scholarly journals Intelligence Algorithms for Protein Classification by Mass Spectrometry

2018 ◽  
Vol 2018 ◽  
pp. 1-11 ◽  
Author(s):  
Zichuan Fan ◽  
Fanchen Kong ◽  
Yang Zhou ◽  
Yiqing Chen ◽  
Yalan Dai
Keyword(s):  
Machine Learning ◽  
Mass Spectrometry ◽  
Classification Performance ◽  
Machine Learning Algorithms ◽  
Learning Approaches ◽  
Classification Methods ◽  
Classifier Selection ◽  
Ensemble Strategy ◽  
Biomarker Analysis ◽  
Data Volume

Mass spectrometry (MS) is an important technique in protein research. Effective classification methods by MS data could contribute to early and less-invasive diagnosis and also facilitate developments in the bioinformatics field. As MS data is featured by high dimension, appropriate methods which can effectively deal with the large amount of MS data have been widely studied. In this paper, the applications of methods based on intelligence algorithms have been investigated. Firstly, classification and biomarker analysis methods using typical machine learning approaches have been discussed. Then those are followed by the Ensemble strategy algorithms. Clearly, simple and basic machine learning algorithms hardly addressed the various needs of protein MS classification. Preprocessing algorithms have been also studied, as these methods are useful for feature selection or feature extraction to improve classification performance. Protein MS data growing with data volume becomes complicated and large; improvements in classification methods in terms of classifier selection and combinations of different algorithms and preprocessing algorithms are more emphasized in further work.

scholarly journals Machine Learning in Football Betting: Prediction of Match Results Based on Player Characteristics

2019 ◽  
Vol 10 (1) ◽  
pp. 46 ◽  
Author(s):  
Johannes Stübinger ◽  
Benedikt Mangold ◽  
Julian Knoll
Keyword(s):  
Machine Learning ◽  
Machine Learning Algorithms ◽  
Learning Approaches ◽  
Home Team ◽  
Ensemble Strategy ◽  
The World ◽  
European Football ◽  
The Individual ◽  
Football Betting ◽  
Betting Odds

In recent times, football (soccer) has aroused an increasing amount of attention across continents and entered unexpected dimensions. In this course, the number of bookmakers, who offer the opportunity to bet on the outcome of football games, expanded enormously, which was further strengthened by the development of the world wide web. In this context, one could generate positive returns over time by betting based on a strategy which successfully identifies overvalued betting odds. Due to the large number of matches around the globe, football matches in particular have great potential for such a betting strategy. This paper utilizes machine learning to forecast the outcome of football games based on match and player attributes. A simulation study which includes all matches of the five greatest European football leagues and the corresponding second leagues between 2006 and 2018 revealed that an ensemble strategy achieves statistically and economically significant returns of 1.58% per match. Furthermore, the combination of different machine learning algorithms could neither be outperformed by the individual machine learning approaches nor by a linear regression model or naive betting strategies, such as always betting on the victory of the home team.

A Machine Learning-based Method for Question Type Classification in Biomedical Question Answering

2017 ◽  
Vol 56 (03) ◽  
pp. 209-216 ◽  
Author(s):  
Said Ouatik El Alaoui ◽  
Mourad Sarrouti
Keyword(s):  
Machine Learning ◽  
Question Answering ◽  
Classification Performance ◽  
Machine Learning Algorithms ◽  
Question Type ◽  
Support Vector ◽  
Learning Approaches ◽  
Answer Extraction ◽  
Improved Performance ◽  
Type Classification

SummaryBackground and Objective: Biomedical question type classification is one of the important components of an automatic biomedical question answering system. The performance of the latter depends directly on the performance of its biomedical question type classification system, which consists of assigning a category to each question in order to determine the appropriate answer extraction algorithm. This study aims to automatically classify biomedical questions into one of the four categories: (1) yes/no, (2) factoid, (3) list, and (4) summary.Methods: In this paper, we propose a biomedical question type classification method based on machine learning approaches to automatically assign a category to a biomedical question. First, we extract features from biomedical questions using the proposed handcrafted lexico-syntactic patterns. Then, we feed these features for machine- learning algorithms. Finally, the class label is predicted using the trained classifiers.Results: Experimental evaluations performed on large standard annotated datasets of biomedical questions, provided by the BioASQ challenge, demonstrated that our method exhibits significant improved performance when compared to four baseline systems. The proposed method achieves a roughly 10-point increase over the best baseline in terms of accuracy. Moreover, the obtained results show that using handcrafted lexico-syntactic patterns as features’ provider of support vector machine (SVM) lead to the highest accuracy of 89.40%.Conclusion: The proposed method can automatically classify BioASQ questions into one of the four categories: yes/no, factoid, list, and summary. Furthermore, the results demonstrated that our method produced the best classification performance compared to four baseline systems.

