scholarly journals The Therapeutic Effect of a Multistrain Probiotic on Diarrhea-Predominant Irritable Bowel Syndrome: A Pilot Study

2018 ◽  
Vol 2018 ◽  
pp. 1-8 ◽  
Author(s):  
Seok-Hoon Lee ◽  
Nam-Seok Joo ◽  
Kwang-Min Kim ◽  
Kyu-Nam Kim
Keyword(s):  
Irritable Bowel Syndrome ◽  
Statistical Significance ◽  
Information Service ◽  
Gastrointestinal Symptoms ◽  
Bacterial Overgrowth ◽  
Fecal Calprotectin ◽  
Beneficial Bacteria ◽  
Research Information ◽  
Fecal Microbiome ◽  
Irritable Bowel

Backgrounds. Recent studies suggest that diarrhea-predominant irritable bowel syndrome (IBS) is associated with intestinal bacterial microflora, colonic inflammation, and small intestinal bacterial overgrowth (SIBO). The purpose of this study was to evaluate the effect of a multistrain probiotic intake on these associated factors in patients with diarrhea-predominant IBS. Methods. The recruited volunteers were adults who were diagnosed with diarrhea-predominant IBS according to the Rome III criteria. After 8 weeks of probiotic ingestion, changes in gastrointestinal symptoms, fecal microbiome, SIBO, and fecal calprotectin were determined. Results. There was an increase in beneficial bacteria (41.2 ± 16.8% vs. 53.7 ± 15.3%, P=0.018) and a decrease in harmful bacteria (13.0 ± 13.9% vs. 4.7 ± 4.0%, P=0.010) in the microbial stool analysis. The SIBO prevalence also decreased at the end of treatment. However, the average levels of fecal calprotectin showed a decreasing tendency, without reaching statistical significance (364.4 ± 729.1 mg/kg vs. 200.9 ± 347.6 mg/kg, P=0.375). Conclusion. Treatment with a multistrain probiotic for 8 weeks led to significant increases in beneficial bacteria in the gut as well as the improvement of gastrointestinal symptoms. This study is registered at the Clinical Research Information Service (KCT0002906).

scholarly journals ANALYSIS OF LACTOSE INTOLERANCE IN STUDENTS WITH SUGGESTIVE SYMPTOMS OF IRRITABLE BOWEL SYNDROME

2019 ◽  
Vol 56 (3) ◽  
pp. 304-311
Author(s):  
Cleise de Jesus SILVA ◽  
Ingrid Dantas Sampaio LEITE ◽  
José Weberton RODRIGUES ◽  
Samara Pereira de ALMEIDA ◽  
Bruna Pessoa NÓBREGA ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Irritable Bowel Syndrome ◽  
Breath Test ◽  
Gastrointestinal Symptom ◽  
Lactose Intolerance ◽  
Gastrointestinal Symptoms ◽  
Bacterial Overgrowth ◽  
Irritable Bowel ◽  
Carbohydrate Intolerance

ABSTRACT BACKGROUND: Irritable bowel syndrome is a clinical condition presenting pain, distension and abdominal fullness, diarrhea, constipation, and other symptoms. It generates significant impacts on the quality of life of those affected. The pathophysiology is uncertain, but the role of various food types has been established in bowel sensitivity and its clinical manifestations. Carbohydrate intolerance, particularly to lactose, generates similar and sometimes indistinguishable symptoms from irritable bowel syndrome, and in clinical practice is both a frequent and underdiagnosed condition. Carbohydrate intolerance is related to enzymatic deficiencies, alterations of intestinal microbiota and even genetic change. The principal test for a diagnosis of lactose intolerance is the breath test, which measures hydrogen emission (produced only by bacteria), after ingestion of the corresponding substrate. OBJECTIVE: The present work aims to verify the prevalence of lactose intolerance in university students, presenting gastrointestinal symptoms suggestive of irritable bowel syndrome. METHODS: In a transversal study, to screen for those with suggestive symptoms, 124 medicine students participated by responding to a form. Those with abdominal pain were referred for anti-parasite treatment in order to exclude intestinal parasites as a secondary cause. Subsequently, using the hydrogen breath test, bacterial overgrowth was investigated, and if negative, lactose intolerance testing would be performed. Patients presenting high hydrogen concentrations of ≥20 ppm above the basal level were considered lactose intolerant. RESULTS: Of the total of students researched (n=124), 7 were excluded because they did not completing all study phases. From those 117 individuals effectively included in the survey; 8 (6.8%) were diagnosed with lactose intolerance and 2 (1.7%) with bacterial overgrowth. Intolerance was more frequent in; female individuals (75%), age range 18 to 25 years (62.5%), being colored (50%), and in their 5th semester of studies (37.5%). The presence of at least one gastrointestinal symptom among those presenting intolerance (100%), and those not presenting intolerance (42.2%) was found (P=0.002). In addition to abdominal pain (100%) (P<0.001), the most recurrent gastrointestinal symptom in the lactose intolerant students was the distension/flatulence (62.5%) (P=0.026). In relation to life habits and food patterns, there was no statistical difference between lactose tolerant and intolerant individuals, or for symptom frequencies. The more advanced students, completing more periods towards graduation, demonstrated more occurrences of gastrointestinal symptoms, yet without presenting significant statistical discrepancies. CONCLUSION: In view of the test sample quantity (n=21), a high prevalence of lactose intolerance (6.8%) in the academic environment, with epidemiological characteristics compatible to those found the literature is demonstrated, generating knowledge with understanding to prevent, diagnose, alleviate and treat lactose intolerant university students, and generate positive impacts towards well-being, improving the quality of life of these individuals.

