Newly Diagnosed Bladder Cancer: The Relationship of Initial Symptoms, Degree of Microhematuria and Tumor Marker Status

2002 ◽  
Vol 168 (5) ◽  
pp. 1955-1959 ◽  
Author(s):  
HANS BOMAN ◽  
HANS HEDELIN ◽  
STEFAN JACOBSSON ◽  
STEN HOLMÄNG
Keyword(s):  
Bladder Cancer ◽  
Tumor Marker ◽  
Newly Diagnosed ◽  
Initial Symptoms ◽  
Marker Status ◽  
Relationship Of ◽  
The Relationship

scholarly journals Copy number signatures predict chromothripsis and clinical outcomes in newly diagnosed multiple myeloma

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Kylee H. Maclachlan ◽  
Even H. Rustad ◽  
Andriy Derkach ◽  
Binbin Zheng-Lin ◽  
Venkata Yellapantula ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Copy Number ◽  
Prognostic Impact ◽  
Newly Diagnosed ◽  
Flexible Tool ◽  
Whole Exome ◽  
Hematological Cancers ◽  
Relationship Of ◽  
The Relationship ◽  
Validation Series

AbstractChromothripsis is detectable in 20–30% of newly diagnosed multiple myeloma (NDMM) patients and is emerging as a new independent adverse prognostic factor. In this study we interrogate 752 NDMM patients using whole genome sequencing (WGS) to investigate the relationship of copy number (CN) signatures to chromothripsis and show they are highly associated. CN signatures are highly predictive of the presence of chromothripsis (AUC = 0.90) and can be used identify its adverse prognostic impact. The ability of CN signatures to predict the presence of chromothripsis is confirmed in a validation series of WGS comprised of 235 hematological cancers (AUC = 0.97) and an independent series of 34 NDMM (AUC = 0.87). We show that CN signatures can also be derived from whole exome data (WES) and using 677 cases from the same series of NDMM, we are able to predict both the presence of chromothripsis (AUC = 0.82) and its adverse prognostic impact. CN signatures constitute a flexible tool to identify the presence of chromothripsis and is applicable to WES and WGS data.

scholarly journals Involvement of the Androgen and Glucocorticoid Receptors in Bladder Cancer

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Lucien McBeth ◽  
Maria Grabnar ◽  
Steven Selman ◽  
Terry D. Hinds
Keyword(s):  
Bladder Cancer ◽  
Glucocorticoid Receptors ◽  
Lifestyle Risk Factors ◽  
Glucocorticoid Signaling ◽  
Major Player ◽  
Inflammatory Processes ◽  
Lifestyle Risk ◽  
Relationship Of ◽  
The Relationship ◽  
Male To Female

Bladder cancer is encountered worldwide having been associated with a host of environmental and lifestyle risk factors. The disease has a male to female prevalence of 3 : 1. This disparity has raised the possibility of the androgen receptor (AR) pathway being involved in the genesis of the disease; indeed, research has shown that AR is involved in and is likely a driver of bladder cancer. Similarly, an inflammatory response has been implicated as a major player in bladder carcinogenesis. Consistent with this concept, recent work on anti-inflammatory glucocorticoid signaling points to a pathway that may impact bladder cancer. The glucocorticoid receptor- (GR-)αisoform has an important role in suppressing inflammatory processes, which may be attenuated by AR in the development of bladder cancer. In addition, a GR isoform that is inhibitory to GRα, GRβ, is proinflammatory and has been shown to induce cancer growth. In this paper, we review the evidence of inflammatory mediators and the relationship of AR and GR isoforms as they relate to the propensity for bladder cancer.

