scholarly journals A Disease Modification Effect of APOEE4 on the Association between Urinary Albumin Excretion and Cognition in Korean Adults

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Min-Ho Shin ◽  
Sun-Seog Kweon ◽  
Jin-Su Choi ◽  
Young-Hoon Lee ◽  
Hae-Sung Nam ◽  
...  
Keyword(s):  
Cognitive Function ◽  
Sex Education ◽  
Mini Mental State Examination ◽  
Cross Sectional Study ◽  
Urinary Albumin ◽  
Cross Sectional ◽  
Korean Adults ◽  
Educational Attainments ◽  
Modifying Effect ◽  
State Examination

Background. No previous study examined a disease modifying effect of APOEE4 status on the association between the urinary albumin-to-creatinine ratio (UACR) and cognition. This study aimed to investigate whether APOEE4 modified the association in Korean adults.Methods. We performed a cross-sectional study in adults aged 45 to 74 who were living in Namwon City, Republic of Korea. Cognitive function was measured with the Korean version of modified Mini-Mental State Examination (K-mMMSE) and cognitive impairment was defined as scores falling below the 25th percentile of the K-mMMSE according to age, sex, and educational attainments.Results. A total of 10,190 participants (4006 men and 6184 women) were analyzed in the present study. Of these, 1698 subjects (16.7%) were APOEE4 carriers. The UACR values were negatively associated with the K-mMMSE scores, even after adjusting for potential confounders including age, sex, education, and vascular risk factors. APOEE4 modified the association significantly, resulting in a steeper decline of cognitive function with the increase in UACR inE4 carriers (Pfor interaction = 0.021).Conclusion. Higher UACR values were significantly associated with cognitive dysfunction in the general Korean population, with cognition in APOEE4 carriers being more severely affected by increased UACR.

scholarly journals Polypharmacy Associated with Cognitive Decline in Newly Diagnosed Parkinson’s Disease: A Cross-Sectional Study

2019 ◽  
Vol 9 (3) ◽  
pp. 338-343
Author(s):  
Nobuyuki Ishii ◽  
Hitoshi Mochizuki ◽  
Katsuya Sakai ◽  
Go Ogawa ◽  
Kazutaka Shiomi ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cognitive Function ◽  
Mini Mental State Examination ◽  
Cross Sectional Study ◽  
Newly Diagnosed ◽  
Sectional Study ◽  
Cross Sectional ◽  
Inverse Probability ◽  
State Examination

Aims: Polypharmacy is well known to affect cognitive function in community-dwelling older adults. However, the effect of polypharmacy on cognitive function in patients with newly diagnosed Parkinson’s disease remains unknown. Here, we evaluated the association between polypharmacy and cognitive function in patients with newly diagnosed Parkinson’s disease. Methods: This cross-sectional study enrolled 131 consecutive hospitalized patients with newly diagnosed Parkinson’s disease. Cognitive function was evaluated with the Mini-Mental State Examination and analyzed between groups of patients with or without polypharmacy. Comparisons were adjusted for confounders by performing inverse probability weighting with propensity scores. Results: After inverse probability weighting, patients in the polypharmacy group had a significantly lower Mini-Mental State Examination score than patients in the nonpolypharmacy group (26.2 vs. 27.7, p = 0.001). Conclusion: Polypharmacy was associated with cognitive decline in patients with newly diagnosed Parkinson’s disease. This finding suggests that medication reduction might serve as a promising intervention to prevent the development of dementia in patients with early Parkinson’s disease. Further prospective studies are needed to determine whether medication reduction improves cognitive function in patients with newly diagnosed Parkinson’s disease.

