Effect of Tobacco on Lipoprotein Profile: A Comparative study among Smokers and Chewers

2021 ◽  
pp. 4973-4976
Author(s):  
Roshan Kumar Jha ◽  
Ranjit S. Ambad ◽  
Priya Koundal ◽  
Akansha Singh
Keyword(s):  
Risk Factors ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Total Cholesterol ◽  
Sample Processing ◽  
Exclusion Criteria ◽  
Future Studies ◽  
Area Of Interest ◽  
Significant Difference ◽  
The Difference

It has been proved that tobacco is one of the cholesterol dependent risk factors pathogenically, and in addition with other risk factors it may lead to coronary heart disease. Thus, a strong interaction exists between hypercholesterolemia and tobacco ingesting in the genesis of coronary heart disease. The aim of this study was to study the effect of tobacco smoking and chewing and compare its effect on lipoproteins. 60 subjects were included in the study, and were grouped into 3 three groups, tobacco smokers, tobacco chewers and tobacco non-abusers. Each group comprises 20 participants: selected on the basis of inclusion and exclusion criteria. Proper sampling and sample processing methods were employed to evaluate lipid profile. Total cholesterol and triglycerides levels were increased in smokers in comparison to non-smokers/non-chewers, and the differences were significant p<0.0001. HDL level was decreased in smokers as compared to non-smokers/non-chewers and the difference was statistically significant p<0.0001. Total cholesterol and LDL levels were increased in smokers in comparison to chewers. HDL level was decreased in chewers as compared to chewers. There was no significant association in any of the parameters. Present study observed increased and significant p<0.0001 differences in levels of total cholesterol and triglycerides while, HDL levels were decreased significantly p<0.0001, and also observed there was no significant difference among tobacco smokers and chewers. This may be a new area of interest for future studies.

Non-invasive assessment of endothelial activity in patients with coronary heart disease and cardiovascular risk factors

VASA ◽  
2008 ◽  
Vol 37 (2) ◽  
pp. 137-142 ◽  
Author(s):  
Fronek ◽  
Allison
Keyword(s):  
Risk Factors ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Cvd Risk ◽  
Hypertension Status ◽  
The Difference ◽  
Highly Correlated ◽  
And Gender

Background: The aim of this study was first to compare the widely used flow mediated dilation ( FMD ) method with the iontophoretically induced acetylcholine vasodilation (IAV ) procedure. The ultimate goal was to examine the endothelial activity ( EA ) in patients with various cardiovascular risk factors compared with control subjects. Patients and methods: In the upper extremities of 27 subjects, comparisons of EA by FMD and IAV measured with laser Doppler flux method (LDF) were conducted. IAV-EA was then measured using LDF in an additional 93 subjects with various cardiovascular ( CVD ) risk factors and/or a diagnosis of coronary heart disease (CHD). Results: The mean age of the subjects was 56.2 years and 54% were male. There was a robust and significant correlation between FMD vs IAV endothelial activity (r = 0.87, p = 0.025). After adjustment for age, there were significant differences in LDF-measured, acetylcholine-induced EA by diagnosis of CHD (p = 0.02), hyperlipidemia (p = 0.03) and diabetes (p < 0.01), as well as by sex (p < 0.01). The difference by hypertension status was of borderline significance (p = 0.07). LDF EA was higher in non-smokers compared to smokers but this difference was not statistically significant (p = 0.3). After adjustment for age and gender, a 10-unit increase in LDF-measured EA was associated with a 12% lower odds for a diagnosis of CHD (p = 0.07). Conclusions: Measurement of IAV-EA by LDF is a simple, noninvasive methodology which is highly correlated with post-occlusive FMD EA and is also significantly associated with a diagnosis of CHD.

Role of known risk factors in explaining the difference in the risk of coronary heart disease between eastern and southwestern Finland

1998 ◽  
Vol 30 (5) ◽  
pp. 481-487 ◽  
Author(s):  
Pekka Jousilahti ◽  
Erkki Vartiainen ◽  
Jaakko Tuomilehto ◽  
Juha Pekkanen ◽  
Pekka Puska
Keyword(s):  
Risk Factors ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
The Difference

scholarly journals Risk factors of coronary heart disease: attitude and behaviour in family practice in Saudi Arabia

1999 ◽  
Vol 5 (1) ◽  
pp. 35-45 ◽  
Author(s):  
M. S. Khattab ◽  
M. A. Abolfotouh ◽  
W. Alakija ◽  
M. A. Al Humaidi ◽  
S. Al Wahat
Keyword(s):  
Risk Factors ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Family Practice ◽  
Physical Inactivity ◽  
Fat Intake ◽  
Significant Difference ◽  
Lifestyle Questionnaire ◽  
Males And Females ◽  
The Mean

