scholarly journals Heavy Metal Levels in Adolescent and Maternal Blood: Association with Risk of Hypospadias

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Tusha Sharma ◽  
Basu Dev Banerjee ◽  
Chandra Shekhar Yadav ◽  
Piyush Gupta ◽  
Sunil Sharma

Background. Hypospadias is a part of testicular digenesis syndrome (TDS) which includes infertility, cryptorchidism, and spermatogenesis. Heavy metals act as endocrine disrupting compounds. Heavy metals such as cadmium, chromium, arsenic, and lead have been associated with male infertility, cryptorchidism, spermatogenesis, cancer, reproductive disorder, and neurological disorder. However, it remains an important issue to corroborate or refute the hypothesis that the role of heavy metals in male reproductive tract disorders. Hence, the present study was designed to investigate the possible association of heavy metal and risk of hypospadias by estimating the blood heavy metal levels. Methods. In this case control study, 50 hypospadias boys diagnosed and confirmed by a pediatric urologist and 50 randomly selected age-matched (1–5 years) healthy control boys not suffering from any clinically detectible illness and their mothers have been included and heavy metal levels in the blood of these subjects have been estimated by Atomic Absorption Spectrophotometer (AAS). Result. Significantly high levels of cadmium and lead have been observed in hypospadias cases; however, all heavy metal levels were present in higher concentration. Conclusion. Higher blood levels of cadmium and lead may be associated with the increased risk of hypospadias.

2023 ◽  
Vol 83 ◽  
Author(s):  
A. A. Banjabi ◽  
K. Kannan ◽  
T. A. Kumosani ◽  
J. M. Yousef ◽  
K. O. Abulnaja ◽  
...  

Abstract Serum toxic metals have been implicated in development of many diseases. This study investigated the association between blood levels of lead and cadmium with abnormal bone mineral density (BMD) and incidence of osteoporosis. Sixty Saudi male adults age matching were assigned into two groups: A healthy control group (n = 30) and osteoporosis patients diagnosed according to T-score (n = 30). Serum calcium, vitamin D, osteocalcin, lead, cadmium were measured. Osteoporotic group showed a highly significant elevation of blood lead and cadmium levels compared to the control group (p <0.001). BMD was negatively correlated with serum osteocalcin level compared with control. There was a significant negative correlation between the cadmium and lead levels (r=-0.465 and p-value = 0.01) and calcium (p < 0.004). Our findings suggested that high cadmium and lead were negative correlated to BMD and increased the risk factor for osteoporosis.


2021 ◽  
Vol 45 (1) ◽  
Author(s):  
Elijah Abakpa Adegbe ◽  
Oluwaseyi Oluwabukola Babajide ◽  
Lois Riyo Maina ◽  
Shola Elijah Adeniji

Abstract Background Heavy metal accumulation in the ecosystem constitutes a potential toxic effect which is hazardous to human health. Increasing environmental pollution has necessitated the use of cattle egrets to evaluate the levels of heavy metal contamination, to establish their use in biomonitoring of heavy metals and to provide data for monitoring pollution in the environment. Results The present study assessed the utilization of Bubulcus ibis in monitoring pollution in five abattoirs, namely Agege, Bariga, Kara, Itire and Idi-Araba, all situated in Lagos State. The concentration of five (5) heavy metals, cadmium (Cd), copper (Cu), nickel (Ni), lead (Pb) and zinc (Zn) was determined in the liver, muscle and feather of Bubulcus ibis using the atomic absorption spectrophotometer. The trend of metal accumulation was in the order: Zn > Cu > Pb > Cd > Ni for all the sampled tissues. The mean tissue concentrations of the metals were significantly different (p < 0.05) among the sites. The highest levels of metal concentration were reported in the liver in all the locations. Mean concentration of Cd in Kara (0.003 ± 0.00058) was significantly (p < 0.05) higher than those found at Agege (0.0013 ± 0.00058) and Idi-Araba (0.001 ± 0.001). A significant difference (p < 0.05) was also observed between the mean concentrations of Cu in Bariga (0.01 ± 0.001) and Idi-Araba (0.003 ± 0.001). Conclusion All the studied heavy metals were present in the liver, muscle and feathers of the cattle egrets. The contamination levels were ascertained from the study which indicated that cattle egrets are useful in biomonitoring studies and the generated data will serve as baseline data which could be compared with data from other locations for monitoring heavy metal pollution.