36 Cognitive functioning in patients aged 60 and older with chronic non- communicable diseases

2020 ◽  
Vol 91 (8) ◽  
pp. e23-e23
Author(s):  
¹Jurate Peceliuniene ◽  
²Guntis Karelis ◽  
³Irena Zukauskaite ◽  
Zane Kalnina ◽  
Diana Blagovescenska ◽  
...  
Keyword(s):  
Mini Mental State Examination ◽  
Cross Sectional Study ◽  
Communicable Diseases ◽  
Chi Square ◽  
Cross Sectional ◽  
Non Communicable Diseases ◽  
Cognitive Failures ◽  
Cognitive Failures Questionnaire ◽  
State Examination ◽  
One Way Anova

ObjectiveIt is well established that chronic non-communicable diseases (CND) are linked to early cognitive impairment (CI) before or at the beginning of the old age, bringing those patients at higher risk for dementia.The aim: to evaluate CI of aged 60 or older cognitively healthy patients visiting doctors due to different CNDMethods107 patients aged 60 or older (mean age 74 years; 44 male, 63 female; 25 were visiting general practitioner (GP), 21 – neurologist (NE), 23 – pulmonologist (PU), 38 – otorhinolaryngologist (OT)) for their CND took part in pilot cross sectional study. They filled The Cognitive Failures Questionnaire (CFQ), Subjective Cognitive Complaints (SCCs), Mini-Mental State Examination (MMSE). Results were compared using Pearson Chi-Square and one-way ANOVA.ResultsOT patients had higher CFQ results (M=30.7) comparing to all groups (GP M=24.3; NE M=22.6, PU M=18.3, p=0.001). PU patients had less problems with Forgetfulness (M=8.6), comparing to GP (M=11.4) or OT (M=12.4) groups (p=0.022). OT (M=9.3) had more problems with Distractibility comparing to PU (M=5.7) and GP (M=6.7) groups (p=0.011). OT had higher scores in False Triggering (M=7.9) comparing to GP (M=5.92), NE (M=5.8) and PU (4.8) groups (p=0.011).The cut-off point of row score 45 was overstepped in18.9% of OT group, 8% of GP group, but none in NE or PU group (p=0.026). Results of MMSE showed alike tendencies: PU patients (M=27.8) had higher results than GP (M=25.7) or OT (M=25.6) groups (p=0.029). CI was found in 39.1% of GP and 35.1% of OT, comparing to 19.0% in NE and 3.7% in PU groups (p=0.020). But groups did not differ by SCCs scores, even if 3 or more complains were found in 50.0% of GP, 52.2% of PU, 42.9% of NE and 71.1% OT groups. The only SCCs question where found differences between groups – limitation of daily activities: concerning about possible mistakes 62.5% of GP and PU groups would ask somebody’s help, while it would be done by 52.4% of NE and only 15.8% of OT group (p<0.001).ConclusionsCognitive health in elderly people with CND is not monitored well. About 2/3 of them have subjective cognitive complains (3 or more by SCCs), 1/4 would be named as having CI by MMSE, 8.5% have problems due to forgetfulness, distractibility, false triggering. Cognitive functions are predominantly impaired in OT group patients, however, they declare less need for helping them.

Interactions Between Handgrip Strength and Serum Folate and Homocysteine Levels on Cognitive Function in the Elderly Chinese Population

2021 ◽  
pp. 1-11
Author(s):  
Yongjie Chen ◽  
Yue Du ◽  
Zhuoyu Sun ◽  
Qian Liu ◽  
Changqing Sun ◽  
...  
Keyword(s):  
Cohort Study ◽  
Cognitive Function ◽  
Handgrip Strength ◽  
The Elderly ◽  
Cross Sectional Study ◽  
Serum Folate ◽  
Folate Level ◽  
Cross Sectional ◽  
Elderly Nutrition ◽  
State Examination

