Impaired Fasting Glucose in Nondiabetic Range: Is It a Marker of Cardiovascular Risk Factor Clustering?

Background. Impaired fasting glucose (IFG) through the nondiabetic range (100–125 mg/dL) is not considered in the cardiovascular (CV) risk profile. Aim. To compare the clustering of CV risk factors (RFs) in nondiabetic subjects with normal fasting glucose (NFG) and IFG. Material and Methods. Cross-sectional study in 3739 nondiabetic subjects. Demographics, medical history, and CV risk factors were collected and lipid profile, fasting glucose levels (FBG), C-reactive protein (hsCRP), blood pressure (BP), anthropometric measurements, and aerobic capacity were determined. Results. 559 (15%) subjects had IFG: they had a higher mean age, BMI, waist circumference, non-HDL cholesterol, BP, and hsCRP (p<0.0001) and lower HDL (p<0.001) and aerobic capacity (p<0.001). They also had a higher prevalence of hypertension (34% versus 25%; p<0.001), dyslipidemia (79% versus 74%; p<0.001), and obesity (29% versus 16%; p<0.001) and a higher Framingham risk score (8% versus 6%; p<0.001). The probability of presenting 3 or more CV RFs adjusted by age and gender was significantly higher in the top quintile of fasting glucose (≥98 mg/dL; OR = 2.02; 1.62–2.51). Conclusions. IFG in the nondiabetic range is associated with increased cardiovascular RF clustering.

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PREVALENCE AND RISK FACTORS OF IMPAIRED FASTING GLUCOSE AMONG ADULTS IN NORTHEAST CHINA: A CROSS-SECTIONAL STUDY

Endocrine Practice ◽

10.4158/ep-2018-0046 ◽

2018 ◽

Vol 24 (7) ◽

pp. 677-683 ◽

Cited By ~ 1

Author(s):

Qian Zhao ◽

Qing Zhen ◽

Yong Li ◽

Ruogu Lv ◽

Kaixin Zhang ◽

...

Keyword(s):

Risk Factors ◽

Impaired Fasting Glucose ◽

Northeast China ◽

Fasting Glucose ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional

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Risk factors of impaired fasting glucose and type 2 diabetes in Yaoundé, Cameroon: a cross sectional study

BMC Public Health ◽

10.1186/s12889-015-1413-2 ◽

2015 ◽

Vol 15 (1) ◽

Cited By ~ 13

Author(s):

Clement Nyuyki Kufe ◽

Kerstin Klipstein-Grobusch ◽

Fezeu Leopold ◽

Felix Assah ◽

George Ngufor ◽

...

Keyword(s):

Risk Factors ◽

Type 2 Diabetes ◽

Impaired Fasting Glucose ◽

Fasting Glucose ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional

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Increased modifiable cardiovascular risk factors in patients with Takayasu arteritis: a multicenter cross-sectional study

Advances in Rheumatology ◽

10.1186/s42358-020-00157-1 ◽

2021 ◽

Vol 61 (1) ◽

Author(s):

Alexandre Moura dos Santos ◽

Rafael Giovani Misse ◽

Isabela Bruna Pires Borges ◽

Bruno Gualano ◽

Alexandre Wagner Silva de Souza ◽

...

Keyword(s):

Quality Of Life ◽

Risk Factors ◽

Muscle Strength ◽

Aerobic Capacity ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Metabolic Equivalent ◽

Handgrip Test

Abstract Background Modifiable cardiovascular risk factors (MCRFs), such as those related to aerobic capacity, muscle strength, physical activity, and body composition, have been poorly studied in Takayasu arteritis (TAK). Therefore, the aim of the study was to investigate MCRFs and their relationships with disease status and comorbidities among patients with TAK. Methods A multicenter cross-sectional study was conducted between 2019 and 2020, in which 20 adult women with TAK were compared with 16 healthy controls matched by gender, age, and body mass index. The following parameters were analyzed: aerobic capacity by cardiopulmonary test; muscle function by timed-stands test, timed up-and-go test, and handgrip test; muscle strength by one-repetition maximum test and handgrip test; body composition by densitometry; physical activity and metabolic equivalent by IPAQ, quality of life by HAQ and SF-36; disease activity by ITAS2010 and NIH score; and presence of comorbidities. Results Patients with TAK had a mean age of 41.5 (38.0–46.3) years, disease duration of 16.0 (9.5–20.0) years, and a mean BMI of 27.7±4.5 kg/m2. Three out of the 20 patients with TAK had active disease. Regarding comorbidities, 16 patients had systemic arterial hypertension, 11 had dyslipidemia, and two had type 2 diabetes mellitus, while the control group had no comorbidities. TAK had a significant reduction in aerobic capacity (absolute and relative VO2 peak), muscle strength in the lower limbs, increased visceral adipose tissue, waist-to-hip ratio, reduced walking capacity, decreased weekly metabolic equivalent, and quality of life (P< 0.05) as compared to controls. However, there were no correlations between these MCRFs parameters and disease activity. Conclusions TAK show impairment in MCRFs; therefore, strategies able to improve MCRF should be considered in this disease.