Prediction of K562 Cells Functional Inhibitors Based on Machine Learning Approaches

2020 ◽  
Vol 25 (40) ◽  
pp. 4296-4302 ◽  
Author(s):  
Yuan Zhang ◽  
Zhenyan Han ◽  
Qian Gao ◽  
Xiaoyi Bai ◽  
Chi Zhang ◽  
...  
Keyword(s):  
Machine Learning ◽  
Inclusion Bodies ◽  
Cross Validation ◽  
Independent Set ◽  
K562 Cells ◽  
Machine Learning Algorithms ◽  
Learning Approaches ◽  
Validation Test ◽  
Excess Number ◽  
Fold Cross Validation

Background: β thalassemia is a common monogenic genetic disease that is very harmful to human health. The disease arises is due to the deletion of or defects in β-globin, which reduces synthesis of the β-globin chain, resulting in a relatively excess number of α-chains. The formation of inclusion bodies deposited on the cell membrane causes a decrease in the ability of red blood cells to deform and a group of hereditary haemolytic diseases caused by massive destruction in the spleen. Methods: In this work, machine learning algorithms were employed to build a prediction model for inhibitors against K562 based on 117 inhibitors and 190 non-inhibitors. Results: The overall accuracy (ACC) of a 10-fold cross-validation test and an independent set test using Adaboost were 83.1% and 78.0%, respectively, surpassing Bayes Net, Random Forest, Random Tree, C4.5, SVM, KNN and Bagging. Conclusion: This study indicated that Adaboost could be applied to build a learning model in the prediction of inhibitors against K526 cells.

scholarly journals Searching for improvements in predicting human eye colour from DNA

2021 ◽  
Author(s):  
Magdalena Kukla-Bartoszek ◽  
Paweł Teisseyre ◽  
Ewelina Pośpiech ◽  
Joanna Karłowska-Pik ◽  
Piotr Zieliński ◽  
...  
Keyword(s):  
Machine Learning ◽  
Regression Models ◽  
Learning Algorithms ◽  
Machine Learning Algorithms ◽  
Sequencing Analysis ◽  
Learning Approaches ◽  
Human Eye ◽  
Software Analysis ◽  
Whole Exome ◽  
Eye Colour

AbstractIncreasing understanding of human genome variability allows for better use of the predictive potential of DNA. An obvious direct application is the prediction of the physical phenotypes. Significant success has been achieved, especially in predicting pigmentation characteristics, but the inference of some phenotypes is still challenging. In search of further improvements in predicting human eye colour, we conducted whole-exome (enriched in regulome) sequencing of 150 Polish samples to discover new markers. For this, we adopted quantitative characterization of eye colour phenotypes using high-resolution photographic images of the iris in combination with DIAT software analysis. An independent set of 849 samples was used for subsequent predictive modelling. Newly identified candidates and 114 additional literature-based selected SNPs, previously associated with pigmentation, and advanced machine learning algorithms were used. Whole-exome sequencing analysis found 27 previously unreported candidate SNP markers for eye colour. The highest overall prediction accuracies were achieved with LASSO-regularized and BIC-based selected regression models. A new candidate variant, rs2253104, located in the ARFIP2 gene and identified with the HyperLasso method, revealed predictive potential and was included in the best-performing regression models. Advanced machine learning approaches showed a significant increase in sensitivity of intermediate eye colour prediction (up to 39%) compared to 0% obtained for the original IrisPlex model. We identified a new potential predictor of eye colour and evaluated several widely used advanced machine learning algorithms in predictive analysis of this trait. Our results provide useful hints for developing future predictive models for eye colour in forensic and anthropological studies.

scholarly journals Attack and Anomaly Detection in IoT Networks Using Supervised Machine Learning Approaches

2021 ◽  
Vol 35 (1) ◽  
pp. 11-21
Author(s):  
Himani Tyagi ◽  
Rajendra Kumar
Keyword(s):  
Machine Learning ◽  
Performance Metrics ◽  
Detection System ◽  
Feature Reduction ◽  
Machine Learning Algorithms ◽  
Supervised Machine Learning ◽  
Testing Time ◽  
Learning Approaches ◽  
Reduction Techniques ◽  
Share Data

