scholarly journals Algorithmic Study of the Characteristics of Electrocardiograph Signals in Patients with Coronary Heart Disease

2021 ◽  
Vol 2021 ◽  
pp. 1-10
Author(s):  
Honger Li ◽  
Lixia Zhao
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Wave Amplitude ◽  
Coronary Intervention ◽  
S Wave ◽  
Pr Interval ◽  
Before And After ◽  
Positive Rate ◽  
Som Algorithm ◽  
The Difference

This work aimed to analyze the electrocardiogram (ECG) characteristics and signal classification of patients with coronary heart disease (CHD) diagnosed by coronary angiography, so as to provide a theoretical basis for the clinical adoption of ECG images. 106 patients with CHD who were admitted to the XXX hospital from January 15, 2019, to May 30, 2020, underwent coronary intervention therapy, and their ECG indicators were recorded during the operation. Then, the LetNet-SoM algorithm designed in this work, as well as the traditional algorithms GoogLeNet and SqueezeNet, was applied to the patient’s ECG classification. It was found that part of ECG wave (QRS) and corrected Q-T interval (QTC) of patients after treatment were higher than those before treatment ( P < 0.05 ), but PR interval, RR interval, Tpeak-Tend (TpTe) interval, and QT interval were not substantially different from those before treatment ( P > 0.05 ). The diagnostic accuracy, sensitivity, and specificity of LetNet-SoM algorithm for patients with CHD were better than those of traditional algorithms, with evident difference ( P < 0.05 ). The classification time of LetNet-SoM algorithm was lower in contrast to that of traditional algorithms, and the difference was also notable ( P < 0.05 ). The R wave and T wave indicators of patients after treatment were higher than before treatment, with notable difference ( P < 0.05 ). The difference between the patient’s S wave indicator before and after treatment was not statistically significant ( P > 0.05 ). The positive rate of S wave amplitude, QRS, and QTC was 68.15%, 60.52%, and 51.36%, respectively. In short, the LetNet-SoM algorithm designed based on lightweight neural network had excellent performance in classification and diagnosis of ECG, and it had the value of further popularization and application. The ECG signals were important indicators in the diagnosis of CHD, among which the S wave amplitude, QRS, and QTC were the most sensitive ones.

Correlation Analysis of CPN, Hp, HCMV Pathogenic Microorganism Infection Status and Serum Inflammation Marker Level in Patients with Coronary Heart Disease

2021 ◽  
Vol 7 (5) ◽  
pp. 3251-3255
Author(s):  
Zhifeng Yao ◽  
Hong Shen ◽  
Minna Tang ◽  
Junbo Ge
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Control Group ◽  
Inflammation Markers ◽  
Double Positive ◽  
Reactive Protein ◽  
Positive Rate ◽  
Single Positive ◽  
The Difference ◽  
Necrosis Factor

Objective: To investigate the correlation between CPN, Hp, HCMV pathogenic microorganism infection status and serum inflammation marker levels in patients with coronary heart disease. Methods: The subjects of this study were all patients with coronary heart disease who came to our hospital from December 2018 to December 2019. A total of 70 patients were selected as the observation group, and non-coronary heart disease patients who came to our hospital for physical examination at the same time 70 cases were used as a control group to detect the IgG antibodies of CPN, Hp and HCMV microorganisms of the two groups, as well as the serum inflammation markers interleukin-6, hypersensitive C-reactive protein and tumor necrosis factor-a. Results: The CPN-IgG single positive rate, Hp-IgG single positive rate, HCMV-IgG single positive rate, double positive rate and triple positive rate in the observation group were 10.0%, 14.3%, 18.6%, 41.4% and 11.4%, respectively., Are significantly higher than the control group, and the difference between the groups is statistically significant (P<0.05); interleukin-6, hypersensitive C-reactive protein and tumor necrosis factor-a in three positive patients are (37.4±8.9) pg/ml, (15.1 ±3.2) mg/L and (36.2±8.6) ng/L, significantly higher than the levels of serum inflammation markers corresponding to double-positive, single-positive and full-negative patients, the difference is statistically significant Significance (P<0.05); serum inflammatory markers of double-positive patients were significantly higher than those of single-positive patients, the difference was statistically significant (P<0.05); serum inflammatory markers of single-positive patients The level of substance was significantly higher than that of serum inflammation markers corresponding to all negative patients, and the difference was statistically significant (P<0.05). Conclusion: The infection load of CPN, Hp and HCMV pathogenic microorganisms in patients with coronary heart disease is positively correlated with the level of serum inflammation markers, which is closely related to the incidence of coronary heart disease. The mixed infection of three pathogenic microorganisms can enhance the inflammatory response of patients by inducing inflammation The reaction causes the occurrence and development of the disease, and the more complicated the pathogenic microbial infection of the patient, the higher the level of inflammation markers of the patient.

