scholarly journals Preventative Effects of Caffeic Acid Phenyl Ester on Cadmium Intoxication Induced Hematological and Blood Coagulation Disturbances and Hepatorenal Damage in Rats

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Tariq Helal Ashour
Keyword(s):  
Blood Coagulation ◽  
Caffeic Acid ◽  
Hemoglobin Concentration ◽  
Thiobarbituric Acid ◽  
Control Group ◽  
Mean Corpuscular Hemoglobin ◽  
Phenyl Ester ◽  
Corpuscular Hemoglobin ◽  
Male Wistar Rats ◽  
Liver And Kidney

The preventative effect of caffeic acid phenyl ester (CAPE) against hematological, blood coagulation, and hepatorenal disturbances in cadmium (Cd) intoxication was investigated in rats. Male Wistar rats were randomly assigned into control group, Cd-group, and Cd + CAPE group. Cd intoxication was induced by intraperitoneal injection (i.p.) of CdCl2 (1 mg/kg/day) for 21 days, and CAPE was daily given (10 micromol/kg; i.p.) for also 21 days. The results showed that Cd intoxication impaired hepatorenal function and significantly prolonged prothrombin time and activated partial thromboplastin time and decreased fibrinogen level, red blood cells and platelets counts, hemoglobin concentration, hematocrit, mean corpuscular volume, mean corpuscular hemoglobin, and mean corpuscular hemoglobin concentration. Interestingly, all these hematological, blood coagulation, and hepatorenal deteriorations of Cd toxicity were significantly prevented by CAPE. Additionally, CAPE significantly reversed the significant decreases in levels of total reduced glutathione and superoxide dismutase and increases in levels of thiobarbituric acid reactive substances that were observed in the sera and liver and kidney homogenates of Cd group. It is concluded that CAPE is a promising compound that can counteract the hematological and blood coagulation disturbances, oxidative stress, and hepatorenal damages in Cd intoxication. However, further studies are crucially needed to improve this treatment in patients.

The association between iron deficiency anemia and febrile seizure

2019 ◽  
Vol 0 (0) ◽  
Author(s):  
Parviz Karimi ◽  
Koroush Sayehmiri ◽  
Milad Azami ◽  
Zeinab Tardeh
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Febrile Seizure ◽  
Hemoglobin Concentration ◽  
Deficiency Anemia ◽  
Control Group ◽  
Case Group ◽  
Mean Corpuscular Hemoglobin ◽  
Protective Effects ◽  
Corpuscular Hemoglobin

Abstract Objective Different studies have reported contradictory results regarding the relationship between iron deficiency anemia (IDA) and febrile seizure (FS). The present study was conducted to determine the effect of IDA on FS in children. Patients and methods This case-control study was conducted among 52 children with FS (the case group) and 18 children with afebrile seizures and 51 children with fever without seizures in the age range of 6 months to 5 years admitted to the pediatric ward of Imam Khomeini Hospital in Ilam from March 2016 to January 2017. Patients were selected using the convenience sampling method. Red blood cell (RBC) count as well as measurement of hemoglobin (Hb), hematocrit (Hct), ferritin, mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH) and mean corpuscular hemoglobin concentration (MCHC) levels were performed in all patients. The collected data were analyzed using SPSS16 software. Results A total of 34.6% in the FS group, 66.7% in the afebrile seizure group and 41.2% in the fever without seizure group suffered from IDA, which was not statistically significant between the three groups. Hb, Hct and RBC levels were higher in the case group and MCV, MCH, MCHC levels in the case group were lower than those in the control group. The odds ratio (OR) for FS compared to the febrile group was 0.756 [95% confidence interval (CI) = 0.34–1.68; p = 0.493] and that for FS compared to seizure was 0.265 (95% CI = 0.085–0.823; p = 0.022). Conclusions This study showed that IDA may have protective effects on the onset of FS, and based on the results, IDA is more common in children with afebrile seizures. Further and more comprehensive studies are recommended.

scholarly journals Markers of Anemia in Children with Type 1 Diabetes

2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
Ewa Rusak ◽  
Anna Rotarska-Mizera ◽  
Piotr Adamczyk ◽  
Bogdan Mazur ◽  
Joanna Polanska ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Vitamin B12 ◽  
Hemoglobin Concentration ◽  
Control Group ◽  
Mean Corpuscular Hemoglobin ◽  
Red Cell ◽  
Cell Distribution ◽  
Corpuscular Hemoglobin ◽  
Distribution Width

