scholarly journals Analysis of Antioxidant Capacity of Chromones in Saposhnikoviae Radix Obtained by Ultrasonic-Assisted Deep Eutectic Solvents Extraction

2020 ◽  
Vol 2020 ◽  
pp. 1-9
Author(s):  
Xianwen Yue ◽  
Fangfei Xu ◽  
Peng Lv ◽  
Huailei Yang ◽  
Huiwei Bao ◽  
...  
Keyword(s):  
Deep Eutectic Solvent ◽  
Cation Radical ◽  
Deep Eutectic Solvents ◽  
Extraction Temperature ◽  
Cation Radicals ◽  
Response Surface Optimization ◽  
Ultrasonic Assisted ◽  
Ethanol Extracts ◽  
Solid Liquid ◽  
Saposhnikoviae Radix

In this paper, ultrasonic-assisted deep eutectic solvent (DES) extraction was applied to the acquisition of chromones (cimicifugin, prim-o-glucosylcimifugin, and 5-o-methylvisamminoside) from Saposhnikoviae radix (SR). The extraction effects of 11 prepared DESs were screened taking contents of chromones as indexes. Furthermore, the optimum extraction conditions were confirmed using a single-factor test and response surface optimization test. Scavenging activities of DPPH anion and ABTS cation radicals of different SR extracts (DES, methanol, and ethanol) were studied. The analysis results of best extraction conditions optimized by Design-Expert software were as follows: extraction time (40 min), extraction temperature (60°C), and the solid/liquid ratio (32 mL/g). Scavenging rates of the DES extract for DPPH anion radical and ABTS cation radical were found to be 75.31% and 65.71%, which were higher than those of methanol and ethanol extracts. In conclusion, the developed extraction method can be regarded as a safe, green, and more effective approach for the extraction of chromones in SR.

scholarly journals Green and Efficient Extraction of Resveratrol from Peanut Roots Using Deep Eutectic Solvents

2018 ◽  
Vol 2018 ◽  
pp. 1-9 ◽  
Author(s):  
Jingnan Chen ◽  
Xingxing Jiang ◽  
Guolong Yang ◽  
Yanlan Bi ◽  
Wei Liu
Keyword(s):  
Choline Chloride ◽  
Deep Eutectic Solvents ◽  
Extraction Yield ◽  
Box Behnken Design ◽  
Assisted Extraction ◽  
Ultrasonic Assisted ◽  
Efficient Extraction ◽  
Ultrasonic Assisted Extraction ◽  
Solid Liquid ◽  
Total Extraction

Deep eutectic solvents (DESs), a new group of ecofriendly solvent combined with the ultrasonic-assisted extraction (UAE) technique, were first successfully used for extraction of resveratrol from peanut roots. Resveratrol in the extract was analyzed and quantified using a HPLC-UV method. A series of DESs consisting of choline chloride (ChCl) and 1,4-butanediol, citric acid, and ethylene glycol were formulated, finding ChCl/1,4-butanediol was a most proper extraction system. The optimal extraction parameters were obtained using a Box–Behnken design (BBD) test combined with response surface methodology as follows: 40% of water in ChCl/1,4-butanediol (1/3, g/g) at 55°C for 40 min and solid/liquid ratio of 1:30 g/mL. The total extraction content and extraction yield of resveratrol from peanut roots could reach 38.91 mg/kg and 88.19%, respectively, under such optimal conditions. The present study will provide a typical example for using DESs to extract natural bioactive compounds from plants.

Research on Ultrasonic-Assisted Extraction Flavonoids of Medlar (Lycium Chinense Miller)

2011 ◽  
Vol 197-198 ◽  
pp. 229-233
Author(s):  
Ling Qin ◽  
Ai Jun Cai ◽  
Yan Ling Qi ◽  
Feng Bao Wang ◽  
Wen Huai Kang
Keyword(s):  
Orthogonal Design ◽  
Extraction Temperature ◽  
Lycium Chinense ◽  
Liquid Ratio ◽  
Optimum Parameters ◽  
Assisted Extraction ◽  
Ultrasonic Assisted ◽  
Extraction Parameters ◽  
Lycium Chinense Miller ◽  
Solid Liquid

The extraction technique of flavonoids from the tender leaves and fruits of medlar (Lycium chinense Miller) were investigated, and the flavonoids content from both was compared. Through single-factor and the L9 (34) orthogonal design, the optimal extraction parameters were determined. The results showed that the content of flavonoids in the tender leaves was significantly higher than in the fruits. There were four important factors influencing the yield of flavonoids, including ethanol concentration, extraction time, solid-liquid ratio and extraction temperature. As for leaves, the optimum extraction parameters were 80% ethanol concent, solid-liquid ratio 1:50, two times per 40min, and 60°С . In order to extract flavonoids from fruits, the optimum parameters of ethanol content, solid-liquid ratio, extract times, and temperature were 80%, 1:50, 2 per 30min and 60С respectively. Under the optimum condition, the yield of flavonoids from leaves and fruits were 47.371 and 9.593 mg.g-1 respectively.

