scholarly journals Experimental Study of Electrical Properties of Pharmaceutical Materials by Electrical Impedance Spectroscopy

2020 ◽  
Vol 10 (18) ◽  
pp. 6576
Author(s):  
Manuel Vázquez-Nambo ◽  
José-Antonio Gutiérrez-Gnecchi ◽  
Enrique Reyes-Archundia ◽  
Wuqiang Yang ◽  
Marco-A. Rodriguez-Frias ◽  
...  
Keyword(s):  
System Identification ◽  
Electrical Properties ◽  
Impedance Spectroscopy ◽  
Electrical Impedance ◽  
Wide Frequency Range ◽  
Electrical Impedance Spectroscopy ◽  
Frequency Range ◽  
Pharmaceutical Materials ◽  
Identification Techniques

The physicochemical characterization of pharmaceutical materials is essential for drug discovery, development and evaluation, and for understanding and predicting their interaction with physiological systems. Amongst many measurement techniques for spectroscopic characterization of pharmaceutical materials, Electrical Impedance Spectroscopy (EIS) is powerful as it can be used to model the electrical properties of pure substances and compounds in correlation with specific chemical composition. In particular, the accurate measurement of specific properties of drugs is important for evaluating physiological interaction. The electrochemical modelling of compounds is usually carried out using spectral impedance data over a wide frequency range, to fit a predetermined model of an equivalent electrochemical cell. This paper presents experimental results by EIS analysis of four drug formulations (trimethoprim/sulfamethoxazole C14H18N4O3-C10H11N3O3, ambroxol C13H18Br2N2O.HCl, metamizole sodium C13H16N3NaO4S, and ranitidine C13H22N4O3S.HCl). A wide frequency range from 20 Hz to 30 MHz is used to evaluate system identification techniques using EIS data and to obtain process models. The results suggest that arrays of linear R-C models derived using system identification techniques in the frequency domain can be used to identify different compounds.

scholarly journals Electrical impedance spectroscopy of plant cells in aqueous buffer media over a wide frequency range of 4 Hz to 20 GHz

MethodsX ◽  
2021 ◽  
Vol 8 ◽  
pp. 101185
Author(s):  
Kian Kadan-Jamal ◽  
Marios Sophocleous ◽  
Aakash Jog ◽  
Dayananda Desagani ◽  
Orian Teig-Sussholz ◽  
...  
Keyword(s):  
Impedance Spectroscopy ◽  
Electrical Impedance ◽  
Plant Cells ◽  
Wide Frequency Range ◽  
Electrical Impedance Spectroscopy ◽  
Frequency Range ◽  
Aqueous Buffer

scholarly journals Use of metallic nanoparticles for characterization of muscle tissue by electrical impedance spectroscopy (EIS)

2019 ◽  
pp. 1-3
Author(s):  
Gustavo Moreno González-Teran ◽  
Andrea Ceja-Fernandez ◽  
Rosario Galindo-González ◽  
José Marco Balleza-Ordaz
Keyword(s):  
Electrical Properties ◽  
Impedance Spectroscopy ◽  
Muscle Tissue ◽  
Metallic Nanoparticles ◽  
Electrical Impedance ◽  
Combustion Method ◽  
Electrical Impedance Spectroscopy ◽  
Chicken Breast ◽  
Chicken Muscle

Objectives. The electrical impedance spectroscopy (EIS) is relatively new technique used in medicine. The main problems that should be solved are its low resolution and that it fails to distinguish between tissue types, so some kind of the contrast should be applied. Magnetical nanoparticles have been used for imaging and other medical applications. For that reason, our research group decided to analyse the changes of electrical properties of chicken muscle tissue caused by three different types of metal nanoparticles at 50KHz. Methodology. Bio-Logic Science Instruments SP-150 was used as EIS device. Three different particles were analysed: two types of nanomagnetite (NM1 and NM2) and one of Gold particles (GNP). NM1 and NM2 samples were synthetized by coprecipitation and combustion method, respectively. GNP were synthetized by Turkevich method. Nanoparticles were characterized by SEM and RAMAN spectroscopy. Four needles were placed in each chicken breast to connect the EIS device. Measurements were obtained from each chicken breast at basal stage and after being injected with nanoparticles. Data was analyzed by bode graphics (module and phase). Contribution. The major changes of electrical properties of tissue were evidenced by using NM1 and GNP.

Electrical impedance spectroscopy for the characterization of skin barrier in atopic dermatitis

Allergy ◽  
2021 ◽  
Author(s):  
Arturo O. Rinaldi ◽  
Angelica Korsfeldt ◽  
Siobhan Ward ◽  
Daniel Burla ◽  
Anita Dreher ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Impedance Spectroscopy ◽  
Electrical Impedance ◽  
Skin Barrier ◽  
Electrical Impedance Spectroscopy

scholarly journals Electrical Impedance Spectroscopy as Electrical Biopsy for Monitoring Radiation Sequelae of Intestine in Rats

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Pei-Ju Chao ◽  
Eng-Yen Huang ◽  
Kuo-Sheng Cheng ◽  
Yu-Jie Huang
Keyword(s):  
Electrical Properties ◽  
Impedance Spectroscopy ◽  
Integrated Circuits ◽  
Electrical Impedance ◽  
Roc Analysis ◽  
Electrical Impedance Spectroscopy ◽  
Electrical Characteristics ◽  
Injury Score ◽  
Histological Changes ◽  
Radiation Sequelae

