Efficacy of Bloodletting Therapy in Patients with Chronic Idiopathic Urticaria: A Randomized Control Trial

Objective. To assess the efficacy of bloodletting therapy (acupoint pricking and cupping) in patients with chronic idiopathic urticaria (CIU) in a randomized, control, parallel-group trial. Methods. A total of 174 patients with CIU enrolled from March 2018 to October 2019 were randomized into three groups: group A treated with bloodletting therapy and ebastine, group B treated with placebo treatment (acupoint pseudopricking and cupping) and ebastine, and group C treated with ebastine only. The intention-to-treat analysis was conducted, and the primary outcome was the effective rate of UAS7 score being reduced to 7 or below after treatment phase. Results. The effective rates at the end of treatment phase were different among the three groups ( P < 0.05 ), which were 73.7% in group A, 45.6% in group B, and 42.9% in group C. Multiple analysis indicated differences between groups A and B ( P < 0.0125 ) and groups A and C ( P < 0.0125 ) and no difference between groups B and C ( P > 0.0125 ). No severe bloodletting therapy-related adverse events were observed. Conclusions. In this study on patients with CIU, one month of bloodletting therapy combined with ebastine is clinically beneficial compared with placebo treatment combined with ebastine and treatment with ebastine only. Thus, bloodletting therapy can be an effective complementary treatment in CIU. This trial is registered with ChiCTR1800015294.

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Post-Operative Outcomes of Intravenous Lidocaine Infusion on Major Abdominal Surgery in Pediatric Patients: A Randomized Control Trial in a Tertiary Care Hospital

Journal of Shaheed Suhrawardy Medical College ◽

10.3329/jssmc.v10i1.38899 ◽

2018 ◽

Vol 10 (1) ◽

pp. 23-27

Author(s):

Nirupama Saha ◽

Nadiuzzaman Khan ◽

Mirza Kamrul Zahid ◽

Shah Alam Talukder ◽

ASM Meftahuzzaman

Keyword(s):

Abdominal Surgery ◽

Tertiary Care ◽

Major Abdominal Surgery ◽

P Value ◽

Care Hospital ◽

Intravenous Lidocaine ◽

Operative Outcomes ◽

Group A ◽

Randomized Control ◽

Group B

Background: Post-operative outcomes of a major abdominal surgery depend on careful & effective post-operative management. But it is a critical job especially in children. Obtaining adequate analgesia after major surgery is a problematic issue and postoperative pain still imposes a major burden of suffering in surgical patients.Objectives: The principle objectives of the study is to evaluate the effects of intravenous lidocaine infusion in pain management of pediatric population undergone in major abdominal surgery; to reduce post-operative morbidity & enhance better surgical outcome in children.Methodology: This is a randomized control trial carried out from January 2015-June2015,in a tertiary care hospital among 60 cases of 4 to 14 years children with major abdominal surgery without having any pulmonary, cardiac, hepatic or renal insufficiency. Grouping of patients that is lidocaine infusion group (Group A) and control group (Group B) was made among admitted cases for elective abdominal surgery by simple random technique by means of lottery. For assessment of postoperative pain FLACC Scale was used in both groups. Clinical examination findings & specifically designed data collection sheet with a set questionnaire were used as research instruments. Formulated data was analyzed by SPSS version 17, taking p value <0.05 as significant.Results: It is noted that, after 24 hours of operation most of the patients 56.7% of group A had mild pain whereas 90% patients of group B had moderate pain (p<0.001)& during that time there was no patient with severe pain in group A whereas in group B 10% patients were with severe pain. At 48 hours, pain was absent in 13.3% children of group A and 6.7% in group B. In group A most of the children 76.7%had mild pain compared to moderate pain 18 (60%) in group B children at that hours (P<0.001). Again, regarding required amount of analgesics, patients received I/V lidocaine required less amount of analgesics than its counterpart. In present study, complications was noted only 3.3% patien in group A, where as in the opposite group it was found in 23.3% & p was <0.05. In group A, in 50% patients post operative bowel sound was returned within 72 hours, compared to 73.3% patients in group B. The p value was 0.001. About post-operative hospital stay, 83.3% children of the group A were released from hospital after 5th P.O.D whereas, in group B, only 50% children were released after 7th P.O.D of operation. The P value was 0.03 that is also significant.Conclusion: Intravenous lidocaine could improve immediate and late post-operative pain with early recovery after major abdominal surgery in children & it can contribute to rapid postoperative rehabilitation programs.J Shaheed Suhrawardy Med Coll, June 2018, Vol.10(1); 23-27

