scholarly journals Platelet Distribution Width at First Day of Hospital Admission in Patients with Hemorrhagic Fever with Renal Syndrome Caused by Hantaan Virus May Predict Disease Severity and Critical Patients’ Survival

2018 ◽  
Vol 2018 ◽  
pp. 1-8 ◽  
Author(s):  
Xiude Fan ◽  
Zitong Liu ◽  
Shiqi Fu ◽  
Jiao Sang ◽  
Huan Deng ◽  
...  
Keyword(s):  
Disease Severity ◽  
Characteristic Curve ◽  
Hemorrhagic Fever ◽  
Hantaan Virus ◽  
Platelet Distribution Width ◽  
Distribution Width ◽  
Large Patient ◽  
Large Patient Population ◽  
Critical Patients ◽  
A Prospective Study

Thrombocytopenia is one of the main characteristics of hemorrhagic fever with renal syndrome (HFRS). This study aimed to evaluate the associations of platelet distribution width (PDW) with the disease severity and critical patients’ survival of HFRS. The demographics, clinical data, and white blood cell and platelet parameters including PDW in 260 patients hospitalized for HFRS were analyzed. The results showed that PDW on the first day (PDW1) was positively associated with the disease severity (p=0.005). Multiple regression analysis showed that in addition to age (odds ratio [OR], 1.091; 95% confidence interval [CI], 1.015–1.172) and occurrence of sepsis (OR, 22.283; 95% CI, 2.985–166.325), PDW1 (OR, 0.782; 95% CI, 0.617–0.992) was a risk factor of the mortality, having an area under the receiver operating characteristic curve of 0.709 (95% CI, 0.572–0.846, p=0.013) for predicting mortality, with a sensitivity of 70% and a specificity of 67% at a cutoff of 16.5 fL, in patients with critical HFRS. These results suggest the potential of PDW at the first day of hospitalization as a valuable parameter for evaluating the severity of HFRS and a moderate parameter for predicting the prognosis of critical HFRS patients. A prospective study in large patient population is needed to validate these findings.

Evaluation of Platelet Activity Markers in Prognostic Value of Children with Crimean-Congo Hemorrhagic Fever

2020 ◽  
Vol 15 (03) ◽  
pp. 123-128
Author(s):  
Ahmet Sami Güven ◽  
Fatma Duksal ◽  
Özge Metin Akcan ◽  
Utku Aygüneş ◽  
Mehmet Burhan Oflaz
Keyword(s):  
Disease Severity ◽  
Prognostic Value ◽  
Severe Disease ◽  
Multivariate Logistic Regression Analysis ◽  
Prognostic Index ◽  
Hemorrhagic Fever ◽  
Healthy Children ◽  
Distribution Width ◽  
Crimean Congo Hemorrhagic Fever ◽  
Significant Difference

Abstract Objective The aim of this study is to investigate the prognostic value of platelet (PLT) activity markers in children with Crimean-Congo hemorrhagic fever (CCHF) and compare results with healthy controls. Materials and Methods A total of 135 patients with CCHF and 100 healthy children were included in this retrospective study. Mean age was 12.4 ± 3.3 years in CCHF group, and 92 patients were male. We measured PLT count, mean platelet volume (MPV), platelet distribution width (PDW), and mean platelet mass (MPM) as PLT activity markers. Results A statistically significant decrease in MPM and PLT, and significantly higher levels of PDW and activated partial thromboplastin time (aPTT) and no significant difference in MPV were observed in patients with CCHF compared with controls. Although there were no significant differences between the severe and nonsevere CCHF groups in term of MPV and PDW, the MPM value was significantly decreased in severe patients (p < 0.001). Furthermore, MPM values were inversely correlated with aPTT (r = −0.617, p = 0.015), and positively correlated with PLT (r = 0.703, p < 0.001) which are considered likely to be indicators of disease severity. Multivariate logistic regression analysis revealed MPM as an independent risk factor for severe disease. Conclusion Our study demonstrated that MPM values were decreased in severe cases compared with nonsevere in children with CCHF. The MPM as an indicator of PLT activation at the time of diagnosis in children with CCHF can be used as a prognostic index for disease severity.

scholarly journals Hantaan Virus RNA Load in Patients Having Hemorrhagic Fever With Renal Syndrome: Correlation With Disease Severity

2012 ◽  
Vol 207 (9) ◽  
pp. 1457-1461 ◽  
Author(s):  
Jing Yi ◽  
Zhuwei Xu ◽  
Ran Zhuang ◽  
Jiuping Wang ◽  
Yusi Zhang ◽  
...  
Keyword(s):  
Disease Severity ◽  
Hemorrhagic Fever ◽  
Hantaan Virus ◽  
Virus Rna

Prognostic impact of platelet distribution width in patients with Crimean-Congo hemorrhagic fever