Aim. The aim of the study was to assess markers of anemia in type 1 diabetes (T1D) children, compare them to results obtained in the control group, and estimate their relation to BMI SDS. Methods. 94 (59% ♀) T1D children without other autoimmune disorders, aged 12.5 ± 4.1 years, T1D duration: 4.2 ± 3.6 years, HbA1c 7.3 ± 1.5% (57 ± 12.6 mmol/mol). Sex- and age-matched controls (43 children). In all children, anthropometric measurements, the blood count, iron turnover parameters, and vitamin B12 concentration were taken. Results. T1DM children had significantly higher red cell distribution width (RDW) (13.6 versus 12.6%; p<0.001), hepcidin (0.25 versus 0.12 ng/ml; p<0.001), and vitamin B12 concentrations (459 versus 397 pg/ml; p<0.01) and lower TIBC (59.09 versus 68.15 μmol/l; p<0.001) than in the control group. Logistic regression revealed that RDW, TIBC (both p<0.001), and hepcidin (p<0.05) significantly differentiated both groups. In T1DM children, BMI SDS negatively correlated with vitamin B12 (p<0.01) concentration and mean corpuscular hemoglobin concentration (p<0.05) and positively with TIBC (p<0.01) and HbA1c (p<0.001). Conclusions. Patients and controls differed especially in terms of RDW and TIBC. In studied T1DM children, BMI SDS was associated to iron metabolism parameters and vitamin B12 concentration.

scholarly journals Hematological parameters in Nile Tilápia, Oreochromis niloticus exposed to sub-letal concentrations of mercury

2007 ◽  
Vol 50 (4) ◽  
pp. 619-626 ◽  
Author(s):  
Nilton Massuo Ishikawa ◽  
Maria José Tavares Ranzani-Paiva ◽  
Julio Vicente Lombardi ◽  
Cláudia Maris Ferreira
Keyword(s):  
Blood Cell ◽  
Cell Count ◽  
Oreochromis Niloticus ◽  
Hematological Parameters ◽  
Hemoglobin Concentration ◽  
Control Group ◽  
Mean Corpuscular Hemoglobin ◽  
Blood Cell Count ◽  
Corpuscular Hemoglobin ◽  
Set Up

Mercury toxicity in tilapia, Oreochromis niloticus, (Linnaeus, 1758) was investigated by the hematological parameters after long-term (14 days) exposure to various Hg concentrations (0.02, 0.002, 0.0002mg/L Hg). Test groups were set up with three replicates for each concentration, plus the control group. Blood samples were collected from six individuals for each concentration at 0, 3, 7, 10 and 14 days of exposure. The hematological parameters analyzed were: total red blood cell count (RBC), hemoglobin concentration (Hb), hematocrit (Ht), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), total white blood cell count (WBC) and differential leukocyte counts and total thrombocyte count (Tr). There were no significant differences among the mean hematological values at the different Hg concentrations indicating that Hg at the concentrations studied was not toxic to tilapia.

scholarly journals Impact of rice fortified with iron, zinc, thiamine and folic acid on laboratory measurements of nutritional status of preschool children

2017 ◽  
Vol 22 (2) ◽  
pp. 583-592 ◽  
Author(s):  
Ceres Mattos Della Lucia ◽  
Laura Luiza Menezes Santos ◽  
Bárbara Pereira da Silva ◽  
Pamella Cristine Anunciação ◽  
Rita de Cássia Gonçalves Alfenas ◽  
...  
Keyword(s):  
Folic Acid ◽  
Nutritional Status ◽  
Dietary Assessment ◽  
Test Group ◽  
Hemoglobin Concentration ◽  
Control Group ◽  
Mean Corpuscular Hemoglobin ◽  
Corpuscular Hemoglobin ◽  
Polished Rice ◽  
The Impact

Abstract Fortification of food constitutes an important strategy for the control of micronutrient deficiency and has advantages such as high population coverage and maintenance of eating habits. This study aimed to assess the impact of using fortified rice (Ultra Rice® - UR®) on the nutritional status of preschoolers. Ninety-nine children enrolled in two philanthropic preschools participated of the study. Children of one of the preschools were offered UR® mixed with polished rice, as part of school meals (test group) and the children of another preschool were offered pure polished rice (control group). Biochemical evaluations were performed before and after 4 months of intervention. Dietary assessment and sensory evaluation of UR® mixed with polished rice were performed during the study. The fortified rice improved the concentrations of zinc (p < 0.001), thiamine (p < 0.001), folic acid (p = 0.003), mean corpuscular hemoglobin (p < 0.001) and mean corpuscular hemoglobin concentration (p < 0.001). The fortified rice showed good acceptability among preschoolers. This study demonstrated the effectiveness of using rice fortified with iron, zinc, thiamine and folic acid on the nutritional status of children.

