scholarly journals Impact of Modality and Intensity of Early Exercise Training on Ventricular Remodeling after Myocardial Infarction

2020 ◽  
Vol 2020 ◽  
pp. 1-6
Author(s):  
Diego Fernando Batista ◽  
Bertha Furlan Polegato ◽  
Renata Candido da Silva ◽  
Renan Turini Claro ◽  
Paula Shmidt Azevedo ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Myocardial Infarction ◽  
Exercise Training ◽  
High Intensity ◽  
Interval Training ◽  
High Intensity Interval Training ◽  
Energetic Metabolism ◽  
Low Intensity ◽  
High Intensity Interval ◽  
Intensity Training

The objective of this study was to analyze the impact of different modalities and intensities of exercise training on cardiac remodeling started early after experimental myocardial infarction (MI). Male Wistar rats, weighing 200–250 g, were subjected to experimental MI. After 5 days, the animals were allocated into three experimental groups and observed for three months: S (sedentary control animals), C (animals subjected to continuous low-intensity training), and HIT (animals subjected to high-intensity interval training). Low-intensity exercise training was performed at a treadmill speed corresponding to 40% VO2 max, which was kept unchanged throughout the entire session (i.e., continuous low-intensity training). High-intensity interval training was performed in such a way that rats run during 3 min at 60% VO2 max, followed by 4-minute intervals at 85% VO2 max (i.e., high-intensity interval training). After the follow-up period, we studied hypertrophy and ventricular geometry, functional alterations in vivo and in vitro, oxidative stress, apoptosis, and cardiac energetic metabolism. Our data showed that both high-intensity interval and continuous low-intensity modalities improved cardiac energetic metabolism variables in comparison with sedentary infarcted animals. In addition, high-intensity interval training decreased cardiac oxidative stress, associated with improved diastolic function. On the other hand, the continuous low-intensity group showed impairment of cardiac function. Therefore, altogether, our data suggest that high-intensity interval training could be the best modality for early physical exercise after MI and should be better studied in this clinical scenario.

High intensity interval training reduces systemic inflammation in post-PCI patients

2011 ◽  
Vol 18 (6) ◽  
pp. 850-857 ◽  
Author(s):  
Peter Scott Munk ◽  
Unni Mathilde Breland ◽  
Pål Aukrust ◽  
Thor Ueland ◽  
Jan Terje Kvaløy ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Exercise Training ◽  
Stable Angina ◽  
High Intensity ◽  
Inflammatory Markers ◽  
Cell Activation ◽  
Interval Training ◽  
High Intensity Interval Training ◽  
Endothelial Cell Activation ◽  
High Intensity Interval

Background: Increased plasma levels of inflammatory markers and markers of endothelial cell activation have been associated with increased risk for cardiovascular events. Exercise training may lower the risk for coronary heart disease by attenuating inflammation and improving endothelial function. The objective of this study was to evaluate effects of regular high-intensity exercise training on a wide range of markers of inflammation and endothelial cell activation. Materials and methods: Consecutively, 40 patients were prospectively randomized to a 6 months supervised high-intensity interval training programme or to a control group following successful percutaneous coronary intervention (PCI). Blood samples of 36 patients with stable angina, drawn at baseline (before PCI) and at 6 months, were analysed. Late luminal loss was measured at 6 months using quantitative coronary angiography. Results: At 6 months, levels of the inflammatory markers interleukin (IL)-6 and IL-8 were reduced and levels of the anti-inflammatory cytokine IL-10 increased in the training group only. The decrease in IL-6 and C-reactive protein levels were significantly correlated with the decrease in luminal loss following PCI. In contrast to these anti-inflammatory effects, training had no effect on markers of platelet-mediated inflammation, and the effect of training on markers on endothelial cell activation were rather complex showing attenuating (von Willebrand factor) and enhancing (E-selectin and vascular cell adhesion molecule 1) effects. Conclusions: Regular exercise training in stable angina patients following PCI may attenuate some, but not all, inflammatory pathways, potentially contributing to the beneficial effects of exercise training on restenosis.

scholarly journals High-intensity interval training modulates retinal microvascular phenotype and DNA methylation of p66Shc gene: a randomized controlled trial (EXAMIN AGE)

2019 ◽  
Vol 41 (15) ◽  
pp. 1514-1519 ◽  
Author(s):  
Lukas Streese ◽  
Abdul Waheed Khan ◽  
Arne Deiseroth ◽  
Shafaat Hussain ◽  
Rosa Suades ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Gene Expression ◽  
Dna Methylation ◽  
High Intensity ◽  
Interval Training ◽  
Retinal Vessel ◽  
High Intensity Interval Training ◽  
Age Related ◽  
High Intensity Interval ◽  
Retinal Arteriolar

