Comparison of the Initiation Time of Enteral Nutrition for Critically Ill Patients: At Admission vs. 24 to 48 Hours after Admission

Objective. To investigate the better time of initiation of enteral nutrition for critically ill patients, such as at admission or 24 to 48 hours after admission. Methods. This was a prospective, randomized, parallel-controlled, single-blind, interventional clinical trial. A total of 100 patients admitted to the intensive care unit (ICU) of our hospital between January 2017 and December 2018 were recruited in this study. These patients had been divided into the control group or intervention group by a computer-generated random number table, and each group had 50 patients. For the control group, a gastric tube was inserted to start enteral nutrition at 24 to 48 hours after admission. For the intervention group, a nasojejunal tube was placed to start enteral nutrition at admission. The main endpoints included serum albumin and prealbumin at admission and on days 3, 7, and 14 after admission, length of ICU stay, ventilator time, and complications such as diarrhea, gastric retention, esophageal reflux, and pulmonary infection. Results. The results showed that serum albumin and prealbumin were significantly higher in the intervention group than in the control group ( P < 0.05). The length of ICU stay ( P < 0.05) and ventilator time ( P < 0.05) were both significantly shorter in the intervention group than in the control group. The incidences of gastric retention, esophageal reflux, and pulmonary infection were significantly lower in the intervention group than those in the control group ( P < 0.05). Conclusion. In the absence of contraindications, enteral nutrition can be initiated immediately after admission to the ICU (within 6 hours), and feeding nasojejunal tube is recommended. It can improve the nutritional status and prognosis of critical patients, improve the feeding effect, shorten the length of stay in the ICU and the use of the ventilator, and reduce the incidence of complications.

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EVALUATION OF EFFECTIVENESS OF AROGYA KASHAYAM-20 IN COVID-19 CASES - A RANDOMIZED CONTROLLED STUDY

10.31219/osf.io/au3ct ◽

2021 ◽

Author(s):

Umesh Shukla ◽

Nitin Ujjaliya

Keyword(s):

Controlled Trial ◽

Care Center ◽

Large Population ◽

Intervention Group ◽

Controlled Study ◽

Control Group ◽

Rt Pcr ◽

Randomized Controlled ◽

Group A ◽

Negative Conversion

Introduction: The characteristic clinical features of Covid-19 disease range between asymptomatic to mild-moderate symptoms. Studies suggest that a large population (80%) presents its asymptomatic or milder form. Remaining 20 percent, owing to severity of the diseases, need hospital-based care. Many treatment protocols and strategies have been promoted and recommended by authorities including WHO, but nothing has actually been finalized till date. The present study was planned to evaluate the effectiveness of an Ayurvedic formulation viz. Arogya Kashayam-20 in the hospitalized cases of Covid-19.Aim: To evaluate the effectiveness of Arogya Kashayam-20 in the cases of COVID-19 particularly the negative conversion of RTPCR in 10 days duration.Material and Methods: This was a randomized controlled trial conducted at COVID-19 Care Center, Pt. Khushilal Sharma Government Ayurveda College & Institute, Bhopal, Madhya Pradesh with a sample size of 112 participants, aged between 16 to 60 years of either sex. Participants were divided in two groups viz. group A and B. Both the groups received Hydroxychloroquine (HCQ), vitamin C and Zinc as per the prevailing ICMR guidelines and group 'A' received additionally Arogya Kashayam-20 for 10 days. Outcome measure of the study was to see the negative conversion RT-PCR test after intervention period of 10 days. CTRI Registration: CTRI/2020/06/026221. Results: Among the 60 cases registered in study group (group A), 51 cases (85.00%) were reported with negative RTPCR on 10th day. Out of 52 cases registered in control group (group B); 39 cases (75.00%) were tested negative RTPCR on 10th day. In both the groups all the cases were discharged asymptomatically on 10th day as per the prevailing ICMR guidelines. No ADR/AE observed during the intervention period.Conclusion: The study observes that the add on intervention group has a better outcome in terms of RT-PCR negative reports after 10 days comparing to the control group.

