scholarly journals Central Odontogenic Myxoma: A Radiographic Analysis

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Ahmad Badruddin Ghazali ◽  
Raweewan Arayasantiparb ◽  
Rachai Juengsomjit ◽  
Aroonwan Lam-ubol
Keyword(s):  
Statistical Analysis ◽  
Cortical Bone ◽  
Root Resorption ◽  
Treatment Decisions ◽  
Periosteal Reaction ◽  
Histopathological Diagnosis ◽  
Radiographic Analysis ◽  
Odontogenic Myxoma ◽  
Exact Test ◽  
Bone Expansion

Objective. This study aimed to determine the radiographic characteristics of odontogenic myxomas (OMs) and their associations. Materials and Methods. The study enrolled radiographs of patients taken between 2005 and 2019 with a confirmed histopathological diagnosis of central OM. OM radiographic features were evaluated, including location, border, locularity, involved area, the number of included teeth, root resorption, tooth displacement, bone expansion, bone perforation, and periosteal reaction. Fisher’s exact test was used for statistical analysis. Results. Significant associations were found between the OM border and the affected jaw ( p = 0.036 ), locularity ( p = 0.036 ), involved areas ( p = 0.009 ), and bone perforation ( p = 0.036 ). OMs with an ill-defined border were associated with maxillary lesions, multilocularity, dentate areas, and cortical bone perforation. The number of included teeth (2 or fewer or 3 or more) was significantly associated with locularity ( p = 0.010 ), involved area ( p = 0.045 ), and bone expansion ( p = 0.010 ). Larger OMs including 3 or more teeth, were associated with a multilocular appearance, dentate areas, and bone expansion. Conclusion. The border of OM and the number of included teeth are related to other radiographic appearances. Understanding these relationships could help in treatment decisions and help better understand the nature of OM.

scholarly journals Central Giant cell Granuloma of the Jaws: A Clinical and Radiologic Study

2003 ◽  
Vol 4 (3) ◽  
pp. 87-97 ◽  
Author(s):  
Metin Güngörmüş ◽  
H. Murat Akgül
Keyword(s):  
Giant Cell ◽  
Root Resorption ◽  
Giant Cell Granuloma ◽  
Chi Square ◽  
Exact Test ◽  
Central Giant Cell Granuloma ◽  
Radiologic Study ◽  
Bone Expansion ◽  
Chi Square Test ◽  
Average Size

Abstract Purpose The purpose of this study is to present the clinical and radiological features of 27 cases of central giant cell granuloma (CGCG) of the jaws. Materials and Methods This study was carried out on 27 cases diagnosed as CGCG, ranging in age from 8 to 70 years. The patient's age, sex, location of the lesion, expansion caused by the lesion, and greatest diameter were evaluated. Radiographs and radiological descriptions were studied for the features of border definition, radiopacity, locularity, root resorption, tooth displacement, and tooth association. Data were analyzed with Chi square test, Fisher's exact test, Mann Whitney U-test, and the Student t-test. Results It was determined 89% of CGCG occurred prior to the age of 40. Seventy-eight percent of the cases were females. In addition, it was observed that these lesions occurred primarily in the mandible mostly anterior to the molar region. It was determined most of the lesions were multilocular. Unilocular lesions averaged 23.75 mm and multilocular lesions were 53.00 mm. In 24 (89%) cases regular borders were seen, and in three cases diffuse borders were observed. There was bone expansion in 44% of the cases. The cases with bone expansion were 60.00 mm in average size, and the cases without bone expansion were 24.00 mm in average size. Seventy-eight percent of lesions were associated with teeth, and there was tooth displacement in 43% of these lesions. The lesions with tooth displacement were 18.33 mm in average size, and the lesions without tooth displacement were 44.00 mm in average size. Conclusions It was determined there is a significant correlation between the locularity, tooth displacement, and bone expansion with the size of the CGCG. Citation Güngörmüs M, Akgül HM. Central Giant Cell Granuloma of the Jaws: A Clinical and Radiologic Study. J Contemp Dent Pract 2003 August;(4)3:087-097.