Electrical impedance is one of the most frequently used parameters for characterizing material properties. The resistive and capacitive characteristics of tissue may be revealed by electrical impedance spectroscopy (EIS) as electrical biopsy. This technique could be used to monitor the sequelae after irradiation. In this study, rat intestinal tissues after irradiation were assessed by EIS system based on commercially available integrated circuits. The EIS results were fitted to a resistor-capacitor circuit model to determine the electrical properties of the tissue. The variations in the electrical characteristics of the tissue were compared to radiation injury score (RIS) by morphological and histological findings. The electrical properties, based on receiver operation curve (ROC) analysis, strongly reflected the histological changes with excellent diagnosis performance. The results of this study suggest that electrical biopsy reflects histological changes after irradiation. This approach may significantly augment the evaluation of tissue after irradiation. It could provide rapid results for decision making in monitoring radiation sequelae prospectively.

Current Source Design for Electrical Bioimpedance Spectroscopy

2008 ◽  
pp. 359-367 ◽  
Author(s):  
Fernando Seoane ◽  
Ramón Bragos ◽  
Kaj Lindecrantz ◽  
Pere Riu
Keyword(s):  
Electrical Properties ◽  
Impedance Spectroscopy ◽  
Biological Tissue ◽  
Electrical Impedance ◽  
Current Source ◽  
Electrical Impedance Spectroscopy ◽  
Bioimpedance Spectroscopy ◽  
Electrical Bioimpedance ◽  
Electronic Instrumentation ◽  
Passive Electrical Properties

The passive electrical properties of biological tissue have been studied since the 1920s, and with time, the use of Electrical Bioimpedance (EBI) in medicine has successfully spread (Schwan, 1999). Since the electrical properties of tissue are frequency-dependent (Schwan, 1957), observations of the bioimpedance spectrum have created the discipline of Electrical Impedance Spectroscopy (EIS), a discipline that has experienced a development closely related to the progress of electronic instrumentation and the dissemination of EBI technology through medicine.

scholarly journals Design of Reconfigurable Time-to-Digital Converter Based on Cascaded Time Interpolators for Electrical Impedance Spectroscopy

Sensors ◽  
2020 ◽  
Vol 20 (7) ◽  
pp. 1889
Author(s):  
Sounghun Shin ◽  
Yoontae Jung ◽  
Soon-Jae Kweon ◽  
Eunseok Lee ◽  
Jeong-Ho Park ◽  
...  
Keyword(s):  
Impedance Spectroscopy ◽  
High Frequency ◽  
Electrical Impedance ◽  
Phase Error ◽  
Electrical Impedance Spectroscopy ◽  
Time Range ◽  
Digital Converter ◽  
Frequency Range ◽  
Input Time ◽  
Interpolation Factor

This paper presents a reconfigurable time-to-digital converter (TDC) used to quantize the phase of the impedance in electrical impedance spectroscopy (EIS). The TDC in the EIS system must handle a wide input-time range for analysis in the low-frequency range and have a high resolution for analysis in the high-frequency range. The proposed TDC adopts a coarse counter to support a wide input-time range and cascaded time interpolators to improve the time resolution in the high-frequency analysis without increasing the counting clock speed. When the same large interpolation factor is adopted, the cascaded time interpolators have shorter measurement time and smaller chip area than a single-stage time interpolator. A reconfigurable time interpolation factor is adopted to maintain the phase resolution with reasonable measurement time. The fabricated TDC has a peak-to-peak phase error of less than 0.72° over the input frequency range from 1 kHz to 512 kHz and the phase error of less than 2.70° when the range is extended to 2.048 MHz, which demonstrates a competitive performance when compared with previously reported designs.

scholarly journals Electrical Impedance Spectroscopy for Monitoring Chemoresistance of Cancer Cells

Micromachines ◽  
2020 ◽  
Vol 11 (9) ◽  
pp. 832
Author(s):  
Lexi Crowell ◽  
Juan Yakisich ◽  
Brian Aufderheide ◽  
Tayloria Adams
Keyword(s):  
Impedance Spectroscopy ◽  
Cancer Cells ◽  
Cancer Cell ◽  
Cellular Response ◽  
Electrical Impedance ◽  
Electrical Impedance Spectroscopy ◽  
Cell Behavior ◽  
Drug Resistant ◽  
Cancerous Cells

Electrical impedance spectroscopy (EIS) is an electrokinetic method that allows for the characterization of intrinsic dielectric properties of cells. EIS has emerged in the last decade as a promising method for the characterization of cancerous cells, providing information on inductance, capacitance, and impedance of cells. The individual cell behavior can be quantified using its characteristic phase angle, amplitude, and frequency measurements obtained by fitting the input frequency-dependent cellular response to a resistor–capacitor circuit model. These electrical properties will provide important information about unique biomarkers related to the behavior of these cancerous cells, especially monitoring their chemoresistivity and sensitivity to chemotherapeutics. There are currently few methods to assess drug resistant cancer cells, and therefore it is difficult to identify and eliminate drug-resistant cancer cells found in static and metastatic tumors. Establishing techniques for the real-time monitoring of changes in cancer cell phenotypes is, therefore, important for understanding cancer cell dynamics and their plastic properties. EIS can be used to monitor these changes. In this review, we will cover the theory behind EIS, other impedance techniques, and how EIS can be used to monitor cell behavior and phenotype changes within cancerous cells.

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