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A CLINICO-COMPARATIVE STUDY ON THE EFFECT OF LASHUNA SIDDHA TAILPANA POORVAK VAMANA KARMA AND NITYA VIRECHANA BY GOMUTRA HARITAKI IN THE MANAGEMENT OF HYPOTHYROIDISM

International Journal of Research in Ayurveda and Pharmacy ◽

10.7897/2277-4343.1204105 ◽

2021 ◽

Vol 12 (4) ◽

pp. 49-55

Author(s):

Sheetal R Tokle

Keyword(s):

Comparative Study ◽

Thyroid Stimulating Hormone ◽

Normal Range ◽

End Of Treatment ◽

Group A ◽

Insignificant Difference ◽

Randomized Control ◽

Drug Dependent ◽

Group B ◽

Stimulating Hormone

Hypothyroidism is a condition in which thyroid gland doesn’t produce enough thyroid hormone. This is more prevalent among women. Management through levothyroxine is safe & may bring the value of Thyroid stimulating hormone and thyroxine to normal range but the increased dosage and continuous medication are cost expensive and make the patient into drug dependent till the end of mortal life. So, better, therapy is needed for the society through the heritage of Ayurveda especially with Shodhana therapy. Aim of Clinico-comparative study was to evaluate and compare the efficacy of Lashuna siddha Tailpana Poorvak Vamana Karma and Nityavirechana by Gomutra Haritaki in the management of Hypothyroidism. Study was conducted at Govt. Akhandanada Ayurvedic hospital, Ahmedabad, Gujarat. This study was Open labelled parallel randomized control trial. 15 patients were treated with Lashuna siddha Tailpana Poorvak Vamana Karma in group A. 15 patients was treated with Nitya Virechana by Gomutra Haritaki in group B. Washout period was 14 days. Triiodothyronine and thyroxine were compared at the end of treatment by paired t-test and Mann Whitney-U test. Lashuna siddha Tailpana Poorvak Vamana Karma was more beneficial than Nitya Virechana by Gomutra Haritaki. Insignificant difference was found on subjective and objective parameters (Weight gain, Basal metabolic rate, Serum triiodothyronine) but significance difference found on objective parameters (Thyroid stimulating hormone, Serum thyroxine).

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Manual Vacuum Aspiration (M.V.A) Versus Conventional Evacuation and Curettage in Early Pregnancy Loss

10.53350/pjmhs211582213 ◽

2021 ◽

Vol 15 (8) ◽

pp. 2213-2215

Author(s):

Uzma Shaheen ◽

Sumaira Yasmin ◽

Nazia Liaqat ◽

Sonia Rafique

Keyword(s):