To study risk factors of attitudes and behaviour towards coronary heart disease [CHD], 280 Saudis > or = 20 years attending a family practice answered a structured health and lifestyle questionnaire and had their weight, height, blood pressure and random total cholesterol measured. Significant difference was found between males and females in the mean number of cardiovascular risk factors [t = -3.03, P < 0.01]. Few people with high dietary fat intake, obesity or physical inactivity perceived their behaviour as harmful. The number of people who perceived an associated risk to their health increased with incidence of smoking and obesity but not with high fat intake. Physically inactive people were least likely to perceive their behaviour as harmful

The correlation of apolipoprotein B, apolipoprotein B/apolipoprotein A-I ratio and lipoprotein(a) with myocardial infarction

Open Medicine ◽  
2008 ◽  
Vol 3 (4) ◽  
pp. 422-429
Author(s):  
Lucia Agoston-Coldea ◽  
Teodora Mocan ◽  
Marc Gatfossé ◽  
Dan Dumitrascu
Keyword(s):  
Risk Factors ◽  
Myocardial Infarction ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Cardiovascular Risk ◽  
Total Cholesterol ◽  
Cardiovascular Risk Factors ◽  
Apolipoprotein B ◽  
Hdl Cholesterol ◽  
Lipoprotein A

AbstractRecent evidence shows that apolipoprotein (apo) B, apoB/apoA-I ratio and lipoprotein(a) are better indicators of coronary risk than the conventional lipid profile. The aim of this study was to evaluate the correlation of apoA-I and B, and lipoprotein(a) with myocardial infarction (MI). We performed a cross-sectional study including 208 patients (100 men and 108 women), with and without previous MI evaluated by coronary angiography. The severity of coronary heart disease was scored on the basis of the number and extent of lesions in the coronary arteries. Lipid levels were measured by the enzymatic method and apolipoprotein levels were measured by the immunoturbidimetric method. The MI group had higher plasmatic levels of lipoprotein(a) (0.37±0.28 vs. 0.29±0.23 g/L, p<0.05), apoB (1.13±0.40 vs. 0.84±0.28 g/L, p<0.05) and of the apoB/apoA-I ratio (0.77±0.37 vs. 0.68±0.20, p<0.05) compared to controls. The area under the receiver operating characteristic (ROC) curves (AUC) suggested a good reliability in the diagnose of coronary heart disease for the apoB/apoA-I ratio (0.756, p<0.05), apoB (0.664, p<0.05), lipoprotein(a) (0.652, p<0.05) and total cholesterol/HDL-cholesterol (0.688, p<0.05). Multivariate analysis performed with adjustments for cardiovascular risk factors, showed that the levels of lipoprotein(a), apoB and apoB/apoA-I ratio are significant independent cardiovascular risk factors. Our results indicate that there is an important relationship among high plasma apoB concentration, lipoprotein(a) concentration, the apoB/apoA-I ratio, and MI. We showed that the apoB/apoA-I ratio has a stronger correlation with MI than the total cholesterol/HDL cholesterol ratio. We therefore suggest using apoB/apoA-I ratio and lipoprotein(a) in clinical practice as a markers of MI risk.

scholarly journals ASSOCIATION OF SELECTED RISK FACTORS OF CORONARY HEART DISEASE WITH LIPID PROFILE

2018 ◽  
Vol 11 (2) ◽  
pp. 366
Author(s):  
Trilochan Sahu ◽  
Lipilekha Patnaik ◽  
Venkata Rao E ◽  
Subhashree Ray ◽  
Sandeep Kumar Panigrahi
Keyword(s):  
Risk Factors ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Total Cholesterol ◽  
Blood Sugar ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Community Based Education

 Objective: The objectives of this study is to assess the association of selected risk factors for coronary heart disease (CHD) with lipid profile.Methods: A cross-sectional study was conducted during May 2013–April 2014 among 350 subjects of 25–64 years selected by systematic random sampling. Data on sociodemographic and medical and personal history along with anthropometric measurements were collected through house-to-house visit. Blood sample was analyzed for fasting blood sugar and lipid profile.Results: In this study, 38.58% belong to the age group of 25–35 years and 58% were female. Majority (45.43%) of the participants belonged to lower socioeconomic status, followed by the middle (40.57%) and upper class (14%). It was observed that total cholesterol was significantly associated with blood sugar (p=0.0008), blood pressure (p=0.001), and body mass index (BMI) (p=0.018). There was no significant association among the risk factors of CHD such as smoking and alcohol with total cholesterol. Low-density lipoprotein level was significantly associated with BMI (p=0.0001) and blood sugar (p=0.003). There was a significant association among the risk factors for CHD such as smoking (p=0.002), alcohol, (p=0.017) blood sugar (p=0.004), and BMI (p=0.014) with triglyceride level.Conclusion: It was concluded from this study that various risk factors for CHD were associated with lipid abnormalities. Hence, a community-based education in this regard is of paramount importance.