scholarly journals Effect of ketorolac administration post bone cavitation surgery on some hematological parameters

2017 ◽  
Vol 41 (1) ◽  
pp. 169-177
Author(s):  
Raffal A. Omar
Keyword(s):  
Blood Cells ◽  
Hematological Parameters ◽  
White Blood Cells ◽  
Hemoglobin Concentration ◽  
Treated Group ◽  
Control Group ◽  
Mean Corpuscular Hemoglobin ◽  
Mean Corpuscular Hemoglobin Concentration ◽  
Corpuscular Hemoglobin ◽  
Post Operation

     This study was designed to determine the effect of ketorolac on some hematological parameters post cavitation surgery in domestic rabbits. Ninety-six adult domestic local breed male rabbits were used in this study, weighing (1.23 ± 0.33) kg. They were divided randomly into two groups in the first one (n= 48/group) which represented control group, while the second one (n=48/group) represented the treated group (Ketorolac group). All rabbits in both groups undergoes surgical operation (bone cavitation in femur bone) under general anesthesia. In the Ketorolac group, animals were treated by using 30 mg/kg of Ketorolac directly post-operation and continued daily for 5 days, while in Control group no treatment was given postoperatively. The hematological parameters were recorded which include white blood cells count; red blood cells count; hemoglobin; packed cell volume; mean corpuscular hemoglobin and mean corpuscular hemoglobin concentration; mean corpuscular volume and platelets at the period of (3, 5, 7, 14, 21, 28, 35, and 42) days post operation were estimated. Results concerning hematological values showed no significant differences in packed cell volume values between control and treated group and within each group, while haemoglobin values showed a significant decrease at period 7 and 14 days between control and treated group. Within control group the significant decrease were noticed clearly at period of 7 days. Data concerning mean corpuscular hemoglobin values within control group showed significant decrease were noticed at 5 day, but within treated group, there were no significant differences. mean corpuscular hemoglobin concentration values showed significant decrease ate period 3; 5 and 21 days between control group and treated group respectively. Within control group the significant decrease were noticed obviously at 5 days while within treated group the significant decrease were noticed at 35 days. mean corpuscular volume values showed significant increase at 3 and 5 days period between control and treated groups. Platelets counts within control group showed significant increase at period of 14 days, within treated group the significant increase were recorded at 42 days. Red blood cells showed significant decrease between control and treated groups, while within control group, the significant decrease were at 7 days. White blood cells count within treated group showed significant increase recorded at 21 days. Differential White blood cells count concerning Lymphocytes cells within control group the significant increase were recorded at 42 days  while the significant decrease were noticed at 21 days, but within treated group the significant increase were recorded at 35 days  and significant decrease were noticed at 14 days. Neutrophils counts showed significant decrease at periods 3, 14, 28 and 42 days between control and treated groups respectively; while within control group there were significant decrease at 3 days, but within treated group the significant decrease were noticed at 42 days. Monocytes cells showed significant increase at 35 days between control and treated groups, within control group there were significant increase at 35 days, while within treated group the significant increase recorded at 7 days.

scholarly journals A comparative study between normal and chronic kidney patients during Hemodialysis

2019 ◽  
Vol 6 (1) ◽  
pp. 184-194
Author(s):  
Mehri Mirhaj Muhammadsalih ◽  
Rezhna Adil Rashid ◽  
Rowkhosh Ishaq Mekha
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Hematological Parameters ◽  
Hemoglobin Concentration ◽  
Control Group ◽  
Mean Corpuscular Hemoglobin ◽  
Corpuscular Hemoglobin ◽  
Kidney Dialysis ◽  
Study Results ◽  
Before And After