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Effect of Beta-casomorphin-7 on Renal Function and Immunity in Aging Mice

Indian Journal of Animal Research ◽

10.18805/ijar.b-1333 ◽

2021 ◽

Author(s):

Hong Yin ◽

Fangpeng Chen ◽

Xiaqing Su ◽

Jingyi Wang ◽

Yan Xu ◽

...

Keyword(s):

Renal Function ◽

Adrenocorticotropic Hormone ◽

Inflammatory Cell ◽

Histopathological Examination ◽

Intervention Group ◽

Control Group ◽

Paraffin Sections ◽

Gain Rate ◽

Group A ◽

Medium Dose

Background: Most studies have shown that Beta-Casomorphin-7 (BCM-7) has many physiological functions, this study aims to investigate the effects of BCM-7 on renal function and immunity in naturally aging mice and to reveal the effects of BCM-7 on health and provide more theoretical reference for inflammatory aging.Methods: All mice were weighed weekly and the organ indexes were calculated, Paraffin sections were prepared for kidney histopathological examination with conventional Haematoxylin and Eosin (HE) staining, renal function indexes and cytokines were main measured by ELISA and biochemical colorimetry.Result: The weight of each group increased during gastric perfusion and the higher the intervention concentration, the lower the weight gain rate. The renal index was not affected by BCM-7, but the spleen index was significantly decreased by medium-dose BCM-7. There were inflammatory cell infiltration and other renal lesions in the aging control group and intervention group. A medium dose of BCM-7 can significantly reduce Cystatin C (Cys-C) content in aging mice, the content of Adrenocorticotropic hormone (ACTH) in aged mice decreased with the increase of BCM-7 intervention dose. BCM-7 and aging caused cytokine imbalance in mice.

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Pengaruh Pendidikan Kesehatan dengan Lembar Balik Terhadap Perilaku Pemberian Asi pada Ibu Post Partum

Jurnal Kebidanan Midwiferia ◽

10.21070/mid.v3i2.1522 ◽

2017 ◽

Vol 3 (2) ◽

pp. 40

Author(s):

Luluk Fajria Maulida

Keyword(s):

Health Education ◽

Healthy Lifestyle ◽

Post Partum ◽

Intervention Group ◽

Average Score ◽

Control Group ◽

Chi Square ◽

Group A ◽

And Control ◽

Breastfeeding Attitude

One of the obstacles in breastfeeding attitude is the lack of lactation communication and counseling. Breastfeeding health education is designed to enforce healthy lifestyle of breastfeeding by delivering proof based information. Flipchart media usage can be easily understood by health counsellors and clients. The study is to investigate the influence of health education using flipchart over breastfeeding attitude in post-partum mothers. This research was used a quasi experiment design with posttest only design with control group. A random assignment sampling design was used to 42 respondents which were divided into 2 groups; intervention group and control group. The samples were randomized using numbers and were divided into intervention and control group. The intervention group was given health education after delivery and questionnaires were given in intervention and control group a week after postpartum. The average score postpartum maternal behavior in the intervention group (18,43) is higher than the control group (15,14). The results of chi square test p = 0.00; RR = 3.16; CI = 1,58-6,31. External variables related to the behavior of breastfeeding is the education level of p = 0.02. Health education using flipchart significantly affects breastfeeding behavior in postpartum mothers.

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Effect of Flowable Thrombin-Containing Collagen-Based Hemostatic Matrix for Preventing Pancreatic Fistula after Pancreatectomy: A Randomized Clinical Trial

Journal of Clinical Medicine ◽

10.3390/jcm9103085 ◽

2020 ◽

Vol 9 (10) ◽

pp. 3085

Author(s):

Yejong Park ◽

Jae Hyung Ko ◽

Dae Ryong Kang ◽

Jun Hyeok Lee ◽

Dae Wook Hwang ◽

...

