scholarly journals Effects of rhBMP-2 on Sandblasted and Acid Etched Titanium Implant Surfaces on Bone Regeneration and Osseointegration: Spilt-Mouth Designed Pilot Study

2015 ◽  
Vol 2015 ◽  
pp. 1-11 ◽  
Author(s):  
Nam-Ho Kim ◽  
So-Hyoun Lee ◽  
Jae-Jun Ryu ◽  
Kyung-Hee Choi ◽  
Jung-Bo Huh
Keyword(s):  
Pilot Study ◽  
Bone Regeneration ◽  
Titanium Implant ◽  
Surface Characteristics ◽  
Contact Ratio ◽  
Control Groups ◽  
Mean Values ◽  
Implant Coating ◽  
Open Defect ◽  
And Control

This study was conducted to evaluate effects of rhBMP-2 applied at different concentrations to sandblasted and acid etched (SLA) implants on osseointegration and bone regeneration in a bone defect of beagle dogs as pilot study using split-mouth design.Methods. For experimental groups, SLA implants were coated with different concentrations of rhBMP-2 (0.1, 0.5, and 1 mg/mL). After assessment of surface characteristics and rhBMP-2 releasing profile, the experimental groups and untreated control groups (n= 6 in each group, two animals in each group) were placed in split-mouth designed animal models with buccal open defect. At 8 weeks after implant placement, implant stability quotients (ISQ) values were recorded and vertical bone height (VBH, mm), bone-to-implant contact ratio (BIC, %), and bone volume (BV, %) in the upper 3 mm defect areas were measured.Results. The ISQ values were highest in the 1.0 group. Mean values of VBH (mm), BIC (%), and BV (%) were greater in the 0.5 mg/mL and 1.0 mg/mL groups than those in 0.1 and control groups in buccal defect areas.Conclusion. In the open defect area surrounding the SLA implant, coating with 0.5 and 1.0 mg/mL concentrations of rhBMP-2 was more effective, compared with untreated group, in promoting bone regeneration and osseointegration.

scholarly journals Some hematimetric findings in human Giardia lambia infection

1996 ◽  
Vol 38 (2) ◽  
pp. 91-95 ◽  
Author(s):  
Jairo Ivo dos Santos ◽  
Cidônia de Lourdes Vituri
Keyword(s):  
Giardia Lamblia ◽  
Mean Corpuscular Volume ◽  
Hemoglobin Concentration ◽  
Absolute Number ◽  
Control Groups ◽  
Mean Values ◽  
Significant Difference ◽  
The Mean ◽  
And Control ◽  
Eosinophil Counts

Up to now few reports about haematological alterations induced by Giardia lamblia infection have been described. Because there are questions on this matter still not answered, we carried out a study to evaluate some erythrometric and leucometric parameters in a sample that consisted of 55 patients exclusively infected with G. lamblia and of 55 sex and age matched parasite-free individuals. The haematological parameters evaluated were: mean corpuscular volume (MCV), hemoglobin concentration, and relative and absolute number of eosinophils and lymphocytes. No significant differences in the mean values of MCV, hemoglobin levels and absolute relative lymphocyte numbers between the two groups could be detected. When the giardiasis and control groups were separated by pediatric (0-18 years old) and adult (older than 18 years) classes, a very significant difference in both relative and absolute number of eosinophils in the adult class was observed. With respect of the pediatric class, no differences, either in relative and absolute number of eosinophils, could be observed. Our findings suggest that, during G. lamblia infection, some kind of parasite allergen(s) could be secreted and be responsible for the increasing of eosinophil counts in peripheral blood of adults.

Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration: A Pilot Study to Evaluate the Utility of the ProCore Biopsy Needle for Lymph Node Sampling

2016 ◽  
Vol 60 (3) ◽  
pp. 254-259 ◽  
Author(s):  
Juan Xing ◽  
Steven Manos ◽  
Sara E. Monaco ◽  
David O. Wilson ◽  
Liron Pantanowitz
Keyword(s):  
Pilot Study ◽  
Lymph Nodes ◽  
Needle Aspiration ◽  
Endobronchial Ultrasound ◽  
Study Group ◽  
Ultrasound Guided ◽  
Control Groups ◽  
Transbronchial Needle Aspiration ◽  
Biopsy Needle ◽  
And Control