2009 ◽  
Vol 3 (2) ◽  
pp. 48-64
Author(s):  
Kadhim M. Ibrahim ◽  
Shaimaa A. Yousir

Several experiments were carried out to study heavy metal tolerance in tissue cultures or whole plants of S. grandiflora., Callus was induced and maintained on modified Murashige and Skoog, 1962 medium (MS) supplemented with (0.5)mg/l benzyl adenine and (2)mg/l 2,4-phenoxy acetic acid . Heavy metals (Cd, Co, Cu, Cr or Zn) were added to the culture medium at different concentrations as contamination agents. In order to asses the effect of these heavy metals on seed germination; seeds were sown in soil contaminated with different concentrations of heavy metals for 3 weeks. Atomic Absorption Spectrophotometer was used for analysis of samples taken from whole plants and callus cultures. Results showed that callus fresh weight decreased with increasing heavy metal concentration in cultural medium. Germination percentages and plant heights increased over time. However, a reduction occurred in these parameters with increasing heavy metal levels. Percentages of metals accumulated in calli were (0.001, 0.011, 0.012 and 0.013%) at (0.0, 0.05, 0.075 and 0.1)mg/l Cd respectively; (0.001, 0.008, 0.016 and 0.006%) at (0.0, 0.1, 0.25 and 0.5)mg/l Co respectively; (0.001, 0.020, 0.034 and 0.015%) at (0.0, 0.075, 0.2 and 0.5)mg/l Cu respectively; (0.001, 0.013, 0.012 and 0.010%) at (0.0, 0.25, 0.4 and 0.5)mg/l Cr respectively and (0.027, 0.051, 0.059 and 0.056%) at (0.0 , 0.75, 1.0 and 1.5)mg/l Zn respectively. Percentages of metals accumulated in whole plants were (0.08, 0.55, 1.11, 0.83 and 0.44%) at (0.0, 1.0, 2.0, 3.0 and 4.0)mg/Kg soil Cd respectively; (0.11, 0.22, 0.55, 0.47 and 0.44%) at (0.0, 15.0, 30.0 45.0 and 60.0)mg/Kg soil Co respectively; (0.01, 0.10, 0.57, 0.58 and 0.72%) at (0.0, 25.0, 50.0, 75.0 and 100.0)mg/Kg soil Cu respectively. (0.08, 0.80, 1.28, 1.31 and 0.88%) at (0.0, 25.0, 50.0, 75.0 and 100.0)mg/Kg soil Cr respectively and (0.06, 1.11, 1.20, 1.83 and 2.22%) at (0.0, 100.0, 200.0, 300.0 and 400.0)mg/Kg soil Zn respectively.


2020 ◽  
Author(s):  
Francis Hamwiinga ◽  
Chisala D. Meki ◽  
Patricia Mubita ◽  
Hikabasa Halwiindi

Abstract Background: One of the factors impeding access to safe water is water pollution. Of particular concern is heavy metal contamination of water bodies. This study was aimed at determining the levels of heavy metals in drinking water sources of Chingola District of Zambia. Methods: A cross sectional study was employed. A total of 60 water samples were collected. Thirsty (30) samples were collected in the dry season in the month of October 2016 and another 30 in the wet season in the months of February and March, 2017. For each season 10 water samples were collected from each of the three water sources. i.e. Tap water, Urban ground water sources and Rural ground water sources. Heavy metal analysis was done using Atomic Absorption Spectrophotometer (AAS).Results: This study revealed that the concentrations of Iron, Manganese, Lead, Nickel and Arsenic were beyond maximum permissible levels in various water sources. Combined averages for both dry and wet seasons were as follows: Iron: 2.3, Copper: 0.63, Cobalt: 0.02, Manganese: 0.36, Lead: 0.04, Zinc:3.2, Nickel: 0.03, Arsenic: 0.05. Chromium and Cadmium were below detection limit in all water samples. The median concentrations of iron, arsenic, copper, manganese in drinking water from the Tap, rural and urban ground water sources were different, and this difference was statistically significant (p<0.05). The median concentrations of arsenic, nickel, manganese and cobalt were different between dry and wet season, and this difference was statistically significant (p<0.05).Conclusions: Sources of heavy metals in water seems to be both natural and from human activities. The concentration of heavy metals in different water sources in this study was found to be above the recommended levels. This calls for improvement in water monitoring to protect the health of the public. Therefore, there is need for continuous monitoring of heavy metals in drinking water sources by regulatory authorities.


