scholarly journals Electrical Impedance Spectroscopy as Electrical Biopsy for Monitoring Radiation Sequelae of Intestine in Rats

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Pei-Ju Chao ◽  
Eng-Yen Huang ◽  
Kuo-Sheng Cheng ◽  
Yu-Jie Huang
Keyword(s):  
Electrical Properties ◽  
Impedance Spectroscopy ◽  
Integrated Circuits ◽  
Electrical Impedance ◽  
Roc Analysis ◽  
Electrical Impedance Spectroscopy ◽  
Electrical Characteristics ◽  
Injury Score ◽  
Histological Changes ◽  
Radiation Sequelae

Electrical impedance is one of the most frequently used parameters for characterizing material properties. The resistive and capacitive characteristics of tissue may be revealed by electrical impedance spectroscopy (EIS) as electrical biopsy. This technique could be used to monitor the sequelae after irradiation. In this study, rat intestinal tissues after irradiation were assessed by EIS system based on commercially available integrated circuits. The EIS results were fitted to a resistor-capacitor circuit model to determine the electrical properties of the tissue. The variations in the electrical characteristics of the tissue were compared to radiation injury score (RIS) by morphological and histological findings. The electrical properties, based on receiver operation curve (ROC) analysis, strongly reflected the histological changes with excellent diagnosis performance. The results of this study suggest that electrical biopsy reflects histological changes after irradiation. This approach may significantly augment the evaluation of tissue after irradiation. It could provide rapid results for decision making in monitoring radiation sequelae prospectively.

Current Source Design for Electrical Bioimpedance Spectroscopy

2008 ◽  
pp. 359-367 ◽  
Author(s):  
Fernando Seoane ◽  
Ramón Bragos ◽  
Kaj Lindecrantz ◽  
Pere Riu
Keyword(s):  
Electrical Properties ◽  
Impedance Spectroscopy ◽  
Biological Tissue ◽  
Electrical Impedance ◽  
Current Source ◽  
Electrical Impedance Spectroscopy ◽  
Bioimpedance Spectroscopy ◽  
Electrical Bioimpedance ◽  
Electronic Instrumentation ◽  
Passive Electrical Properties

The passive electrical properties of biological tissue have been studied since the 1920s, and with time, the use of Electrical Bioimpedance (EBI) in medicine has successfully spread (Schwan, 1999). Since the electrical properties of tissue are frequency-dependent (Schwan, 1957), observations of the bioimpedance spectrum have created the discipline of Electrical Impedance Spectroscopy (EIS), a discipline that has experienced a development closely related to the progress of electronic instrumentation and the dissemination of EBI technology through medicine.

scholarly journals Electrical characteristics of cells with electrical impedance spectroscopy

2020 ◽  
Vol 69 (16) ◽  
pp. 163301
Author(s):  
Jia-Feng Yao ◽  
Jian-Fen Wan ◽  
Lu Yang ◽  
Kai Liu ◽  
Bai Chen ◽  
...  
Keyword(s):  
Impedance Spectroscopy ◽  
Electrical Impedance ◽  
Electrical Impedance Spectroscopy ◽  
Electrical Characteristics

scholarly journals Effects of Lead Exposure on Blood Electrical Impedance Spectroscopy of Mice

2021 ◽  
Author(s):  
Binying Yang ◽  
Jia Xu ◽  
Shao Hu ◽  
Boning You ◽  
Qing Ma
Keyword(s):  
Electrical Properties ◽  
Impedance Spectroscopy ◽  
Lead Exposure ◽  
Electrical Impedance ◽  
Equivalent Circuit Model ◽  
Impedance Spectrum ◽  
Nyquist Plot ◽  
Electrical Impedance Spectroscopy ◽  
Impedance Method ◽  
Range Data

