scholarly journals Antihyperlipidemic Activity of Aloe succotrina in Rats: Possibly Mediated by Inhibition of HMG-CoA Reductase

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Dinesh Dhingra ◽  
Deepak Lamba ◽  
Ramesh Kumar ◽  
Pashupati Nath ◽  
Satyaprakash Gauttam
Keyword(s):  
High Fat Diet ◽  
The Body ◽  
Atherogenic Index ◽  
Heart Weight ◽  
Albino Rats ◽  
High Fat ◽  
Hmg Coa Reductase ◽  
Antihyperlipidemic Activity ◽  
Per Se ◽  
Coa Reductase

The present study was designed to investigate antihyperlipidemic activity of dried pulp of Aloe succotrina leaves in Wistar albino rats. Hyperlipidemia was induced in rats by feeding them high fat diet (HFD) or D-fructose (25% w/v) for 4 successive weeks. From 15th to 28th day, dried pulp (100 and 200 mg/kg, p.o) and atorvastatin (10 mg/kg, p.o.) per se were administered 2 h prior to feeding rats with HFD or fructose. Aloe succotrina did not significantly decrease the body weight of rats. The dried pulp and atorvastatin per se significantly decreased relative liver weight but did not significantly affect relative heart weight. HFD or fructose significantly increased serum total cholesterol, triglycerides, LDL-c, and VLDL, and decreased HDL-c; significantly increased liver MDA and decreased GSH levels. The dried pulp (200 mg/kg p.o.) significantly reversed high fat diet-induced and fructose-induced hyperlipidemia and atherogenic index. Aloe succotrina significantly decreased HMG Co-A reductase activity. Antihyperlipidemic effect of the dried pulp was comparable to atorvastatin. Thus, Aloe succotrina produced significant antihyperlipidemic activity in both HFD and fructose-induced hyperlipidemic rats, possibly through normalization of serum lipid profile, HMG-CoA reductase inhibitory activity, and amelioration of oxidative stress in liver.

scholarly journals Antihyperlipidemic and Antioxidant Effects of Averrhoa Carambola Extract in High-Fat Diet-Fed Rats

Biomedicines ◽  
2019 ◽  
Vol 7 (3) ◽  
pp. 72 ◽  
Author(s):  
Saleem Aladaileh ◽  
Sultan Saghir ◽  
Kisantini Murugesu ◽  
Amirin Sadikun ◽  
Ashfaq Ahmad ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
High Fat Diet ◽  
Atherogenic Index ◽  
Antioxidant Defenses ◽  
Dependent Manner ◽  
High Fat ◽  
Hmg Coa Reductase ◽  
Averrhoa Carambola ◽  
Coa Reductase

The present study explored the antihyperlipidemic potential of a standardized methanolic extract of Averrhoa carambola (A. carambola) leaf (MEACL) in high-fat diet (HFD)-fed rats. The standardized MEACL was orally administered at different doses (250, 500, and 1000 mg/kg) to HFD-induced hyperlipidemic rats for five weeks. Serum lipid profile, body weight changes, body mass index (BMI), daily food intake, relative organ weight, and histology of the liver were evaluated. In addition, the effect of MEACL on HMG-CoA reductase and pancreatic lipase activities as well as hepatic and fecal lipids was demonstrated. MEACL supplementation reduced serum lipids in HFD-fed rats in a dose-dependent manner. Histopathological scores revealed that 1000 mg/kg MEACL restored the damage to liver tissue in hyperlipidemic rats. MEACL decreased the body mass index (BMI), atherogenic index, and hepatic cholesterol and triglycerides and increased fecal cholesterol and bile acids in HFD-fed rats. Also, MEACL ameliorated lipid peroxidation and improved antioxidant defenses in the liver of HFD-fed rats. Furthermore, HMG-CoA reductase and lipase were suppressed by MEACL. In conclusion, this study shows the potential effect of MEACL to ameliorate hyperlipidemia and oxidative stress in HFD-fed rats. It prevented hepatic lipid accumulation and exerted an inhibitory effect on HMG-CoA reductase and lipase.

scholarly journals Antiobesity and Hypolipidemic Activity of Moringa oleifera Leaves against High Fat Diet-Induced Obesity in Rats

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Souravh Bais ◽  
Guru Sewak Singh ◽  
Ramica Sharma
Keyword(s):  
Body Weight ◽  
Body Temperature ◽  
Total Cholesterol ◽  
High Fat Diet ◽  
Moringa Oleifera ◽  
Chronic Administration ◽  
The Body ◽  
Atherogenic Index ◽  
High Fat ◽  
Diet Induced Obesity