Avaliação do Uso do Lactobacillus reuteri em Pacientes Portadores da Síndrome de Supercrescimento Bacteriano Diagnosticados por Teste Respiratório / Evaluation of the Use of Lactobacillus reuteri in Patients with Bacterial Overgrowth Syndrome Diagnosed

1970 ◽  
Vol 3 (2) ◽  
pp. 5-17
Author(s):  
Juliana Totti De Souza ◽  
Jussara Coelho Rosa ◽  
Thalita Amaral Amaro Adami
Keyword(s):  
Irritable Bowel Syndrome ◽  
Breath Test ◽  
Lactobacillus Reuteri ◽  
Gastrointestinal Symptoms ◽  
Bacterial Overgrowth ◽  
Small Intestinal Bacterial Overgrowth ◽  
Test Methods ◽  
Overgrowth Syndrome ◽  
Abdominal Symptoms ◽  
Irritable Bowel

Objetivo: Avaliar a ação de probiótico constituído pelo Lactobacillus reuteri em pacientes selecionados como portadores da síndrome do supercrescimento bacteriano do intestino delgado (SSCBID), através do teste respiratório da lactulose. Métodos: Foram incluídos 21 pacientes que apresentavam sintomas gastrointestinais inespecíficos, mas sugestivos de SSCBID. Foram selecionados através do questionário específico, para serem submetidos ao teste respiratório para lactulose. Os indivíduos com teste positivo foram convocados para iniciarem tratamento com probiótico composto por 100.000.000 UFC de Lactobacillus reuteri por quatro semanas e posterior reavaliação dos sintomas. Resultados: O resultado do teste respiratório foi positivo em 13 (61,90%) participantes (p=0,0391). A principal queixa foi a dor e/ou desconforto abdominal, com 46,15% (6/13) dos casos. A síndrome do intestino irritável representou o diagnóstico prévio de 30,77% (4/13) dos casos. 9 dos 13 pacientes tratados (69,23%) obtiveram melhora do quadro clínico inicial com o uso do probiótico. Conclusão: As evidências indicam que novos estudos devem ser realizados sobre os probióticos, para que sua aplicação clínica na síndrome do supercrescimento bacteriano seja definida. Neste estudo, o probiótico reduziu a sintomatologia abdominal em pacientes com SSCBID, com impacto na qualidade de vida destes indivíduos.  Palavras chave: supercrescimento bacteriano, teste respiratório, síndrome do intestino irritável, probióticos.   ABSTRACT Objective: To assess the efficacy of probiotic Lactobacillus reuteri made by patients selected as having syndrome of small intestinal bacterial overgrowth (SSCBID) through the lactulose breath test. Methods: We included 21 patients who had nonspecific gastrointestinal symptoms, but suggestive of SSCBID, who were selected through specific questionnaire to be submitted to the breath test lactulose. Individuals with a positive test were called for starting treatment with probiotic composed of Lactobacillus reuteri UFC 100 million for four weeks and subsequent reassessment of symptoms. Results: The results of the breath test was positive in 13 (61.90%) participants (p=0.0391). The main complaint was pain and/or abdominal discomfort, with 46.15% (6/13) of cases. The irritable bowel syndrome represented the previous diagnosis of 30.77% (4/13) of cases. Nine out of the 13 patients (69.23%) had clinical improvement starting with the use of probiotics. Conclusion: Evidence indicates that further studies should be conducted on probiotics, so its clinical application in bacterial overgrowth syndrome is defined. In this study, the probiotic reduced abdominal symptoms in patients with SSCBID, with impact on the quality of life of these individuals.  Keywords: bacterial overgrowth, breath test, irritable bowel syndrome, probiotics.

