scholarly journals Fecal S100A12 in Healthy Infants and Children

2013 ◽  
Vol 35 ◽  
pp. 295-299 ◽  
Author(s):  
A. S. Day ◽  
M. Ehn ◽  
R. B. Gearry ◽  
D. A. Lemberg ◽  
S. T. Leach
Keyword(s):  
Young Children ◽  
Elevated Level ◽  
Gastrointestinal Symptoms ◽  
Infants And Children ◽  
Healthy Children ◽  
Term Infants ◽  
Healthy Infants ◽  
Stool Samples ◽  
Serial Samples ◽  
In Infants And Children

Background and Aims. Fecal S100A12 is shown to be a useful noninvasive marker of gut inflammation. However, the studies to date have not characterised the patterns of expression in healthy young children. This study aimed to determine S100A12 levels in infants and children without symptoms of underlying gut disease.Methods. Stool samples were collected from healthy infants (<12 months) and children without gastrointestinal symptoms. Faecal S100A12 was measured by immunoassay.Results. Fifty-six children were recruited. Serial samples were obtained from seven term infants over the first 6 months of life. Single samples were obtained from 49 healthy children ranging from 0.16 to 13.8 years of age. Median S100A12 levels were 0.5 mg/kg (ranging from 0.39 to 25) in the healthy children, with high values (>10 mg/kg) in five infants only. There was no variation between gender. Median S100A12 levels in healthy infants remained below the established normal cut-off from birth to six months of age.Conclusion. S100A12 levels in well infants and children are almost exclusively lower than the standard cut-off. Transiently higher levels may be seen in early infancy. An elevated level of S100A12 in children older than 12 months of age is likely to represent organic gut disease.

scholarly journals The Role of TLR4 Asp299Gly and TLR4 Thr399Ile Polymorphisms in the Pathogenesis of Urinary Tract Infections: First Evaluation in Infants and Children of Greek Origin

2019 ◽  
Vol 2019 ◽  
pp. 1-9 ◽  
Author(s):  
Panagiota Karananou ◽  
Despoina Tramma ◽  
Socrates Katafigiotis ◽  
Anastasia Alataki ◽  
Alexandros Lambropoulos ◽  
...  
Keyword(s):  
Urinary Tract ◽  
Urinary Tract Infections ◽  
Bacterial Infections ◽  
Pediatric Population ◽  
Infants And Children ◽  
Healthy Children ◽  
Healthy Infants ◽  
Tract Infections ◽  
In Infants And Children

Urinary tract infections are one of the most common and serious bacterial infections in a pediatric population. So far, they have mainly been related to age, gender, ethnicity, socioeconomic level, and the presence of underlying anatomical or functional, congenital, or acquired abnormalities. Recently, both innate and adaptive immunities and their interaction in the pathogenesis and the development of UTIs have been studied. The aim of this study was to assess the role and the effect of the two most frequent polymorphisms of TLR4 Asp299Gly and Thr399Ile on the development of UTIs in infants and children of Greek origin. We studied 51 infants and children with at least one episode of acute urinary tract infection and 109 healthy infants and children. We found that 27.5% of patients and 8.26% of healthy children carried the heterozygote genotype for TLR4 Asp299Gly. TLR4 Thr399Ile polymorphism was found to be higher in healthy children and lower in the patient group. No homozygosity for both studied polymorphisms was detected in our patients. In the group of healthy children, a homozygote genotype for TLR4 Asp299Gly (G/G) as well as for TLR4 Thr399Ile (T/T) was showed (1.84% and 0.92 respectively). These results indicate the role of TLR4 polymorphism as a genetic risk for the development of UTIs in infants and children of Greek origin.