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Evaluation of the Fibromyalgia and Related Risk Factors in Patients with Advanced Kidney Failure Undergoing Hemodialysis

Current Rheumatology Reviews ◽

10.2174/1573397117666211021170438 ◽

2021 ◽

Vol 17 ◽

Author(s):

Seyed Mostafa Seyedmardani ◽

Saeed Abkhiz ◽

Azadeh Megrazi ◽

Aarefeh Jafarzade ◽

Golshan Kamali Zonouz

Keyword(s):

Risk Factors ◽

Kidney Failure ◽

Fibromyalgia Syndrome ◽

Cross Sectional Study ◽

Hemodialysis Patients ◽

Cross Sectional ◽

Age And Gender ◽

Significant Difference ◽

Symptom Severity Score ◽

And Gender

Background : Fibromyalgia syndrome (FMS) is defined as widespread and persistent pain in the musculoskeletal system. There are limited reports regarding the prevalence of fibromyalgia syndrome in patients with advanced kidney failure undergoing regular hemodialysis. Therefore, this study aimed to evaluate the prevalence of fibromyalgia syndrome and its risk factors in a large proportion of patients under the hemodialysis condition. Materials and Methods: In this cross-sectional study, 293 patients who were admitted to the hemodialysis ward were evaluated for fibromyalgia syndrome in an educational hospital. The questionnaire was designed according to symptom severity score (SS score) and widespread pain index (WPI) criteria. The correlation between FMS and various variables, including demographic, clinical, and biochemistry biomarkers, was also precisely calculated by logistic regression. Data were analyzed using SPSS v.17 statistics software. Results: The results showed that, of 293 hemodialysis patients, 130 patients (44.4%) had fibromyalgia, the mean age of patients with and without fibromyalgia was 61.09 ± 15.36 and 53.49 ± 15.38 years old, respectively (P = 0.001). Moreover, there was a significant difference in terms of gender among patients with fibromyalgia syndrome (P = 0.001). To note, there was no significant relationship between the kidney failure etiopathogenesis, duration of dialysis, body mass index (BMI), Kt/v index, history of peritoneal dialysis, and laboratory parameters with fibromyalgia in hemodialysis patients (P > 0.05). However, our findings revealed that both age and gender could be considered as the predictor variables associated with fibromyalgia in patients undergoing hemodialysis. Conclusion: Taken together, in this study, we found that age and gender would be the critical factors in terms of the fibromyalgia syndrome in patients undergoing hemodialysis.

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Associations between Dietary Patterns and Impaired Fasting Glucose in Chinese Men: A Cross-Sectional Study

Nutrients ◽

10.3390/nu7095382 ◽

2015 ◽

Vol 7 (9) ◽

pp. 8072-8089 ◽

Cited By ~ 15

Author(s):

Meilin Zhang ◽

Yufeng Zhu ◽

Ping Li ◽

Hong Chang ◽

Xuan Wang ◽

...

Keyword(s):

Impaired Fasting Glucose ◽

Dietary Patterns ◽

Fasting Glucose ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Chinese Men

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Rapid HIV Testing in Al Buraimi Governorate Sultanate of Oman: A Cross Sectional Study

Global Journal of Health Science ◽

10.5539/gjhs.v10n11p153 ◽

2018 ◽

Vol 10 (11) ◽

pp. 153

Author(s):

Saad Rashid Saud Al Alawi ◽

Muhammad Muqeet Ullah ◽

Ahmed Yar Mohammed Dawood Al Balushi ◽

Rajeev Kashyap ◽

Vandita Kailas Patil

Keyword(s):

