Correlation of Uric Acid Levels and Parameters of Metabolic Syndrome

Hyperuricemia has been described as associated with the risk of development metabolic syndrome; however the relationship between the uric acid level and particular parameters of metabolic syndrome remained unclear. We performed a cross-sectional study on a cohort of 833 dyslipidemic patients and correlated their levels of uric acid with parameters of insulin resistance, lipid metabolism, C-reactive protein, anthropometric parameters. We also defined patients with hypertriglyceridemic waist phenotype and compered their uric acid levels with those without this phenotype. We found that levels of uric acid are associated with parameters of metabolic syndrome. Specifically, dyslipidemia characteristic for metabolic syndrome (low HDL cholesterol and high triglycerides) correlates better with uric acid levels than parameters of insulin resistance. Also waist circumference correlates better with uric acid levels than body mass index. Patients with hypertriglyceridemic waist phenotype had higher levels of uric acid when compared with patients without this phenotype. Serum uric acid levels are even in low levels linearly correlated with parameters of metabolic syndrome (better with typical lipid characteristics than with parameters of insulin resistance) and could be associated with higher cardiovascular risk.

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Psychosocial job conditions and biomarkers of cardiovascular disease: A cross-sectional study in the Swedish CArdioPulmonary bioImage Study (SCAPIS)

Scandinavian Journal of Public Health ◽

10.1177/14034948211064097 ◽

2022 ◽

pp. 140349482110640

Author(s):

Mia Söderberg ◽

Helena Eriksson ◽

Kjell Torén ◽

Göran Bergström ◽

Eva Andersson ◽

...

Keyword(s):

Metabolic Syndrome ◽

Ldl Cholesterol ◽

High Strain ◽

Density Lipoprotein ◽

Hdl Cholesterol ◽

Cross Sectional Study ◽

Cross Sectional ◽

Diastolic Hypertension ◽

Low Hdl ◽

Job Conditions

Aims: The aim of this study was to investigate associations between psychosocial work exposure and the presence of biological and imaging biomarkers of cardiovascular disease. Methods: This cross-sectional study was conducted in a sub-cohort of the Swedish CArdioPulmonary bioImage Study (SCAPIS). Psychosocial exposure was evaluated with the job demand–control model, and analysed according to the standard categorization: high strain, active, passive and low strain (reference). Biomarkers (blood pressure, high-density lipoprotein (HDL) and low-density lipoprotein (LDL) cholesterol, coronary artery calcification (CAC) and metabolic syndrome) were measured, or derived through measurements, from clinical examinations. Gender-specific prevalence ratios (PRs) and 95% confidence intervals (CIs) were calculated with regression models and adjusted for age, education, smoking, physical activity, general life stress and body mass index (BMI). Results: The analyses included 3882 participants (52.5% women). High strain (high demands–low control) was linked to increased PR for low HDL cholesterol in women, adjusted for all covariates (PR 1.76; 95% CI 1.25–2.48). High strain was also related to moderately increased PR for metabolic syndrome in men, after adjustments for all covariates except BMI (PR 1.25; 95% CI 1.02–1.52). In addition, passive work (low demands–low control) was associated with diastolic hypertension in women (fully adjusted: PR 1.29; 95% CI 1.05–1.59). All relationships between psychosocial factors and LDL cholesterol or CAC (both genders), or hypertension (men), were non-significant. Conclusions: Poor psychosocial job conditions was associated with the presence of low HDL cholesterol and diastolic hypertension in women, and metabolic syndrome in men. These findings contribute to the knowledge of potential pathways between stressful work and coronary heart disease.

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Prevalence of metabolic syndrome and its associated factors among Iranian steel workers

Work ◽

10.3233/wor-203367 ◽

2021 ◽

pp. 1-8

Author(s):

Elham Heidary ◽

Seyed Mahmoud Latifi ◽

Davood Afshari

Keyword(s):