Comparative Evaluation of Total Flavonoid Contents in Different Parts of Ficus microcarpa

2012 ◽  
Vol 560-561 ◽  
pp. 423-427
Author(s):  
Qiang Lin ◽  
Hao Yue Du ◽  
You Bin Liu ◽  
Yu Kai Chen ◽  
Jing Xu
Keyword(s):  
Extraction Yield ◽  
Total Flavonoid ◽  
Extraction Temperature ◽  
Assisted Extraction ◽  
Ultrasonic Assisted ◽  
Ficus Microcarpa ◽  
Ultrasonic Assisted Extraction ◽  
Pharmaceutical Properties ◽  
Solid Liquid ◽  
Different Parts

This study was designed to comparative evaluate total flavonoid contents (TFC) in leaf, aerial root, twig, root and bark parts of Ficus microcarpa L.f. (Moraceace). Ultrasonic-assisted extraction was adopted using benign solvent: ethanol and water to determine the extraction efficiency under the condition of ethanol concentration 40%, solid/liquid ratio of 1:25, extraction time 35 min and extraction temperature at 60 °C. According to the experimental results, the TFC values varied considerably and the extraction yield of 2.67±0.02%, 3.70±0.043%, 2.99±0.04%, 6.56±0.83% and 4.26±0.18% were obtained from different parts, respectively. The root part was characterized as containing a high amount of flavonoids, which might be the active compounds responsible for the pharmaceutical properties of the plant. The study offers theoretic basis for further utilization of the traditional folk herb F. microcarpa.

Study on Ultrasonic Assisted - Precipitation Method Combined Purification of Tea Saponin

2013 ◽  
Vol 634-638 ◽  
pp. 1552-1556 ◽  
Author(s):  
Yu Qiong Wu ◽  
Wei Dong Man
Keyword(s):  
Ethanol Concentration ◽  
Extraction Time ◽  
Precipitation Method ◽  
Optimum Operating ◽  
Ultrasonic Power ◽  
Extraction Temperature ◽  
Liquid Ratio ◽  
Tea Saponin ◽  
Ultrasonic Assisted ◽  
Solid Liquid

Commercial crude tea saponin as raw material, ultrasonic assisted extraction technology of tea saponin was investigated. Five influence factors of ethanol concentration, extraction temperature, extraction time, solid-liquid ratio, ultrasonic power on the extraction of tea saponin were studied in detail. Orthogonal experiment through the single factor experiment design, the experimental results show that the optimum operating conditions for the ethanol concentration of 80%, solid-liquid ratio 1: 40, extraction temperature 40°C, ultrasonic power of 300W, ultrasonic extraction time 45 minutes. Under the optimum conditions obtained tea saponin extract with ethanol- acetone precipitation method is further purified, tea saponin content increased from 52.1% to 93.6%. The result indicated that the purity of the tea saponin could be effectively improved through the ultrasonic assisted- precipitation combined method.

Ultrasonic-Assisted Extraction and Antioxidant Activities of Polysaccharides from Radix astragali

2013 ◽  
Vol 864-867 ◽  
pp. 549-552 ◽  
Author(s):  
Ming Wu ◽  
Chuan Fu Ma ◽  
Jun Man Kan ◽  
Li Quan Guo
Keyword(s):  
Superoxide Anion ◽  
Antioxidant Activities ◽  
Radical Scavenging ◽  
Ultrasonic Power ◽  
Extraction Temperature ◽  
Radix Astragali ◽  
Assisted Extraction ◽  
Ultrasonic Assisted ◽  
Ultrasonic Assisted Extraction ◽  
Solid Liquid

Ultrasonic-assisted extraction (UAE) method was used to polysaccharides from Radix Astragali (RAP), and the orthogonal test was applied to optimize extraction conditions. Furthermore, the antioxidant activities of RAP were evaluated by DPPH and superoxide anion radical scavenging activities assay. The results indicated that the optimal conditions for RAP extraction as followings: solid/liquid ratios of 1:20, extraction time of 10 min, ultrasonic power of 65 W and extraction temperature of 60°C. Meanwhile, RAP had relatively higher scavenging activities on DPPH and superoxide anion radicals.

scholarly journals Natural Deep Eutectic Solvents for the Extraction of Phenyletanes and Phenylpropanoids of Rhodiola rosea L.