In the present study, the methanolic extract of Moringa oleifera leaves (MEMOL) was evaluated for antiobesity activity in rats. The antiobesity potential of MEMOL was studied against high fat diet-induced obesity (HFD) in rats. In this study, chronic administration of HFD in rats produced hypercholesterolemia (116.2 ± 0.27 mg/dL), which led to an increase in the body weight (225 gr), total cholesterol, triglycerides (263.0 ± 4.69 mg/dL), and attenuation in the levels of HDL (34.51 ± 2.20 mg/dL) as well as changes in body temperature of animals. Treatment of obese rats with MEMOL for 49 days resulted in a significant (P<0.001) change in body weight, total cholesterol, triglycerides, and LDL level along with a significant (P<0.001) increase in body temperature as compared to the HFD-induced obesity. MEMOL treated rats also showed a significant decrease in the level of liver biomarkers, organ weight, and blood glucose level. Further, rats treated with MEMOL (200 mg and 400 mg/kg) show reduced atherogenic index (1.7 ± 0.6 and 0.87 ± 0.76). The results indicate that the rats treated with Moringa oleifera (MO) have significantly attenuated the body weight without any change in the feed intake and also elicited significant thermogenic effect and to act as hypolipidemic and thermogenic property in obesity related disorders.

Tetrahydrocurcumin: Beneficial Effects on HMG-CoA Reductase enzyme and Lipoprotein Lipase Enzymes in High-fat diet-induced Hypercholesteremia Rabbits

2012 ◽  
Vol 2 (2) ◽  
pp. 50-60 ◽  
Author(s):  
Kalavarasariel Gopinathanpillai ◽  
Eluri Kalpana ◽  
Balasubramaniam Dineshkumar ◽  
Elumalai Monogaran ◽  
Govindharajalu Geetha ◽  
...  
Keyword(s):  
Lipoprotein Lipase ◽  
High Fat Diet ◽  
High Fat ◽  
Hmg Coa Reductase ◽  
Beneficial Effects ◽  
Coa Reductase

scholarly journals Identification of liver CYP51 as a gene responsive to circulating cholesterol in a hamster model

2016 ◽  
Vol 5 ◽  
Author(s):  
Haiqiu Huang ◽  
Zhuohong Xie ◽  
Wallace Yokoyama ◽  
Liangli Yu ◽  
Thomas T. Y. Wang
Keyword(s):  
High Fat Diet ◽  
Cholesterol Metabolism ◽  
Ldl Receptor ◽  
High Fat ◽  
Hamster Model ◽  
Hmg Coa Reductase ◽  
Cholesterol Levels ◽  
Reductase Mrna ◽  
Coa Reductase ◽  
The Relationship

AbstractHypercholesterolaemia is a risk factor for CVD, which is a leading cause of death in industrialised societies. The biosynthetic pathways for cholesterol metabolism are well understood; however, the regulation of circulating cholesterol by diet is still not fully elucidated. The present study aimed to gain more comprehensive understanding of the relationship between circulating cholesterol levels and molecular effects in target tissues using the hamster model. Male golden Syrian hamsters were fed with chow or diets containing 36 % energy from fat with or without 1 % cholesteyramine (CA) as a modulator of circulating cholesterol levels for 35 d. It was revealed that the expression of lanosterol 14α-demethylase (CYP51) instead of 3-hydroxy-3-methyl-glutaryl (HMG)-CoA reductase mRNA expression was responsive to circulating cholesterol in hamsters fed hypercholesterolaemic diets. The high-fat diet increased circulating cholesterol and down-regulated CYP51, but not HMG-CoA reductase. The CA diet decreased cholesterol and increased CYP51 expression, but HMG-CoA reductase expression was not affected. The high-fat diet and CA diet altered the expression level of cholesterol, bile acids and lipid metabolism-associated genes (LDL receptor, cholesterol 7α-hydroxylase (CYP7A1), liver X receptor (LXR) α, and ATP-binding cassette subfamily G member 5/8 (ABCG5/8)) in the liver, which were significantly correlated with circulating cholesterol levels. Correlation analysis also showed that circulating cholesterol levels were regulated by LXR/retinoid X receptor and PPAR pathways in the liver. Using the hamster model, the present study provided additional molecular insights into the influence of circulating cholesterol on hepatic cholesterol metabolism pathways during hypercholesterolaemia.

scholarly journals EFFECTS OF NIGELLA SATIVA AND SUNFLOWER OIL DIET ON WEIGHT OF ALBINO RATS