Risk Factors ◽

Metabolic Syndrome ◽

Heart Diseases ◽

Hdl Cholesterol ◽

Cross Sectional Study ◽

Steel Workers ◽

Chi Square ◽

Cross Sectional ◽

Work Related ◽

Low Hdl

BACKGROUND: Metabolic syndrome (MetS) is composed of a collection of risk factors for heart diseases and diabetes. In recent decades, metabolic syndrome has been identified as one of the important risk factors leading to the development of work-related diseases. OBJECTIVE: Since few studies have been conducted on evaluating the prevalence of MetS among Iranian workers, this cross-sectional study aimed at assessing the prevalence of MetS and the factors affecting it among Iranian steel workers. METHODS: This study was carried out on 510 employees working in a large steel producing company. The data pertaining to blood pressure, triglycerides, cholesterol, glucose, and demographic information were collected and the Adult Treatment Panel (ATP III) criteria were implemented to diagnose MetS. RESULTS: The prevalence of Mets was obtained equal to 13% and a significant positive relationship was observed between age and the prevalence of metabolic syndrome. From among MetS elements, low HDL cholesterol and increased waist circumference were recognized as the most and the least frequently involved elements with 39.3% and 6.5% prevalence, respectively. Chi-square test was run and the results showed that the prevalence of MetS and some of its components rose at higher BMI values. It was also indicated that MetS and its components had no significant relationship with shift work. CONCLUSION: The current findings revealed that the prevalence of MetS increased with aging. Low HDL and high triglycerides levels were among the main risk factors for MetS. Therefore, considering these risk factors, it should be attempted to develop relevant strategies at workplace to encourage workers to go for a healthier lifestyle so that they can prevent the incidence of MetS.

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Insertion/deletion polymorphism of angiotensin-1 converting enzyme is associated with metabolic syndrome in Hungarian adults

Journal of the Renin-Angiotensin-Aldosterone System ◽

10.1177/1470320310394231 ◽

2011 ◽

Vol 12 (4) ◽

pp. 531-538 ◽

Cited By ~ 10

Author(s):

Szilvia Fiatal ◽

Endre Szigethy ◽

György Széles ◽

Réka Tóth ◽

Róza Ádány

Keyword(s):

Metabolic Syndrome ◽

International Diabetes Federation ◽

Hdl Cholesterol ◽

Cross Sectional Study ◽

Sex Distribution ◽

Cross Sectional ◽

Low Hdl ◽

Study Population ◽

Hungarian Population ◽

M235t Polymorphism

The aim of our study was to evaluate whether any association exists between metabolic syndrome (MS) and ACE I/D and AGT M235T gene polymorphisms in Hungarians as an example of European Caucasian population. Study subjects of our cross-sectional study were recruited from the Hungarian General Practitioners’ Morbidity Sentinel Stations Program. The study population ( n = 1762) approximates very well the age and sex distribution of the general Hungarian population. MS was defined according to the latest diagnostic criteria proposed by the International Diabetes Federation. The frequency of DD genotype (31.36% vs. 25.42%, p = 0.006) and the frequency of D allele (0.56 vs. 0.51, p = 0.006) were significantly higher in the metabolic group than in the non-metabolic group. The distribution of the AGT M235T polymorphism was similar in each group investigated. Association was shown in the case of patients in whom central obesity was combined with elevated TG and low HDL cholesterol level ( p = 0.024 and p = 0.022). It suggests that ACE I/D polymorphism is likely to be involved in lipid metabolism.

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Peripheral polyneuropathy in severely obese patients with metabolic syndrome but without diabetes: Association with low HDL-cholesterol

Revista da Associação Médica Brasileira ◽

10.1590/1806-9282.63.04.324 ◽

2017 ◽

Vol 63 (4) ◽

pp. 324-331 ◽

Cited By ~ 4

Author(s):

Otto Henrique Nienov ◽

Luciana Matte ◽

Lisiane Stefani Dias ◽

Helena Schmid

Keyword(s):

Metabolic Syndrome ◽

Univariate Analysis ◽

Hdl Cholesterol ◽

Serum Levels ◽

Cross Sectional Study ◽

Serum Triglycerides ◽

Cross Sectional ◽

Peripheral Polyneuropathy ◽

Low Hdl ◽

Severely Obese

Summary Introduction: The purpose of this study was to evaluate the prevalence of peripheral polyneuropathy (PPN) in subjects with grade II and III obesity (Ob-II,III) and metabolic syndrome (MetS) but without diabetes and to investigate possible associated factors. Method: A cross-sectional study was performed in non-diabetic Ob-II,III,MetS patients using the Michigan Neuropathy Screening Instrument (MNSI) to assess the presence of PPN. Results: A total of 24 of 218 non-diabetic Ob-II,III,MetS patients had PPN. Based on univariate analysis, serum levels of LDL-cholesterol (p=0.046) were significantly associated with PPN, while serum triglycerides (p=0.118) and low HDL-cholesterol (p=0.057) showed a tendency toward this association. On a Poisson regression analysis, when the three possible associations were included, low HDL-cholesterol (p=0.047) remained independently associated. Conclusion: In non-diabetic Ob-II,III,MetS patients, PPN defined by the MNSI showed a high prevalence and was associated with low levels of HDL-cholesterol. In order to diagnose that complication, neurological evaluation should be performed in these patients.