The present study, included 71 patients (41males and 30 females), suffering from chronic renal failure, who were attending Kidney Dialysis Center of Hawler Teaching Hospital in Erbil government, and 50 healthy individuals included as a control group. The sera were separated from patients and controls blood samples subjected to hematological studies. The aim of this study was to estimate changes in various hematological parameters in chronic renal failure patients before and after hemodialysis.      The study results showed that most of the hematological parameters were changed by hemodialysis in chronic kidney disease. Erythrocytes, hemoglobin, hematocrite were found to increase post-HD. The mean corpuscular volume, mean corpuscular hemoglobin and mean corpuscular hemoglobin concentration showed mild increase after hemodialysis. Leukocyte and platelet counts also showed mild increase after hemodialysis. It can be concluded that complete hematological parameters were found to increase after hemodialysis. Therefore, it is recommended that patients on hemodialysis should be investigated before and after hemodialysis to control the risk of anemia, bleeding or thrombosis.

scholarly journals ASSESSMENT OF HEMATOLOGICAL INDICES AMONG WORKERS IN SILVER JEWELRY UNITS

2017 ◽  
Vol 10 (9) ◽  
pp. 144
Author(s):  
Shalini Kv ◽  
Ayyappa Das Mp
Keyword(s):  
Tamil Nadu ◽  
Hemoglobin Concentration ◽  
Cross Sectional Study ◽  
Control Group ◽  
Differential Count ◽  
Mean Corpuscular Hemoglobin ◽  
Corpuscular Hemoglobin ◽  
Cross Sectional ◽  
Distribution Width ◽  
Hematological Indices

  Objective: Workers in the silver jewelry manufacturing units are exposed to heavy metals and toxic compounds during manufacturing. Hence, the present study aimed to assess the hematological indices among the workers in silver jewelry manufacturing units.Methods: A cross-sectional study was conducted in various silver jewelry manufacturing units located in Coimbatore, Tamil Nadu. One hundred and forty eight exposed and 35 unexposed (control) participants were included in this study. Their hematological indices were assessed.Results: There was significant (p<0.05) increase of serum silver (Ag) and hematological profile such as red blood cell (RBC), hematocrit, and the hemoglobin levels of exposure groups (B, C, D, and E) were found to be significantly decreased (p<0.05) compared to control group (A). There was also significant increase (p<0.05) in differential count and mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), platelet (PLT), platelet distribution width (PDW), and mean platelet volume (MPV) levels in exposed groups (B, C, D, and E) than controls (A).Conclusion: Decrease in RBC indices and the increased differential count of MCH, MCHC, PLT, PDW, and MPV levels might be due to the exposure to Ag in the jewelry units. In view of these results, it appears that ionized Ag induces hematological disturbances and the present study clearly establish that there were minimal negative effects of Ag exposure on hematological indices.

scholarly journals DETERMINATION OF ACUTE AND SUBACUTE TOXICITY OF THE DRUG BASED ON CHLORTETRACYCLINE HYDROCHLORIDE

2020 ◽  
Vol 21 (2) ◽  
pp. 71-75
Author(s):  
І. Ya. Kotsyumbas ◽  
I. P. Patereha ◽  
V. I. Kushnir ◽  
T. V. Yurynets ◽  
S. Ya. Martynyk ◽  
...  
Keyword(s):  
Hemoglobin Concentration ◽  
Control Group ◽  
Mean Corpuscular Hemoglobin ◽  
Corpuscular Hemoglobin ◽  
Internal Organs ◽  
Subacute Toxicity ◽  
White Rats ◽  
Therapeutic Doses

The article presents the results of determination of acute and subacute toxicity of the drug "Chloracil", which was made on the basis of chlortetracycline hydrochloride. In result of the conducted researches, it was found out, that a single intragastric administration of the drug according to SOU 85.2-37-736: 2011 belongs to the 4th class of toxicity - low-toxic substances. In determining the toxicity of the drug by the long-term use, it was found out, that the use of Chloracil in therapeutic and in 10 times higher than the therapeutic doses did not cause death of white rats. The animals of the experimental groups were active, ate well food , and the general condition of the animals did not differ from the condition of the animals of the control group, but there was a tendency to decrease the weights of liver, spleen, heart, lungs, thymus and kidneys on the background of an increase of body weight by 3.4 and 7.3% (p <0.05), compared to the values of the control group. Therefore, the use of the tested drug in above doses for 14 days does not significantly affect on the functional state of the internal organs of experimental animals. The study of the effect of the drug on the hematological parameters of blood by long-term use showed that in therapeutic and in 10-time higher therapeutic doses observed a tendency to decrease the hemoglobin concentration, amount of erythrocytes, leukocytes, hematocrit value, on the background of a slight an increase of platelet. In determining the value of erythrocyte indices, it was noted that the use of the drug "Chloracil" in animals of I and II experiments did not cause significant changes in mean corpuscular hemoglobin (MCH). Mean corpuscular volume (MCV), mean corpuscular hemoglobin concentration (MCHC) were at the level of the control group. When studying the effect of the drug on the biochemical parameters of blood serum in animals of I and II experimental groups, there was a tendency to decrease the level of creatinine, activity of AST, ALT and LP activity on the background of a slight an increase of total protein content. Analysis of the obtained data shows that the use of the drug "Chloracil" to white rats for 14 days in therapeutic and in 10-time higher therapeutic doses caused a slight decrease in the weight of internal organs, hematological and biochemical parameters of blood, which that in turn did not significantly effect on the general condition of animals.