Noninvasive Monitoring of Oxygenation in Infants and Children: Practical Considerations and Areas of Concern

PEDIATRICS ◽  
1994 ◽  
Vol 93 (5) ◽  
pp. 737-746
Author(s):  
Christian F. Poets ◽  
David P. Southall
Keyword(s):  
Infants And Children ◽  
Preterm Neonates ◽  
Skin Thickness ◽  
Term Infants ◽  
Movement Artifact ◽  
Sensor Temperature ◽  
Technical Principles ◽  
Pulse Oximeters ◽  
In Infants And Children

Objective. To review the technical principles of transcutaneous Po2 (tcPo2) monitors and pulse oximeters and to discuss methodological and practical issues related to the use of these devices in infants and children. Design. Literature review and summary of personal experience. Results. tcPo2 measurements are influenced by skin thickness, sensor temperature, amount of contact gel used, and state of peripheral perfusion. The average in vivo response time to a rapid decrease in Pao2 is approximately 16 seconds. Sensitivity to both hypoxemia (Pao2 &lt; 50 mm Hg) and hyperoxemia (Pao2 &gt; 80 to 100 mm Hg) is approximately 85%. Pulse oximeters require careful sensor placement (to avoid optical shunts) and adequate pulse pressures (&gt; 20 mm Hg). They are prone to movement artifact. There are considerable differences in bias and precision between different brands, resulting, for example, in quite different upper alarm limits required to detect hyperoxemia reliably. The normal range of oxygen saturation measured by pulse oximetry, measured with one brand of pulse oximeter (Nellcor) during regular breathing, is 95% to 100% in preterm infants and 97% to 100% in full-term infants and children. Conclusions. Because both devices have their specific shortfalls, they should ideally be used in combination, particularly in critically ill preterm neonates. Where this is not feasible or necessary, clinicians must be aware of the limitations of the device they are using.

scholarly journals Docosahexaenoic Acid and Neurodevelopmental Outcomes of Term Infants

2016 ◽  
Vol 69 (Suppl. 1) ◽  
pp. 22-28 ◽  
Author(s):  
Suzanne Meldrum ◽  
Karen Simmer
Keyword(s):  
Docosahexaenoic Acid ◽  
Observational Studies ◽  
Chain Polyunsaturated Fatty Acid ◽  
Normal Brain ◽  
Healthy Children ◽  
Neurodevelopmental Outcomes ◽  
Term Infants ◽  
Lactating Women ◽  
Healthy Infants ◽  
Normal Brain Development

Docosahexaenoic acid (DHA), a long-chain polyunsaturated fatty acid, is essential for normal brain development. DHA is found predominantly in seafood, fish oil, breastmilk and supplemented formula. DHA intake in Western countries is often below recommendations. Observational studies have demonstrated an association between DHA intake in pregnancy and neurodevelopment of offspring but cannot fully adjust for confounding factors that influence child development. Randomised clinical trials of DHA supplementation during pregnancy and/or lactation, and of term infants, have not shown a consistent benefit nor harm on neurodevelopment of healthy children born at term. The evidence does not support DHA supplementation of healthy pregnant and lactating women, nor healthy infants.

scholarly journals Clinical Investigations: Somatosensory Evoked Potentials in Full-Term Neonates With Perinatal Asphyxia

Folia Medica ◽  
2014 ◽  
Vol 56 (2) ◽  
pp. 88-95 ◽  
Author(s):  
Ina E. Geneva ◽  
Maya B. Krasteva ◽  
Stefan S. Kostianev
Keyword(s):  
Evoked Potentials ◽  
Somatosensory Evoked Potentials ◽  
Amplitude Ratio ◽  
Perinatal Asphyxia ◽  
Nerve Fibers ◽  
Full Term ◽  
Healthy Children ◽  
Term Infants ◽  
Healthy Infants ◽  
Term Newborns

