The Value of Safflower Yellow Injection for the Treatment of Acute Cerebral Infarction: A Randomized Controlled Trial

Background. Safflower Yellow Injection has been reported as a treatment for acute cerebral infarction in recent studies in China. However, there is a lack of availability of the evidence for the efficacy and safety of Safflower Yellow Injection for the treatment of acute ischemic stroke. So we investigated the effects of Safflower Yellow Injection for the treatment of acute cerebral infarction.Method. All subjects were randomly divided into Safflower Yellow Injection group given Safflower Yellow Injection (80 mg) and control group given placebo (0 mg) injection by intravenous drop once daily for 14 days. National Institute of Health Stroke Scale (NIHSS); hemorheological detection; coagulation function; and serum inflammatory markers, tumor necrosis factor-alpha (TNF-α), interleukin-1β(IL-1β), and interleukin-6 (IL-6), were used to investigate the effects before and 14 days after the treatment.Results. The scores of NIHSS were decreased on day 7 and day 14 after treatment. The hemorheological index of RBC deformation and RBC aggregation were significantly improved, prothrombin time (PT) increased, and fibrinogen (FIB) and TNF-α, IL-1β, and IL-6 were decreased in patients treated with Safflower Yellow injection on day 14 after treatment (P<0.05).Conclusion. Data suggests that Safflower Yellow Injection therapy may be beneficial for acute cerebral infarction.

Download Full-text

Oxidative-antioxidative status and hepatic and renal factors following melatonin administration in castrated and intact dogs

Basic and Clinical Andrology ◽

10.1186/s12610-019-0094-6 ◽

2019 ◽

Vol 29 (1) ◽

Cited By ~ 2

Author(s):

Asghar Mogheiseh ◽

Farzaneh Koohi ◽

Saeed Nazifi ◽

Aidin Shojaee Tabrizi ◽

Pegah Taheri ◽

...

Keyword(s):

Liver Enzymes ◽

Controlled Trial ◽

Oxidation Products ◽

Control Group ◽

Once Daily ◽

Antioxidative Status ◽

Melatonin Administration ◽

Mixed Breed ◽

And Control ◽

And Oxidative Stress

Abstract Backgrounds Melatonin has significant antioxidant and hepatoprotective effects in normal and oxidative stress conditions. The aim of the present study was to assess the effects of melatonin on antioxidant, hepatic, and renal factors in intact and castrated dogs. Twenty male mixed-breed adult dogs were aligned in an experimental randomized and controlled trial. The dogs were randomly divided into four equal groups: melatonin, castrated, castrated and melatonin, and control. They were treated with melatonin (0.3 mg/Kg, once daily, orally) immediately after the castration for 1 month and their blood samples were collected weekly from 2 days after treatment with melatonin. Results Treating castrated dogs with melatonin increased the level of glutathione peroxidase, superoxide dismutase, and catalase compared with that of the control and castrated groups. The malondialdehyde level increased significantly following castration. Melatonin treatment decreased malondialdehyde concentration in the castrated dogs. Castration increased the level of alkaline phosphatase, aspartate aminotransferase, and alanine aminotransferase significantly in comparison with that of the control group. Treating the castrated dogs with melatonin decreased significantly liver enzymes compared with those of the castrated dogs. Blood urea nitrogen and creatinine levels increased in the castrated dogs in comparison with that of the control group. Conclusions The administration of melatonin in castrated dogs increased antioxidant activity and decreased oxidation products, compared with those of the castrated and untreated dogs, without adverse effects on liver enzymes and kidney function.

Download Full-text

Suppression of Tumorigenesis: Modulation of Inflammatory Cytokines by Oral Administration of Microencapsulated Probiotic Yogurt Formulation

International Journal of Inflammation ◽

10.4061/2010/894972 ◽

2010 ◽

Vol 2010 ◽

pp. 1-10 ◽

Cited By ~ 14

Author(s):

Aleksandra Malgorzata Urbanska ◽

Arghya Paul ◽

Jasmine Bhahena ◽

Satya Prakash

Keyword(s):