Do longitudinal orthodontic trials use appropriate statistical analyses? A meta-epidemiological study

2021 ◽  
Author(s):  
Samer Mheissen ◽  
Haris Khan ◽  
Mohammed Almuzian ◽  
Emad Eddin Alzoubi ◽  
Nikolaos Pandis
Keyword(s):  
Statistical Analysis ◽  
Epidemiological Study ◽  
Data Extraction ◽  
Statistical Significance ◽  
Repeated Measure ◽  
Exact Test ◽  
Optimal Analysis ◽  
Study Characteristics ◽  
Measure Analysis ◽  
Repeated Measure Analysis

Summary Background In orthodontic trials, longitudinal designs with multiple outcome measurements over time are common. The aim of this epidemiological study was to examine whether optimal statistical analysis approaches have been used in longitudinal orthodontic trials. Methods Pubmed was searched in August 2021 for longitudinal orthodontic trials with at least three time points of outcome assessment published in the 2017–20 period. Study selection and data extraction were done independently and in duplicate. The analysis approaches undertaken were tabulated and associations between study characteristics and the use of optimal analysis or not were assessed using Fisher’s exact test and logistic regression. Results One hundred forty-seven out of 563 unique records were deemed eligible for inclusion. Only 26.50% of these trials used an optimal statistical analysis for longitudinal data where the data structure is accounted for. None of the study characteristics except the statistical significance of the results were associated with the appropriateness of the statistical analysis. The odds of significant results in studies with suboptimal analyses were higher than that in studies with optimal longitudinal analyses (odds ratio: 3.48, 95% confidence interval: 1.62, 7.46, P = 0.001). For the studies with optimal analysis, the most frequent test was repeated-measure analysis of variance (RM-ANOVA). The reporting of the statistical analysis section was suboptimal in the majority of the trials. Conclusion Most longitudinal orthodontic trials are not analysed using optimal statistical approaches. Inferences and interpretation of their results are likely to be compromised.

scholarly journals Hypermobility and sports injury

2018 ◽  
Vol 4 (1) ◽  
pp. e000366 ◽  
Author(s):  
Joseph Alexander Nathan ◽  
Kevin Davies ◽  
Ian Swaine
Keyword(s):  
Statistical Analysis ◽  
Sports Injury ◽  
The Other ◽  
Anecdotal Evidence ◽  
Demographic Information ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Exact Test ◽  
Joint Dislocation ◽  
Ligament Sprain

ObjectiveTo determine whether there is an association between hypermobility and sports injury.MethodsA quantitative observational approach using a cross-sectional survey was adopted. Individuals were identified as hypermobile or not. All participants were asked to complete two questionnaires: one asking demographic information and the other injury-specific. Fisher’s exact test was used for statistical analysis.Results114 individuals participated in the study, 62 women and 52 men. 26% of the participants were hypermobile. There was no significant association between hypermobility and sports injury (p=0.66). There was a significant increase in joint and ligament sprain among the non-hypermobile (NH) group covering all sports (p=0.03). Joint dislocation was found exclusively among hypermobile individuals. The duration of injury in hypermobile individuals was higher than NH. The use of oral painkillers or anti-inflammatories in the semiprofessional group was greater than the general population.ConclusionHypermobility is relatively common among individuals, and there is a lot of anecdotal evidence associating it with increased rates of injuries. This project finds that NH individuals are more likely to sustain a ligament or joint sprain in sports. This is due to increased joint laxity and flexibility preventing injury. There were important limitations to this study which will be addressed in further work. These include assessing for pauciarticular hypermobility and focusing on one sport to investigate its association with sports injury in those who are hypermobile or not. It would also be important to focus on one specific joint, assessing its flexibility and association with injury.

scholarly journals Mutation of the Galectin-3 Glycan Binding Domain (Lgals3-R200S) Enhances Cortical Bone Expansion in Male and Trabecular Bone Mass in Female Mice

2020 ◽  
Author(s):  
Kevin A. Maupin ◽  
Daniel Dick ◽  
VARI Vivarium ◽  
Transgenics Core ◽  
Bart O. Williams
Keyword(s):  
Bone Mass ◽  
Trabecular Bone ◽  
Cortical Bone ◽  
Mutant Mice ◽  
Slight Variation ◽  
Female Mice ◽  
Bone Phenotype ◽  
Bone Expansion ◽  
Galectin 3 ◽  
Trabecular Bone Mass