Early Pregnancy ◽

Gestational Age ◽

Pregnancy Loss ◽

Cervical Ripening ◽

Early Pregnancy Loss ◽

Vacuum Aspiration ◽

Manual Vacuum Aspiration ◽

Group A ◽

Randomized Control ◽

Group B

Objective: The aim of this study is to compare the efficacy of manual vacuum aspiration and conventional evacuation and curettage in early pregnancy loss Study Design: Randomized control trial Place and Duration: Study was conducted at department of obstetrics and gynecology Lady Reading Hospital Peshawar from 1st January 2019 to 31st August 2020. Methods Patients were early pregnancy loss (12 weeks or lesser gestational age) were enrolled. Patients were divided into two groups by lottery method. Group A were the patients who had conventional evacuation and curettage treatment. Group B were patient in which MVA was used. Patients’ demographics were recorded after taking written consent. Gestational age was calculated from first day of last menstrual cycle and by ultrasound. Cervical ripening was done by (misoprostol 400mcg) two hours before procedure. Procedure was carried out under aseptic measures. Complete uterine evacuation by either procedure was assessed by ultrasound after procedure and complications were noted. Data was analyzed by SPSS 24.0. Results: mean age in Group A was 29 years with SD ± 8.65 while mean age in Group B mean age was 30 years with SD ±7.62. Group B (Manual Vacuum Aspiration) was effective in 96% patients while Group A(Conventional Evacuation and Curettage) was effective in 89% patients. Complications were fewer in MVA as compared to conventional evacuation and curettage Keywords: MVA, Evacuation and curettage , Early pregnancy loss.

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Application of Peppermint Water Spray Combined With Cucumber Slice External Application or Lip Balm and Conventional Dipping in ICU Dry Mouth Patients

Tobacco Regulatory Science ◽

10.18001/trs.7.5.61 ◽

2021 ◽

Vol 7 (5) ◽

pp. 1428-1434

Author(s):

Yang Gao ◽

Liang Li ◽

Qingyun Peng ◽

Yahui Yang ◽

Huifen Xu ◽

...

Keyword(s):

Effective Rate ◽

Salivary Secretion ◽

The Self ◽

Dry Mouth ◽

Water Spray ◽

External Application ◽

Self Evaluation ◽

Evaluation Scores ◽

Group A ◽

Group B

to analyze the effect of peppermint water spray combined with external application of cucumber slice or lip balm and conventional dipping in patients with dry mouth in intensive care unit (ICU). Methods: 120 patients with secondary xerostomia in our hospital from January 2018 to December 2019 were selected as the subjects. According to the different treatment methods, the patients were divided into A group (Peppermint water spray combined with cucumber slices for external application), group B (Peppermint water spray combined with lip gloss smear), group C (cotton swab dipped in normal saline), 40 cases in each group, and the saliva secretion and dry mouth before and after intervention in three groups were compared between the three groups. The degree of self-evaluation score and the evaluation of throat comfort and satisfaction after intervention. Results: after the intervention, the self-evaluation scores of salivary secretion and dry mouth degree of patients in group A and B were significantly higher than those before the intervention (P < 0.01), the self-evaluation scores of salivary secretion and dry mouth degree of patients in group A were significantly higher than those in group B and C (P < 0.01), and the self-evaluation scores of salivary secretion and dry mouth degree of patients in group B were significantly higher than those in group C (P < 0.01). After intervention, the total effective rate of improvement of throat comfort in group A was 87.50%, which was significantly higher than 40.00% in group B and 0.00% in group C (P < 0.01). The total effective rate of improvement of throat comfort in group B was significantly higher than that in group C (P < 0.01). 97.50% of the patients in group A were significantly higher than 72.50% in group B and 2.50% in group C (P < 0.01), and the patients in group B were significantly higher than those in group C (P < 0.01). Conclusion: homemade peppermint water spray combined with external application of cucumber spray can effectively improve the symptoms of dry mouth and throat discomfort in patients with ICU, improve their satisfaction with treatment, and is conducive to the recovery of patients’ diseases, which is worthy of clinical promotion and application.