The Preventive Effect of Alprostadil on the Contrast-Induced Nephropathy of Coronary Heart Disease Treated by Percutaneous Coronary Intervention in Moderate and High-Risk Population Stratified by Mehran Score

Angiology ◽  
2021 ◽  
pp. 000331972110155
Author(s):  
Xiaogang Liu ◽  
Peng Zhang ◽  
Jing Zhang ◽  
Xue Zhang ◽  
Shicheng Yang ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Percutaneous Coronary Intervention ◽  
Heart Disease ◽  
High Risk ◽  
Risk Groups ◽  
Coronary Intervention ◽  
Preventive Effect ◽  
Moderate Risk ◽  
Contrast Induced Nephropathy ◽  
Percutaneous Coronary

The Mehran risk score (MRS) was used to classify patients with coronary heart disease and evaluate the preventive effect of alprostadil on contrast-induced nephropathy (CIN) after percutaneous coronary intervention. The patients (n = 1146) were randomized into an alprostadil and control group and then divided into 3 groups on the basis of the MRS: low-risk, moderate-risk, and high-risk groups. The primary end point was the occurrence of CIN (alprostadil + hydration vs simple hydration treatment); secondary end points included serum creatinine, blood urea nitrogen, creatinine clearance rate, cystatin C, interleukin-6, C-reactive protein, proteinuria, and differences in the incidence of major adverse events. In the low-risk, moderate-risk, and high-risk groups, the incidence of CIN in the control and alprostadil group was 2.9 versus 2.6% ( P = .832), 11.4 versus 4.9% ( P = .030), 19.1 versus 7.7% ( P = .041), respectively. Multivariate logistic regression analysis showed that alprostadil treatment was a favorable protective factor for moderate-risk and high-risk CIN patients (OR = 0.343, 95% CI: 0.124-0.951, P = .040). Alprostadil can be used as a preventive treatment for moderate- and high-risk CIN patients classified by the MRS. The reduction of CIN by alprostadil may be related to an anti-inflammatory effect.

Abstract P276: Differential Association of D-dimer with Stroke and Coronary Heart Disease: The REasons for Geographic and Racial Differences in Stroke (REGARDS) Study

Circulation ◽  
2013 ◽  
Vol 127 (suppl_12) ◽  
Author(s):  
Neil A Zakai ◽  
George Howard ◽  
Leslie A McClure ◽  
Suzanne E Judd ◽  
Brett M Kissela ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Vascular Disease ◽  
Racial Differences ◽  
Statistical Significance ◽  
Female Gender ◽  
Cox Models ◽  
The Difference ◽  
Chd Risk Factors ◽  
D Dimer