Determination of Risk Factors of the Youth for Coronary Heart Disease Based on Gender

2018 ◽  
Vol 9 (09) ◽  
pp. 20613-20620
Author(s):  
Betül ÖZEN ◽  
Özlem CEYHAN ◽  
Zeliha KAYA ERTEN ◽  
Meltem SOYLU
Keyword(s):  
Risk Factors ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Young People ◽  
University Students ◽  
Fast Food ◽  
Female Students ◽  
Male Students ◽  
Significant Difference ◽  
The University

Objective: This study was conducted to determine the risk factors of the youth for coronary heart disease. Methods: This cross-sectional study was completed with 216 students who were studying in a university located in Kayseri and selected for the sample by using the stratified simple random sampling method. Results: In the study, 40.3% of the university students were 20-21 years old, 69% were female, and 21.3% had the history of heart disease in their family. 47.8% of the male students were smoker, 17.9% were drinking alcohol, 22.4% did not do physical exercise and no significant difference was determined compared to the female students (p<0.05). More than 65% of the university students described themselves as stressed. 20.1% of the female students and 35.8% of the male students were eating fast food. It was found that BMI and body fat percentage of the male students were significantly higher than female students. On the other hand, waist-to-hip ratio of the female students was significantly higher than the male students. In addition, the male students had higher systolic (p = .001) and diastolic blood pressures (p = .004). Conclusion: This study showed that young people were at risk for coronary heart disease. This reveals the importance of recognizing risky behaviors among young people and conducting studies to encourage young people for lifestyle change.

scholarly journals Prevalence and risk factors of coronary heart disease in a rural population of Bangladesh

1970 ◽  
Vol 4 (2) ◽  
pp. 37-43 ◽  
Author(s):  
M Abu Sayeed ◽  
Hajera Mahtab ◽  
Shurovi Sayeed ◽  
Tanjima Begum ◽  
Parvin Akter Khanam ◽  
...  
Keyword(s):  
Risk Factors ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Social Class ◽  
Family History ◽  
Rural Population ◽  
Significant Risk ◽  
Family History Of Diabetes ◽  
Significant Difference ◽  
History Of

Coronary heart disease (CHD) is a major global health problem with the majority of burden observed increasingly in the developing countries. There has been no estimate of CHD in Bangladesh. This study addresses the prevalence of CHD in a Bangladeshi rural population which also aimed to determine the risk factors related to CHD. Ten villages of Nandail sub-district under Mymensingh were selected purposively. All subjects of age ≥20y were considered eligible and were interviewed about family income, family history of T2DM, CHD and HTN. The investigations included height, weight, waist-girth, hip-girth, systolic and diastolic blood pressure (SBP & DBP), fasting blood glucose (FBG), triglycerides (TG), cholesterol (Chol) and high density lipoprotein (HDL). Hemoglobin A1c (HbA1c) and albumin-creatinine ratio (ACR) were also estimated. Finally, electrocardiography (ECG) was undertaken in all participants who had family history of diabetes or hypertension or CHD. Diagnosis of CHD was based on history of angina or changes in ECG or diagnosed by a cardiologist. A total of 6235 subjects were enlisted as eligible (age ≥20y) participants. Of them, 4141 (m / f: 1749 / 2392) subjects volunteered for the study. The age-adjusted (20-69y) prevalence of CHD was 1.85 with 95% CI, 1.42 - 2.28. There was no significant difference between men and women. The mean (SD) values of age (p<0.001), SBP (p<0.01), DBP (p<0.05), HbA1c (p<0.05) and ACR (p<0.01) were significantly higher among subjects with CHD than those without; whereas, there were no significant differences in BMI and WHR, TG, Chol and HDL. Logistic regression analysis showed that adjusted for age, sex, social class and obesity, the subjects with higher age (≥45y), higher 2hBG (≥7.0mmol/l), higher ACR (≥17.2) and family history of CHD had significant risk for CHD. The prevalence of CHD is comparable with other Asian population. Family history of CHD and age over 45 years, and who had hyperglycemia and higher ACR were proved to be the independent predictors of CHD. CHD was found to affect participants irrespective of sex, social class, obesity and lipid status. Though the IFG and diabetes groups appeared to have similar biophysical characteristics, only the diabetes group had significant risk for CHD. Further study in a larger sample may be undertaken to confirm the study findings and to explore some unidentified risk factors of CHD. DOI: 10.3329/imcj.v4i2.6494Ibrahim Med. Coll. J. 2010; 4(2): 37-43

Abstract P364: Recent Trends In Mortality From Coronary Heart Disease Mortality And Its Risk Factors In Selected Developed Countries