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Efficacy of Tamsulosin in the Medical Management of Juxtavesical Ureteral Stones: A Randomized Control Trial

Bangladesh Medical Research Council Bulletin ◽

10.3329/bmrcb.v42i2.32051 ◽

2017 ◽

Vol 42 (2) ◽

pp. 78-83 ◽

Cited By ~ 1

Author(s):

Abu Sayeed Md. Feroz Mustafa ◽

Md. Saiful Islam ◽

Abdullah Al Mamun ◽

Muhammad Syeef Khalid

Keyword(s):

Urinary Tract Infection ◽

Urinary Tract ◽

Tract Infection ◽

Randomized Control Trial ◽

Dose Titration ◽

Ureteral Stones ◽

Common Disease ◽

Group A ◽

Randomized Control ◽

Group B

Urolithiasis is the third most common disease of the urinary tract. Among all urinary tract stones, majorities are ureteral stones located in the distal part of the ureters. At present, multimodalities of treatment are available to the urologists. The purpose of the present study was to observe the efficacy of Tamsulosin in conventional treatment of juxtavesical ureteric stone having size up to 8 mm. This was a single centered, parallel randomized control trial carried out in the outpatient department of Urology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka from July 2007 to June 2008. The patients with unilateral, juxtavesical ureteral stone with normal functioning kidney and absence of clinical and laboratory signs of urinary tract infection and stone size up to 8 mm were included in the study. Patients were divided into two groups according to the computer generated simple random sampling. Patients of Group-A were given conventional hydrotherapy treatment and patients of Group-B were given Tamsulosin 0.4mg/day along with the conventional hydrotherapy. Each patient was followed-up weekly until stone expulsion for 4 weeks. In Group-A and Group-B, the mean age with SD was 38.55±10.05 and 37.7±9.33 years. Expulsion occurred in 32 (53.33%) of 60 patients in Group-A and 51 (85%) of 60 patients in Group-B (p <0.05). The number of pain episodes in this study was statistically significantly lower in Group-B patients compared to Group-A (p <0.05). Urinary tract infection was encountered in 12 (20%) patients of Group-A and 2 (3.33%) patients of Group-B (p <0.05) during four weeks therapy which was treated by appropriate antibiotics. No side effects of Tamsulosin were encountered in any patients of Group-B which could require the cessation of the medication or might need for dose titration. Findings of the study revealed that the Tamsulosin supplemented conventional therapy is more effective than conventional hydrotherapy alone in management of juxtavesical ureteral stones.

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Surgical versus Conservative Management of Granular Myringitis: A single-centre Randomized Control Trial

Journal of National Institute of Neurosciences Bangladesh ◽

10.3329/jninb.v5i1.42172 ◽

2019 ◽

Vol 5 (1) ◽

pp. 64-68

Author(s):

Ali Imam Ahsan ◽

Nasimul Jamal ◽

Ashfaq Ahmad ◽

Syed Farhan Ali ◽

Momenul Haque

Keyword(s):

Surgical Treatment ◽

Medical Treatment ◽

Granulation Tissue ◽

Randomized Control Trial ◽

Simple Random Sampling ◽

Secondary Outcome ◽

Group A ◽

Randomized Control ◽

Group B

Background: Treatment of granular myringitis (GM) is diverse with no definitive management. Objective: The aim of the present study was to see the effectiveness of different interventions for treating granular myringitis. Methodology: This was a single centred, parallel, randomized control trial. This study was done at the Specialized ENT Hospital of SAHIC, Dhaka from July 2010 to June 2012. Patients presenting with granular myringitis of 18 years of age or more with both sexes were included. All patients were divided into two groups by simple random sampling method of which patients of group A were treated by surgical treatment and that of group B were treated by medical treatment. Medical treatment was given in the form of topical ear drops and surgical treatment was performed by surgical debridement of granulation tissue followed by chemical cauterization. Repeated follow up was performed up to 6 months in both groups of treated patients. The primary outcome was the resolution of granulation tissue. During follow-up the secondary outcome variables were recurrence, perforation of the TM and any other complications or complain from the patients. Results: A total number of 60 patients were studied of which 30 patients were treated medically and 30 patients were treated surgically. The cure rate was higher in surgical treatment (80%) than conservative (16.7%) (p=0.011). The recurrence rate (17.24%) is also less in surgical group compared to medical treatment group (77.27%) (p=0.001). Conclusion: Surgical treatment is a more successful treatment modality for granular myringitis. Journal of National Institute of Neurosciences Bangladesh, 2019;5(1): 64-68