Abstract Aims Impairments of retinal vessel diameter are associated with major adverse cardiovascular (CV) events. Promoter DNA methylation is a repressor of the mitochondrial adaptor p66Shc gene transcription, a key driver of ageing-induced reactive oxygen species. The study aimed to investigate whether high-intensity interval training (HIIT) affects retinal microvascular phenotype as well as p66Shc expression and oxidative stress in ageing subjects with increased CV risk from the EXAMIN AGE cohort. Methods and results Eighty-four sedentary subjects (mean age 59.4 ± 7.0 years) with ≥2 CV risk factors were randomized into either a 12-week HIIT or standard physical activity recommendations. Retinal arteriolar and venular diameters were measured by use of a retinal vessel analyser. As a marker of oxidative stress plasma 3-nitrotyrosine (3-NT) level was determined by ELISA. Gene expression of p66Shc and DNA methylation were assessed in mononuclear cells by RT-qPCR and methylated-DNA capture (MethylMiner Enrichment Kit) coupled with qPCR, respectively. High-intensity interval training reduced body mass index, fat mass, low-density lipoprotein and increased muscle mass, as well as maximal oxygen uptake (VO2max). Moreover, HIIT restored microvascular phenotype by inducing retinal arteriolar widening (pre: 175 ± 14 µm vs. post: 181 ± 13 µm, P = 0.001) and venular narrowing (pre: 222 ± 14 µm vs. post: 220 ± 14 µm, P = 0.007). After HIIT, restoration of p66Shc promoter methylation (P = 0.034) reduced p66Shc gene expression (P = 0.037) and, in turn, blunted 3-NT plasma levels (P = 0.002). Conclusion High-intensity interval training rescues microvascular dysfunction in ageing subjects at increased CV risk. Exercise-induced reprogramming of DNA methylation of p66Shc gene may represent a putative mechanistic link whereby exercise protects against age-related oxidative stress. Clinical trial registration  ClinicalTrials.gov: NCT02796976 (https://clinicaltrials.gov/ct2/show/NCT02796976).

scholarly journals High-Intensity Interval Training in Cardiac Rehabilitation: Impact on Fat Mass in Patients With Myocardial Infarction

2019 ◽  
Vol 94 (9) ◽  
pp. 1718-1730 ◽  
Author(s):  
Yaoshan Dun ◽  
Randal J. Thomas ◽  
Jose R. Medina-Inojosa ◽  
Ray W. Squires ◽  
Hsuhang Huang ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Cardiac Rehabilitation ◽  
Fat Mass ◽  
High Intensity ◽  
Interval Training ◽  
High Intensity Interval Training ◽  
High Intensity Interval

scholarly journals Anthropometric, Cardiopulmonary and Metabolic Benefits of the High-Intensity Interval Training Versus Moderate, Low-Intensity or Control for Type 2 Diabetes: Systematic Review and Meta-Analysis

2019 ◽  
Vol 16 (22) ◽  
pp. 4524 ◽  
Author(s):  
Lora-Pozo ◽  
Lucena-Anton ◽  
Salazar ◽  
Galán-Mercant ◽  
Moral-Munoz
Keyword(s):  
Type 2 Diabetes ◽  
Body Mass Index ◽  
Body Mass ◽  
High Intensity ◽  
Meta Analysis ◽  
Interval Training ◽  
High Intensity Interval Training ◽  
High Intensity Interval ◽  
Intensity Training

Abstract: This study aims to evaluate the effectiveness of high-intensity interval training compared with no intervention and other types of training interventions for people with Type 2 Diabetes. A systematic review and meta-analysis of randomized controlled trials that used high-interval intensity training to improve anthropometric, cardiopulmonary and metabolic conditions were conducted. The search was performed during October–December 2017 using the databases PubMed, Web of Science and Physiotherapy Evidence Database (PEDro). The methodological quality of the studies was evaluated using the PEDro scale. A total of 10 articles were included in this meta-analysis. After statistical analysis, favorable results were obtained for high-Intensity Interval Training compared with control (non-intervention): [Weight: Standardized mean difference (SMD) = −2.09; confidence interval (CI) 95%: (−3.41; −0.78); body-mass index: SMD = −3.73; CI 95%: (−5.53; −1.93); systolic blood pressure: SMD = −4.55; CI 95%: (−8.44; −0.65); VO2max: SMD = 12.20; CI 95%: (0.26; 24.14); HbA1c: SMD = −3.72; CI 95%: (−7.34; −0.10)], moderate intensity continuous training: [body-mass index: SMD = −0.41; CI 95%: (−0.80; −0.03); VO2max: SMD = 1.91; CI 95%: (0.18; 3.64)], and low intensity training: [Weight: SMD = −2.06; CI 95%: (−2.80; −1.31); body-mass index: SMD = −3.04; CI 95%: (−5.16; −0.92); systolic blood pressure: SMD = −2.17; CI 95%: (−3.93; −0.41); HbA1c: SMD = −1.58; CI 95%: (−1.84; −1.33)]. The results show that high-intensity interval training can be a useful strategy in order to improve anthropometric, cardiopulmonary and metabolic parameters in people with Type 2 diabetes. Despite this, it could be essential to clarify and unify criteria in the intervention protocols, being necessary new lines of research.