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Relationship of TSH levels with cardiometabolic risk factors in US youth and reference percentiles for thyroid function

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/clinem/dgaa900 ◽

2020 ◽

Author(s):

Xinlei Chen ◽

Shuliang Deng ◽

Cecilia Sena ◽

Chuhan Zhou ◽

Vidhu V Thaker

Keyword(s):

Risk Factors ◽

Insulin Resistance ◽

Abdominal Obesity ◽

Cardiometabolic Risk ◽

Hdl Cholesterol ◽

Cross Sectional Study ◽

Cardiometabolic Risk Factors ◽

Cross Sectional ◽

Low Hdl ◽

Tsh Levels

Abstract Context Thyroid hormones play an important role in the metabolic homeostasis and higher levels have been associated with cardiometabolic risk. Objective To examine the association of cardiometabolic risk factors with TSH levels in US youth. Design & Setting Cross-sectional study of youth aged 12-18 years without known thyroid abnormalities from five National Health and Nutrition Examination Survey cycles (n=2,818) representing 15.4 million US children. Subclinical hypothyroidism (SH) was defined as TSH levels 4.5-10 mIU/L. Assessed cardiometabolic risk factors include abdominal obesity (waist circumference > 90 th percentile), hypertriglyceridemia (TG ≥130 mg/dL), low HDL cholesterol (HDL-C < 40 mg/dL), elevated blood pressure (SBP and DBP ≥90 th percentile), hyperglycemia (FBG ≥100 mg/dL, or known diabetes), insulin resistance (HOMA-IR > 3.16) and elevated alanine transferase (ALT ≥ 50 U/L for boys and ≥ 44 U/L for girls). Age and sex- specific percentiles for thyroid parameters were calculated. Results In this cohort of youth (51.3% male), 31.2% had overweight/obesity. The prevalence of SH was 2.0 % (95% CI 1.2-3.1). The median TSH levels were higher in youth with overweight/obesity (p<.001). Adjusting for age, sex, race/ethnicity and obesity, youth with TSH in the 4 th quantile had higher odds of abdominal obesity (OR 2.53 [1.43-4.46], p = .002), insulin resistance (OR 2.82 [1.42-5.57], p=.003) and ≥ 2 CMRF (OR 2.20 [1.23-3.95], p=.009). Conclusions The prevalence of SH is low in US youth. The higher odds of insulin resistance and cardiometabolic risk factors in youth with TSH levels > 75 th percentile requires further study.

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The prevalence of the metabolic syndrome increases through the quartiles of thyroid stimulating hormone in a population-based sample of euthyroid subjects

Arquivos Brasileiros de Endocrinologia & Metabologia ◽

10.1590/0004-2730000003538 ◽

2014 ◽

Vol 58 (9) ◽

pp. 926-932 ◽

Cited By ~ 10

Author(s):

Alexander Shinkov ◽

Anna-Maria Borissova ◽

Roussanka Kovatcheva ◽

Iliana Atanassova ◽

Jordan Vlahov ◽

...

Keyword(s):