scholarly journals Association of Habitual Dietary Fiber Intake and Fecal Microbiome Gene Abundance with Gastrointestinal Symptoms in an Irritable Bowel Syndrome Cohort

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 1581-1581
Author(s):  
Nicole Roy ◽  
Phoebe Heenan ◽  
Catherine Wall ◽  
Wayne Young ◽  
Caterina Carco ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Dietary Fibre ◽  
Functional Gastrointestinal Disorders ◽  
Daily Intake ◽  
Gastrointestinal Symptoms ◽  
Anxiety And Depression ◽  
Fecal Microbiome ◽  
Fibre Intake ◽  
Gi Symptoms ◽  
Irritable Bowel

Abstract Objectives Dietary fibre supplementation is recognised as important for functional gastrointestinal disorders (FGID). The exact role of the microbiome in this relationship remains unclear. We explored differences in dietary fibre intake, GI symptoms and the fecal microbiome in those with FGID. Methods The COMFORT cohort is an observational case control study examining FGID, particularly irritable bowel syndrome (IBS) aetiology (Ethics 16/NTA/21). Participants prospectively completed a food and GI symptoms diary over 3 days. Severity of GI symptoms and mood disorders were assessed using clinical questionnaires; SAGIS and PROMIS for GI symptoms and HADS for anxiety and depression. Fecal samples were analysed by shotgun sequencing; 95 healthy controls (HC), 22 constipation IBS (IBS-C) and 50 diarrhea IBS (IBS-D). Taxonomic classifications were assigned by aligning sequences against the NCBI non-redundant database using DIAMOND. Results Diet diaries were completed by 292 participants (176 cases, 71.2% female). Average daily fibre intake was higher in HC compared to FGID (23.99g, 95% CI = –2.06-0.55; 20.28g, 95% CI = -1.96-0.45; P &lt; 0.05). Low fibre daily intake (&lt; 15g) was associated with higher depression scores (P &lt; 0.05) and increased anxiety in those with functional diarrhea (r2 = -0.554, P = 0.03). A negative association between fibre consumption and increased bloating in IBS (r2 = -0.19, P = 0.04) was also found. The GI microbiome in IBS was characterised by differences in Firmicutes belonging to the Lachnospiraceae family (e.g., Blautia and Ruminococcus, P &lt; 0.05). Other differentiating taxa included Bilophila (higher in IBS-D) and Methanobrevibacter (lower in IBS-D) (P &lt; 0.05). At the phylum level, bloating and constipation were correlated with Firmicutes relative abundance, and negatively correlated with Bacteroides (canonical r &gt; |0.5|). At the genus level, Blautia were correlated with diarrhea and faecal incontinence (canonical r &gt; 0.5). Conclusions Higher fibre consumption was associated with decreased bloating, anxiety and depression in different FGID subgroups. IBS was also associated with altered fecal microbiome composition including some taxa linked to carbohydrate and hydrogen metabolism. Funding Sources Funded by the Ministry of Business, Innovation and Employment through the High-Value Nutrition National Science Challenge.

scholarly journals Effect of Rice, Wheat, and Mung Bean Ingestion on Intestinal Gas Production and Postprandial Gastrointestinal Symptoms in Non-Constipation Irritable Bowel Syndrome Patients

Nutrients ◽  
2019 ◽  
Vol 11 (9) ◽  
pp. 2061 ◽  
Author(s):  
Sittikorn Linlawan ◽  
Tanisa Patcharatrakul ◽  
Nicha Somlaw ◽  
Sutep Gonlachanvit
Keyword(s):  
Irritable Bowel Syndrome ◽  
Mung Bean ◽  
Statistical Significance ◽  
Gastrointestinal Symptoms ◽  
Gas Production ◽  
Intestinal Gas ◽  
Gi Symptoms ◽  
Ch4 Concentration ◽  
Irritable Bowel

