. This cross-sectional study examines plasma adipokine levels in 428 adult men who were subgrouped according to low (<6.5 μg/mL)and high (≥6.5 μg/mL)adiponectin levels or a low or high ratio of adiponectin/leptin.Results. Men with high adiponectin/leptin ratio had lower plasma triglyceride and higher HDL cholesterol than those with low ratio. Similarly, those with high adiponectin/leptin ratio had lower TG/HDL cholesterol ratio and HOMA2-IR than those with low ratio. In contrast, levels of adiponectin or the ratio of adiponectin/leptin did not associate with systolic blood pressure. But the ratio of adiponectin/leptin decreased progressively with the increase in the number of risk factors for metabolic syndrome.Conclusion. Adipokine levels may reflect adipose tissue triglyceride storage capacity and insulin sensitivity. Leptin is an index of fat mass, and adiponectin is a biomarker of triglyceride metabolism and insulin sensitivity. Men with high adiponectin/leptin ratios have better triglyceride profile and insulin sensitivity than men with a low ratio regardless of waist girth.

scholarly journals DYSLIPIDEMIA AMONG THE ELDERLY IN SLUMS OF WEST DELHI

2018 ◽  
Vol 11 (2) ◽  
pp. 410
Author(s):  
Zaozianlungliu Gonmei ◽  
Supriya Dwivedi ◽  
Gurudayal Singh Toteja ◽  
Karuna Singh ◽  
Naval Kishore Vikram ◽  
...  
Keyword(s):  
Ldl Cholesterol ◽  
Lifestyle Modification ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
The Elderly ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Low Hdl ◽  
High Triglyceride

  Objective: The objective of this study is to assess the prevalence of dyslipidemia among the elderly in slums of West Delhi.Methods: A cross-sectional study was carried out in slums of West Delhi covering a total of 234 elderly aged 60 and above. 5 ml blood was collected from 103 elderly and was analyzed for serum total cholesterol, triglyceride, high-density lipoprotein (HDL) cholesterol, and low-density lipoprotein (LDL) cholesterol by enzymatic method using fully automatic analyzer (Roche Hitachi-902). Dyslipidemia was defined using the National Cholesterol Education Program, ATP-III guidelines.Results: The overall prevalence of high cholesterol (≥200 mg/dl), high triglyceride (≥150 mg/dl), low HDL cholesterol (male - <40 mg/dl; female - <50 mg/dl), and high LDL cholesterol (≥130 mg/dl) was 20.39%, 45.63%, 64.08%, and 17.31%, respectively.Conclusion: Low HDL cholesterol and high triglyceride were the most form of dyslipidemia among the elderly. Awareness on dietary and lifestyle modification for management of dyslipidemia needs to be imparted.

scholarly journals Anthropometric Parameters and Total Cholesterol to HDL Cholesterol Ratio in Long-Distance Cyclists (Indonesia North Coast and Tour de Borobudur 2017 Study)

2018 ◽  
Author(s):  
Mahalul Azam ◽  
Sri Ratna Rahayu ◽  
Arulita Ika Fibriana ◽  
Hardhono Susanto ◽  
Martha Irene Kartasurya ◽  
...  
Keyword(s):  
Total Cholesterol ◽  
Binary Logistic Regression ◽  
Hdl Cholesterol ◽  
Cross Sectional Study ◽  
North Coast ◽  
P Value ◽  
Anthropometric Parameters ◽  
Long Distance ◽  
Cross Sectional ◽  
Cholesterol Ratio

Total-Cholesterol(TC) to HDL-Cholesterol(HDL-C) ratio in athletes is well-known better than sedentary people. However, there is lack of information about comparison of TC/HDL-C in different groups of cyclists based on cycling touring characteristics and anthropometry parameters. This study was to compare TC/HDL-C ratio among groups based on type of tour participated in cyclists population.Eighty-eight participants were recruited in this cross-sectional study. Mean differences of parameters between groups analyzed by One-Way Anova test and independent t-test, while multivariate analyses was done by binary logistic-regression. P value &lt;0.05 was considered to statistical significance.TC/HDL-C ratio in all groups were less than 4.5. There is no differences of TC-levels (NC240K: 216.6±55.04, TdB140K: 208.1±27.13, TdB100K: 203.1±31.95; p=0.427). But there is significantly different of HDL-C (NC240K: 68.9±19.09, TdB140K: 52.1±13.9, TdB100K: 53.6±12.45; p=0.0001) and TC/HDL-C ratio (NC240K: 3.3±1.12, TdB140K: 4.2±1.07, TdB100K: 4.0±1.06; p=0.007). Based on TC/HDL ratio (≥4 or &lt;4) groups, there were differences of weight, BMI, waist-circumference, hip-circumference and type of cycling-touring (p&lt;0.05). Finally BMI and type of cycling-touring were the most-influenced factor.Long-distance cyclists have a synergistic effect of lipid profile and anthropometry measurements, and the heavier cycling touring participated that represent cycling training habits tend to have lower TC/HDL ratio(&lt; 4).