Abstract OBJECTIVE: To explore the capacity of somatosensory evoked potentials (SEP) to assess maturation processes in the development of the nervous system, and the characteristics of SEP in healthy full-term infants and full-term newborns with perinatal asphyxia and their follow up until the age of 14 months. MATERIALS AND METHODS: SEP were studied in 21 healthy full-term infants and 38 full-term newborns with perinatal asphyxia. The children with asphyxia were studied longitudinally until they were 14 months old. To assess the SEP we measured the latency of the P15, N20 and P25 components, the amplitude ratio N20/ P25 and inter-peak intervals P15-N20 and N20-P25. RESULTS: The component that was most typically always found in the SEP recordings of both healthy infants and those with perinatal asphyxia was N20. The mean latency values of P15, N20 and P25 were higher in the children with perinatal asphyxia (p ⋋ 0.001). The SEP amplitude was highly variable (CoV% = 76.6%). The latencies became shorter with age in asphyxia patients aged 0 to 14 months, the shortening being the greatest in the first trimester, while they showed no statistically significant differences in infants aged 6 to 12 months. CONCLUSIONS: SEPs in the neonatal period differ considerably from those of adults and older children in the morphology and longer potential latency, which can be accounted for by the incomplete myelination of nerve fibers. The changes in SEP latency in patients with HIE stages I and II follow the same pattern found in healthy children - latency became shorter with increasing age, which was most pronounced in the first 3 months. SEP latency was found to be correlated with height and age. No differences were found in the latency of potentials between healthy infants and infants with brain hemorrhage. Recording SEP is a sensitive method to assess the CNS in children with perinatal asphyxia and to monitor the maturation of the somatosensory pathway.

Assessment of Clinicopathological Features in Infants and Children with Cow�s Milk Protein Allergy

2019 ◽  
Vol 69 (12) ◽  
pp. 3573-3576
Author(s):  
Ileana Puiu ◽  
Elena Catalina Bica ◽  
Venera Cristina Dinescu ◽  
Otilia Constantina Rogoveanu ◽  
Alexandra Oltea Dan ◽  
...  
Keyword(s):  
Young Children ◽  
Milk Protein ◽  
Milk Proteins ◽  
Clinicopathological Features ◽  
Infants And Children ◽  
Pediatric Clinic ◽  
Number Of Patients ◽  
The Status ◽  
In Infants And Children ◽  
Infants And Young Children

The aim of our study was to evaluate the clinicopathological features in infants and young children with cow�s milk protein allergy. Cow�s milk protein allergy (CMPA) is one of the most common food allergy in children. Thus, we conducted a descriptive observational study, which was carried out in the First Pediatric Clinic of the Craiova County Emergency Clinical Hospital, in the period 2015-2017, which included 138 infants and young children diagnosed with cow�s milk protein allergy. An improvement in digestive symptomatology during the status period of the disease was observed, especially in what diarrheal stools are concerned as their incidence has decreased. In fact, gastroesophageal reflux is the most common manifestation in infants and children with CMPA, while mean acute otitis is present only in a small number of patients. In conclusion we can say that a good knowledge of the clinicopathological features in children with allergy to cow�s milk proteins allows a superior therapeutic attitude and ensures a normal life for children and infants suffering from this type of allergy.

Naloxone Use in Newborns

PEDIATRICS ◽  
1980 ◽  
Vol 65 (3) ◽  
pp. 667-669
Author(s):  
Sydney Segal ◽  
Walter R. Anyan ◽  
Reba M. Hill ◽  
Ralph E. Kauffman ◽  
Howard Mofenson ◽  
...  
Keyword(s):  
Respiratory Depression ◽  
Opiate Receptors ◽  
Endogenous Opioids ◽  
Infants And Children ◽  
Narcotic Antagonist ◽  
Narcotic Analgesics ◽  
Antagonist Activity ◽  
Drug Of Choice ◽  
Healthy Infants ◽  
In Infants And Children