Background: Handgrip strength (HGS) and serum folate and homocysteine (Hcy) levels were associated with cognitive function. However, little was known whether there were interactions between HGS and serum folate and Hcy levels on cognitive function. Objective: To examine the interactions between HGS and serum folate and Hcy levels on cognitive function. Methods: This study analyzed the baseline data of the Tianjin Elderly Nutrition and Cognition Cohort study. All participants aged ≥60 years were potential eligible. HGS was measured using a grip strength dynamometer. Serum folate and Hcy levels were assayed using standard laboratory protocol. A Mini-Mental State Examination was used to assess cognitive function. Linear regressions were employed to examine the interactions between HGS and serum folate and Hcy levels on cognitive function. Results: 4,484 participants were included in this study. There were interactions between HGS and serum folate and Hcy levels on cognitive function. Furthermore, subjects with strong HGS and sufficient folate level had the best cognitive function (β= 2.018), sequentially followed by those with strong HGS and insufficient folate level (β= 1.698) and with poor HGS and sufficient folate level (β= 0.873). Similarly, cognitive function was ranked in the descending order of subjects with strong HGS and normal Hcy level (β= 1.971), strong HGS and high Hcy level (β= 1.467), and poor HGS and normal Hcy level (β= 0.657). Conclusion: There were interactions between HGS and serum folate and Hcy levels on cognitive function. However, the temporal associations cannot be examined in a cross-sectional study. Further cohort study should be conducted to confirm these associations in the future.

scholarly journals HUBUNGAN AKTIVITAS FISIK TERHADAP KUALITAS TIDUR DAN FUNGSI KOGNITIF PADA KELOMPOK LANSIA DHARMA SENTANA, BATUBULAN

2021 ◽  
Vol 17 (2) ◽  
pp. 110
Author(s):  
I Made Dhita Prianthara ◽  
I.A Pascha Paramurthi ◽  
I Putu Astrawan
Keyword(s):  
Quality Index ◽  
Mini Mental State Examination ◽  
Pittsburgh Sleep Quality Index ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Chi Square ◽  
Cross Sectional ◽  
Activity Scale ◽  
State Examination ◽  
Physical Activity Scale

Peningkatan jumlah populasi lansia menyebabkan semakin banyak masalah kesehatan yang akan dialami oleh lansia yang disebabkan karena kurangnya aktivitas fisik seperti gangguan kualitas tidur dan penurunan fungsi kognitif. Seiring dengan pertambahan usia dan berkurangnya aktivitas fisik, semakin besar kemungkinan seseorang mengalami gangguan kualitas tidur dan penurunan fungsi kognitif. Aktivitas fisik yang rutin dilakukan oleh lansia dapat mencegah terjadinya gangguan kualitas tidur dan mencegah penurunan fungsi kognitif. Semakin meningkat aktivitas fisik maka semakin meningkat kualitas tidur dan fungsi kognitif pada lansia. Tujuan dari penelitian ini adalah untuk mengetahui hubungan antara aktivitas fisik terhadap kualitas tidur dan fungsi kognitif pada kelompok lansia Dharma Sentana, Batubulan. Penelitian ini adalah cross sectional study dengan teknik pengambilan sampel purposive sampling. Penelitian dilakukan di kelompok lansia Dharma Sentana, Batubulan. Sampel penelitian ini berjumlah 50 orang lansia. Aktivitas fisik diukur dengan International Physical Activity Scale (IPAQ), kualitas tidur diukur dengan Pittsburgh Sleep Quality Index (PSQI), dan fungsi kognitif diukur dengan Mini-Mental State Examination (MMSE). Berdasarkan hasil uji chi-square didapatkan nilai p=0,007 yang artinya ada hubungan antara aktivitas fisik dengan kualitas tidur dan nilai p=0,000 yang artinya ada hubungan antara aktivitas fisik dengan fungsi kognitif. Simpulan penelitian ini adalah ada hubungan antara aktivitas fisik terhadap kualitas tidur dan fungsi kognitif pada kelompok lansia Dharma Sentana, Batubulan. Kata kunci: Lansia, Aktivitas Fisik, Kualitas Tidur, Fungsi Kognitif

scholarly journals GAMBARAN FUNGSI KOGNITIF PADA PASIEN RAWAT JALAN DENGAN RIWAYAT STROKE DI POLIKLINIK SARAF RSUP PROF. DR. R.D. KANDOU MANADO