Risk Factors ◽

Personal Information ◽

Cross Sectional Study ◽

Ethical Review ◽

Age Group ◽

Cross Sectional ◽

Entire Study ◽

Male Clients ◽

Hiv Rapid Testing ◽

And Gender

BACKGROUND: Due to one of the highest HIV prevalent province in Oman, Voluntary Counselling Testing (VCT) services were integrated in health system of Al Buraimi Governorate, Oman since December 2014. AIM & OBJECTIVE: The study aimed to analyze the situation on HIV rapid testing in Al Buraimi Governorate with objective to identify client’s risk factor among common age group and gender. METHODOLOGY: Cross sectional retrospective study was conducted in Al Buraimi Governorate, Oman among 1412 registered adult VCT clients, unbooked pregnant women with no documented HIV status at the time of delivery or abortion at Buraimi Hospital and clients during outreach community awareness activities on HIV. Retrospective analysis was performed for 3 years from December 2014 to December 2017 on parameters like Age, gender, nationality, risk factors, outcome and place of testing (Hospital and Outreach) using standard national client information form. Descriptive statistics was applied in Microsoft excel and SPSS version 24. Clients’ personal information and confidentiality of the record was maintained during entire study period with approval from regional research and ethical review committee. RESULTS: Of 1412 clients for Rapid Diagnostic Tests (RDTs), 990 (70.1%) were females and 422 (29.9%) were males with mean age 27.13±7.02. Majority, 806 (57.1%) RDTs were in outreach followed by 470 (33.3%) and 136 (9.6%) at Maternity ward and Couselling Clinic respectively. Clients included 1294 (91.6%) Omani nationals and 118 (8.4%) non-Omani nationals. The risky behavior was found to be 126 (9%) among clients with heterosexual contributes 65 (4.6%). Among all risk factors, male clients contributed 124 (8.7%) with common age group 26-35 years 56 (3.9%). CONCLUSION: RDTs were utilized mainly during outreach activities that highlight the need of promoting VCT facilities in the clinical setting as services are available 24/7 through hotline. This baseline study would facilitate to develop plan for client’s risk reduction.

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Leptin G-2548A Gene Polymorphism is Positively Associated with Increased Plasma Leptin and Glucose Levels in Obese Saudi Patients Irrespective Status of Blood Pressure

10.21203/rs.3.rs-148642/v2 ◽

2021 ◽

Author(s):

Lotfi S. Bin Dahman ◽

Nasser M. Al-Daghri

Keyword(s):

Blood Pressure ◽

Gene Polymorphism ◽

Plasma Glucose ◽

Hdl Cholesterol ◽

Cross Sectional Study ◽

Cross Sectional ◽

Glucose Levels ◽

Lep Gene ◽

Plasma Leptin ◽

Saudi Patients

Abstract The association between LEP G-2548A gene polymorphism with increased plasma leptin and glucose levels and blood pressure in a sample of obese Saudi patients has been evaluated. This is a cross-sectional study involved 206 Saudi adult subjects (94 males and 112 females), randomly selected from the primary health care centers, Riyadh, Saudi Arabia. The study sample was categorized into three groups: 50 normotensive ND controls (age: 47.9±5.4 yr.; BMI 22.9±2.1 Kg/m2), 80 obese normotensive ND (age: 47.7±6.0 yr.; BMI 34.1±4.2 Kg/m2) and 76 obese hypertensive with T2D patients (age: 49.4±5.9 yr.; BMI: 35.1±4.7 Kg/m2). Analyses of LEP G-2548A gene polymorphism were determined using polymerase chain reaction (PCR), followed by restriction fragment length polymorphism (RFLP) with 2U of HhaI restriction enzyme. Plasma leptin and insulin levels were measured using the Luminex instrument. Fasting plasma glucose, total cholesterol, HDL-cholesterol, and triglycerides were measured using a chemical autoanalyzer Konelab machine. Also, blood pressure and anthropometric data were measured. The association analysis with metabolic parameters showed that homozygous AA of the LEP gene had significantly higher plasma glucose levels and HOMA-IR compared with homozygous GG (6.8±0.55 vs. 5.8±0.30; p< 0.04; 4.1±0.84 vs. 2.6±0.67; p=0.03) respectively. Besides, heterozygous GA had significantly higher plasma leptin levels compared with homozygous GG (40.0±2.6 vs. 29.6±2.6; P= 0.04). GA, AA, GA+AA genotypes of the LEP G-2548A gene polymorphism are more prevalent among individuals with hyperglycemia (OR= 3.7, 95% CI= 1.6 to 8.4, P= 0.001; OR= 3.2, 95% CI= 1.2 to 8.6, P= 0.03; OR= 3.5, 95%CI= 1.6 to 7.7, P= 0.001) respectively. A allele of the LEP gene is more prevalent among subjects with hyperglycemia (OR= 1.9, 95%CI= 1.2 to 3.0, P=0.006). G-2548A variant of the LEP gene may not be considered as a genetic risk factor for hypertension in Saudi obese patients. However, the genotypes (GA and AA) and -2548AA allele of this gene may represent important risk factors predisposing healthy subjects to develop T2DM irrespective of the status of blood pressure.