Introduction: D-dimer, a marker of coagulation activation, has higher levels in blacks than whites and has been variably associated with stroke and coronary heart disease (CHD). Methods: REGARDS recruited 30,239 participants in their homes across the continental US between 2003-07; by design 55% were female, 41% black, and 56% lived in the southeast. In a case-cohort study, D-dimer was measured in 646 participants with incident stroke, 515 with incident CHD, and 1104 in a cohort random sample. D-dimer was log transformed and modeled per 1-unit increase. Cox models were used to determine the HR for vascular disease for D-dimer and the difference in HR (95% CI) by race and vascular disease calculated by bootstrapping with 1000 replicate samples and using the 2.5 and 97.5 percentiles of the distribution (see Table for model variables). Results: Median D-dimer was higher in blacks (0.45 mcg/mL; IQR 0.26, 0.85) than whites (0.38 mcg/mL; IQR 0.23, 0.69); p <0.001. D-dimer was higher with increasing age, female gender, diabetes, hypertension and prebaseline cardiovascular disease (all p <0.05). The table shows the HR of stroke and CHD by baseline D-dimer. In minimally-adjusted models, D-dimer was associated with both stroke and CHD. Accounting for Framingham stroke and CHD risk factors, D-dimer remained associated with CHD (HR 1.45; 95% CI 1.18, 1.79), but was marginally associated with stroke (HR 1.20; 95% CI 0.99, 1.45). The difference in the HR of D-dimer between CHD and stroke was 0.22 in the basic model and 0.25 in the Framingham model, but this difference was of marginal statistical significance (Table). There was no difference in the HRs for stroke or CHD for D-dimer in blacks compared to whites (Table). Discussion: The association of D-dimer with stroke appeared smaller than for CHD with similar associations by race. Findings suggest that hemostasis activation may play a greater role in pathogenesis of CHD than stroke. Further study is needed to confirm these findings and evaluate the association of D-dimer with different stroke subtypes.

Effect of Tobacco on Lipoprotein Profile: A Comparative study among Smokers and Chewers

2021 ◽  
pp. 4973-4976
Author(s):  
Roshan Kumar Jha ◽  
Ranjit S. Ambad ◽  
Priya Koundal ◽  
Akansha Singh
Keyword(s):  
Risk Factors ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Total Cholesterol ◽  
Sample Processing ◽  
Exclusion Criteria ◽  
Future Studies ◽  
Area Of Interest ◽  
Significant Difference ◽  
The Difference

It has been proved that tobacco is one of the cholesterol dependent risk factors pathogenically, and in addition with other risk factors it may lead to coronary heart disease. Thus, a strong interaction exists between hypercholesterolemia and tobacco ingesting in the genesis of coronary heart disease. The aim of this study was to study the effect of tobacco smoking and chewing and compare its effect on lipoproteins. 60 subjects were included in the study, and were grouped into 3 three groups, tobacco smokers, tobacco chewers and tobacco non-abusers. Each group comprises 20 participants: selected on the basis of inclusion and exclusion criteria. Proper sampling and sample processing methods were employed to evaluate lipid profile. Total cholesterol and triglycerides levels were increased in smokers in comparison to non-smokers/non-chewers, and the differences were significant p<0.0001. HDL level was decreased in smokers as compared to non-smokers/non-chewers and the difference was statistically significant p<0.0001. Total cholesterol and LDL levels were increased in smokers in comparison to chewers. HDL level was decreased in chewers as compared to chewers. There was no significant association in any of the parameters. Present study observed increased and significant p<0.0001 differences in levels of total cholesterol and triglycerides while, HDL levels were decreased significantly p<0.0001, and also observed there was no significant difference among tobacco smokers and chewers. This may be a new area of interest for future studies.

scholarly journals EFFECTIVENESS OF TICAGRELOR COMPARED TO CLOPIDOGREL IN REDUCING THE RISK OF MAJOR ADVERSE CARDIOVASCULAR EVENTS IN PATIENTS WITH CORONARY HEART DISEASE AFTER PERCUTANEOUS CORONARY INTERVENTION

2017 ◽  
Vol 9 (9) ◽  
pp. 178 ◽  
Author(s):  
Hendra Wana Nur’amin ◽  
Iwan Dwiprahasto ◽  
Erna Kristin
Keyword(s):  
Myocardial Infarction ◽  
Coronary Heart Disease ◽  
Percutaneous Coronary Intervention ◽  
Heart Disease ◽  
Cardiovascular Events ◽  
Coronary Intervention ◽  
Population Based ◽  
Major Adverse Cardiovascular Events ◽  
Repeat Revascularization ◽  
Percutaneous Coronary