Abstract Background: Lead is a nonessential heavy metal, which can inhibit heme synthesis and has significant cytotoxic effects. Nevertheless, its effect on the electrical properties of red blood cells (RBCs) remains unclear. Consequently, this study aimed to investigate the electrical properties and the electrophysiological mechanism of lead exposure in mouse blood using Electrical Impedance Spectroscopy (EIS). Methods: AC impedance method was used to measure the electrical impedance of healthy and lead exposure blood of mice in 0.01-100 MHz frequency range. Data characteristic of the impedance spectrum, Bodes plot, Nyquist plot and Nichols plot, and three elements equivalent circuit model were used to explicitly analyze the differences in amplitude-frequency, phase-frequency, and the frequency characteristic of blood in electrical impedance properties. Results: Compared with the healthy blood in control mice, the changes in blood exposed to lead was as follows: (I) the hematocrit decreased; (II) the amplitude-frequency and phase-frequency characteristics of electrical impedance decreased; (III) the characteristic frequencies ( f 0 ) were significantly increased; (IV) the electrical impedance of plasma, erythrocyte membrane, and hemoglobin decreased, while the conductivity increased. Conclusion: Therefore, EIS can be used as an effective method to monitor blood and RBCs abnormalities caused by lead-exposure.

scholarly journals Experimental Study of Electrical Properties of Pharmaceutical Materials by Electrical Impedance Spectroscopy

2020 ◽  
Vol 10 (18) ◽  
pp. 6576
Author(s):  
Manuel Vázquez-Nambo ◽  
José-Antonio Gutiérrez-Gnecchi ◽  
Enrique Reyes-Archundia ◽  
Wuqiang Yang ◽  
Marco-A. Rodriguez-Frias ◽  
...  
Keyword(s):  
System Identification ◽  
Electrical Properties ◽  
Impedance Spectroscopy ◽  
Electrical Impedance ◽  
Wide Frequency Range ◽  
Electrical Impedance Spectroscopy ◽  
Frequency Range ◽  
Pharmaceutical Materials ◽  
Identification Techniques

The physicochemical characterization of pharmaceutical materials is essential for drug discovery, development and evaluation, and for understanding and predicting their interaction with physiological systems. Amongst many measurement techniques for spectroscopic characterization of pharmaceutical materials, Electrical Impedance Spectroscopy (EIS) is powerful as it can be used to model the electrical properties of pure substances and compounds in correlation with specific chemical composition. In particular, the accurate measurement of specific properties of drugs is important for evaluating physiological interaction. The electrochemical modelling of compounds is usually carried out using spectral impedance data over a wide frequency range, to fit a predetermined model of an equivalent electrochemical cell. This paper presents experimental results by EIS analysis of four drug formulations (trimethoprim/sulfamethoxazole C14H18N4O3-C10H11N3O3, ambroxol C13H18Br2N2O.HCl, metamizole sodium C13H16N3NaO4S, and ranitidine C13H22N4O3S.HCl). A wide frequency range from 20 Hz to 30 MHz is used to evaluate system identification techniques using EIS data and to obtain process models. The results suggest that arrays of linear R-C models derived using system identification techniques in the frequency domain can be used to identify different compounds.

scholarly journals Temperature Dependent Electrical Properties and Catalytic Activities ofLa2O3–CO2–H2OPhase System

2009 ◽  
Vol 2009 ◽  
pp. 1-4 ◽  
Author(s):  
Bahcine Bakiz ◽  
Frédéric Guinneton ◽  
Madjid Arab ◽  
Sylvie Villain ◽  
Abdeljalil Benlhachemi ◽  
...  
Keyword(s):  
Heat Treatment ◽  
Thermal Decomposition ◽  
Electrical Properties ◽  
Impedance Spectroscopy ◽  
Electrical Impedance ◽  
Catalytic Properties ◽  
Electrical Impedance Spectroscopy ◽  
Temperature Dependent ◽  
Catalytic Activities ◽  
Coprecipitation Route

We present a study of electrical properties and catalytic activities of materials belonging to the hydrated carbonated systemLa2O3–CO2–H2O. The polycrystalline hydroxycarbonate, dioxycarbonate, and oxide are prepared via a coprecipitation route followed by heat treatment. The electrical conduction of the phases obtained by thermal decomposition fromLaOHCO3,H2Ois analyzed by electrical impedance spectroscopy, from25°Cto950°C, under air. The catalytic properties ofLaOHCO3,La2O2CO3andLa2O3polycrystalline phases are studied by FTIR spectroscopy, in presence of gas mixtures CO-air andCH4-air, at temperatures ranging between100°Cto525°C. The three materials behave differently in presence of CO orCH4gases.