Naloxone hydrochloride (Narcan) is a pure narcotic antagonist that is the drug of choice in the treatment of central nervous system and cardiores-piratory depression due to narcotic agonist drugs. It has virtually no agonist activity and therefore produces no narcotic effect even when administered in greater than recommended doses, in contrast to nalorphine hydrochloride and levallorphan tartrate, which have mixed agonist-antagonist activity. In 1975 the FDA approved a dosage form of naloxone in a concentration of 0.02 mg/ml that was specifically designed for use in newborns whose mothers receive narcotic analgesics during labor and who are born with narcotic-induced respiratory depression; this drug was marketed for general prescription use. Three years after its introduction, the role of naloxone in the management of the depressed newborn merits clarification. In addition, recent information regarding opiate receptors and endogenous opioids raises questions concerning the long-term safety of naloxone in neonates. A review of available published and unpublished data pertaning to naloxone use in the newborn infant by the Committee on Drugs forms the basis for the following commentary and recommendations. EFFICACY The potent narcotic antagonist activity of naloxone is well documented in infants and children as well as in adults. Naloxone has been effectively used postoperatively to reverse respiratory depression in infants and children who received narcotics for analgesia.1,2 Additional cases have been reported in which naloxone was successfully and safely used to treat children who were poisoned with narcotic agonists such as diphenoxylate hydrochloride (Lomotil),3,4 methadone hydrochloride, 57 and propoxyphene hydrochloride (Darvon).8 Most of the controlled clinical trials to study the safety and efficacy of naloxone in treating respiratory depression in the narcotic-exposed newborn have been carried out on full-term, healthy infants whose mothers received morphine or meperidine hydrochloride during labor, but who showed no overt clinical evidence of respiratory or CNS depression at birth.

ELECTROCARDIOGRAM IN 679 HEALTHY INFANTS AND CHILDREN

PEDIATRICS ◽  
1950 ◽  
Vol 5 (3) ◽  
pp. 396-407
Author(s):  
MARGARET MARONEY ◽  
LOWELL A. RANTZ
Keyword(s):  
Infants And Children ◽  
Healthy Children ◽  
P Waves ◽  
Healthy Infants ◽  
Apparently Healthy

An ECG was taken on each of 683 apparently healthy children. Flat, inverted or diphasic T or P waves never occurred in Lead I, rarely occurred in Lead II and frequently occurred in Lead III. The QRS interval tends to be shorter in children than in adults and increases with age from 6 months to 9 years. Measurements less than 0.04 sec. or greater than 0.08 sec. are rare in healthy children under the age of 9 years. The PR (PQ) interval tends to be shorter in children than in adults and increases with age from 6 months to 9 years. PR (PQ) intervals of 0.15 sec. or more are rare in healthy children under the age of 4 years. PR (PQ) intervals of 0.16 sec. or more are very rare in healthy children from 4 to 9 years of age.

Carbohydrate Malabsorption Following Fruit Juice Ingestion in Young Children

PEDIATRICS ◽  
1988 ◽  
Vol 82 (1) ◽  
pp. 64-68 ◽  
Author(s):  
Jeffrey S. Hyams ◽  
Nancy L. Etienne ◽  
Alan M. Leichtner ◽  
Richard C. Theuer
Keyword(s):  
Young Children ◽  
Analysis Of Variance ◽  
Apple Juice ◽  
Fruit Juice ◽  
Gastrointestinal Symptoms ◽  
Grape Juice ◽  
Healthy Children ◽  
Breath Hydrogen ◽  
Carbohydrate Malabsorption ◽  
Pear Juice

We performed breath hydrogen analyses in 13 healthy children (9 to 36 months of age) and seven children (14 to 27 months of age) with chronic nonspecific diarrhea after they had ingested pear, grape, and apple juices and a 2% sorbitol solution. Excess breath H2 excretion was found in virtually all study subjects following the ingestion of either pear juice (with approximately 2% sorbitol content) or the 2% sorbitol solution, in approximately 50% of those ingesting apple juice (0.5% sorbitol), and in 25% of those ingesting grape juice (no sorbitol) (P &lt; .001, analysis of variance). No differences were noted between the healthy children and those with chronic nonspecific diarrhea. Forty percent of all study subjects in whom excess breath hydrogen excretion occurred also had diarrhea and abdominal cramping. Carbohydrate malabsorption appears to be frequent following the ingestion of common fruit juices and in some children may be associated with nonspecific gastrointestinal symptoms.