Objective: Antiplatelet therapy is recommended in patients with coronary heart disease (CHD) who had the percutaneous coronary intervention (PCI) procedure to reduce major adverse cardiovascular events (MACE). There has been a lack of population-based studies that showed the superior effectiveness of ticagrelor over clopidogrel and similar studies have not been conducted in Indonesia yet. The aim of the study was to investigate the effectiveness of ticagrelor compared to clopidogrel in reducing the risk of MACE in patients with CHD after PCI.Methods: A retrospective cohort study with 1-year follow-up was conducted. 361 patients consisted of 111 patients with ticagrelor exposure and 250 patients with clopidogrel exposure. The primary outcome was MACE, defined as a composite of repeat revascularization, myocardial infarction, or all-cause death. The association between antiplatelet exposure and the MACE was analyzed with Cox proportional hazard regression, adjusted for sex, age, comorbid, PCI procedures and concomitant therapy.Results: MACE occurred in 22.7% of the subjects. Clopidogrel had a significantly higher risk of MACE compared with ticagrelor (28.8%, vs 9.0%, hazard ratio (HR): 1.96 (95% CI 1.01 to 3.81, p=0.047). There were no significant differences in risk of repeat revascularization (20.40% vs 5.40%, HR: 2.32, 95% CI 0.99 to 5.42, p = 0.05), myocardial infarction (11.60% vs 3.60%, HR: 2.08, 95% CI, 0.73 to 5.93, p = 0.17), and death (1.60% vs 1.80%, HR: 0.77, 95% CI, 0.14 to 4.25, p = 0.77).Conclusion: Clopidogrel had a higher risk of MACE compared to clopidogrel in patients with CHD after PCI, but there were no significant differences in the risk of repeat revascularization, myocardial infarction, and all-cause death. 

scholarly journals Comparative trends in coronary heart disease subgroup hospitalisation rates in England and Australia

Heart ◽  
2019 ◽  
Vol 105 (17) ◽  
pp. 1343-1350 ◽  
Author(s):  
Lee Nedkoff ◽  
Raphael Goldacre ◽  
Melanie Greenland ◽  
Michael J Goldacre ◽  
Derrick Lopez ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Unstable Angina ◽  
Coronary Intervention ◽  
Population Based ◽  
Limited Data ◽  
Hospital Data ◽  
Percutaneous Coronary ◽  
Coronary Syndromes ◽  
Coronary Procedures

BackgroundPopulation-based coronary heart disease (CHD) studies have focused on myocardial infarction (MI) with limited data on trends across the spectrum of CHD. We investigated trends in hospitalisation rates for acute and chronic CHD subgroups in England and Australia from 1996 to 2013.MethodsCHD hospitalisations for individuals aged 35–84 years were identified from electronic hospital data from 1996 to 2013 for England and Australia and from the Oxford Region and Western Australia. CHD subgroups identified were acute coronary syndromes (ACS) (MI and unstable angina) and chronic CHD (stable angina and ‘other CHD’). We calculated age-standardised and age-specific rates and estimated annual changes (95% CI) from age-adjusted Poisson regression.ResultsFrom 1996 to 2013, there were 4.9 million CHD hospitalisations in England and 2.6 million in Australia (67% men). From 1996 to 2003, there was between-country variation in the direction of trends in ACS and chronic CHD hospitalisation rates (p<0.001). During 2004–2013, reductions in ACS hospitalisation rates were greater than for chronic CHD hospitalisation rates in both countries, with the largest subgroup declines in unstable angina (England: men: −7.1 %/year, 95% CI −7.2 to –7.0; women: −7.5 %/year, 95% CI −7.7 to –7.3; Australia: men: −8.5 %/year, 95% CI −8.6 to –8.4; women: −8.6 %/year, 95% CI −8.8 to –8.4). Other CHD rates increased in individuals aged 75–84 years in both countries. Chronic CHD comprised half of all CHD admissions, with the majority involving angiography or percutaneous coronary intervention.ConclusionsSince 2004, rates of all CHD subgroups have fallen, with greater declines in acute than chronic presentations. The slower declines and high proportion of chronic CHD admissions undergoing coronary procedures requires greater focus.

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