scholarly journals Correlation of Uric Acid Levels and Parameters of Metabolic Syndrome

2017 ◽  
pp. 481-487 ◽  
Author(s):  
L. CIBIČKOVÁ ◽  
K. LANGOVÁ ◽  
H. VAVERKOVÁ ◽  
V. KUBÍČKOVÁ ◽  
D. KARÁSEK
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Uric Acid ◽  
Hdl Cholesterol ◽  
Cross Sectional Study ◽  
Anthropometric Parameters ◽  
Cross Sectional ◽  
Hypertriglyceridemic Waist ◽  
Low Hdl ◽  
Hypertriglyceridemic Waist Phenotype

Hyperuricemia has been described as associated with the risk of development metabolic syndrome; however the relationship between the uric acid level and particular parameters of metabolic syndrome remained unclear. We performed a cross-sectional study on a cohort of 833 dyslipidemic patients and correlated their levels of uric acid with parameters of insulin resistance, lipid metabolism, C-reactive protein, anthropometric parameters. We also defined patients with hypertriglyceridemic waist phenotype and compered their uric acid levels with those without this phenotype. We found that levels of uric acid are associated with parameters of metabolic syndrome. Specifically, dyslipidemia characteristic for metabolic syndrome (low HDL cholesterol and high triglycerides) correlates better with uric acid levels than parameters of insulin resistance. Also waist circumference correlates better with uric acid levels than body mass index. Patients with hypertriglyceridemic waist phenotype had higher levels of uric acid when compared with patients without this phenotype. Serum uric acid levels are even in low levels linearly correlated with parameters of metabolic syndrome (better with typical lipid characteristics than with parameters of insulin resistance) and could be associated with higher cardiovascular risk.

scholarly journals Psychosocial job conditions and biomarkers of cardiovascular disease: A cross-sectional study in the Swedish CArdioPulmonary bioImage Study (SCAPIS)

2022 ◽  
pp. 140349482110640
Author(s):  
Mia Söderberg ◽  
Helena Eriksson ◽  
Kjell Torén ◽  
Göran Bergström ◽  
Eva Andersson ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Ldl Cholesterol ◽  
High Strain ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Diastolic Hypertension ◽  
Low Hdl ◽  
Job Conditions

Aims: The aim of this study was to investigate associations between psychosocial work exposure and the presence of biological and imaging biomarkers of cardiovascular disease. Methods: This cross-sectional study was conducted in a sub-cohort of the Swedish CArdioPulmonary bioImage Study (SCAPIS). Psychosocial exposure was evaluated with the job demand–control model, and analysed according to the standard categorization: high strain, active, passive and low strain (reference). Biomarkers (blood pressure, high-density lipoprotein (HDL) and low-density lipoprotein (LDL) cholesterol, coronary artery calcification (CAC) and metabolic syndrome) were measured, or derived through measurements, from clinical examinations. Gender-specific prevalence ratios (PRs) and 95% confidence intervals (CIs) were calculated with regression models and adjusted for age, education, smoking, physical activity, general life stress and body mass index (BMI). Results: The analyses included 3882 participants (52.5% women). High strain (high demands–low control) was linked to increased PR for low HDL cholesterol in women, adjusted for all covariates (PR 1.76; 95% CI 1.25–2.48). High strain was also related to moderately increased PR for metabolic syndrome in men, after adjustments for all covariates except BMI (PR 1.25; 95% CI 1.02–1.52). In addition, passive work (low demands–low control) was associated with diastolic hypertension in women (fully adjusted: PR 1.29; 95% CI 1.05–1.59). All relationships between psychosocial factors and LDL cholesterol or CAC (both genders), or hypertension (men), were non-significant. Conclusions: Poor psychosocial job conditions was associated with the presence of low HDL cholesterol and diastolic hypertension in women, and metabolic syndrome in men. These findings contribute to the knowledge of potential pathways between stressful work and coronary heart disease.