Treatment Group ◽

Intestinal Inflammation ◽

Interleukin 1 ◽

Control Group ◽

Necrosis Factor Alpha ◽

Western Blots ◽

Reactive Protein ◽

Probiotic Yogurt ◽

Factor Alpha ◽

Irritable Bowel

The objective of this study was to examine the ability of a novel microencapsulated probiotic yogurt formulation to suppress the intestinal inflammation. We assessed its anticancer activity by screening interleukin-1, 6, and 12 (IL-1, 6, 12), secretory levels of tumor necrosis factor-alpha (TNF-α), interferon-gamma (IFN-γ), prostaglandinE2 (PGE2), and thromboxane B2 in the digesta obtained from the duodenum, jejunum, proximal, and distal segments of the ileum of C57BL/6J-ApcMin/J mice. Formulation-receiving animals showed consistently lower proinflammatory cytokines' levels when compared to control group animals receiving empty alginate-poly-L-lysine-alginate (APA) microcapsules suspended in saline. The concentrations of IL-12 found in serum in control and treatment group animals were significant:46.58±16.96 pg/mL and158.58±28.56 pg/mL for control and treatment animals, respectively. We determined a significant change in plasma C-reactive protein:81.04±23.73 ng/mL in control group and64.21±16.64 ng/mL in treatment group. Western blots showed a 71% downregulation of cyclooxygenase-2 (COX-2) protein in treatment group animals compared to control. These results point to the possibility of using this yogurt formulation in anticancer therapies, in addition to chronic gut diseases such as Crohn's disease, irritable bowel syndrome (IBS), and inflammatory bowel disease (IBD) thanks to its inflammation lowering properties.

Download Full-text

Comparative study on the efficacy and safety of alteplase and urokinase in the treatment of acute cerebral infarction

Technology and Health Care ◽

10.3233/thc-202382 ◽

2020 ◽

pp. 1-6

Author(s):

Hua Bao ◽

Hao-Ran Gao ◽

Min-Lu Pan ◽

Lei Zhao ◽

Hai-Bin Sun

Keyword(s):

Treatment Group ◽

Cerebral Infarction ◽

Early Stage ◽

Intravenous Thrombolysis ◽

Acute Cerebral Infarction ◽

Neurological Injury ◽

Control Group ◽

Efficacy And Safety ◽

Time Period ◽

And Control

BACKGROUND: Acute cerebral infarction (ACI) is a common cerebrovascular disease in clinical practice. OBJECTIVE: The present study aims to investigate the efficacy and safety of alteplase and urokinase in treating ACI. METHODS: A total of 96 patients with ACI, who were treated with alteplase and urokinase, were selected as the main subjects. Among these patients, 45 patients with ultra-early acute cerebral infarction, who received intravenous thrombolysis with RT-PA (alteplase), were included in the treatment group, while 51 patients with acute cerebral infarction, who were treated with urokinase in the same time period, were included in the control group. RESULTS: The National Institute of Health Stroke Scale (NIHSS) scores were significantly lower in the treatment group and control group (P< 0.05) at two hours, seven days and 14 days after thrombolysis, when compared to those before thrombolysis. The bleeding rate was significantly lower in the control group, when compared to the treatment group (P< 0.05). CONCLUSION: The intravenous thrombolysis with urokinase or alteplase in the ultra-early stage of acute cerebral infarction can reduce the neurological injury symptoms and effectively improve the prognosis of patients with stroke. Urokinase is lower in risk of bleeding, but better in safety, when compared to alteplase.

Download Full-text

Clinical Evidence-Based Evaluation of ZFXNY in Treatment of Acute Cerebral Infarction

10.21203/rs.3.rs-689587/v1 ◽

2021 ◽

Author(s):

Wei Hu ◽

Chenhui Zhang ◽

Hong Zhang

Keyword(s):

Chinese Medicine ◽

Traditional Chinese Medicine ◽

Cerebral Infarction ◽

Controlled Trial ◽

Case Fatality ◽

Test Group ◽

Acute Cerebral Infarction ◽

Control Group ◽

Chronic Obstructive ◽

Evidence Based

Abstract Background: Stroke is a severe and life-threatening disease, owns high rates of disability and mortality.[1] Stroke and ischemic heart disease, chronic obstructive pulmonary disease are the world’s three main killers.Ischemic strokes account for the vast majority of strokes.[2] Modern medicine has some advantages in treating ischemic stroke, but there are also limitations. Traditional Chinese medicine has thousands of years of experience in treating stroke, but there are few high quality clinical Randomized controlled trial.Methods: This is a multicenter, randomized, double-blind, placebo-controlled trial. 286 patients were randomly divided into test group and Control Group. Both groups received General Western medicine treatment, the test group combined with Chinese medicine treatment, the control group combined with placebo treatment. The duration of treatment was 30 days and the follow-up was 90 days. evaluation indicators include: Modified Rankin Scale, NIH stroke Scale, Glasgow Coma Scale, Barthel Index, Case fatality rate.Laboratory specifications and safety assessments will also be taken into account.Discussion: The aim of this study was to evaluate the safety and efficacy of ZFXNY in the treatment of acute cerebral infarction. Our research will provide a reliable evidence-based medicine basis for the treatment of acute cerebral infarction with traditional Chinese medicine, and provide another option for the treatment of acute cerebral infarction.Trial registration: ChiCTR2100043796, Registered February 28th, 2021.