2011 ◽  
Vol 18 (03) ◽  
pp. 530-534
Author(s):  
MUHAMMAD ANWAR BURIRO ◽  
MUHAMMAD TAYYAB ◽  
ALLAH DTTTA
Keyword(s):  
Body Weight ◽  
Bile Salt ◽  
Sunflower Oil ◽  
High Fat Diet ◽  
Baseline Level ◽  
Nigella Sativa ◽  
The Body ◽  
Albino Rats ◽  
High Fat ◽  
Control Groups

Objective: To study the effects of nigella sativa and sunflower oil on weight of albino rats. Study Design: Experimental study. Period: 1996 to 1997. Setting: PGMI, Lahore. Material & Methods: A study was conducted to determine the effects of nigella sativa and sunflower oil diet intake on body weight in albino rats. Fifty six albino rats with equal number of males and females were selected for the study, they were divided into four different groups, Control groups I and III were given diet (20%), high fat diet supplemented with bile salt (1% colic acid) and antithyroid drug (0.5% propylthiouracil).The experimental group II and IV were given the above diets with supplemented nigella sativa. The high fat diet when given at different intervals increased the body weight as compared to baseline level. Results: The high fat diet when given at different intervals increased the body weight as compared to baseline level. The high fat diet with propylthiouracil and bile salt also increased the body weight and the increase was more as compared to previous groups. The supplements of nigella sativa in the groups decreased body weight significantly as compared to the control groups, which was significantly increased in all the experimental groups as compared to the control groups. Conclusions: These observation confirm that nigella sativa decreased body weight. The above effects will be beneficial for patient with obesity. On the basis of these findings conclusions are made, that nigella sativa has got body weight reducing effects. Both nigella sativa and sunflower oil have got low atherogenic index (TC/HDL) and may be recommended in hyperlipidaemic obese patients or normal individuals. Nigella sativa has got weight reducing potential thus affecting obesity and may indirectly prevent atherosclerosis. Nigella sativa is curative remedy for all diseases except death, is the saying of our Holy Prophet Hazrat Muhammad Sallallaho Alaihe Wasalam. 

scholarly journals Activation of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase during high fat diet feeding

2013 ◽  
Vol 1832 (10) ◽  
pp. 1560-1568 ◽  
Author(s):  
Nan Wu ◽  
Lindsei K. Sarna ◽  
Sun-Young Hwang ◽  
Qingjun Zhu ◽  
Pengqi Wang ◽  
...  
Keyword(s):  
High Fat Diet ◽  
Coenzyme A ◽  
High Fat ◽  
Hmg Coa Reductase ◽  
Coa Reductase

scholarly journals The modulating effect of ferulic acid on high fat diet induced hyperlipidemia and obesity:A dose response study in male Sprague Dawleyrats

Biomedicine ◽  
2021 ◽  
Vol 41 (2) ◽  
pp. 413-420
Author(s):  
Mumtaz Khan Mohamed ◽  
V. Ramamurthy
Keyword(s):  
Body Weight ◽  
Ferulic Acid ◽  
High Fat Diet ◽  
Blood Lipids ◽  
Density Lipoprotein ◽  
Lipid Lowering ◽  
Serum Adiponectin ◽  
High Fat ◽  
Hmg Coa Reductase ◽  
Coa Reductase

Introduction and Aim: Ferulic acid (FA) is a phenolic compound predominantly found in cereals have been used in traditional Chinese medicine. Here, we studied the effect of FA on high-fat diet (HFD) induced hyperlipidemia and obesity in rats.   Materials and Methods:Hyperlipidemia was induced in male Sprague Dawley rats by feeding HFD for 14 weeks. The hypolipidemic effect was evaluated by co-administering 50,100, 200 and 250 mg/kg body weight of FA. At the end of the experimental period, rats were sacrificed and serum/plasma levels of total cholesterol (TC), triglycerides (TG), high-density lipoprotein (HDL), low-density lipoprotein (LDL), aspartate transaminase (AST), alanine transaminase (ALT), 3-hydroxy-3methyl-glutaryl-coenzyme A reductase (HMG CoA reductase) and adiponectin were determined. Moreover, Histopathological examination of liver and visceral adipose tissue (AT) was also carried out.   Results:HFD treatment significantly increased weight gain, body mass index, total fat pad mass, blood lipids, LDL cholesterol and serum transaminases.HFD +FA fed rats showed a significant decrease in blood lipids and an increase in antioxidant enzymes when compared to the HFD control rats. The activity of HMG CoA reductase and serum adiponectin levels were elevated in rats administered with FA. Among the 4 doses studied, 200 mg of FA/kg body weight exhibited optimum hypolipidemic activity. Histological observations in the liver and visceral AT added additional evidence for the lipid-lowering effect of FA.   Conclusion:These findings indicate that FA can act as a hypolipidemic agent, probably by modulating the activity of HMG CoA reductase and serum adiponectin levels.