Metabolic Syndrome ◽

Hdl Cholesterol ◽

Population Based ◽

Cross Sectional Study ◽

Thyroid Stimulating Hormone ◽

Cross Sectional ◽

The Metabolic Syndrome ◽

Low Hdl ◽

C 32 ◽

Serum Tsh

Objective The aim of the study was to assess the prevalence and characteristics of metabolic syndrome (MetS) and its elements in relation to TSH in euthyroid subjects. Materials and methods In the cross-sectional study, 2,153 euthyroid adults, 47.2 ± 14.5 years (20-94) with no current antithyroid or thyroid replacement therapy were enrolled. All participants filled a questionnaire on past and current morbidities, medication and smoking. Body weight, height, waist circumference, serum TSH, glucose and lipids were measured. The subjects were stratified by quartiles of TSH (QTSH) and the prevalence of the MetS elements was calculated. MetS was determined by the IDF 2005 criteria. Results Overweight prevalence was 37.2% (35.2-39.2), obesity in 25.1% (23.3-26.9), abdominal obesity – 61.4% (59.3-63.5), hypertension – 42.1% (38.9-43.1), diabetes/increased fasting glucose – 13.6% (12.1-15), low HDL-cholesterol – 27.6% (25.7-29.5), hypertriglyceridemia – 24.1% (22.3-25.9), MetS – 32.2% (30.2-34.2). MetS was more prevalent in the highest QTSH (34.9%, 30.9-38.9) than the lowest (27%, 23.3-30.9), p < 0.001, as were low HDL-C (32%, 28-35.9 vs. 25%, 21.3-28.7, p < 0.001) and hypertriglyceridemia (26.8%, 23-30.5 vs. 20.4%, 17-23.8, p = 0.015). Each QTSH increased the risk of MetS by 14%, p < 0.001, of hypertriglyceridemia by 20%, p = 0.001 and of low LDL-C by 9%, p = 0.042. Other significant factors for MetS were age, male gender and obesity. Conclusion The prevalence of MetS increased with higher QTSH within the euthyroid range, mostly by an increase in the dyslipidemia. Arq Bras Endocrinol Metab. 2014;58(9):926-32

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Association of Alcohol Drinking Patterns with Metabolic Syndrome and Its Components in Korean Adults: The Korea National Health and Nutrition Examination Survey 2016–2018

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph18126433 ◽

2021 ◽

Vol 18 (12) ◽

pp. 6433

Author(s):

Seung Won Lee ◽

Sung-In Jang

Keyword(s):

Metabolic Syndrome ◽

Binge Drinking ◽

Alcohol Drinking ◽

Hdl Cholesterol ◽

Cross Sectional Study ◽

Drinking Patterns ◽

Cross Sectional ◽

Korean Adults ◽

Alcohol Drinking Patterns ◽

Drinking Frequency

This study examined the association of alcohol drinking patterns with metabolic syndrome (MetS) and its components in a nationally representative sample of South Korean adults. The cross-sectional study included 12,830 current drinkers (6438 men and 6392 women) who were at least 20 years old. Measures of alcohol drinking patterns included average drinking frequency, usual quantity, and binge drinking frequency over the past year. Multivariate logistic regression was performed to estimate odds ratios and 95% confidence intervals for MetS and its components according to alcohol drinking patterns, and also to examine linear trends in these relationships. The prevalence of MetS was 1822 (26.2%) in men and 1313 (17.5%) in women. After adjusting for potential confounding factors, drinking quantity and binge drinking frequency were positively associated with MetS in both sexes. Regarding components of MetS, while the risk of low HDL cholesterol decreased as drinking frequency increased, other MetS components (abdominal obesity, high blood pressure, and impaired fasting glucose) worsened. Our results suggest that separate management of each component of MetS will be required to protect cardio-metabolic health, and a healthy drinking culture that refrains from binge drinking should be established in the context of public health.

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Relation between uric acid and metabolic syndrome in subjects with cardiometabolic risk

Einstein (São Paulo) ◽

10.1590/s1679-45082015ao3194 ◽

2015 ◽

Vol 13 (2) ◽

pp. 202-208 ◽

Cited By ~ 14

Author(s):

Hellen Abreu da Silva ◽

Júlia Cristina Cardoso Carraro ◽

Josefina Bressan ◽

Helen Hermana Miranda Hermsdorff

Keyword(s):

Metabolic Syndrome ◽

Uric Acid ◽

Serum Uric Acid ◽

Abdominal Obesity ◽

Health Program ◽

Cardiovascular Health ◽

Cardiometabolic Risk ◽

Cross Sectional Study ◽

Cross Sectional ◽

Potential Biomarker

Objective To identify possible relations between serum uric acid levels and metabolic syndrome and its components in a population with cardiometabolic risk. Methods This cross-sectional study included 80 subjects (46 women), with mean age of 48±16 years, seen at the Cardiovascular Health Program. Results The prevalence of hyperuricemia and metabolic syndrome was 6.3% and 47.1%, respectively. Uric acid level was significantly higher in individuals with metabolic syndrome (5.1±1.6mg/dL), as compared to those with no syndrome or with pre-syndrome (3.9±1.2 and 4.1±1.3mg/dL, respectively; p<0.05). The uric acid levels were significantly higher in men presenting abdominal obesity, and among women with abdominal obesity, lower HDL-c levels and higher blood pressure (p<0.05). Conclusion Uric acid concentrations were positively related to the occurrence of metabolic syndrome and its components, and there were differences between genders. Our results indicate serum uric acid as a potential biomarker for patients with cardiometabolic risk.