2013 ◽  
Vol 5 (1) ◽  
Author(s):  
Tirzha N. Paparang ◽  
Corry N. Mahama ◽  
Denny J. Ngantung
Keyword(s):  
Cognitive Function ◽  
Mini Mental State Examination ◽  
Trail Making Test ◽  
Cross Sectional ◽  
Clock Drawing Test ◽  
Clock Drawing ◽  
Drawing Test ◽  
Trail Making ◽  
Cross Sectional Design ◽  
State Examination

Abstract: Stroke is a major cause of cognitive dysfunction. The incidences of cognitive dysfunction increase three-fold after strokes, usually involving impairement of abilities in visuo-spacial, memory, orientation, speech, attention, and performance functions. The rapid, practical, and approved examinations used to evaluate and confirm the decline in cognitive functions are the Mini Mental State Examination (MMSE), the Clock Drawing Test (CDT), and the Trail Making Test (TMT). This study aimed to reveal the cognitive functions of outpatients with stroke histories in the Neurology Polyclinic, Prof. Dr. R.D. Kandou Hospital Manado by using the above mentioned examinations. This was a descriptive study with a cross-sectional design conducted in November 2012. The results showed that there were 51 respondents who fulfilled the inclusion criteria consisting of 32 males and 19 females. The highest decline of cognitive function by age, the educational level, and employment was 60-79 years, more than 9 years of education, and retired workers, respectively. The results of the MMSE, CDT, and TMT examinations for cognitive impairment evaluation were as follow: MMSE 62.75%, CDT 56.86%, TMT A 96.08%, and TMT B 84.31%. Conclusion: Most of the outpatients with stroke histories in the Neurology Polyclinic, Prof. Dr. R.D. Kandou Hospital Manado showed cognitive impairments. Keywords: CDT, cognitive function, MMSE, stroke, TMT-A and B.   Abstrak: Stroke merupakan penyebab utama gangguan fungsi kognitif. Insiden gangguan kognitif meningkat tiga kali lipat setelah stroke, dan biasanya melibatkan kemampuan visuospasial, memori, orientasi, bahasa, perhatian dan fungsi eksekutif. Pemeriksaan yang digunakan untuk mengevaluasi dan mengonfirmasi penurunan  fungsi kognitif yang cepat dan praktis namun bernilai tinggi ialah Mini Mental State Examination (MMSE), Clock Drawing Test (CDT), dan Trail Making Test (TMT). Penelitian ini bertujuan untuk mengetahui gambaran fungsi kognitif pada pasien rawat jalan dengan riwayat stroke di Poliklinik Saraf RSUP Prof. Dr. R.D. Kandou Manado. Penelitian ini bersifat deskriptif dengan cross-sectional design dan dilaksanakan selama bulan November 2012. Hasil penelitian memperlihatkan bahwa 51 responden memenuhi kriteria inklusi, terdiri dari 32 laki-laki dan 19 perempuan. Berdasarkan usia, tingkat pendidikan, dan pekerjaan, penurunan fungsi kognitif terbanyak pada usia 60-79 tahun, tingkat pendidikan terakhir >9 tahun, dan pekerjaan pensiunan. Hasil pemeriksaan MMSE, CDT, dan TMT terhadap fungsi kognitif responden ialah: MMSE 62,75%, CDT 56,86%, TMT A 96,08%, dan TMT B 84,31%. Simpulan: Sebagian besar pasien rawat jalan dengan riwayat stroke di Poliklinik Saraf RSUP Prof. Dr. R.D. Kandou Manado telah memperlihatkan gagguan fungsi kognitif.Kata kunci: stroke, fungsi kognitif, MMSE, CDT, TMT-A dan B.