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Inhaled Tobramycin in Children with Acute Bacterial Rhinopharyngitis

International Journal of Immunopathology and Pharmacology ◽

10.1177/205873920601900113 ◽

2006 ◽

Vol 19 (1) ◽

pp. 205873920601900 ◽

Cited By ~ 10

Author(s):

A. Varricchio ◽

D. Tricarico ◽

A. DE Lucia ◽

R. Utili ◽

M.-F. Tripodi ◽

...

Keyword(s):

Nasal Obstruction ◽

Resistant Bacteria ◽

Double Blind ◽

Oral Amoxicillin ◽

Parallel Group ◽

Blind Children ◽

Amoxicillin Clavulanate ◽

Group A ◽

Adenoidal Hypertrophy ◽

Group B

Antibiotic abuse for treating rhinopharyngitis induces the occurrence of resistant bacteria. As topical drugs might reduce this phenomenon, the aims of our study were to evaluate inhaled tobramycin in children with acute bacterial rhinopharyngitis and to compare it with oral amoxicillin/clavulanate. The trial was conducted as randomized, parallel group and double blind. Children, aged 3–6 years, with acute bacterial rhinopharyngitis were treated with 15 mg of aerosolized tobramycin (Group A) or 50 mg/Kg of amoxicillin/clavulanate (Group B) twice daily for 10 days. The following parameters were assessed: nasal obstruction, mucopurulent rhinorrhea, post-nasal drip, adenoidal hypertrophy, tympanic inflammation, tympanogramm, rhinomanometry and cultures. Of 416 patients screened, 311 children (178 females and 133 males), median age 4.5 years, completed the study: 156 in Group A and 155 in Group B. Both treatments improved all parameters (p<0.01 for all). Intergroup analysis showed that inhaled tobramycin induced a better improvement versus amoxicillin/clavulanate concerning nasal obstruction (p<0.05), adenoidal hypertrophy (p<0.01), tympanic inflammation (p<0.01), rhinomanometry (p<0.01) and cultures (p<0.05). In conclusion, inhaled tobramycin may represent a valid treatment for acute bacterial rhinopharyngitis in children, as it is effective, safe, economic and simple to use.

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Treatment of knee osteoarthritis with traditional Chinese medicine sloughingClinical efficacy study

Journal of Integrative Medicine ◽

10.30564/jim.v8i2.2060 ◽

2020 ◽

Vol 8 (2) ◽

Author(s):

Liang Wen

Keyword(s):

Chinese Medicine ◽

Traditional Chinese Medicine ◽

Knee Osteoarthritis ◽

Western Medicine ◽

Clinical Effect ◽

Effective Rate ◽

Control Group ◽

Observation Group ◽

Group A ◽

Group B

Objective: To explore the clinical effect of the treatment of knee osteoarthritis with traditional Chinese medicine.Methods: 152 patients with knee osteoarthritis who were treated in our hospital from July 2018 to April 2020 were divided into two groups. Group A (control group) was treated with conventional western medicine, i.e. celecoxib 200 mg capsule +Glucosamine hydrochloride capsule 0.75g, group B (observation group): the treatment of traditional Chinese medicine sloughing using our experience formula, and further comparative evaluation of the treatment effect of the two groups. Results: the effective rate was 75% in the control group and 92% in the observation group. Conclusion: in the treatment of knee osteoarthritis, traditional Chinese medicine is more effective than western medicine.