High-intensity interval exercise induces 24-h energy expenditure similar to traditional endurance exercise despite reduced time commitment

2014 ◽  
Vol 39 (7) ◽  
pp. 845-848 ◽  
Author(s):  
Lauren E. Skelly ◽  
Patricia C. Andrews ◽  
Jenna B. Gillen ◽  
Brian J. Martin ◽  
Michael E. Percival ◽  
...  
Keyword(s):  
Oxygen Consumption ◽  
Energy Expenditure ◽  
High Intensity ◽  
Interval Training ◽  
Moderate Intensity ◽  
High Intensity Interval Training ◽  
Interval Exercise ◽  
Time Commitment ◽  
High Intensity Interval ◽  
Intensity Training

Subjects performed high-intensity interval training (HIIT) and continuous moderate-intensity training (END) to evaluate 24-h oxygen consumption. Oxygen consumption during HIIT was lower versus END; however, total oxygen consumption over 24 h was similar. These data demonstrate that HIIT and END induce similar 24-h energy expenditure, which may explain the comparable changes in body composition reported despite lower total training volume and time commitment.

scholarly journals Personalized Moderate-Intensity Exercise Training Combined with High-Intensity Interval Training Enhances Training Responsiveness

2019 ◽  
Vol 16 (12) ◽  
pp. 2088 ◽  
Author(s):  
Bryant R. Byrd ◽  
Jamie Keith ◽  
Shawn M. Keeling ◽  
Ryan M. Weatherwax ◽  
Paul B. Nolan ◽  
...  
Keyword(s):  
Resistance Training ◽  
Exercise Training ◽  
Training Program ◽  
High Intensity ◽  
Interval Training ◽  
Moderate Intensity ◽  
Z Score ◽  
High Intensity Interval Training ◽  
Resistance Training Program ◽  
High Intensity Interval

This study sought to determine if personalized moderate-intensity continuous exercise training (MICT) combined with high-intensity interval training (HIIT) was more effective at improving comprehensive training responsiveness than MICT alone. Apparently healthy, but physically inactive men and women (n = 54) were randomized to a non-exercise control group or one of two 13-week exercise training groups: (1) a personalized MICT + HIIT aerobic and resistance training program based on the American Council on Exercise guidelines, or (2) a standardized MICT aerobic and resistance training program designed according to current American College of Sports Medicine guidelines. Mean changes in maximal oxygen uptake (VO2max) and Metabolic (MetS) z-score in the personalized MICT + HIIT group were more favorable (p < 0.05) when compared to both the standardized MICT and control groups. Additionally, on the individual level, there were positive improvements in VO2max (Δ > 4.9%) and MetS z-score (Δ ≤ −0.48) in 100% (16/16) of participants in the personalized MICT + HIIT group. In the present study, a personalized exercise prescription combining MICT + HIIT in conjunction with resistance training elicited greater improvements in VO2max, MetS z-score reductions, and diminished inter-individual variation in VO2max and cardiometabolic training responses when compared to standardized MICT.

The effects of short-term high-intensity interval training vs. moderate-intensity continuous training on plasma levels of nesfatin-1 and inflammatory markers

2015 ◽  
Vol 21 (3) ◽  
Author(s):  
Sajad Ahmadizad ◽  
Alireza Salimi Avansar ◽  
Khosrow Ebrahim ◽  
Mohsen Avandi ◽  
Mansour Ghasemikaram
Keyword(s):  
Insulin Resistance ◽  
Exercise Training ◽  
Weight Management ◽  
High Intensity ◽  
Inflammatory Markers ◽  
Interval Training ◽  
Moderate Intensity ◽  
High Intensity Interval Training ◽  
Tnf Α ◽  
High Intensity Interval

AbstractExercise training is an effective method of weight management, and knowing about its influence on the hormones involved in the regulation of food intake and inflammation could be useful for body weight management. Therefore, the purpose of this study was to compare the effects of 6 weeks of high-intensity interval training (HIIT) and moderate-intensity continuous exercise training (MCT) on nesfatin-1, interleukin (IL)-6, and tumor necrosis factor alpha (TNF-α).Thirty sedentary overweight men (Mean±SD; age, 25±1 years) were divided into three (n=10) body mass index-matched groups. The participants in the training groups performed either HIIT or MCT protocols 3 days per week for 6 weeks followed by a week of detraining.Plasma IL-6 and TNF-α did not significantly change after training, but nesfatin increased significantly only with HIIT compared with the control group (p<0.05). In addition, fasting glucose, insulin, and homeostasis model estimated insulin resistance (HOMA-IR), decreased significantly following both HIIT and MCT training (p<0.05). After a detraining period, the plasma nesfatin-1 did not return to pre-training levels in the HIIT group.Both the HIIT and MCT groups had similar effects on inflammatory markers and insulin resistance in men who are overweight, but the HIIT seems to have better anorectic effects (as indicated by nesfatin) compared with MCT.

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