Molecules ◽  
2020 ◽  
Vol 25 (8) ◽  
pp. 1826 ◽  
Author(s):  
Alexander N. Shikov ◽  
Vera M. Kosman ◽  
Elena V. Flissyuk ◽  
Irina E. Smekhova ◽  
Abdelhameed Elameen ◽  
...  
Keyword(s):  
Particle Size ◽  
Water Content ◽  
Deep Eutectic Solvent ◽  
Deep Eutectic Solvents ◽  
Extraction Yield ◽  
Rhodiola Rosea ◽  
Extraction Temperature ◽  
Natural Deep Eutectic Solvents ◽  
Predicted Values ◽  
Natural Deep Eutectic Solvent

The extraction of Rhodiola rosea rhizomes using natural deep eutectic solvent (NADES) consisting of lactic acid, glucose, fructose, and water was investigated. A two-level Plackett–Burman design with five variables, followed by the steepest ascent method, was undertaken to determine the optimal extraction conditions. Among the five parameters tested, particle size, extraction modulus, and water content were found to have the highest impact on the extrability of phenyletanes and phenylpropanoids. The concentration of active compounds was analyzed by HPLC. The predicted results showed that the extraction yield of the total phenyletanes and phenylpropanoids (25.62 mg/g) could be obtained under the following conditions: extraction time of 154 min, extraction temperature of 22 °C, extraction modulus of 40, molar water content of 5:1:11 (L-lactic acid:fructose:water, mol/mol), and a particle size of rhizomes of 0.5–1 mm. These predicted values were further verified by validation experiments in predicted conditions. The experimental yields of salidroside, tyrosol, rosavin, rosin, cinnamyl alcohol and total markers (sum of phenyletanes and phenylpropanoids in mg/g) were 11.90 ± 0.02, 0.36 ± 0.02, 12.23 ± 0.21, 1.41 ± 0.01, 0.20 ± 0.01, and 26.10 ± 0.27 mg/g, respectively, which corresponded well with the predicted values from the models.

scholarly journals A Study of the Ionic Liquid-Based Ultrasonic-Assisted Extraction of Isoliquiritigenin from Glycyrrhiza uralensis

2020 ◽  
Vol 2020 ◽  
pp. 1-9
Author(s):  
Jingwei Hao ◽  
Jiahui Liu ◽  
Lei Zhang ◽  
Yunrong Jing ◽  
Yubin Ji
Keyword(s):  
Ionic Liquid ◽  
Extraction Procedure ◽  
Extraction Yield ◽  
Glycyrrhiza Uralensis ◽  
Extraction Temperature ◽  
Assisted Extraction ◽  
Ultrasonic Assisted ◽  
Ultrasonic Assisted Extraction ◽  
The Times ◽  
Solid Liquid

We successfully extracted isoliquiritigenin from Glycyrrhiza uralensis through the utilization of an ionic liquid-based ultrasonic-assisted extraction (ILUAE) approach. Briefly, we utilized the solution of 1-butyl-3-methylimidazolium bromide ([BMIM]Br) as solvent and optimized key ILUAE parameters such as solid-liquid ratios, concentrations of ionic liquids, and the times of ultrasonication. Based on a single-factor experiment, we utilized the response surface method (RSM) approach to optimize the extraction procedure. The approach revealed that the optimal energy consumption time was 120 min, with the ultrasonic extraction temperature of 60°C. Using these optimized parameters together with the solid-liquid ratio (dried G. uralensis powder: [BMIM]Br of 0.3 mol/L) of 1 : 16.163 and the [BMIM]Br of 0.3 mol/L, we achieved a 0.665 mg/g extraction yield. Overall, these findings thus indicate that we were able to effectively use ILUAE as an efficient approach to reliably extract isoliquiritigenin in a reproducible and environmentally friendly manner.

scholarly journals DES Based Efficient Extraction Method for Bioactive Coumarins from Angelica dahurica (Hoffm.) Benth. & Hook.f. ex Franch. & Sav.