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Associations of Residential Greenness with Diabetes Mellitus in Chinese Uyghur Adults

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph16245131 ◽

2019 ◽

Vol 16 (24) ◽

pp. 5131

Author(s):

Shujun Fan ◽

Zhenxiang Xue ◽

Jun Yuan ◽

Ziyan Zhou ◽

Yuzhong Wang ◽

...

Keyword(s):

Rural Areas ◽

Vegetation Index ◽

Normalized Difference Vegetation Index ◽

Fasting Glucose ◽

Cross Sectional Study ◽

Diabetes Prevalence ◽

Protective Effects ◽

Cross Sectional ◽

Glucose Levels ◽

Lower Odds Ratio

Greenness exposure is nominated as a potential beneficial factor for health, but evidence is limited on its diabetes effects. We conducted a cross-sectional study between May and September 2016 in rural areas of northwestern China, including 4670 Uyghur adults, to explore the associations between residential greenness and fasting glucose levels and diabetes prevalence. Fasting glucose levels were determined, and information on covariates was collected by questionnaire. Normalized difference vegetation index (NDVI) and soil-adjusted vegetation index (SAVI) were calculated to assess greenness levels. Generalized linear mixed models were applied to evaluate the associations of greenness with fasting glucose levels and diabetes prevalence. The prevalence of diabetes was 11.6%. We found that living in rural areas characterized by increased amounts of greenness was associated with reduced diabetes prevalence (e.g., NDVI1000m: OR, 0.92; 95% CI, 0.86, 0.99). Stratified analyses showed that the protective effects of greenness on diabetes prevalence were found only in women (NDVI1000m: OR, 0.90; 95% CI, 0.82, 0.99). However, none of the interaction was statistically significant. Our study suggests that greater residential greenness levels were associated with a lower odds ratio of diabetes prevalence in Xinjiang Uyghur adults. Further well-designed longitudinal studies are needed to confirm our findings.

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Does Good Aerobic Capacity Attenuate the Effects of Aging on Cardiovascular Risk Factors? Results from a Cross-Sectional Study in a Latino Population

International Journal of Endocrinology ◽

10.1155/2017/8351635 ◽

2017 ◽

Vol 2017 ◽

pp. 1-7 ◽

Cited By ~ 1

Author(s):

Giovanna Valentino ◽

Mónica Acevedo ◽

Lorena Orellana ◽

María José Bustamante ◽

Verónica Kramer ◽

...

Keyword(s):

Aerobic Capacity ◽

Stress Test ◽

Age Groups ◽

Logistic Models ◽

Exercise Stress Test ◽

Cross Sectional Study ◽

Exercise Stress ◽

Sectional Study ◽

Cross Sectional ◽

Glucose Levels

Background. High aerobic capacity is associated with low cardiovascular (CV) risk. The aim of this study was to determine the CV RF burden in subjects with aerobic capacity ≥10 METs and compare it with those having <10 METs.Methods. Cross-sectional study in 2646 subjects (mean age 48 ± 12 years). Demographics, medical history, physical activity, cardiovascular RFs, fasting lipids and blood glucose levels, blood pressure, and anthropometric measurements were collected. Aerobic capacity was determined by exercise stress test. The ACC/AHA 2013 pooled cohort equation was used to calculate CV risk. Logistic models were built to determine the probability of having ≥2 RFs versus 0‐1 RF, by age and sex, according to aerobic capacity.Results. 15% of subjects had aerobiccapacity<10METs. The ACC/AHA scores were 15% in men and 6% in women with <10 METs and 5% and 2%, respectively, in those with ≥10 METs. The probability of having ≥2 RFs increased with age in both groups; however, it was significantly higher in subjects with <10 METs (odds ratio [OR]: 2.54; 95% CI: 1.92–3.35).Conclusions.Aerobic capacity≥10METs is associated with a better CV RF profile and lower CV risk score in all age groups, regardless of gender.

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