Astaxanthin Attenuates Adiponectin, Calprotectin, miRNA222 and miRNA378 in Obesity induced by High-Fat Diet in Rats

2021 ◽  
Vol 22 ◽  
Author(s):  
Sylvia A. Boshra
Keyword(s):  
Insulin Resistance ◽  
Adipose Tissue ◽  
High Fat Diet ◽  
Group Iv ◽  
The Body ◽  
Albino Rats ◽  
High Fat ◽  
Aberrant Expression ◽  
Group Iii ◽  
Group I

Background: Astaxanthin suppressed obesity in rats fed with high-fat diet(HFD) via the restriction of adipose tissue build-out, therefore, improving insulin sensitivity and inflammation. Metformin reduces insulin resistance and may reduce weight. Aim: Investigation of the effects of astaxanthin and metformin in obesity prompted by a high-fat diet. Objective: The present article investigates the effects of astaxanthin and metformin in obesity prompted by a high-fat diet in rats through measuring miRNA222 and 378. Materials: The rats were classified into four classes containing ten albino rats each: Group I(Normal group): nourished with ordinary diet for 8weeks. Group II(Control positive): nourished with a high-fat diet for 8 weeks. Group III: nourished with astaxanthin(50mg/kg)(1/40 LD50) orally plus a high-fat diet for 8weeks. Group IV: nourished with metformin (500mg/kg) orally plus a high-fat diet for 8 weeks. Results: Astaxanthin and metformin have anti-obesity and antioxidant actions and significantly decreased the weight of the body, glucose, insulin, triglycerides, total cholesterol, triglycerides and leptin, as well as plasma calprotectin & IL-6 and increased HDL-C and adiponectin. The liver TNF-αgene expression, adipose tissue miRNA222 and miRNA378 expression were decreased compared to HFD control rats. Discussion and conclusion: Astaxanthin has regulated the aberrant expression of miRNA222 and 378 that may be related to hyperlipidemia and insulin resistance. Accordingly, astaxanthin deserves a clinical trial in the future due to its effects on miRNAs involved in obesity.

scholarly journals ANTIHYPERLIPIDEMIC ACTIVITY OF ECLIPTA ALBA IN HIGH FAT DIET-INDUCED HYPERLIPIDEMIC ALBINO RATS

2019 ◽  
pp. 230-232
Author(s):  
SATHEESH NAIK K ◽  
GURUSHANTHAIAH M ◽  
NAGESH RAJU G ◽  
LOKANADHAM S ◽  
SESHADRI REDDY V
Keyword(s):  
High Fat Diet ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Albino Rats ◽  
High Fat ◽  
Serum Glutamic Oxaloacetic Transaminase ◽  
Eclipta Alba ◽  
Wistar Strain ◽  
Antihyperlipidemic Activity ◽  
Effective Role

Objective: The objective is to study the antihyperlipidemic activity of Eclipta alba in hyperlipidemic albino rats and the use of herbal plants and their parts such as seeds, berries, leaves, roots, barks, or flowers for the development of drugs for therapeutic purposes which have an effective role in recent years. Methods: A total of 30 adult albino rats of Wistar strain weighing 165–215 g were utilized. Animals were treated with high fat diet for 8 weeks followed by post-treatment of E. alba for 1 week, 2 weeks, and 3 weeks, respectively. After 12 h of fasting on the last day of experiment, serum blood samples were collected in EDTA vials and processed for biochemical analysis. Results: A significant decrease in levels of total cholesterol and triglycerides was noted on animals treated with E. alba compared to high fat diet animals. Treatment of hypercholesterolemic rats with E. alba showed a marked decrease of serum low-density lipoprotein (LDL) and very LDL-cholesterol concentrations compared to the hypercholesterolemic rats. High fat diet feeding worsened the levels of serum glutamic oxaloacetic transaminase, serum glutamic pyruvic transaminase, and alkaline phosphatase enzymes, whereas the same markers were significantly improved by supplementation with E. alba compared to normal group. Conclusion: E. alba acts as antihyperlipidemic agent in hyperlipidemic conditions and helps for better health.

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