scholarly journals Anthropometric-Parameters and Total-Cholesterol to HDL-Cholesterol Ratio are Better in Long-Distance Cyclists (Indonesia North Coast and Tour de Borobudur 2017 Study)

2018 ◽  
Vol 14 (2) ◽  
pp. 186-194
Author(s):  
Mahalul Azam ◽  
Sri Ratna Rahayu ◽  
Arulita Ika Fibriana ◽  
Hardhono Susanto ◽  
Martha Irene Kartasurya ◽  
...  
Keyword(s):  
Total Cholesterol ◽  
Hdl Cholesterol ◽  
Cross Sectional Study ◽  
Influential Factor ◽  
North Coast ◽  
P Value ◽  
Anthropometric Parameters ◽  
Long Distance ◽  
Cross Sectional ◽  
Cholesterol Ratio

Total-Cholesterol (TC) to HDL-Cholesterol (HDL-C) ratio in athletes is well-known to be better than sedentary people. However, information about comparison of TC/HDL-C in different groups of cyclists based on cycling touring characteristics and anthropometry parameters is lacking. This study aimed to compare TC/HDL-C ratio between groups based on the type of tour in cyclists population. Eighty-eight participants were recruited in this cross-sectional study. Mean differences of parameters between groups was analyzed by One-Way Anova and independent t-test, whereas multivariate analyses was conducted by binary logistic-regression. P value <0.05 was considered statistically significant. TC/HDL-C ratio in all groups were less than 4.5. There is no differences of TC-levels (NC240K: 216.6±55.04, TdB140K: 208.1±27.13, TdB100K: 203.1±31.95; p=0.427). But there is significantly different level of HDL-C (NC240K: 68.9±19.09, TdB140K: 52.1±13.9, TdB100K: 53.6±12.45; p=0.0001) and TC/HDL-C ratio (NC240K: 3.3±1.12, TdB140K: 4.2±1.07, TdB100K: 4.0±1.06; p=0.007). Between TC/HDL ratio groups (≥4 or <4), there were differences of weight, BMI, waist-circumference, hip-circumference and type of tour (p<0.05). Finally, BMI and type of tour were the most influential factor. Long-distance cyclists have a synergistic effect of lipid profile and anthropometry measurements, and heavier cycling tour participant, that represent cycling training habits, tend to have lower TC/HDL ratio(< 4).

The effect of 25-hydroxyvitamin D on insulin sensitivity in obesity: is it mediated via adiponectin?

2013 ◽  
Vol 91 (6) ◽  
pp. 496-501 ◽  
Author(s):  
Olivia R.L. Wright ◽  
Ingrid J. Hickman ◽  
William G. Petchey ◽  
Clair M. Sullivan ◽  
Cynthia Ong ◽  
...  
Keyword(s):  
Insulin Sensitivity ◽  
Waist Circumference ◽  
Hdl Cholesterol ◽  
Cross Sectional ◽  
Cholesterol Ratio ◽  
Hydroxyvitamin D ◽  
Enhanced Production ◽  
Hmw Adiponectin ◽  
Total Adiponectin ◽  
25 Hydroxyvitamin D

There has been substantial recent interest in using vitamin D to improve insulin sensitivity and preventing/delaying diabetes in those at risk. There is little consensus on the physiological mechanisms and whether the association is direct or indirect through enhanced production of insulin-sensitising chemicals, including adiponectin. We examined cross-sectional associations between serum 25-hydroxyvitamin D (25(OH)D) and insulin sensitivity (Matsuda index), parathyroid hormone (PTH), waist circumference, body mass index (BMI), triglycerides (TG), total and high molecular weight (HMW) adiponectin, HMW : total adiponectin ratio (HMW : total adiponectin), and total cholesterol : HDL cholesterol ratio (TC:HDL cholesterol) in 137 Caucasian adults of mean age 43.3 ± 8.3 years and BMI 38.8 ± 6.9 kg/m2. Total adiponectin (standardised β = 0.446; p < 0.001), waist circumference (standardised β = –0.216; p < 0.05), BMI (standardised β = –0.212; p < 0.05), and age (standardised β = –0.298; p < 0.001) were independently associated with insulin sensitivity. Serum 25(OH)D (standardised β = 0.114; p = 0.164) was not associated with insulin sensitivity, total or HMW adiponectin, HMW : total adiponectin, or lipids. Our results provide the novel finding that 25(OH)D is not associated with HMW adiponectin or HMW : total adiponectin in nondiabetic, obese adults and support the lack of association between 25(OH)D and lipids noted by others in similar groups of patients.