Circulation ◽  
2014 ◽  
Vol 129 (suppl_1) ◽  
Author(s):  
Akira Sekikawa ◽  
Katsuyuki Miura ◽  
Bradley Willcox ◽  
Kamal H Masaki ◽  
Russell P Tracy ◽  
...  
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Total Cholesterol ◽  
Developed Countries ◽  
Men And Women ◽  
The Us ◽  
Recent Trends ◽  
The Uk

Objectives: Mortality from coronary heart disease (CHD) in developed countries started to decline in the late 1960’s and early 1970’s and age-adjusted CHD mortality fell about 50%. This decline is attributed to favorable changes in risk factors in the general population, i.e., total cholesterol, blood pressure, smoking, etc., and improved treatment of CHD. We examined recent trends in CHD mortality and its risk factors in selected developed countries. Methods: We selected Australia, Canada, France, Italy, Japan, Spain, Sweden, the UK, and the US. Data on CHD mortality between 1980 and 2005-08 were obtained from the WHO Statistical Information System. To define CHD mortality, codes I20-25 in ICD-10 and corresponding codes in ICDs 8 and 9 were used. Data on risk factors, primarily total cholesterol and systolic blood pressure during the same period were obtained from national surveys as well as literature. Results: in 1980, there was a 2 to 3-fold difference in age-adjusted CHD mortality among these countries both in men and women, with the UK, the US and Canada being high and Japan and France being low. Although between 1980 and 2005-08, age-adjusted CHD mortality continuously declined in all these countries, a 2 to 3-fold difference in the mortality remained with the similar order among these countries. Between 1980 and 2008, age-adjusted mean levels of total cholesterol fell by 21 to 31 mg/dl in men and by 8 to 31 mg/dl in women in these countries except for Japan. Age-adjusted levels of total cholesterol in Japan have continuously increased by 16 mg/dl for both men and women during this period. Meanwhile, between 1980 and 2008 age-adjusted levels of systolic blood pressure fell by 5 to 8 mmHg in men and 6 to 13 mmHg in women in these countries without exception. In 1980, the rate of cigarette smoking in men in Japan was the highest among these countries. Although the rate of smoking in men fell in all these countries, the rates remained the higher in Japan. Conclusions: Age [[Unable to Display Character: &#8211;]]adjusted CHD mortality has continuously declined between 1980 and 2005-08 in these developed countries. The decline was accompanied by a constant decrease in population-levels of total cholesterol by 20 to 30 mg/dl except for Japan where levels of total cholesterol have increased by 16 mg/dl. The reasons for persistently low CHD mortality and its downward trend in Japan are unexplained by traditional risk factors. Identifying preventive factors that determine low CHD rates in the Japanese and implementing such factors to the US would eliminate most of CHD epidemics in the US.

scholarly journals D-dimer and the Risk of Stroke and Coronary Heart Disease

2017 ◽  
Vol 117 (03) ◽  
pp. 618-624 ◽  
Author(s):  
Leslie A. McClure ◽  
Suzanne E. Judd ◽  
Brett Kissela ◽  
George Howard ◽  
Monika M. Safford ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Cardiovascular Risk ◽  
Vascular Disease ◽  
Cardiovascular Risk Factors ◽  
Hazard Ratio ◽  
The Difference ◽  
D Dimer

SummaryD-dimer, a biomarker of coagulation, is higher in blacks than in whites and has been associated with stroke and coronary heart disease (CHD). It was our objective to assess the association of higher D-dimer with stroke and CHD in blacks and whites. REGARDS recruited 30,239 black and white participants across the contiguous US and measured baseline D-dimer in stroke (n=646) and CHD (n=654) cases and a cohort random sample (n=1,104). Cox models adjusting for cardiovascular risk factors determined the hazard ratio (HR) for increasing D-dimer for cardiovascular disease with bootstrapping to assess the difference in HR for CHD versus stroke by race. D-dimer was higher with increasing age, female sex, diabetes, hypertension, pre-baseline cardiovascular disease and higher C-reactive protein (CRP). Accounting for cardiovascular risk factors, each doubling of D-dimer was associated with increased stroke (hazard ratio [HR] 1.15; 95 % confidence interval [CI] 1.01, 1.31) and CHD (HR 1.27; 95 % CI 1.11, 1.45) risk. The difference in the HR between CHD and stroke was 0.20 (95 % CI >0.00, 0.58) for blacks and 0.02 (95 % CI –0.30, 0.27) for whites. CRP mediated 22 % (95 % CI 5 %, 41 %) of the association between D-dimer and CHD and none of the association with stroke. Higher D-dimer increased the risk of stroke and CHD independent of cardiovascular risk factors and CRP, with perhaps a stronger association for CHD versus stroke in blacks than whites. These findings highlight potential different pathophysiology of vascular disease by disease site and race suggesting potential further studies targeting haemostasis in primary prevention of vascular disease.

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