The relationship of histamine H2 receptor-bearing suppressor cells with the growth and metastasis of FANFT-induced bladder cancer

1983 ◽  
Vol 24 (1) ◽  
pp. 53-58 ◽  
Author(s):  
Richard K. Babayan ◽  
Michael E. Osband ◽  
Gennaro A. Carpinito ◽  
Zheng Sen Ho ◽  
Ellen B. Cohen ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Suppressor Cells ◽  
Histamine H2 Receptor ◽  
H2 Receptor ◽  
Relationship Of ◽  
The Relationship

The Relationship of Local Control to Distant Metastasis in Muscle Invasive Bladder Cancer

1995 ◽  
pp. 2059-2063 ◽  
Author(s):  
Alan Pollack ◽  
Gunar K. Zagars ◽  
Christopher J. Cole ◽  
Colin P. N. Dinney ◽  
David A. Swanson ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Local Control ◽  
Distant Metastasis ◽  
Invasive Bladder Cancer ◽  
Muscle Invasive Bladder Cancer ◽  
Muscle Invasive ◽  
Relationship Of ◽  
The Relationship

scholarly journals Association between Growth Differentiation Factor 15 and Non-Dipping Circadian Pattern in Patients with Newly Diagnosed Essential Hypertension

2019 ◽  
Vol 28 (6) ◽  
pp. 566-572 ◽  
Author(s):  
Erdoğan Sökmen ◽  
Cahit Uçar ◽  
Serkan Sivri ◽  
Mustafa Çelik ◽  
Yalçın Boduroğlu ◽  
...  
Keyword(s):  
Ventricular Hypertrophy ◽  
Left Ventricular ◽  
Newly Diagnosed ◽  
Growth Differentiation Factor 15 ◽  
Differentiation Factor ◽  
Linear Correlation Analysis ◽  
Normotensive Subjects ◽  
Relationship Of ◽  
Independent Marker ◽  
The Relationship

Objective: Non-dipper hypertension (HT) confers greater risk compared with dipper HT. Growth differentiation factor 15 (GDF-15) recently emerged as a novel and independent marker of cardiovascular disease, both in diagnostic and prognostic scopes. Our aim was to evaluate the relationship of circadian blood pressure (BP) pattern with serum GDF-15 level in newly diagnosed HT patients without left ventricular hypertrophy. Subjects and Methods: Newly diagnosed non-dipper (n = 66) and dipper (n = 60) HT patients were selected according to 24-h ambulatory BP monitoring (ABPM). The controls comprised healthy normotensive subjects (n = 31). Data was collected through physical examination, laboratory analysis, ABPM, and echocardiography. GDF-15 was measured using ELISA. Results: Greater GDF-15 level was found in the non-dippers compared with the dippers and the controls (557.53 ± 91.7, 513.79 ± 62.86, and 494.44 ± 79.30 ng/L, respectively, p < 0.001). In bivariate linear correlation analysis, GDF-15 correlated positively with glomerular filtration rate (r = 0.180, p =0.030), total cholesterol (r = 0.170, p = 0.038), septal E/E′ ratio (r = 0.344, p = 0.001), lateral E/E′ ratio (r = 0.366, p < 0.001), nighttime systolic BP (r = 0.166, p = 0.046), and nighttime diastolic BP (r = 0.188, p = 0.024); however, it correlated negatively with septal and lateral E′ velocities (r = 0.268, p = 0.005 and r = 0.236, p = 0.013, respectively). Furthermore, GDF-15 level and nighttime diastolic BP remained independently associated with non-dipper HT. In ROC analysis, optimal cutoff value for GDF-15 was 524.6 ng/L with 56.7% sensitivity and 72.4% specificity (AUC: 0.676, 95% CI: 0.580–0.772, p < 0.05). Conclusion: Our results showed GDF-15 upregulation in the non-dipper HT group. GDF-15 and nighttime diastolic BP were independently associated with the non-dipping pattern. This study may suggest possible utilization of GDF-15 in the prediction of non-dipper HT.

Race, Oncotype DX, and other characteristics in a highly screened population.