Author(s):  
Özgür Canpolat ◽  
Metin Çalta

Keban Dam Lake is the second largest dam lake in Turkey. In addition, it has the feature of being one of the most important dam lakes in our country in terms of both aquaculture potential and electricity generation. In this study, fish samples belong to Capoeta trutta caught from Örencik region of Keban Dam Lake were used. The concentrations of some heavy metals (copper, iron, zinc, chromium, nickel, cadmium, arsenic and mercury) in muscle of Capoeta trutta and the potential health risk from consumption of this fish species were examined. In addidion, the relationship between the heavy metal levels and some biological aspects of fish (weight, length and sex) were determined. As a result of the study, it was determined that the most and the least accumulated heavy metals in the muscle tissue of Capoeta trutta were zinc and cadmium respectively. The concentration of heavy metals showed differences according to weight, length and sex of fish. The results were found indicated that heavy metal levels in the muscle tissue of Capoeta trutta are below the tolerable values recommended by EPA, WHO and FAO. Therefore, there is not any risk for human consumption of this fish species.


Author(s):  
Himalaya Bhardwaj ◽  
Chanchal Singh ◽  
Shashi Nayyar ◽  
Sandeep Sodhi ◽  
Rajesh Jindal

Background: Farm animals may serve as bio-indicators of environmental pollution. Environmental heavy metals may disrupt the normal physiological and biochemical profile of the animals. The present study was planned to reduce the stress caused by heavy metal pollution by oral feeding of vitamin E and Selenium in heavy metals exposed buffaloes.Methods: Twenty buffaloes were selected on the basis of blood levels of heavy metals and divided into exposed and non-exposed groups. Exposed animals (n=10) were orally supplemented with 20 ml/day of Cargill E care Se® containing vitamin E, 100mg/ml and Se 0.5mg/ml for 30 days. Antioxidants, biochemical parameters and the expression of metallothionein-2 were analyzed after supplementation on 0, 15 and 30 days.Result: The levels of heavy metal were found to be elevated even after 30 days of supplementation. No significant alterations were observed in activity of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) after 30 days of supplementation. There was significantly (p less than 0.05) higher activity of blood glutathione and plasma Vitamin E. In supplemented group, plasma glucose, total cholesterol, aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), lactic dehydrogenase (LDH), creatine kinase (CK) and total Immunoglobulin were found to be significantly reduced in supplemented group. Expression of metal binding protein, metallothionein-2 was found to be elevated in exposed animals despite supplementation with Vitamin E and Se for 30 days.


2019 ◽  
Vol 7 (12) ◽  
pp. 697 ◽  
Author(s):  
Chaolin Fang ◽  
Varenyam Achal

The global energy crisis and heavy metal pollution are the common problems of the world. It is noted that the microbial fuel cell (MFC) has been developed as a promising technique for sustainable energy production and simultaneously coupled with the remediation of heavy metals from water and soil. This paper reviewed the performances of MFCs for heavy metal removal from soil and water. Electrochemical and microbial biocatalytic reactions synergistically resulted in power generation and the high removal efficiencies of several heavy metals in wastewater, such as copper, hexavalent chromium, mercury, silver, thallium. The coupling system of MFCs and microbial electrolysis cells (MECs) successfully reduced cadmium and lead without external energy input. Moreover, the effects of pH and electrode materials on the MFCs in water were discussed. In addition, the remediation of heavy metal-contaminated soil by MFCs were summarized, noting that plant-MFC performed very well in the heavy metal removal.