Objective: The ProCore ultrasound biopsy needle, used primarily to obtain intra-abdominal tissue core biopsies, has not been widely used for endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA). In this pilot study we evaluated the utility of the ProCore needle for sampling mediastinal or hilar lymph nodes during EBUS-TBNA. Design: Thirty-two patients were identified using both ProCore and conventional fine-needle aspiration (FNA) needles for sampling mediastinal or hilar lymph nodes (the study group). Another 33 patients underwent EBUS-TBNA using an FNA needle only (the control group). Specimen satisfactory rates were compared between the study and control groups. Aspirate smears and cell blocks were evaluated for the cellularity of lesional cells and bronchial contamination in a subset of patients in the study group. Results: Overall, the ProCore needle did not show additive value to specimen adequacy when comparing the satisfactory rates of the study and control groups (94 vs. 89%). The ProCore needle also did not procure significantly more lesional cells than the FNA needle. Conclusion: Our experience shows that the ProCore needle does not provide additive value when performing an FNA of mediastinal or hilar lymph nodes. The evaluation of more cases with this new technique is necessary to better determine the clinical utility of using ProCore during EBUS-TBNA.

scholarly journals A pilot study to determine the feasibility of a cluster randomised controlled trial of an intervention to change peer attitudes towards children who stutter

2018 ◽  
Vol 65 (1) ◽  
Author(s):  
Rizwana B. Mallick ◽  
Lehana Thabane ◽  
A.S.M. Borhan ◽  
Harsha Kathard
Keyword(s):  
Pilot Study ◽  
Treatment Effect ◽  
Dropout Rate ◽  
Control Group ◽  
Control Groups ◽  
Post Intervention ◽  
Peer Attitudes ◽  
Significant Difference ◽  
Randomised Controlled ◽  
And Control

Background: While randomised controlled trials (RCTs) are considered the gold standard of research, prior study is needed to determine the feasibility of a future large-scale RCT study. Objectives: This pilot study, therefore, aimed to determine feasibility of an RCT by exploring: (1) procedural issues and (2) treatment effect of the Classroom Communication Resource (CCR), an intervention for changing peer attitudes towards children who stutter. Method: A pilot cluster stratified RCT design was employed whereby the recruitment took place first at school-level and then at individual level. The dropout rate was reported at baseline, 1 and 6 months post-intervention. For treatment effect, schools were the unit of randomisation and were randomised to receive either the CCR intervention administered by teachers or usual practice, using a 1:1 allocation ratio. The stuttering resource outcomes measure (SROM) measured treatment effect at baseline, 1 and 6 months post-intervention overall and within the constructs (positive social distance, social pressure and verbal interaction). Results: For school recruitment, 11 schools were invited to participate and 82% (n = 9) were recruited. Based on the school recruitment, N = 610 participants were eligible for this study while only n = 449 were recruited, where there was n = 183 in the intervention group and n = 266 in the control group. The dropout rate from recruitment to baseline was as follows: intervention, 23% (n = 34), and control, 6% (n = 15). At 1 month a dropout rate of 7% (n = 10) was noted in the intervention and 6% (n = 15) in the control group, whereas at 6 months, dropout rates of 7% (n = 10) and 17% (n = 44) were found in the intervention and control groups, respectively. For treatment effect on the SROM, the estimated mean differences between intervention and control groups were (95% Confidence Interval (CI): -1.07, 5.11) at 1 month and 3.01 (95% CI: -0.69, 6.69) at 6 months. A statistically significant difference was observed at 6 months on the VI subscale of the SROM, with 1.35 (95% CI: 0.58, 2.13). Conclusion: A high recruitment rate of schools and participants was observed with a high dropout rate of participants. Significant differences were only noted at 6 months post-intervention within one of the constructs of the SROM. These findings suggest that a future RCT study is warranted and feasible.

scholarly journals Improving Clinical Outcomes and Quality of Life with Massage Therapy in Youth and Young Adults with Cystic Fibrosis: a Pilot Study

2019 ◽  
Vol 12 (1) ◽  
pp. 4-15
Author(s):  
Kathleen (Kate) Zink, MSN, RN, AHN-BC, LMT ◽  
Barbara Chini, MD ◽  
Joyce Cowens, LMT ◽  
Lois Kremer, BSN, RN ◽  
Li Lin, MS, BS
Keyword(s):  
Quality Of Life ◽  
Cystic Fibrosis ◽  
Pilot Study ◽  
Clinical Outcomes ◽  
Massage Therapy ◽  
Control Groups ◽  
Convenience Sample ◽  
Muscle Tightness ◽  
And Control