Keyword(s):

Pancreatic Fistula ◽

Distal Pancreatectomy ◽

Intervention Group ◽

Length Of Hospital Stay ◽

Multivariate Logistic Regression Model ◽

Control Group ◽

Drain Removal ◽

Parallel Group ◽

Secondary Endpoints ◽

Group A

Background: The aim of this study was to evaluate the safety and efficacy of a flowable hemostatic matrix, and their effects for postoperative pancreatic fistula (POPF) after pancreatectomy. Methods: This was a randomized, clinical, single-center, single-blind (participant), non-inferiority, phase IV, and parallel-group trial. The primary endpoint was the incidence of POPF. The secondary endpoints were risk factors for POPF, drain removal days, incidence of complication, 90-day mortality, and length of hospital stay. Results: This study evaluated a total of 53 patients, of whom 26 patients were in the intervention group (flowable hemostatic matrix) and 27 patients were in the control group (thrombin-coated collagen patch). POPF was more common in the control group than in the intervention group (59.3% vs. 30.8%, p = 0.037). Among participants who underwent distal pancreatectomy, POPF (33.3% vs. 92.3%, p = 0.004), and clinically relevant POPF (8.3% vs. 46.2%, p = 0.027) was more common in the control group. A multivariate logistic regression model identified flowable hemostatic matrix use as an independent negative risk factor for POPF, especially in cases of distal pancreatectomy (DP) (odds ratio 17.379, 95% confidential interval 1.453–207.870, p = 0.024). Conclusion: Flowable hemostatic matrix application is a simple, feasible, and effective method of preventing POPF after pancreatectomy, especially for patients with DP. Non-inferiority was demonstrated in the efficacy of preventing POPF in the intervention group compared to the control group.

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A 10-Month Physical Activity Intervention Improves Body Composition in Young Black Boys

Journal of Obesity ◽

10.1155/2011/358581 ◽

2011 ◽

Vol 2011 ◽

pp. 1-8 ◽

Cited By ~ 13

Author(s):

Cheryl A. Howe ◽

Ryan A. Harris ◽

Bernard Gutin

Keyword(s):

Physical Activity ◽

Body Composition ◽

Physical Activity Intervention ◽

Intervention Group ◽

Skills Development ◽

After School ◽

Control Group ◽

Black Boys ◽

X Ray ◽

Group A

Objective. To determine if a 10-month after-school physical activity (PA) intervention could prevent deleterious changes in body composition and cardiovascular (CV) fitness in young black boys.Methods. Following baseline measures, 106 boys (8–12 yrs) were randomized to either a control group or an intervention group, further divided into attenders (ATT) and nonattenders (NATT), participating in ≥60% or <60% of the intervention, respectively. The daily intervention consisted of skills development (25 min), vigorous PA (VPA, 35 min), and strengthening/stretching (20 min) components. Body composition was measured by dual-energy X-ray absorptiometry.Results. Following the intervention, the ATT exhibited an increase in moderate-to-vigorous PA and a significant reduction in BMI, fat mass, and %BF compared to the control group. A significant association among the intervention energy expenditure and changes in body composition and CV fitness was observed only in the ATT group.Conclusion. An after-school PA program of sufficient length and intensity can promote healthy changes in body composition and fitness levels in black boys who attend at least 3 days/week.

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The Role of IgM-Enriched Immunoglobulin (Pentaglobin) in Septic Patients with Hematological Disease

International Journal of Hematology-Oncology and Stem Cell Research ◽

10.18502/ijhoscr.v15i2.6041 ◽

2021 ◽

Author(s):

Pedro Amoedo Fernandes ◽

Flavia Tobaldini Russo ◽

Lucas Augusto Monetta da Silva ◽

Lafayete Willian Ferreira Ramos ◽

Aline de Almeida Simões ◽

...

Keyword(s):

Septic Shock ◽

Intervention Group ◽

Serum Levels ◽

Control Group ◽

Hematological Disease ◽

Hematopoietic Stem ◽

Humoral Immunodeficiency ◽

Group A ◽

Low Serum

Background: Patients with hematological disease are 15 times more likely to develop sepsis than the general population. The patient with hematological disease and, mainly, those undergoing hematopoietic stem cell transplantation (HSCT), develop a severe secondary humoral immunodeficiency, with low serum levels of IgM, which may take more than a year to be restored. Materials and Methods: This is a retrospective, controlled and observational study that analyzed 51 patients with underlying hematological disease, who were diagnosed with sepsis or septic shock during the study period, to evaluate whether IgM-rich Ig replacement decreases the 30-day mortality. Results: Of the 51 patients, 35 patients received IgM-rich immunoglobulin (group A) and 16 (31%) received conventional therapy. Eleven (69%) patients in the control group were alive after 30 days compared to 11 (34%) patients in the intervention group, p= 0.013. Conclusion: There are no apparent benefits in the use of IgM-rich immunoglobulin in septic patients with hematological disease.