scholarly journals Low HDL and high triglycerides predict COVID-19 severity

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Lluís Masana ◽  
◽  
Eudald Correig ◽  
Daiana Ibarretxe ◽  
Eva Anoro ◽  
...  
Keyword(s):  
Lipid Profile ◽  
Plasma Lipid ◽  
Hdl Cholesterol ◽  
Cross Sectional Study ◽  
Infection Process ◽  
Plasma Lipid Profile ◽  
Cross Sectional ◽  
Cholesterol Levels ◽  
Atherogenic Dyslipidaemia ◽  
Low Hdl

AbstractLipids are indispensable in the SARS-CoV-2 infection process. The clinical significance of plasma lipid profile during COVID-19 has not been rigorously evaluated. We aim to ascertain the association of the plasma lipid profile with SARS-CoV-2 infection clinical evolution. Observational cross-sectional study including 1411 hospitalized patients with COVID-19 and an available standard lipid profile prior (n: 1305) or during hospitalization (n: 297). The usefulness of serum total, LDL, non-HDL and HDL cholesterol to predict the COVID-19 prognosis (severe vs mild) was analysed. Patients with severe COVID-19 evolution had lower HDL cholesterol and higher triglyceride levels before the infection. The lipid profile measured during hospitalization also showed that a severe outcome was associated with lower HDL cholesterol levels and higher triglycerides. HDL cholesterol and triglyceride concentrations were correlated with ferritin and D-dimer levels but not with CRP levels. The presence of atherogenic dyslipidaemia during the infection was strongly and independently associated with a worse COVID-19 infection prognosis. The low HDL cholesterol and high triglyceride concentrations measured before or during hospitalization are strong predictors of a severe course of the disease. The lipid profile should be considered as a sensitive marker of inflammation and should be measured in patients with COVID-19.

Prevalence of metabolic syndrome and its associated factors among Iranian steel workers

Work ◽  
2021 ◽  
pp. 1-8
Author(s):  
Elham Heidary ◽  
Seyed Mahmoud Latifi ◽  
Davood Afshari
Keyword(s):  
Risk Factors ◽  
Metabolic Syndrome ◽  
Heart Diseases ◽  
Hdl Cholesterol ◽  
Cross Sectional Study ◽  
Steel Workers ◽  
Chi Square ◽  
Cross Sectional ◽  
Work Related ◽  
Low Hdl

BACKGROUND: Metabolic syndrome (MetS) is composed of a collection of risk factors for heart diseases and diabetes. In recent decades, metabolic syndrome has been identified as one of the important risk factors leading to the development of work-related diseases. OBJECTIVE: Since few studies have been conducted on evaluating the prevalence of MetS among Iranian workers, this cross-sectional study aimed at assessing the prevalence of MetS and the factors affecting it among Iranian steel workers. METHODS: This study was carried out on 510 employees working in a large steel producing company. The data pertaining to blood pressure, triglycerides, cholesterol, glucose, and demographic information were collected and the Adult Treatment Panel (ATP III) criteria were implemented to diagnose MetS. RESULTS: The prevalence of Mets was obtained equal to 13% and a significant positive relationship was observed between age and the prevalence of metabolic syndrome. From among MetS elements, low HDL cholesterol and increased waist circumference were recognized as the most and the least frequently involved elements with 39.3% and 6.5% prevalence, respectively. Chi-square test was run and the results showed that the prevalence of MetS and some of its components rose at higher BMI values. It was also indicated that MetS and its components had no significant relationship with shift work. CONCLUSION: The current findings revealed that the prevalence of MetS increased with aging. Low HDL and high triglycerides levels were among the main risk factors for MetS. Therefore, considering these risk factors, it should be attempted to develop relevant strategies at workplace to encourage workers to go for a healthier lifestyle so that they can prevent the incidence of MetS.

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