Background: Cystic Fibrosis (CF) is an autosomal recessive disorder of exocrine glands characterized by abnormal production of thick mucus, primar-ily in bronchi of the lungs. Individuals experience recurrent respiratory infections, increased work of breathing, cough and musculoskeletal changes with pain. Previous research found that massage therapy (MT) decreased pain, muscle tightness, and anxiety in individuals with CF, but did not use valid/reliable measurements of quality of life (QOL).Purpose: To evaluate the effects of MT on QOL and clinical outcomes in individuals 8 to 21 years old with CF. Setting: A 622-bed nonprofit pediatric hospital in Ohio in the United States.Participants: Convenience sample of 24 patients with CF; 12 randomly assigned to treatment and control groups, respectively. Research Design and Intervention: Prospective two-group controlled pre/post pilot study using deep tissue myofascial trigger point massage over 10 to 12 weeks.Measurements: Pediatric Quality of Life Inven-tory (Peds QL 4.0); Cystic Fibrosis Questionnaire-Revised (CFQ-R); numeric rating scales (NRS) for pain, muscle tightness, ease of breathing, relax-ation; pulmonary function (PFT); single breath count; thoracic excursion (TE).Results: All participants were Caucasian; mean age 15.7 (SD = 3.5) years; 16 (66.6%) female. No significant differences were found in terms of age, gender, baseline pain between MT and control groups. At the final visit, compared to the control group, the children in MT group showed statistically significantly reduced muscle tight-ness (p = .048) with a large effect size (?²=0.163) and marginally statistically significantly higher levels of relaxation (p = .052), less pain (p = .076), and improved upper TE (p = .078) and lower TE (p = .056) scores with large and moderate effect sizes (?² = 0.156, ?² = 0.095, ?² = 0.083, and ?² = 0.073). No statistically significant differences in children’s and caregivers’ QOL scores between the two groups were found.Conclusions: Massage therapy was found to significantly reduce muscle tightness, marginally significantly help pain, relaxation, and thoracic excursion in participants with CF

scholarly journals Serum Magnesium in Acute Myocardial Infarction: Observation from Bangladeshi Patients

2020 ◽  
Vol 14 (2) ◽  
pp. 71-73
Author(s):  
Mohammad Rezaul Quader ◽  
Sharmin Rahman ◽  
Nasima Sultana ◽  
Suranjit Kumar Saha
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Serum Magnesium ◽  
Serum Magnesium Level ◽  
Control Groups ◽  
Mean Values ◽  
Medical College ◽  
Important Trace Element ◽  
The Mean ◽  
And Control

Dyslipidemia is an established risk factor of acute myocardial infarction (AMI), but measurement of macro metals like magnesium can be helpful in the prevention and better management of AMI. The aim of this study was to estimate serum magnesium in AMI. This is a case control type of study carried out in the Department of Biochemistry, Dhaka Medical College, Dhaka during the period of January 2015 to December 2015 with a total number of 100 study subjects. Acute myocardial infarction patients were selected as case (50) from coronary care unit (CCU), Department of Cardiology, Dhaka Medical College Hospital. Normal healthy individuals were selected as control (50) from the attendants of patients, relatives and doctors. Serum level of magnesium were assessed for both case and control groups. The mean values of the variable were compared between them by statistical analysis using SPSS version 16. For all the statistical analysis P<0.05 was considered as significant. The mean values of serum magnesium were 1.63±0.27mg/dl in cases. The mean values of serum magnesium were 2.35±0.28 mg/dl in control group. Significant differences were found in mean values between case and control groups and differences were highly significant (p<0.001). In AMI, serum magnesium level was found to be lower in this study. Serum magnesium is an important trace element that act as cofactor in many biochemical reactions. Decrease level of this important trace element may contribute to pathogenesis of AMI. So with other biochemical risk parameters, routine assessment of serum magnesium level is advocated, which might be helpful for prevention and better management of AMI. Faridpur Med. Coll. J. Jul 2019;14(2): 71-73

scholarly journals The Use of Bovine Pericardial Buttress on Linear Stapler Fails to Reduce Pancreatic Fistula Incidence in a Porcine Pancreatic Transection Model