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Insulin resistance in PLHIV on HAART and HAART naïve PLHIV: A Cross-sectional Study

10.36106/ijar/3506686 ◽

2020 ◽

pp. 1-3

Author(s):

Prabir Kumar Ganguly ◽

Niladri Das

Keyword(s):

Insulin Resistance ◽

Metabolic Syndrome ◽

Antiretroviral Therapy ◽

Cross Sectional Study ◽

Metabolic Effects ◽

People Living With Hiv ◽

Model Assessment ◽

Sectional Study ◽

Cross Sectional ◽

Group I

ABSTRACT HAART (Highly active antiretroviral therapy) has transformed a fatal disease to a chronic, manageable disease. But long term toxicities are emerging after prolonged exposure to antiretroviral therapy(ART). Adverse metabolic effects like dyslipidemia, increased blood pressure, and insulin resistance(IR) have been attributed to HAART. Therefore, the use of HAART raises concerns regarding metabolic disorders and cardiovascular risk in HIV(Human immunodeficiency virus) infected patients. Objective: To determine the prevalence of insulin resistance in a cohort of HIV infected patients on HAART as compared to HAART naïve PLHIV(People living with HIV) Methods: A cross sectional study includes 53 subjects, out of which 26 were PLHIV on ART –Group I, 27 were ART naïve PLHIV-Group II was conducted. Insulin resistance was determined by homeostasis model assessment (HOMA-IR) mathematical model. Statistical analysis was performed to assess the association between demographic, clinical characteristics, laboratory results and insulin resistance. Results: 69.5 % PLHIV on HAART showed IR, as compared to 37 % of ART naïve PLHIV (p= 0.01). MetS(Metabolic Syndrome) was found in 53.8% among PLHIV on ART , compared to 11.1% among ART naïve PLHIV(p= 0.001) .In the multivariate analysis, presence of metabolic syndrome was found to be directly associated with insulin resistance.

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The Higher Plasma Malondialdehyde Concentrations Are Determined by Metabolic Syndrome-Related Glucolipotoxicity

Oxidative Medicine and Cellular Longevity ◽

10.1155/2014/505368 ◽

2014 ◽

Vol 2014 ◽

pp. 1-7 ◽

Cited By ~ 10

Author(s):

Fernando Moreto ◽

Erick P. de Oliveira ◽

Rodrigo M. Manda ◽

Roberto C. Burini

Keyword(s):

Insulin Resistance ◽

Metabolic Syndrome ◽

Regression Analysis ◽

Cross Sectional Study ◽

Sectional Study ◽

Free Living ◽

Cross Sectional ◽

Sugar Intake ◽

Dietary Sugar ◽

Plasma Malondialdehyde

This study aimed to elucidate the determinants of higher plasma malondialdehyde (MDA) in free-living adults. In a cross-sectional study we evaluated 148 free-living subjects (54 ± 11 years, 78% women) at high risk for or with metabolic syndrome (MetS). They were assessed by anthropometry and body composition, dietary intake, and clinical and laboratorial analysis. The analysis of plasma MDA was performed by HPLC, and concentration values were used to provide four groups according to percentile distribution. Subjects with higher plasma MDA showed higher prevalence of MetS and higher values of waist circumference (WC), glucose, triglycerides (TG),γ-glutamyltransferase (γ-GT), and higher energy intake. Multiadjusted logistic regression analysis identified as determinants of higher plasma MDA the altered values of WC andγ-GT followed by hypertriglyceridemia, hyperglycemia, insulin resistance, higher dietary sugar-intake, and presence of MetS. In conclusion, the glucolipotoxic state predisposed by the presence of MetS seems to be the major determinant of higher plasma MDA concentrations.

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