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Does Reading a Book in Bed Make a Difference to Sleep in Comparison to Not Reading a Book in Bed? The People's Trial- an Online, Pragmatic, Randomised Trial

10.21203/rs.3.rs-239596/v1 ◽

2021 ◽

Author(s):

Elaine Finucane ◽

Ann O’Brien ◽

Shaun Treweek ◽

John Newell ◽

Kishor Das ◽

...

Keyword(s):

Sleep Quality ◽

Randomised Trial ◽

Intervention Group ◽

Control Group ◽

Randomised Trials ◽

Media Campaigns ◽

The Public ◽

Equal Chance ◽

Group A ◽

Sleep Control

Abstract BackgroundThe best way of comparing healthcare treatments is through a randomised trial. In a randomised trial, we compare something (a treatment or intervention) to something else, often another treatment. Who gets what is decided at random, meaning everyone has an equal chance of getting any of the treatments. This means any differences found can be put down to the treatment received rather than other things, such as where people live, or health conditions they might have.The People’s Trial aimed to help the public better understand randomised trials by inviting them to design and carry out a trial. The question chosen by the public for The People’s Trial was:‘Does reading a book in bed make a difference to sleep, in comparison to not reading a book in bed?’ This paper describes that trial, called ‘The Reading Trial’.MethodsThe Reading Trial was an online, randomised trial. Members of the public were invited to take part through social media campaigns. People were asked to either read a book in bed before going to sleep (intervention group) or not read a book in bed before going to sleep (control group). We asked everyone to do this for seven days, after which they measured their sleep quality. Results During December 2019, a total of 991 people took part in The Reading Trial, half (496 (50%)) in the intervention group and half (495 (50%)) in the control group. Not everyone finished the trial: 127 (25.6%) people in the intervention group, and 90 (18.18%) people in the control group. Of those providing data, 156/369 (42%) people in the intervention group felt their sleep improved, compared to 112/405 (28%) of those in the control group, a difference of 14%. When we consider how certain we are of this finding, we estimate that, in The Reading Trial, sleep improved for between 8% and 22% more people in the intervention group compared to the control group.ConclusionsReading a book in bed before going to sleep improved sleep quality, compared to not reading a book in bed.Trial Registration Registered 4th December 2019, ClinicalTrials.gov ID: NCT04185818.

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Pengaruh Pendidikan Kesehatan Menggunakan Booklet Berbahasa Madura Terhadap Self Management Pada Klien Hipertensi di Poli Jantung Rsud dr. Abdoer Rahem Situbondo

Jurnal Keperawatan Muhammadiyah ◽

10.30651/jkm.v4i2.2703 ◽

2019 ◽

Vol 4 (2) ◽

Author(s):

Silvia Nuruddani ◽

Handono Fatkhur Rahman ◽

Setiyo Adi Nugroho ◽

Sri Astutik Andayani ◽

Abdul Hamid Wahid

Keyword(s):

Health Education ◽

Quantitative Research ◽

Intervention Group ◽

T Test ◽

Self Management ◽

Uncontrolled Hypertension ◽

Control Group ◽

P Value ◽

Before And After ◽

Group A

Objective: Hypertension is one of the main problems of public health, and if still a big challenge in indonesia with a high prevelention amounting to 34,1% (percent). Uncontrolled hypertension will cause complication and death. One of the factors that can cause hypertension is a bad self management. To improve self management on hypertensive dilent is health education needs to be done.Methods: The kind of quantitative research with Quasi Experiment design in the form of a Pretest-Posttest Nonequivalent Control Group sampale selection with Simple Random Samping as many as 40 respondets 20 intervention groups, 20 control graups data collection techniaques with self management questioner (H-SCALE).Results: Paired T-test results of the intervention group obtained a P-value of 0,000, and in the control group a P-value of 0.106 was obtained. While the results of the Independent T-test in the intervention group and the control group obtained a value of 0,000. So it can be said that there are effects and differences before and after health education is given to hypertension client self management. Conclusion: Expected by health education obout hypertension can improve self management on hypertension drent.