2009 ◽  
Vol 620-622 ◽  
pp. 125-128 ◽  
Author(s):  
Sung Won Kang ◽  
Seog Ku Kim ◽  
Sang Leen Yun ◽  
Hye Cheol Oh ◽  
Jae Hwan Ahn

This research was conducted to investigate the application of the novel upflow-type filtration device using hydrophobia media made of expanded polypropylene (EPP) from driveways site. The higher level of motorway-derived heavy metal contamination exists in stormwater runoff from a road section and the heavy metal levels were higher than the regulated Korean environmental guideline in lake and river. For Cd, Cr, Cu, Pb and Zn, the influent event mean concentrations (EMCs) during 8 storm periods were 2.75, 37.3, 90.5, 118.5 and 546.5 µg/L, respectively. The novel upflow-type filtration device with main mechanism of filtration and adsorption showed removal (>91%, >93%, >85%, >91% and >80%) of the studied heavy metals (Cd, Cr, Cu, Pb and Zn) and differences of medians of removal efficiencies among heavy metals were not statistically signficant by Kruskal-Wallis test (p>0.05) during 8 storm events. It is found that EPP media is very effective at the removal of the heavy metals, and the magnitude of heavy metal removal in a decreasing order is Cr, Cd, Pb, Cu and Zn.


Author(s):  
Jehru C. Magahud ◽  
Rodrigo B. Badayos ◽  
Pearl B. Sanchez ◽  
Pompe C. Sta. Cruz

Industrialization, urbanization and intensive use of farm inputs can pollute agricultural areas. The study was then conducted to assess the levels of chromium (Cr), nickel (Ni), copper (Cu), cobalt (Co), zinc (Zn), arsenic (As), molybdenum (Mo), cadmium (Cd), mercury (Hg), and lead (Pb) in the country’s major rice areas. The study also determined the contributions of soil properties, land uses, irrigation water, and farm inputs to the metal levels. Strategic collections of soil, plant and water samples in the country’s major soil series planted to rice, analyses of samples using x-ray fluorescence or atomic absorption spectroscopy, and farmer interviews were done. Metal levels were very high in Zambales and Negros Occidental soils due to deposition or use of metal-enriched mine tailings and irrigation water. Soil metal concentrations in Zambales far exceeded the intervention values of 180 mg/kg for Cr and 100 mg/kg for Ni. Soil metal levels in Negros Occidental exceeded the intervention value of 190 mg/kg for Cu and Mo. Rice plants in Negros Occidental exceeded the toxic levels of 30 mg/kg for Cu and 10-50 mg/kg for Mo due to the very high soil Cu and Mo concentrations in the area. Molybdenum concentrations of rice plants in Sultan Kudarat and Camarines Sur exceeded the toxic level due to the high amounts of foliar chemicals applied at >66 sprayer loads per year. The study implies that rice areas deposited with mine wastes have high heavy metal levels, and foliar chemicals can increase metal levels in rice.   Keywords - Environmental toxicology, heavy metals, heavy metal sources, rice soils, Philippines


Author(s):  
P.V. Yeotikar ◽  
S. Nayyar ◽  
C. Singh ◽  
C.S. Mukhopadhyay ◽  
S.Sodhi Kakkar ◽  
...  

The parameters related to oxidative stress and heavy metal levels were assessed during summer and winter seasons in buffaloes from environmentally exposed areas (n=60) of Ludhiana district of Punjab (India) and control area (n=40). Buffaloes of heavy metal exposed areas exhibited significantly (p less than 0.05) increased blood levels of Cr, Ni, As and Pb along with significantly (p less than 0.05) higher erythrocytic malondialdehyde (MDA) levels; whereas significant (p less than 0.05) decrease was observed in superoxide dismutase activity and the levels of reduced glutathione (GSH), vitamins C and E as compared to buffaloes from control area. The level of oxidative stress was higher in all buffaloes during summer as compared to winter as indicated by significantly (p less than 0.05) higher MDA level, and lower concentrations of GSH, vitamins C and E irrespective of the area. Blood Cr, Ni, As and Pb levels showed highly significant positive correlation (p less than 0.01) with MDA level but negative correlation with SOD activity and the concentrations of GSH, vitamins C and E. Thus, it may be concluded that buffaloes exposed to heavy metals encounter significant oxidative stress and potential to quench free radicals is compromised during summer.


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