Download Full-text

Clinical Effect of Ozagrel Sodium Combined with Eureklin on Acute Cerebral Infarction

E3S Web of Conferences ◽

10.1051/e3sconf/202123302025 ◽

2021 ◽

Vol 233 ◽

pp. 02025

Author(s):

Shen Shiheng ◽

Yan Shaoxiong

Keyword(s):

Cerebral Infarction ◽

Clinical Effect ◽

Acute Cerebral Infarction ◽

Control Group ◽

Cerebrovascular Event ◽

Human Society ◽

Observation Group ◽

Disability Rate ◽

And Control ◽

Very High

Cerebral infarction, as a serious cerebrovascular event, can lead to symptoms of various neurological disorders. The disability rate, mortality rate and recurrence rate are also very high, which is the health and economic burden of individuals, families and even human society. In this paper, 60 patients with cerebral infarction treated in our hospital were divided into observation group and control group. The observation group was treated with Ozagrel sodium combined with Eureklin, and the control group was given a single Ozagrel regimen The results showed that Ozagrel sodium combined with Yuclin was effective in the treatment of acute cerebral infarction.

Download Full-text

AdultBrugia malayimitochondrial and nuclear fractions impart Th1-associated sizeable protection against infective larval challenges inMastomys coucha

Journal of Helminthology ◽

10.1017/s0022149x08133582 ◽

2009 ◽

Vol 83 (1) ◽

pp. 83-95 ◽

Cited By ~ 3

Author(s):

S. Shakya ◽

A.K. Srivastava ◽

S. Misra-Bhattacharya

Keyword(s):

Interleukin 1 ◽

Peritoneal Macrophages ◽

Control Group ◽

Rodent Host ◽

Necrosis Factor Alpha ◽

Tnf Α ◽

Antibody Isotypes ◽

Factor Alpha ◽

Mastomys Coucha

AbstractProtective immunity to the subperiodic human filariid,Brugia malayi, was explored in the rodent host,Mastomys couchaafter vaccination with subcellular fractions derived from the adult stage of the parasite. The highest level of protection was conferred in animals vaccinated with the ‘mitochondria rich’ (MT) fraction, in which microfilaraemia and worm burden were markedly reduced by 67.2 and 65.9%, respectively, followed by the ‘nucleus rich’ (NR) fraction, showing reductions of 62 and 52.3%, respectively, over the non-immunized control group. Mastomys vaccinated with MT and NR, displayed a significant increase in the level of antigen-specific serum immunoglobulin G (IgG). The levels of IgG2a, IgG2b and IgM antibody isotypes were remarkably elevated in both the MT and NR immunized groups, while IgG1 and IgG3 levels were low. Apart from antibodies, both these fractions also led to marked antigen-specific lymphoproliferationin vitro, along with enhanced release of nitric oxide by peritoneal macrophages. There was an increased population of CD4+ and CD8a+T-cells in MT immunized animals, as measured by flow cytometry, accompanied by elevated levels of proinflammatory cytokines; interferon gamma (IFN-γ), tumour necrosis factor alpha (TNF-α) and interleukin-1 beta (IL-1β) in the culture supernatants of the activated splenocytes. The results suggest that both NR and MT contain proinflammatory molecules which evoke a protective Th1 type of immune response.

Download Full-text

Donepezil Improves Gait Performance in Patients with an Acute Cerebral Infarction: A Prospective Observational Cohort Study

Current Neurovascular Research ◽

10.2174/1567202617666200413130101 ◽

2020 ◽

Vol 17 (3) ◽

pp. 304-311 ◽

Cited By ~ 1

Author(s):

Ying-Ying Lin ◽

Shi-Jie Guo ◽

Hui Quan ◽

Yan-Xin Zhao ◽

Dong-Ya Huang

Keyword(s):