scholarly journals Determination of acute and subacute toxicity of the drug “Tilovet 20 %”

2021 ◽  
Vol 23 (101) ◽  
pp. 15-20
Author(s):  
V. I. Kushnir ◽  
I. P. Patereha ◽  
I. M. Kushnir ◽  
B. V. Gutyj ◽  
S. Yа. Martynyk ◽  
...  
Keyword(s):  
Total Protein ◽  
Hemoglobin Concentration ◽  
Control Group ◽  
Total Protein Content ◽  
Mean Corpuscular Hemoglobin ◽  
Corpuscular Hemoglobin ◽  
Subacute Toxicity ◽  
Alp Activity ◽  
White Rats

The article presents the results of determination of acute and subacute toxicity of the drug “Tilovet 20 %”, which was made on the basis of tylosin tartrate. In result of the conducted researches, it was found out, that LD50 of the drug “Tilovet 20 %” by intramuscular injection to white mice (calculated by the method of G. Kerber) is 10000 and mg/kg, and for white rats – 9583.33 mg/kg. Long-term use of the drug in a therapeutic dose caused a tendency to the decrease of hemoglobin concentration, amount of erythrocytes, platelets, hematocrit value, mean corpuscular hemoglobin (MCH), mean corpuscular volume (MCV), content of the total protein, creatinine level, ALP activity on the background of a slight an increase of amount of leukocytes, urea level, AST and ALT activity compared to the values of the control group. The use of the drug in a dose that is 10 times higher than the therapeutic, caused a probable decrease of hemoglobin concentration by – 6.6 % (P < 0.05), platelet count by – 32.5 % (P < 0.05), mean corpuscular hemoglobin (MCH) by – 4.2 % (P < 0.05), mean corpuscular hemoglobin concentration (MCHC) by – 1.5 % (P < 0.1), hematocrit value by – 4.95 %, and total protein content by – 10.7 % (P < 0.05), on the background of a slight an increase of amount of leukocytes by 5.3 %, ALP activity by – 17.5 %, compared to the values oft he control group. Therefore, all of the above may indicate to the suppression of hematopoietic processes and a decrease in the protein-synthesizing function of the liver.

Pharmacological studies of Pediococcus on performance and some hematological and biochemical parameters in cattle

2019 ◽  
Vol 20 (2) ◽  
pp. 60-69
Author(s):  
Gehad El-Sayed ◽  
Mohamed El-Diasty ◽  
Shaimaa Zayed
Keyword(s):  
Body Weight ◽  
Hemoglobin Concentration ◽  
Liver Function Tests ◽  
Mean Corpuscular Hemoglobin ◽  
Corpuscular Hemoglobin ◽  
Control Groups ◽  
Blood Electrolytes ◽  
Calcium Phosphorus ◽  
Hematological And Biochemical Parameters ◽  
Drinking Milk

The use of Pediococcus (23×106 CFU/calf/day) orally in drinking milk once daily for one month in Holstein calves have highly significant effect on blood picture ,liver function tests, kidney function test ,blood electrolytes and body weight in cow calves. There were a significant increase in total erythrocytes count , hemoglobin content, packed cell volume, mean corpuscular volume, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration, thrombocyte count, total leucocytes count, neutrophils counts, eosinophil, basophils, total protein and its fractions, level of alkaline phosphatase (ALP),level of sodium ,calcium ,phosphorus and body weight . On the other hand there were significant decrease in urea and potassium level in groups treated by Pediococcus compared to the control groups. Moreover there were a non-significant changes in lymphocytes, monocytes, creatinine, alanine transaminase (ALT), aspartate transaminase (AST), in the same groups compared to the control groups.

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