AbstractThe study of galectin-3 is complicated by its ability to function both intracellularly and extracellularly. While the mechanism of galectin-3 secretion is unclear, studies have shown that the mutation of a highly conserved arginine to a serine in human galectin-3 (LGALS3-R186S) blocks glycan binding and secretion. To gain insight into the roles of extracellular and intracellular functions of galectin-3, we generated mice with the equivalent mutation (Lgals3-R200S) using CRISPR/Cas9-directed homologous recombination. Consistent with a reduction in galectin-3 secretion, we observed significantly reduced galectin-3 protein levels in the plasma of heterozygous and homozygous mutant mice. We observed a similar increased bone mass phenotype in Lgals3-R200S mutant mice at 36 weeks as we previously observed in Lgals3-KO mice with slight variation. Like Lgals3-KO mice, Lgals3-R200S females, but not males, had significantly increased trabecular bone mass. However, only male Lgals3-R200S mice showed increased cortical bone expansion, which we had previously observed in both male and female Lgals3-KO mice and only in female mice using a separate Lgals3 null allele (Lgals3). These results suggest that the trabecular bone phenotype of Lgals3-KO mice was driven primarily by loss of extracellular galectin-3. However, the cortical bone phenotype of Lgals3-KO mice may have also been influenced by loss of intracellular galectin-3. Future analyses of these mice will aid in identifying the cellular and molecular mechanisms that contribute to the Lgals3-deficient bone phenotype as well as aid in distinguishing the extracellular vs. intracellular roles of galectin-3 in various signaling pathways.

scholarly journals Enhanced cortical bone expansion in Lgals3-deficient mice during aging

Bone Research ◽  
2018 ◽  
Vol 6 (1) ◽  
Author(s):  
Kevin A. Maupin ◽  
Kevin Weaver ◽  
Alexis Bergsma ◽  
Cheryl Christie ◽  
Zhendong A. Zhong ◽  
...  
Keyword(s):  
Cortical Bone ◽  
Bone Expansion ◽  
Deficient Mice

scholarly journals Decrease in Mandibular Cortical in Patients With Type 1 Diabetes Mellitus Combined with Poor Glycemic Control

2017 ◽  
Vol 28 (5) ◽  
pp. 552-558 ◽  
Author(s):  
Francisco Ivison Rodrigues Limeira ◽  
Patrícia Ravena Meneses Rebouças ◽  
Denise Nóbrega Diniz ◽  
Daniela Pita de Melo ◽  
Patrícia Meira Bento
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Cortical Bone ◽  
Age Groups ◽  
Exact Test ◽  
Chi Squared ◽  
Panoramic Images ◽  
And Gender

Abstract In this study we analyzed the mandibular cortical bone of patients with type 1 diabetes mellitus (T1DM) and non-diabetic. Fifty patients with T1DM and 100 non-diabetic ones paired by age and gender were analyzed. Two double-blinded observers evaluated 150 digital panoramic images of both groups. The mandibular cortical bone was analyzed using the Mandibular Cortical Index (MCI), Mental Index (MI), Gonial Index (GI), Antegonial Index (AI) and Upper and Lower Panoramic Mandibular Indexes (UPMI and LPMI), with the aid of RADIOIMP® software. Influence of T1DM in the morphology of the mandibular cortical bone was studied based on obtaining data related to T1DM diagnosis time, blood glucose level, T1DM control and the presence of chronic complications. Collected data were submitted to descriptive (mean and standard deviation) and inferential analyzes (Pearson’s chi-squared test and Fisher’s exact test) (p≤0.05). According to the MCI, individuals with T1DM had higher frequencies of mandibular cortical alterations, in both sexes and all age groups (p<0.01). For quantitative indexes, MI, GI, AI, UPMI and LPMI, female patients showed statistically significant differences for GI and AI, while male patients had statistically significant differences for all indexes (p<0.05), presenting the individuals with TDM1 inferior measures. Individuals with poor T1DM control showed significantly higher frequency of mandibular cortical alteration (92.3%), with lower means for MI, GI, AI and LPMI (p≤0.05). In conclusion, patients with T1DM showed decrease in the mandibular cortical bone when compared to non-diabetic ones, indicating that poor disease control is associated with these alterations.