HPB Surgery ◽  
2011 ◽  
Vol 2011 ◽  
pp. 1-6 ◽  
Author(s):  
A. Maciver ◽  
M. McCall ◽  
D. Mihalicz ◽  
D. Al-Adra ◽  
R. Pawlick ◽  
...  
Keyword(s):  
Pilot Study ◽  
Pancreatic Fistula ◽  
Laparoscopic Distal Pancreatectomy ◽  
Linear Stapler ◽  
Control Groups ◽  
Surgical Stapler ◽  
Surgical Model ◽  
Pancreatic Transection ◽  
Pancreatic Neck ◽  
And Control

We investigate the effectiveness of buttressing the surgical stapler to reduce postoperative pancreatic fistulae in a porcine model. As a pilot study, pigs (n=6) underwent laparoscopic distal pancreatectomy using a standard stapler. Daily drain output and lipase were measured postoperative day 5 and 14. In a second study, pancreatic transection was performed to occlude the proximal and distal duct at the pancreatic neck using a standard stapler (n=6), or stapler with bovine pericardial strip buttress (n=6). Results. In pilot study, 3/6 animals had drain lipase greater than 3x serum on day 14. In the second series, drain volumes were not significantly different between buttressed and control groups on day 5 (55.3 ± 31.6 and 29.3 ± 14.2 cc, resp.), nor on day 14 (9.5 ± 4.2 cc and 2.5 ± 0.8 cc, resp., P=0.13). Drain lipase was not statistically significant on day 5 (3,166 ± 1,433 and 6,063 ± 1,872 U/L, resp., P=0.25) or day 14 (924 ± 541 and 360 ± 250 U/L). By definition, 3/6 developed pancreatic fistula; only one (control) demonstrating a contained collection arising from the staple line. Conclusion. Buttressed stapler failed to protect against pancreatic fistula in this rigorous surgical model.

scholarly journals Neutralized Dicalcium Phosphate and Hydroxyapatite Biphasic Bioceramics Promote Bone Regeneration in Critical Peri-Implant Bone Defects

Materials ◽  
2020 ◽  
Vol 13 (4) ◽  
pp. 823 ◽  
Author(s):  
Hao-Hueng Chang ◽  
Chun-Liang Yeh ◽  
Yin-Lin Wang ◽  
Kang-Kuei Fu ◽  
Shang-Jye Tsai ◽  
...  
Keyword(s):  
Bone Formation ◽  
Bone Regeneration ◽  
Bone Defects ◽  
Dicalcium Phosphate ◽  
Control Group ◽  
New Bone Formation ◽  
Control Groups ◽  
Fast Bone ◽  
And Control ◽  
Bone Coverage

The aim of this study was to evaluate the efficacy of bone regeneration in developed bioceramics composed of dicalcium phosphate and hydroxyapatite (DCP/HA). Critical bony defects were prepared in mandibles of beagles. Defects were grafted using DCP/HA or collagen-enhanced particulate biphasic calcium phosphate (TCP/HA/Col), in addition to a control group without grafting. To assess the efficacy of new bone formation, implant stability quotient (ISQ) values, serial bone labeling, and radiographic and histological percentage of marginal bone coverage (PMBC) were carefully evaluated four, eight, and 12 weeks after surgery. Statistically significant differences among the groups were observed in the histological PMBC after four weeks. The DCP/HA group consistently exhibited significantly higher ISQ values and radiographic and histological PMCB eight and 12 weeks after surgery. At 12 weeks, the histological PMBC of DCP/HA (72.25% ± 2.99%) was higher than that in the TCP/HA/Col (62.61% ± 1.52%) and control groups (30.64% ± 2.57%). After rigorously evaluating the healing of biphasic DCP/HA bioceramics with a critical size peri-implant model with serial bone labeling, we confirmed that neutralized bioceramics exhibiting optimal compression strength and biphasic properties show promising efficacy in fast bone formation and high marginal bone coverage in peri-implant bone defects.