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Comparison of Rocuronium and Succinylcholine for Rapid Sequence Induction in patients undergoing surgery under General Anaesthesia

Journal of Rawalpindi Medical College ◽

10.37939/jrmc.v24i2.1258 ◽

2020 ◽

Vol 24 (2) ◽

pp. 134-138

Author(s):

Fasial Wahid ◽

Aftab Hussain ◽

Faiz Ur Rahman ◽

Obaid Ur Rahman

Keyword(s):

General Anesthesia ◽

Randomized Control Trial ◽

Rapid Sequence Induction ◽

Rapid Sequence ◽

Study Results ◽

Sequence Induction ◽

Group A ◽

Randomized Control ◽

Group B ◽

Intubation Condition

Objectives: To compare the frequency of excellent intubation condition with Succinylcholine and rocuronium for rapid sequence induction in patients undergoing surgery under general anesthesia. Design: Randomized control trial. Place and duration of study: Department of anesthesiology and pain medicine, Combined Military Hospital Malir Cantt Karachi from 25th June to 10th August 2019. Methodology: In this randomized control trial, a non-probability consecutive sampling technique was used. Anesthesia was given through a standard approach. Then patients were randomly divided into two equal groups. In group A, succinylcholine (1mg/Kg) was given while in group B, rocuronium (1mg/Kg) was given. Laryngoscopy was attempted after 60 seconds. Intubating conditions were labeled as excellent, good, poor, and impossible. All the data was collected in two groups, the data was entered and analyzed on SPSS version 21. Results: The mean age of the patients was 40.11±9.49 years. The male to female ratio of the patients was 0.7:1. The study results showed the excellent intubation conditions were noted in 11 from group A and 9 from group B, good intubation condition was noted in 29 from group A and 25 from group B, poor conditions were noted in 17 from group A and 16 from group B and the impossible intubation conditions were noted in 13 from group A and 20 from group B. Statistically insignificant difference was found between the study groups with intubation conditions i.e. p-value=0.570. Conclusion: It has been proved in our study that both the succinylcholine and rocuronium are statically equally effective in terms of excellent intubation conditions in the management of rapid sequence induction in patients undergoing surgery under general anesthesia.

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Efficacy and tolerability of DAAs in HCV-monoinfected and HCV/HIV-coinfected patients with psychiatric disorders

10.21203/rs.2.14807/v2 ◽

2020 ◽

Author(s):

Nicolò de Gennaro ◽

Lucia Diella ◽

Laura Monno ◽

Gioacchino Angarano ◽

Michele Milella ◽

...

Keyword(s):

Psychiatric Patients ◽

Antiviral Agents ◽

Careful Evaluation ◽

Intention To Treat ◽

Psychiatric Drugs ◽

Single Centre Study ◽

Group A ◽

Direct Antiviral Agents ◽

Group B ◽

Few Data

Abstract Background few data are available regarding use of direct antiviral agents (DAAs) for chronic hepatitis C in psychiatric patients. The aim of the study is to assess safety and outcome of DAAs in patients with psychiatric comorbidities. Methods this retrospective, observational, single-centre study enrolled patients treated with psychiatric drugs who initiated DAAs between 2015-2018. Patients were classified into two groups: A (on anxiolitycs/antidepressant) and B (on antipsychotics). Week-12 sustained virological response (SVR-12) and adverse events (AEs) were evaluated. Results 144 patients were included (A:101; B:43). Patients were 49.3% males, mean age 60 years (SD±13.5); 31.9% cirrhotic; 125 (86.8%) HCV-monoinfected and 19 (13.2%) HIV/HCV-coinfected. Twenty patients (13.8%) required a change of psychiatric therapy before DAAs-initiation. Overall, SVR-12 was achieved in 88.2% of subjects in intention-to-treat(ITT)-analysis. Lower SVR rates were observed in group B vs A (79% vs 92%, p=0.045) and in those changing psychiatric drugs vs others (30% vs 8%, p=0.015). At least one AE occurred in 60 patients (41.6%), including 10 SAEs, leading to 3 discontinuations. AEs were more frequently reported in group A (p=0.015). Conclusions the study confirms effectiveness and safety of DAA-based treatment also in this special population, even if a careful evaluation of history and drug-drug interactions is warranted.

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