Correlations of radiographic analysis of healing fractures with strength: A statistical analysis of experimental osteotomies

1985 ◽  
Vol 3 (2) ◽  
pp. 212-218 ◽  
Author(s):  
Manohar M. Panjabi ◽  
Stephen D. Walter ◽  
Mark Karuda ◽  
Augustus A. White ◽  
Jack P. Lawson
Keyword(s):  
Statistical Analysis ◽  
Radiographic Analysis

Audit of histomorphology and immunohistochemistry of the brain tumors: Revisited in context to the WHO 2016 molecular classification

2017 ◽  
Vol 2 (1) ◽  
pp. 15
Author(s):  
Tanushri Mukherjee ◽  
Rajat Dutta ◽  
Joydeep Ghosh
Keyword(s):  
Social Sciences ◽  
Statistical Analysis ◽  
Brain Tumors ◽  
Molecular Classification ◽  
Histopathological Diagnosis ◽  
Treatment Change ◽  
Tumor Patients ◽  
The Brain

<p><span class="Bold">Background:</span><span> The WHO 2016 molecular classification corroborating with the histology has given more significant diagnostic objectivity to the diagnosis of brain tumors and it is more reliable for instituting therapy as the heterogeneity and observer subjectivity are bypassed with the addition of isocitrate dehydrogenase, ATRX, and 1p19q, and other molecular markers. </span><span class="Bold">Aim:</span><span> Our aim is to review the histopathology of diagnosed brain tumors and correlate with immunohistochemical (IHC) findings to note for any disparity to reform the diagnosis in order to benefit the patient and report to the clinician if any treatment change is to be considered. </span><span class="Bold">Materials and Methods:</span><span> This article is based on studies of screening and diagnostic test. A total of 150 brain tumors were retrospectively analyzed. Age, gender, and the tumor histological type and grade were systematically recorded. We compared our histopathological diagnosis before the introduction of the WHO 2016 molecular classification of central nervous system tumors and later after the relevant IHC and fluorescence </span><span class="Italic">in situ</span><span> hybridization studies. </span><span class="Bold">Statistical Analysis:</span><span> The statistical analysis was done by using Statistical Package for Social Sciences version recent for Windows. </span><span class="Bold">Results:</span><span> Out of the total 150 brain tumor patients, 65 were males and 45 were females. About 37 were glial and the rest were in other categories. </span><span class="Bold">Conclusions:</span><span> </span><span lang="en-US">The molecular diagnosis that substantiated with the histomorphology is more objective and beneficial in the treatment of the patients.</span></p>

scholarly journals RELATIONSHIP BETWEEN PIGMENTS PRODUCTION AND BIOFILM FORMATION FROM LOCAL PSEUDOMONAS AERUGINOSA ISOLATES

2020 ◽  
Vol 51 (5) ◽  
pp. 1413-1419
Author(s):  
Mahmood & et al.
Keyword(s):  
Cystic Fibrosis ◽  
Pseudomonas Aeruginosa ◽  
Statistical Analysis ◽  
Urinary Tract ◽  
Biofilm Formation ◽  
Respiratory Tract Infections ◽  
Production Medium ◽  
Exact Test ◽  
Biofilm Production ◽  
Tract Infections

The current study was designed to explore the association between the pigments production and biofilm construction in local Pseudomonas aeruginosa isolates. Out of 143 patients suffering from burns, urinary tract infections (UTI), respiratory tract infections and cystic fibrosis obtained from previous study by Mahmood (2015), twenty two isolates  (15.38%) were identified  from (11) hospitals in Iraq, splitted  into three provinces, Baghdad, Al-Anbar and Karbala for the duration of June 2017 to April 2018.  Characterization was carried out by using microscopical, morphological and biochemical methods which showed that all these isolates belong to P. aeruginosa.  Screening of   biofilm production isolates was carried out by using nutrient broth supplemented with glucose (0.25%) production medium which encourage this biofilm production. The percentage of pigmented isolates were collected from a total of 143 samples, 2.8% of the isolates from burns, 2.1% isolates from cystic fibrosis and 0.7% isolates from UTI.  Quantitative assays for biofilm formation were conducted using ELIZA technique. The results showed that all (22) isolates produced biofilm except one (B1 isolate). Biofilm quantities were varied from strong to medium production in comparison with control (0.0663). Statistical analysis results using Fischer's Exact test (p<0.05) were non-significant, therefore the pigment production has no association with biofilm formation for all of them.

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