The effect of increased energy demand through walking exercise on intake and ruminal characteristics of sheep fed a roughage diet

1987 ◽  
Vol 109 (1) ◽  
pp. 53-59 ◽  
Author(s):  
P. H. Henning
Keyword(s):  
Retention Time ◽  
Energy Demand ◽  
Energy Output ◽  
Control Groups ◽  
Demand And Supply ◽  
Mean Values ◽  
Exercise Period ◽  
Walking Exercise ◽  
The Difference ◽  
And Control

SummarySheep were exercised on a treadmill to study the effect of increased energy demand on roughage intake and ruminal characteristics.The experiment consisted of a pre-exercise period during which exercise sheep walked for 30 min/day at 2 km/h against a gradient of 0° followed by a full exercise period during which they walked a total of 9 km/day at 3 km/h against a 10°gradient during six daily sessions of 30 min each. Control sheep received no exercise but were treated similarly to exercise sheep in all other respects.The mean values obtained during the pre-exercise period for the exercise and control groups and during the full exercise period for the exercise and control groups respectively were 1347, 1125; 1177 and 1114 g/day for organic matter (OM) intake; 956, 921; 803 and 848 g for rumen OM contents; 11·8, 13·6; 12·2 and 12·3 h for rumen retention time of water; 17·5, 20·2; 16·8 and 17·6 h for rumen retention time of fermentable OM; 27·3, 28·2; 26·4 and 26·7 h for rumen retention time of unfermentable OM and 46·9, 48·1, 44·4 and 45·9 kg for empty body weight. Only the decline in OM intake from pre-exercise to full exercise period differed significantly between exercise and control groups.It is concluded from these results that an increase in the difference between energy demand and supply per se is not responsible for the apparent increase in the upper limit to OM accumulation in the rumen and concomitant increase in roughage intake observed during other situations of increased energy output such as lactation and severe cold.

scholarly journals Grand Corruption in the Contracting Out of Public Services: Lessons from a Pilot Study in Colombia

2021 ◽  
Author(s):  
Philip Keefer ◽  
Benjamin Roseth
Keyword(s):  
Pilot Study ◽  
Significant Influence ◽  
Public Services ◽  
Text Messages ◽  
The Political ◽  
Control Groups ◽  
Corrupt Behavior ◽  
High Level ◽  
And Control ◽  
Operator Behavior

Do targeted transparency interventions reduce corrupt behavior when corrupt actors are few and politically influential; their behavior imposes small costs on numerous individuals; and corrupt behavior is difficult to observe? Results from a study of informal audits and text messages to parents, meant to curb corruption in the School Meals Program of Colombia, suggests that they can. Theory is pessimistic that transparency interventions can change the behavior of actors who exert significant influence over supervisory authorities. Moreover, inherent methodological obstacles impede the identification of treatment effects. Results substantiate the presence of these obstacles, especially considerable spillovers from treated to control groups. Despite spillovers, we find that parental and operator behavior are significantly different between treatment and control groups. Additional evidence explains why operator behavior changed: out of concern that systematic evidence of corrupt behavior would trigger enforcement actions by high-level enforcement agencies outside of the political jurisdictions where they are most influential.

scholarly journals Peningkatan Kemampuan Perawat dalam Interpretasi EKG Normal dan Aritmia dengan Metode Angka “3”

2021 ◽  
Vol 4 (2) ◽  
pp. 405-414
Author(s):  
Ii Ismail ◽  
Dewi Purnamawati ◽  
Wati Jumaiyah ◽  
Fitrian Rayasari
Keyword(s):  
Intervention Group ◽  
Average Score ◽  
Control Group ◽  
P Value ◽  
Control Groups ◽  
Treatment Variable ◽  
Mean Values ◽  
Linear Pattern ◽  
Significant Difference ◽  
And Control

This study aims to determine the effect of the number 3 method on nurses' ability to interpret normal ECG and arrhythmias. The research method used a quasi-experimental design with one group pre-test and a post-test with a control group. The results showed that there was a significant difference in the mean score of nurses in the interpretation of normal ECG and arrhythmias in both the intervention and control groups (p-value 0.007 and 0.002). The multiple linear regression test showed that the treatment variable contributed to the nurse's ability to interpret normal ECG and arrhythmias with a p-value of 0.002 with a negative linear pattern (Nurses' ability = 66.099 - 9.156 (treatment). In conclusion, there is a significant difference in the average score of nurses in interpretation. Normal ECG and arrhythmia in both the intervention and control groups. However, the intervention group with the number 3 method had a greater difference in mean values ​​than the control group. Statistically, the more research treatments, the nurses' ability to interpret normal ECG and arrhythmias would decrease.   Keywords: Arrhythmia, Normal EKG, Interpretation of ECG, Number Method 3

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