Risk Factors ◽

Cerebral Infarction ◽

Acute Cerebral Infarction ◽

Control Group ◽

Observation Group ◽

Gait Performance ◽

Nihss Score ◽

Significant Difference ◽

Independent Risk Factors ◽

And Control

Background: Hemiplegia is a common symptom after acute cerebral infarction. Objective: This study aimed to explore the influence factors of gait performance and investigate whether donepezil could improve gait performance in patients with an acute cerebral infarction. Methods: A total of 107 patients who experienced unilateral paresis after an acute cerebral infarction incident were enrolled in this prospectively observational study. Participants underwent a 3- month assessment. At the study's conclusion, patients were divided into 2 groups-those who received donepezil daily (observation Group) and those who did not (Control Group). Results: There was a significant difference (t=3.269, P=0.001) of Wisconsin Gait Scale (WGS) score between single site infarction (27.11±6.65) and multiple sites infarction (31.54±6.42). For gender, smoking, drinking, hypertension, hyperlipidemia and diabetes, there was no difference in WGS scores between subgroups (P>0.05), respectively. The patient's admission National Institute of Health Stroke Scale(NIHSS) score had a strongly positive correlation with WGS score (r=0.850, P<0.001). Besides, age (r=0.218, P=0.024), glycosylated hemoglobin (r=0.274, P=0.004), MMSE (r=-0.261, P=0.007) and Montreal Cognitive Assessment (MoCA) (r=-0.272, P=0.005) had a weak correlation with WGS scores. Multivariate analysis showed age (95% CI: 0.042~0.188, P=0.002), admission NIHSS score (95% CI: 2.405~3.137, P<0.001) and multiple sites infarction (95% CI: 0.044~2.983, P=0.044) were independent risk factors of WGS scores. WGS scores of both observation and control groups gradually decreased after admission (P<0.001). At 3 months after admission, WGS score of the observation group was significantly lower than the control group (t=2.468, P=0.015). There were no significant differences between observation and control group at admission and 1 month after admission (P>0.05) and WGS scores of both single site and multiple sites infarction gradually decreased at one month and three months after admission (P<0.001), while there was no significant difference between two groups (P>0.05). Conclusion: Admission NIHSS score, age and multiple sites infarction were independent risk factors of WGS score. Donepezil could improve gait performance in patients with acute cerebral infarction.

Download Full-text

Simulation stress model of the undersea environment activates the central nervous, neuroendocrine and immune systems and anxiety in rats

Undersea and Hyperbaric Medicine ◽

10.22462/03.07.2020.5 ◽

2020 ◽

pp. 445-453

Author(s):

Ying Tang ◽

Ying-Xin Zou ◽

Wei Fan ◽

Shuang-Hong Chen ◽

Yi-Qun Fang ◽

...

Keyword(s):

Stress Responses ◽

Interleukin 1 ◽

Control Group ◽

Stress Model ◽

Necrosis Factor Alpha ◽

Immune Systems ◽

Tnf Α ◽

The Central Nervous System ◽

Factor Alpha ◽

Necrosis Factor

The present study was designed to assess the stress responses to a simulation model of the undersea environment that is similar to some undersea working conditions such as submarine rescue, underwater salvage and underwater construction. Restraint, hyperbaric air and immersion were chosen to produce the simulation stress model in rats for four hours. Rats were randomized into five groups: control group, restraint (R) group, hyperbaric air (H) group, restraint plus hyperbaric air (RH) group, and restraint plus hyperbaric air plus immersion (RHI) group. The results showed that the responses to the simulation stress model of the undersea environment induced by R, H, RH and RHI involved the upregulated norepinephrine (NE), dopamine (DA) and 5-hydroxytryptamine (5-HT) of the central nervous system (CNS), upregulated adrenocorticotropic hormone (ACTH), corticosterone (CORT) and blood glucose of the neuroendocrine system, upregulated interleukin-1 (IL-1), interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-α) of the immune system, and increased anxiety in rats. Compared with hyperbaric air, restraint tended to activate stronger stress responses. Conclusively, this work established a simulation stress model of the undersea environment induced by restraint, hyperbaric air and immersion. It further provided experimental data of such a model that showed significant activation of the CNS, neuroendocrine and immune systems and anxiety in rats. In this experiment we provided an experimental basis for undersea work such as working aboard a submarine.