2014 ◽  
Vol 32 (26_suppl) ◽  
pp. 32-32
Author(s):  
Jennifer Chun ◽  
Freya Ruth Schnabel ◽  
Shira Schwartz ◽  
Jessica Billig ◽  
Elizabeth Kern ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Nodal Status ◽  
Oncotype Dx ◽  
College Level ◽  
Newly Diagnosed ◽  
Node Negative ◽  
Significant Difference ◽  
Gene Assay ◽  
Relationship Of ◽  
The Relationship

32 Background: Oncotype DX breast cancer 21 gene assay recurrence score (RS) is used to predict disease recurrence and response to chemotherapy in order to offer patients the highest treatment benefit to risk ratio. There is a dearth of literature on the relationship of Oncotype RS and race in women with hormone receptor positive and node negative/positive disease. The purpose of this study was to investigate the relationship of race and clinical characteristics (including Oncotype RS) in an insured population of highly screened women with newly diagnosed breast cancer. Methods: The Breast Cancer Database of our institution was queried for patients who were newly diagnosed with breast cancer. We looked at demographics, risk factors, tumor characteristics, and Oncotype RS. Statistical analyses included Pearson’s Chi-Square and Fisher’s Exact Tests. Results: A total of 1,767 women were diagnosed with breast cancer from 1/2010 to 4/2014. The median age was 59 years. There was a total of 1327 (75%) Whites, 162 (9%) Blacks, 163 (9%) Asians, and 108 (6%) Hispanics. Majority of patients had a college-level education (83%), had annual/biannual screening mammography (78%), and clinical breast exams (89%). Majority of patients had invasive ductal carcinoma (61%), early stage (0, I, II) tumors (94%), ER+ (85%), PR+ (72%), Her2-negative (86%), and node-negative disease (80%). Compared to Whites, there was a significantly higher proportion of later stage disease among Blacks (p = 0.001) and Asians (p = 0.003), more triple negative breast cancers among Blacks (p < 0.0001) and higher Ki-67 scores among Blacks (p < 0.001) and Asians (p < 0.001). Oncotype RS was not significantly different among the race categories and a majority of patients had a low Oncotype RS (57%). These results did not change after stratifying for nodal status. Conclusions: In a population of women who had health insurance and were highly screened, we found clinical differences among races with respect to tumor histology. However, we did not find a statistically significant difference among race and Oncotype RS, even after stratifying for nodal status. Further studies are warranted to determine which tumor proliferation markers are contributing to ethnic differences in breast cancer mortality.

The Role of Adipokines in the Development of Arterial Stiffness and Hypertension

Angiology ◽  
2020 ◽  
Vol 71 (8) ◽  
pp. 754-761
Author(s):  
Agata Bielecka-Dabrowa ◽  
Marcin A. Bartlomiejczyk ◽  
Agata Sakowicz ◽  
Marek Maciejewski ◽  
Maciej Banach
Keyword(s):  
Arterial Stiffness ◽  
Pulse Wave ◽  
Augmentation Index ◽  
Elevated Serum ◽  
Control Group ◽  
Newly Diagnosed ◽  
Potential Mechanism ◽  
Relationship Of ◽  
The Relationship

The study aimed to assess the role and the relationship of adipokines as well as parameters of arterial stiffness in newly diagnosed hypertension. Forty-nine newly diagnosed hypertensive cases (median age 47 ± 6 years) and 48 normotensive patients (median age 47 ± 6 years) were enrolled to this study. Patients underwent echocardiography, noninvasive assessment of hemodynamic parameters using SphygmoCor tonometer (Atcor Med). The levels of the adipokines—leptin, adiponectin, and resistin—were investigated. The augmentation pressure, augmentation index, and pulse wave velocity (PWV) were higher in patients with hypertension compared with controls ( Ps < .05). Patients with hypertension had higher E/ E′ ratio, higher diameter of left atrium, and lower tricuspid annular plane systolic excursion compared with the control group ( Ps < .05). Patients with hypertension had significant higher levels of leptin (ng/mL) and lower levels of adiponectin (μg/mL) compared with normotensive patients. The multivariate analysis showed that PWV (odds ratio [OR] 1.95, 95% CI, 1.2-2.9; P = .002) and leptin level (OR 1.01, 95% CI, 1.004-1.031; P = .01) were significantly associated with hypertension. Arterial stiffness as determined by PWV and leptin are associated with newly diagnosed hypertension. Elevated serum leptin level may influence the potential mechanism leading to sympathetic activation.

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