The aim of this study is to evaluate the effect of rice, mung bean, and wheat noodle ingestion on intestinal gas production and postprandial gastrointestinal (GI) symptoms in non-constipation irritable bowel syndrome (IBS) patients. Methods: Twenty patients (13 F, 46 ± 11 y) underwent 8 h breath test studies and GI symptom evaluations after standard rice, wheat, or mung bean noodle meals at 8:00 a.m. in a randomized crossover study with a 1-week washout period. The same meal was ingested at 12:00 p.m. Results: The H2 and CH4 concentration in the breath samples were similar at baseline (rice:wheat:mung bean, H2 = 3.6 ± 0.5:4.1 ± 0.5:4.0 ± 0.7 ppm, CH4 = 1.3 ± 0.3:2.1 ± 0.4:1.9 ± 0.4 ppm, p > 0.05). Beginning at the fifth hour after breakfast, H2 and CH4 concentrations significantly increased after wheat compared to rice and mung bean (8 h AUC H2 = 4120 ± 2622:2267 ± 1780:2356 ± 1722, AUC CH4 = 1617 ± 1127:946 ± 664:943 ± 584 ppm-min, respectively) (p < 0.05). Bloating and satiety scores significantly increased after wheat compared to rice (p < 0.05), and increased but did not reach statistical significance compared to mung bean (p > 0.05). A higher bloating score after wheat compared to rice and mung bean was observed clearly after lunch but not after breakfast. Conclusion: Wheat ingestion produced more intestinal gas and more bloating and satiety scores compared to rice and mung bean, especially after lunch. This provides insight into the role of intestinal gas in the development of bloating symptoms in IBS.

scholarly journals Digestive symptoms in daily life of chronic adrenal insufficiency patients are similar to irritable bowel syndrome symptoms

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
L. Quénéhervé ◽  
D. Drui ◽  
J. Blin ◽  
M. Péré ◽  
E. Coron ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Irritable Bowel Syndrome ◽  
Adrenal Insufficiency ◽  
Gastrointestinal Symptoms ◽  
Control Group ◽  
Non Profit ◽  
Acute Adrenal Insufficiency ◽  
Irritable Bowel ◽  
Rome Iv

AbstractGastrointestinal symptoms are frequent in acute adrenal insufficiency. Although digestive symptoms can significantly reduce quality of life, they are rarely described in patients with treated chronic adrenal insufficiency (CAI). We aimed to characterize digestive symptoms in CAI patients. We used the section pertaining functional bowel disorders of the Rome IV questionnaire. A questionnaire was published on the website of the non-profit patient association “Adrenals” (NPPA of CAI patients) for five months. Information on demographics, characteristics of adrenal insufficiency, digestive symptoms and quality of life was collected. The relatives of CAI patients served as a control group. We analyzed responses of 33 control subjects and 119 patients (68 primary adrenal insufficiency (PAI), 30 secondary adrenal insufficiency (SAI) and 21 congenital adrenal hyperplasia (CAH)). Abdominal pain at least once a week over the past 3 months was reported by 40%, 47% and 33% of patients with PAI, SAI and CAH respectively versus 15% for the controls (p = 0.01). Symptoms were consistent with the Rome IV criteria for irritable bowel syndrome in 27%, 33% and 33% of patients respectively versus 6% for the controls (p < 0.0001). Quality of life was described as poor or very poor in 35%, 57% and 24% of patients respectively versus 5% for the controls (p < 0.0001). In conclusion, digestive symptoms are frequent and incapacitating in CAI patients and similar to symptoms of irritable bowel syndrome in 30% of CAI patients. Assessment and management of digestive symptoms should be considered a priority for physicians treating patients with CAI.

scholarly journals Irritable bowel syndrome in midlife women: a narrative review

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Pei-Lin Yang ◽  
Margaret M. Heitkemper ◽  
Kendra J. Kamp
Keyword(s):  
Irritable Bowel Syndrome ◽  
Management Strategies ◽  
Gastrointestinal Symptoms ◽  
Midlife Women ◽  
Pelvic Surgery ◽  
Poor Sleep ◽  
Hormonal Changes ◽  
Seek Health Care ◽  
Multiple Challenges ◽  
Irritable Bowel

AbstractMidlife women between the ages of 40 and 65 years have reported multiple challenges due to menopausal, developmental, and situational transitions from younger to older adulthood. During the midlife period, many women seek health care for gastrointestinal symptoms and irritable bowel syndrome (IBS). Multiple factors including stress, poor sleep, diet, and physical inactivity may contribute to IBS or gastrointestinal symptoms in midlife women. As such, a comprehensive assessment and treatment approach is needed for midlife women suffering gastrointestinal symptoms. This article reviews the main aspects of the menopausal transition, sex hormonal changes, abdominal and pelvic surgery, psychosocial distress, behavioral factors, and gut microbiome, as well as their relevance on IBS and gastrointestinal symptoms in midlife women. Also, management strategies for IBS in midlife women are discussed. To date, gastrointestinal symptoms during midlife years remain a critical area of women’s health. Additional research is needed to better understand the contributors to gastrointestinal symptoms in this group. Such efforts may provide a new window to refine or develop treatments of gastrointestinal symptoms for midlife women.

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