scholarly journals Interferon-Mediated Response to Human Metapneumovirus Infection

Viruses ◽  
2018 ◽  
Vol 10 (9) ◽  
pp. 505 ◽  
Author(s):  
Ifeanyi Uche ◽  
Antonieta Guerrero-Plata
Keyword(s):  
Young Children ◽  
Respiratory Diseases ◽  
Human Metapneumovirus ◽  
Infants And Children ◽  
Commercial Vaccine ◽  
Hmpv Infection ◽  
In Infants And Children

Human metapneumovirus (HMPV) is one of the leading causes of respiratory diseases in infants and children worldwide. Although this pathogen infects mainly young children, elderly and immunocompromised people can be also seriously affected. To date, there is no commercial vaccine available against it. Upon HMPV infection, the host innate arm of defense produces interferons (IFNs), which are critical for limiting HMPV replication. In this review, we offer an updated landscape of the HMPV mediated-IFN response in different models as well as some of the defense tactics employed by the virus to circumvent IFN response.

scholarly journals Determination of aflatoxin M1 and deoxynivalenol biomarkers in infants and children urines from Bangladesh

2020 ◽  
Vol 94 (11) ◽  
pp. 3775-3786 ◽  
Author(s):  
Nurshad Ali ◽  
M. Manirujjaman ◽  
Sohel Rana ◽  
Gisela H. Degen
Keyword(s):  
Young Children ◽  
Daily Intake ◽  
Infants And Children ◽  
Aflatoxin M1 ◽  
Detection Frequency ◽  
Current Maximum ◽  
Food Commodities ◽  
Aflatoxin B ◽  
In Infants And Children

Abstract The mycotoxins aflatoxin B1 (AFB1) and deoxynivalenol (DON) are found worldwide in crops and dietary staples. The prevalence and levels of these contaminants can vary greatly, and data in Bangladeshi food commodities are scarce. To characterize human exposure, we have conducted biomonitoring, analyzing AFM1 (a metabolite of AFB1) and DON levels in urines of adult cohorts in Bangladesh. Yet, AFM1 and DON occurrence has not been studied in the very young population of this country. Thus, the same methods, HPLC-FD for AFM1 and LC–MS/MS for DON analysis, were now applied to determine these biomarkers in urines of infants (n = 49) and young children (n = 105) in Rajshahi and Dhaka district. Overall, AFM1 and DON detection frequency was 43.5% and 33.4%, with 34.7% and 11.5% in infant and 47.6% and 39.4% in children urines, respectively. The mean AFM1 levels in all infants (9.1 ± 14.3, max 55.6 pg/mL) and children (8.8 ± 12.9, max 75.3 pg/mL) were not significantly different. The AFM1 mean level was slightly higher in Dhaka (9.4 ± 12.4) compared to Rajshahi (8.5 ± 13.9 pg/mL) district. The average DON level was about 2-fold higher in infant (3.8 ± 2.9, max 6.8 ng/mL) than children urines (1.6 ± 1.8, max 8.6 ng/mL), and higher in Rajshahi (2.1 ± 2.3 ng/mL) than Dhaka (1.4 ± 1.6 ng/mL) district. The biomarker-based estimated average daily DON intake (29.6 ± 108.3 ng/kg bw in infants and 36.4 ± 81.8 ng/kg bw in children) or the maximum exposure (560 ng/kg bw) do not exceed the current maximum provisional tolerable daily intake value of 1 µg/kg bw for DON, although DON exposure in infants and children is higher than that of Bangladeshi adults. The AFM1 urine levels in young children are somewhat lower than those found previously in adult cohorts in Bangladesh, but the frequent detection of this biomarker for AFB1 exposure raises further concerns, also for this vulnerable part of the population. Therefore, continuous surveillance for aflatoxins in Bangladeshi food commodities is clearly required, first to identify major sources of intake and then to reduce exposure.

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