scholarly journals Use of metallic nanoparticles for characterization of muscle tissue by electrical impedance spectroscopy (EIS)

2019 ◽  
pp. 1-3
Author(s):  
Gustavo Moreno González-Teran ◽  
Andrea Ceja-Fernandez ◽  
Rosario Galindo-González ◽  
José Marco Balleza-Ordaz
Keyword(s):  
Electrical Properties ◽  
Impedance Spectroscopy ◽  
Muscle Tissue ◽  
Metallic Nanoparticles ◽  
Electrical Impedance ◽  
Combustion Method ◽  
Electrical Impedance Spectroscopy ◽  
Chicken Breast ◽  
Chicken Muscle

Objectives. The electrical impedance spectroscopy (EIS) is relatively new technique used in medicine. The main problems that should be solved are its low resolution and that it fails to distinguish between tissue types, so some kind of the contrast should be applied. Magnetical nanoparticles have been used for imaging and other medical applications. For that reason, our research group decided to analyse the changes of electrical properties of chicken muscle tissue caused by three different types of metal nanoparticles at 50KHz. Methodology. Bio-Logic Science Instruments SP-150 was used as EIS device. Three different particles were analysed: two types of nanomagnetite (NM1 and NM2) and one of Gold particles (GNP). NM1 and NM2 samples were synthetized by coprecipitation and combustion method, respectively. GNP were synthetized by Turkevich method. Nanoparticles were characterized by SEM and RAMAN spectroscopy. Four needles were placed in each chicken breast to connect the EIS device. Measurements were obtained from each chicken breast at basal stage and after being injected with nanoparticles. Data was analyzed by bode graphics (module and phase). Contribution. The major changes of electrical properties of tissue were evidenced by using NM1 and GNP.

Evaluation of electrical characteristics of biological tissue with electrical impedance spectroscopy

2020 ◽  
Vol 41 (16-17) ◽  
pp. 1425-1432 ◽  
Author(s):  
Jiafeng Yao ◽  
Li Wang ◽  
Kai Liu ◽  
Hongtao Wu ◽  
Hao Wang ◽  
...  
Keyword(s):  
Impedance Spectroscopy ◽  
Biological Tissue ◽  
Electrical Impedance ◽  
Electrical Impedance Spectroscopy ◽  
Electrical Characteristics

scholarly journals Performance Evaluation of Multiple Electrodes Based Electrical Impedance Spectroscopic Probe for Screening of Cervical Intraepithelial Neoplasia

Electronics ◽  
2021 ◽  
Vol 10 (16) ◽  
pp. 1933
Author(s):  
Tingting Zhang ◽  
Youjeong Jeong ◽  
Dongchoon Park ◽  
Tongin Oh
Keyword(s):  
Electrical Properties ◽  
Impedance Spectroscopy ◽  
Cervical Intraepithelial Neoplasia ◽  
Electrical Impedance ◽  
Low Cost ◽  
High Sensitivity ◽  
Intraepithelial Neoplasia ◽  
Electrical Impedance Spectroscopy ◽  
Voltage Measurement ◽  
Wide Range

As regular cervical cancer screening becomes more common, the detection of cervical intraepithelial neoplasia (CIN) is increasing. We proposed a noninvasive and low-cost multi-channel electrical impedance spectroscopy (EIS) and probe with multiple active electrodes for screening CIN. Compared with four-electrode probes for impedance spectroscopy, the multiple active electrodes facilitated more flexible combination of current injection and voltage measurement, which allowed well-designed measurement protocols for focused sensitivity underneath the large size of the probe. Furthermore, the multiple active electrodes reduced the negative effects of the cabling between the system and probe inserted into the cervix. After presenting the basic performance, the EIS probe was tested by three different experimental phantoms using four different materials of electrical properties. The corresponding experimental results were presented to prove the functionality of the EIS probe and characterize the electrical properties at a wide range of frequencies from 0.625 to 100 kHz. It had high sensitivity underneath the surface of the probe and a rapidly decreased outer. Furthermore, we verified the frequency-dependent impedance changes using the giant vesicle phantoms with different amounts of extra- and intra-fluids separated by the insulating membranes. This study facilitates the feasibility into clinical practice for identifying CIN in the future.

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