Separations ◽  
2021 ◽  
Vol 9 (1) ◽  
pp. 5
Author(s):  
Ting Wang ◽  
Qian Li
Keyword(s):  
Choline Chloride ◽  
Radical Scavenging ◽  
Deep Eutectic Solvents ◽  
Extraction Yield ◽  
Molar Ratio ◽  
Angelica Dahurica ◽  
Extraction Temperature ◽  
Solid Ratio ◽  
Before And After ◽  
Ultrasonic Assisted

In this study, a simple and environmentally friendly method was developed for the extraction of seven active coumarins from Angelica dahurica (Hoffm.) Benth. & Hook.f. ex Franch. & Sav.(A. dahurica) based on deep eutectic solvents (DESs). Among the 16 kinds of DES based on choline chloride, the DES system with the molar ratio of choline chloride, citric acid, and water as 1:1:2 had the best extraction effect. Ultrasonic-assisted response surface methodology (RSM) was used to investigate the optimal extraction scheme. The results showed that the optimal extraction conditions were a liquid–solid ratio of 10:1 (mL/g), an extraction time of 50 min, an extraction temperature of 59.85 °C, and a moisture content of 49.28%. Under these conditions, the extraction yield reached 1.18%. In addition, scanning electron microscopy (SEM) was used to observe the degree of powder fragmentation before and after extraction with different solvents. The cells of A. dahurica medicinal materials obtained by DES ultrasonic-assisted treatment were the most seriously broken, indicating that DES had the highest efficiency in the treatment of A. dahurica. The 1,1-diphenyl-2-picrylhydrazyl (DPPH) DPPH radical scavenging model was used to evaluate the biological activity of DES extract. The results showed that DES extract had better scavenging ability of DPPH free radical. Therefore, DES is a green solvent suitable for extracting coumarin compounds of A. dahurica, with great potential to replace organic solvents.

scholarly journals Application of Natural Deep Eutectic Solvents in the Extraction of Quercetin from Vegetables

Molecules ◽  
2019 ◽  
Vol 24 (12) ◽  
pp. 2300 ◽  
Author(s):  
Yunliang Dai ◽  
Kyung Ho Row
Keyword(s):  
Choline Chloride ◽  
Chemical Properties ◽  
Deep Eutectic Solvents ◽  
Research Attention ◽  
Natural Deep Eutectic Solvents ◽  
Significant Research ◽  
Prevention And Health Promotion ◽  
Ultrasonic Assisted ◽  
Solid Liquid ◽  
Physical And Chemical

Quercetin is a phytochemical with disease prevention and health promotion activities that has attracted significant research attention. In this study, choline chloride and betaine-based natural deep eutectic solvents were prepared using a heating method. Their physical and chemical properties were also tested. Then, they were applied to extract quercetin from onion and broccoli with ultrasonic-assisted solid liquid method coupled with HPLC. Three factors (temperature, amount, and time) were considered for the optimization of the extraction assays. In the optimal conditions, the extraction recoveries were 88.91–98.99%, 88.45–99.01%, and 89.56–98.74% for quercetin, isorhamnetin, and kaempferol. Tailor-made natural deep eutectic solvents could be applied as sustainable and safe extraction media for biochemical applications.

scholarly journals The Role of Charge Transfer in the Formation of Type I Deep Eutectic Solvent-Analogous Ionic Liquid Mixtures

Molecules ◽  
2019 ◽  
Vol 24 (20) ◽  
pp. 3687 ◽  
Author(s):  
Dinis O. Abranches ◽  
Nicolas Schaeffer ◽  
Liliana P. Silva ◽  
Mónia A. R. Martins ◽  
Simão P. Pinho ◽  
...  
Keyword(s):  
Ionic Liquid ◽  
Deep Eutectic Solvent ◽  
Deep Eutectic Solvents ◽  
Liquid Mixtures ◽  
Chloride Ions ◽  
Melting Point Depression ◽  
Type I ◽  
Chloride Complexes ◽  
Charge Delocalization ◽  
Solid Liquid

It was recently shown that tetramethylammonium chloride presented negative deviations to ideality when mixed with tetraethylammonium chloride or tetrapropylammonium chloride, leading to a strong decrease of the melting points of these salt mixtures, in a behavior akin to that observed in the formation of deep eutectic solvents. To better rationalize this unexpected melting point depression between two structurally similar compounds devoid of dominant hydrogen bonding capability, new solid–liquid equilibria data for tetramethylammonium-based systems were measured and analyzed in this work. Molecular dynamics was used to show that the strong negative deviations from ideality presented by these systems arise from a synergetic share of the chloride ions. A transfer of chloride ions seems to occur from the bigger cation in the mixture (which possesses a more disperse charge) to the smaller cation (tetramethylammonium), resembling the formation of metal–chloride complexes in type I deep eutectic solvents. This rearrangement of the charged species leads to an energetic stabilization of both components in the mixture, inducing the negative deviations to the ideality observed. The conclusions presented herein emphasize the often-neglected contribution of charge delocalization in deep eutectic solvents formation and its applicability toward the design of new ionic liquid mixtures.

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