scholarly journals Role of Tumor Necrosis Factor-Alpha in Schizophrenia and Cognitive Impairment

2021 ◽  
Vol 9 (T3) ◽  
pp. 160-163
Author(s):  
Elmeida Efffendy ◽  
Mustafa Mahmud Amin ◽  
Nurul Utami
Keyword(s):  
Cognitive Function ◽  
Mental State ◽  
Mini Mental State Examination ◽  
Cognitive Disorders ◽  
Chronic Schizophrenia ◽  
Necrosis Factor Alpha ◽  
Cross Sectional ◽  
Tnf Α ◽  
Schizophrenic Patients ◽  
State Examination

Background: Neuroinflammation and excitotoxicity play a key role as triggers and support for neurodegenerative processes, increase levels of TNF-α have been found in schizophrenic patients. Improved inflammatory processes have been demonstrated in acute and chronic schizophrenia. In schizophrenia is characterized by a collection of core symptoms that trigger individuals experiencing several cognitive disorders. Objective: To investigate the relationship of serum TNF-α levels to impaired cognitive function in schizophrenic patients in Medan, Indonesia. Method: This research is cross sectional analytical correlative study involving 40 male schizophrenic patients at Prof. Dr. M. Ildrem Mental Hospital through July to September 2019 that fulfilled our inclusion and exclusion criteria. Serum TNF-α levels were analyzed using Quantikine HS Human TNF-α Assay with a minimum detection limit of  0.1062 pg/ml while in the other hand, cognitive function test was carried out by using the Mini Mental State Examination. Results: Serum TNF-α levels with a mean of 25.1216 with a standard deviation of 1.7629. There is a positive correlation with moderate correlation (r = 0.4 - <0.6) on cognitive function with the strength of correlation r = 0.434 Conclusion: We found that there is a link between serum TNF-α level and cognitive function as assessed with the Mini-Mental State Examination (MMSE).

scholarly journals Nutritional status, dementia, and mobility among nursing home’s residents: First exhaustive cross-sectional study in Limousin territory (France)

PLoS ONE ◽  
2021 ◽  
Vol 16 (4) ◽  
pp. e0250595
Author(s):  
Philippe Fayemendy ◽  
Gustave Mabiama ◽  
Thibault Vernier ◽  
Aude Massoulard-Gainant ◽  
Carole Villemonteix ◽  
...  
Keyword(s):  
Nutritional Status ◽  
Mini Mental State Examination ◽  
Nutritional Assessment ◽  
Mini Nutritional Assessment ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Mobility Patterns ◽  
Cross Sectional ◽  
Nutritional Data ◽  
State Examination

Background Aging is accompanied by a drop in the level of health and autonomy, within Western countries more and more people being cared for in nursing homes (NH). The nutritional data in NH in France remain poor, not exhaustive and not representative. The objective of the study was to assess the nutritional status, dementia and mobility patterns among residents of NH in the Limousin territory of France. Methods The study was cross-sectional, descriptive and exhaustive, conducted with the residents of 13 voluntary NH. Undernutrition was identified using French High Authority for Health criteria, and obesity if Body Mass Index >30, in the absence undernutrition criterion. The Mini Mental State examination scores was used for dementia assessment at the threshold of 24. The Mini Nutritional AssessmentTM was used for mobilitity assessment. The statistics were significant at the 5% threshold. Results 866 residents (70.6% women) included with an average age of 85.3 ± 9.3 years. Undernutrition was 27.5%, obesity 22.9%, dementia 45.7% and very low mobility 68.9%. Women were older than men, more often undernourished, more often demented and more often had very low mobility (p<0.01). Undernutrition (p<0.0001) and low mobility (p<0.0001) were significantly higher among those with dementia versus those without dementia. Very low mobility was higher among undernourished (p<0.05). Conclusions Undernutrition and obesity are important problems in NH in France. Being a woman, having dementia and having a very low mobility may induce undernutrition.

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