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Plaque Removal Efficacy of Dental floss Compare to Water Jet Following Single Use

10.53350/pjmhs2115123439 ◽

2021 ◽

Vol 15 (12) ◽

pp. 3439-3441

Author(s):

Syed Midhat Batool ◽

Madiha Rasheed ◽

Kawish Syed ◽

Afaq Farooq ◽

Zain Ayub ◽

...

Keyword(s):

Controlled Trial ◽

Intervention Group ◽

Water Jet ◽

Tooth Brushing ◽

Control Group ◽

Dental Floss ◽

Plaque Removal ◽

Group A ◽

The Mean ◽

Group B

Background: Dental plaque (biofilm) is a well-known contributor to the onset and progression of many dental illnesses. Plaque is a natural biofilm that develops on oral surfaces and contains a wide variety of organisms. As a result, it is critical to control plaque formation, particularly in the young population, by implementing effective preventive strategies. Objective: To assess and compare plaque removal efficacy of water flosser and string floss in patients. Study design: Randomized controlled trial Place and Duration of study: Department of Periodontology, Sardar Begum Dental College, Gandhara University from 1st March 2019 to 31st May 2019. Methodology: Seventy patients were enrolled. Patients were randomly allocated to one of two groups, group A (using dental floss) as the control group and group B (using waterpik) as the intervention group, using the lottery technique. Patients were randomly allocated to one of two groups, group A (control group), using dental floss and group B (intervention group), using waterpik utilizing the lottery technique. All participants were taught correct brushing technique utilizing the Modified Bass technique and manufacturer's instructions for using waterpik as well as normal flossing instructions for using Dental floss. Results: The mean age presentation was 34.23±6.78 years. The females were 42 (60%) males were 28 (40%). The mean percentage showed that those using water flosser with tooth brushing had low plaque score than using string floss with tooth brushing. The independent t test showed that water flosser is significantly more effective (p=0.001) in plaque reduction than conventional string floss. Conclusion: A water flosser coupled with hand brushing is more effective in eliminating plaque than string floss. Plaque removal was 20-30% higher in the group that used a water flosser. Key words: Efficacy, Dental floss, Water jet

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The effects of explicit instruction on L2 learners’ acquisition of verb–noun collocations

Language Teaching Research ◽

10.1177/1362168818795188 ◽

2018 ◽

Vol 24 (2) ◽

pp. 138-162

Author(s):

Mei-Hsing Tsai

Keyword(s):

Explicit Instruction ◽

Relative Effectiveness ◽

Intervention Group ◽

Control Group ◽

Image Schemas ◽

Group A ◽

Recognition Testing ◽

Based Instruction ◽

Positive Effect ◽

English Verb

This study investigates the relative effectiveness of two methods for teaching a set of English verb–noun collocations: form-focused instruction (FFI) and concept-based instruction (CBI). The sample comprised 73 Chinese-speaking learners of English taking intermediate English courses, who were randomly assigned to one of three groups: an FFI intervention group, a CBI intervention group, and a control group. In order to determine the effects of the two instructional methods, the participants’ collocational knowledge was measured in three ways: via form recall testing, form recognition testing, and meaning recall testing. Specifically, all of the participants took pretests, immediate posttests, and one-week delayed posttests. The results of a comparison of the learning gains between the three groups showed that the CBI and FFI approaches each had a positive effect on establishing initial form–meaning relationships for verb–noun collocations. The CBI group significantly outperformed the FFI group on both collocational acquisition and retention. This result suggests that CBI’s focus on learning verbal meanings through image schemas and conceptualization practice is associated with a deeper understanding of English verb–noun collocations. The study concludes with pedagogical implications for teaching second language (L2) collocations.

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