Download Full-text

Effect of Argatroban Injection on Clinical Efficacy in Patients with Acute Cerebral Infarction: Preliminary Findings

European Neurology ◽

10.1159/000512813 ◽

2021 ◽

pp. 1-5

Author(s):

Pan Huang ◽

Xiao-ying He ◽

Min Xu

Keyword(s):

Treatment Group ◽

Cerebral Infarction ◽

Clinical Efficacy ◽

Adverse Reactions ◽

National Institutes Of Health ◽

Acute Cerebral Infarction ◽

Control Group ◽

Scale Scores ◽

The Difference ◽

And Control

Objective: The aim is to observe the effects of argatroban injection and butylphthalide injection on blood flow rheology, clinical efficacy, and safety in patients with acute cerebral infarction. Methods: 344 patients with acute cerebral infarction within 48 h after admission were divided into treatment group and control group, with 172 cases in each group. The control group received routine treatment. The treatment group received argatroban injection 60 mg on the basis of the control group, intravenously guttae (ivgtt) was used for 2 days and then changed to argatroban injection 10 mg, ivgtt bid for 5 days, and the total course of treatment was 7 days. The neurological changes, activities of daily living, and the rheology indicators (fibrinogen [Fib], platelet aggregation rate [Pag], whole blood high shear viscosity [Whsv], hematocrit [Hct]) were compared between the 2 groups, clinical efficacy and adverse drug reactions. Results: After treatment, the total effective rates of the treatment group and the control group were 90.70% (156 /172 cases) and 74.41% (128 and 172 cases), respectively, and the difference was statistically significant (p < 0.05). After treatment, the National Institutes of Health Stroke Scale scores of the treatment group and the control group were (7.05 ± 1.97) and (8.30 ± 1.79), respectively, and the Barthel index was (68.02 ± 11.07) and (62.32 ± 11.46), respectively. The difference was statistically significant (p < 0.05). After treatment, the treatment group and the control group were (2.66 ± 0.22) g/L and (3.50 ± 0.22) g/L, respectively, and Pag were (0.68 ± 0.06)% and (0.81 ± 0.09)%, respectively, and Whsv was (6.44 ± 0.76) mPs/s and (6.87 ± 0.91) mPs/s, Hct were (8.19 ± 1.21)% and (10.44 ± 1.04)%, respectively, and the differences were statistically significant (p < 0.05). The incidence of adverse reactions in the treatment group and the control group was 6.97 and 5.81%, respectively, and the difference was not statistically significant (p > 0.05). Conclusion: Argatroban injection is effective in the treatment of acute cerebral infarction, which can significantly improve the hemorheology of patients with good safety.

Download Full-text

Concomitant effect of low dose of lindane and intranasal lipopolysaccharide on respiratory system of mice

Human & Experimental Toxicology ◽

10.1177/0960327116685889 ◽

2017 ◽

Vol 36 (11) ◽

pp. 1201-1211 ◽

Cited By ~ 8

Author(s):

A Tewari ◽

RS Sethi ◽

HS Banga ◽

B Singh ◽

JPS Gill

Keyword(s):

Normal Saline ◽

Control Group ◽

Swiss Albino Mouse ◽

Necrosis Factor Alpha ◽

Lps Challenge ◽

Cell Counts ◽

Tnf Α ◽

Leukocyte Counts ◽

Factor Alpha ◽

And Control

Lindane is very commonly used organochlorine pesticide and has been reported to cause several toxic effects including respiratory insufficiency. However, effects of low concentration of lindane alone or in combination with microbial molecules on lungs are not fully understood. To understand the effects a preliminary study was designed on Swiss albino mouse. Male mice were divided into treatment and control group (20; each). Treatment mice were given lindane in ground nut oil orally at 0.25 mg kg−1 day−1 for 60 days. After treatment, 10 mice were challenged with intranasal Escherichia coli lipopolysaccharide (LPS; 80 μg per mice) and remaining 10 with normal saline. The mice were euthanized 16 h post-LPS exposure. Control mice (10 each) were given normal saline or the LPS alone. Mice exposed with lindane and in combination with LPS had increase in total cell counts and leukocyte counts in broncho-alveolar lavage. Histological examination showed lung injury in the lindane-treated mice. The histopathological changes were more pronounced in lindane along with LPS-exposed mice. Lindane alone and in combination with LPS showed expression of immunopositive Toll-like receptor (TLR)-4 and tumour necrosis factor-alpha (TNF-α) positive reaction in various cells of lungs. While LPS induced acute inflammation in the lungs, combination of lindane and LPS exacerbated histological signs of the inflammation. The data indicate that lindane alone or in combination with LPS caused changes in lung morphology and altered TLR-4 and TNF-α expression which may have led to altered response to LPS challenge.

Download Full-text