2016 ◽  
Vol 88 (11) ◽  
pp. 1862-1866 ◽  
Author(s):  
Hülya Yilmaz ◽  
Gürdal Yilmaz ◽  
Ahmet Menteşe ◽  
Uğur Kostakoğlu ◽  
Süleyman Caner Karahan ◽  
...  
Keyword(s):  
Hemorrhagic Fever ◽  
Prognostic Impact ◽  
Platelet Distribution Width ◽  
Distribution Width ◽  
Crimean Congo Hemorrhagic Fever

scholarly journals The Presence of Circulating Nucleated Red Blood Cells Is Associated With Disease Severity in Patients of Hemorrhagic Fever With Renal Syndrome

2021 ◽  
Vol 8 ◽  
Author(s):  
Jingang Zhang ◽  
Kang Tang ◽  
Yun Zhang ◽  
Ying Ma ◽  
Chunmei Zhang ◽  
...  
Keyword(s):  
Red Blood Cells ◽  
Disease Severity ◽  
Peripheral Blood ◽  
Blood Cells ◽  
Expression Profiles ◽  
Hemorrhagic Fever ◽  
Hantaan Virus ◽  
Pathological Changes ◽  
Hematological Indices ◽  
Nucleated Red Blood Cells

Hemorrhagic fever with renal syndrome (HFRS) is a regional infectious disease of epidemic potential caused by the Hantaan virus (HTNV). Red blood cells (RBCs) are the major components of peripheral blood. However, pathological changes in RBCs and the underlying mechanisms during HTNV infection remain largely unclear. Therefore, this study sought to explore changes in RBCs in the peripheral blood of HFRS patients. We isolated PBMCs from HFRS patients and performed single-cell RNA sequencing. The results showed that clusters of RBCs in the peripheral blood of HFRS could be classified as nucleated red blood cells (NRBC) based on their cellular components, gene expression profiles and cell surface markers. In addition, it was shown that the higher the count of NRBC in peripheral blood, the more severe the disease status was. Moreover, hematological indices related to RBCs were analyzed and the results showed that impairment in the folate pathway might be the possible reason behind the presence of NRBCs. This study, for the first time showed that the presence of NRBCs in the peripheral blood of HFRS patients was associated with disease severity. This was also the first study to show that infection with the HTNV virus hindered the maturation of RBCs. Therefore, this work provides further insights on the role of and pathological changes in RBCs during HTNV infection.

Relationship between polycystic ovary syndrome and platelet distribution width

2015 ◽  
Author(s):  
Ozgur Yilmaz ◽  
Muzaffer Temur ◽  
Mehmet Calan ◽  
Elif Pelin Ozun Ozbay ◽  
Murat Karakulak ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Platelet Distribution Width ◽  
Ovary Syndrome ◽  
Distribution Width

Platelet distribution width in young patients with chronic venous insufficiency

Vascular ◽  
2021 ◽  
pp. 170853812110296
Author(s):  
Mustafa Aldemir ◽  
Ahmet Yuksel ◽  
Mehmet Inanir ◽  
Salih Metin ◽  
Yusuf Velioglu ◽  
...  
Keyword(s):  
Lower Extremity ◽  
Clinical Features ◽  
Chronic Venous Insufficiency ◽  
Venous Insufficiency ◽  
Young Patients ◽  
Control Group ◽  
Platelet Distribution Width ◽  
Distribution Width ◽  
Research Hospital ◽  
Lymphocyte Ratio

Objective Platelet distribution width (PDW) has been reported in a wide range of pathological settings. In this study, we aimed to investigate the relationship between PDW and lower extremity chronic venous insufficiency (CVI) by comparing the levels of PDW and other parameters derived from complete blood count (CBC) tests in young individuals with or without lower extremity CVI. Methods This prospective clinical study was conducted between January 2020 and December 2020. A total of 108 patients, 72 patients with lower extremity CVI (study group) and 36 healthy volunteers (control group) were enrolled from the Bursa Yuksek Ihtısas Educatıon Research Hospıtal and the Bolu Abant Izzet Baysal University Training and Research Hospital. The age range of the participants was between 18 and 50 years old. Participants’ baseline clinical features and CBC parameters including PDW, white blood cell, hemoglobin, hematocrit, mean corpuscular volume, red cell distribution width, neutrophil, lymphocyte, platelet count, mean platelet volume, plateletcrit, neutrophil-to-lymphocyte ratio, and platelet-to-lymphocyte ratio were compared between the two groups. Results The groups were statistically similar in terms of baseline clinical features. The median PDW value was significantly higher for the CVI patients relative to the control group (17.6 vs 16.8; p < 0.001). In terms of other CBC parameters, there were no significant differences between the groups. According to ROC analysis, area under the curve of PDW was 0.749 (95% confidence interval: 0.653–0.846 and p < 0.001). If the value of PDW was accepted as 17, it could predict CVI with 76% sensitivity and 59% specificity, whereas a PDW value of 17.5 could predict CVI with 51% sensitivity and 81% specificity. Conclusion Platelet distribution width might be a useful marker to determine an increased inflammatory response and thrombotic status in young patients with CVI.

Sign in / Sign up

Export Citation Format

Share Document