IoT is characterized by communication between things (devices) that constantly share data, analyze, and make decisions while connected to the internet. This interconnected architecture is attracting cyber criminals to expose the IoT system to failure. Therefore, it becomes imperative to develop a system that can accurately and automatically detect anomalies and attacks occurring in IoT networks. Therefore, in this paper, an Intrsuion Detection System (IDS) based on extracted novel feature set synthesizing BoT-IoT dataset is developed that can swiftly, accurately and automatically differentiate benign and malicious traffic. Instead of using available feature reduction techniques like PCA that can change the core meaning of variables, a unique feature set consisting of only seven lightweight features is developed that is also IoT specific and attack traffic independent. Also, the results shown in the study demonstrates the effectiveness of fabricated seven features in detecting four wide variety of attacks namely DDoS, DoS, Reconnaissance, and Information Theft. Furthermore, this study also proves the applicability and efficiency of supervised machine learning algorithms (KNN, LR, SVM, MLP, DT, RF) in IoT security. The performance of the proposed system is validated using performance Metrics like accuracy, precision, recall, F-Score and ROC. Though the accuracy of Decision Tree (99.9%) and Randon Forest (99.9%) Classifiers are same but other metrics like training and testing time shows Random Forest comparatively better.

scholarly journals Analysis of Residual Current Flows in Inverter Based Energy Systems Using Machine Learning Approaches

Energies ◽  
2022 ◽  
Vol 15 (2) ◽  
pp. 582
Author(s):  
Holger Behrends ◽  
Dietmar Millinger ◽  
Werner Weihs-Sedivy ◽  
Anže Javornik ◽  
Gerold Roolfs ◽  
...  
Keyword(s):  
Machine Learning ◽  
Early Stage ◽  
Residual Current ◽  
Operating Conditions ◽  
Machine Learning Algorithms ◽  
Photovoltaic System ◽  
Detection Methods ◽  
Learning Approaches ◽  
Residual Currents ◽  
Current Flows

Faults and unintended conditions in grid-connected photovoltaic systems often cause a change of the residual current. This article describes a novel machine learning based approach to detecting anomalies in the residual current of a photovoltaic system. It can be used to detect faults or critical states at an early stage and extends conventional threshold-based detection methods. For this study, a power-hardware-in-the-loop approach was carried out, in which typical faults have been injected under ideal and realistic operating conditions. The investigation shows that faults in a photovoltaic converter system cause a unique behaviour of the residual current and fault patterns can be detected and identified by using pattern recognition and variational autoencoder machine learning algorithms. In this context, it was found that the residual current is not only affected by malfunctions of the system, but also by volatile external influences. One of the main challenges here is to separate the regular residual currents caused by the interferences from those caused by faults. Compared to conventional methods, which respond to absolute changes in residual current, the two machine learning models detect faults that do not affect the absolute value of the residual current.

scholarly journals Computer Vision Based Detection and Quantification of Extraneous Water in Raw Milk

2021 ◽  
Author(s):  
Bezuayehu Gutema Asefa ◽  
Legesse Hagos ◽  
Tamirat Kore ◽  
Shimelis Admassu Emire
Keyword(s):  
Machine Learning ◽  
Digital Image Analysis ◽  
Raw Milk ◽  
Classification Performance ◽  
Machine Learning Algorithms ◽  
Machine Learning Technique ◽  
Milk Adulteration ◽  
Learning Technique ◽  
Total Accuracy

Abstract A rapid method based on digital image analysis and machine learning technique is proposed for the detection of milk adulteration with water. Several machine learning algorithms were compared, and SVM performed best with 89.48 % of total accuracy and 95.10 % precision. An increase in the classification performance was observed in extreme classes. Better quantitative determination of the extraneous water was achieved using SVMR with R2(CV) and R2(P) of 0.65 and 0.71 respectively. The proposed technique can be used to screen raw milk based on the level of added extraneous water without the necessity of any additional reagent.

scholarly journals Predicting Student’s Performance Using Machine Learning Algorithm

2021 ◽  
pp. 53-58
Author(s):  
Sheela Rani P ◽  
Dhivya S ◽  
Dharshini Priya M ◽  
Dharmila Chowdary A
Keyword(s):  
Machine Learning ◽  
Support Vector Machine ◽  
Prediction Model ◽  
Naive Bayes ◽  
Learning Algorithm ◽  
Naïve Bayes ◽  
Machine Learning Algorithms ◽  
Support Vector ◽  
Learning Approaches ◽  
K Nearest Neighbors

Machine learning is a new analysis discipline that uses knowledge to boost learning, optimizing the training method and developing the atmosphere within which learning happens. There square measure 2 sorts of machine learning approaches like supervised and unsupervised approach that square measure accustomed extract the knowledge that helps the decision-makers in future to require correct intervention. This paper introduces an issue that influences students' tutorial performance prediction model that uses a supervised variety of machine learning algorithms like support vector machine , KNN(k-nearest neighbors), Naïve Bayes and supplying regression and logistic regression. The results supported by various algorithms are compared and it is shown that the support vector machine and Naïve Bayes performs well by achieving improved accuracy as compared to other algorithms. The final prediction model during this paper may have fairly high prediction accuracy .The objective is not just to predict future performance of students but also provide the best technique for finding the most impactful features that influence student’s while studying.

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