scholarly journals An Update of Anthraquinone Derivatives Emodin, Diacerein, and Catenarin in Diabetes

2021 ◽  
Vol 2021 ◽  
pp. 1-13
Author(s):  
Miquel Martorell ◽  
Natalia Castro ◽  
Montserrat Victoriano ◽  
Xavier Capó ◽  
Silvia Tejada ◽  
...  
Keyword(s):  
Metabolic Diseases ◽  
Chinese Herbs ◽  
World Health ◽  
Food Sources ◽  
Naturally Occurring ◽  
Anthraquinone Derivatives ◽  
Increase Insulin Secretion ◽  
Sugar Levels ◽  
Health Organization ◽  
Antidiabetic Effects

Diabetes is part of metabolic diseases and is characterized by high blood sugar levels over a prolonged period as result of an insulin-deficient production or an inappropriate response to insulin by our cells. This chronic disease was the direct cause of 1.6 million deaths in 2016 as reported by the World Health Organization. Emodin is a natural product and active ingredient of various Chinese herbs with the chemical formula 1,3,8-trihydroxy-6-methylanthraquinone. Diacerein is another naturally occurring anthraquinone (1,8-diacetoxy-3-carboxyanthraquinone) commonly used as commercial drug to treat osteoarthritis. These two anthraquinone derivatives have been shown to exert antidiabetic activities. Emodin seems to enhance the glucose tolerance and insulin sensibility via activation of PPARγ and modulation of metabolic-related genes. Diacerein seems to decrease inflammatory cytokines and increase insulin secretion enhancing insulin sensibility and therefore improving glucose control. Other naturally occurring anthraquinone derivatives, such as catenarin (1,4,6,8-tetrahydroxy-3-methylanthraquinone), have been shown to have antidiabetic activities although few studies have been performed. The synthesis of new emodin derivatives is increasing, but these new molecules have not been tested for diabetes treatment. In the current work, available literature on anthraquinone derivatives' effects in diabetes disease is reviewed. Moreover, we discuss the chemistry, food sources, bioavailability, and toxicity of the naturally occurring anthraquinone with antidiabetic effects.

Phytoconstituents in the Management of Covid-19: Demystifying the Fact

Drug Research ◽  
2022 ◽  
Author(s):  
Md. Abul Barkat ◽  
Pawan Kaushik ◽  
Harshita Abul Barkat ◽  
Mohammad Idreesh Khan ◽  
Hazrina Ab Hadi
Keyword(s):  
Therapeutic Agent ◽  
Clinical Development ◽  
World Health ◽  
Therapeutic Drug ◽  
Scientific Communities ◽  
Synthetic Drugs ◽  
Naturally Occurring ◽  
Deadly Disease ◽  
Novel Coronavirus ◽  
Health Organization

AbstractThe 2019-nCoV (COVID-19; novel coronavirus disease-2019) outbreak is caused by the coronavirus, and its continued spread is responsible for increasing deaths, social and economic burden. COVID-19 created a chaotic situation worldwide and claimed the lives of over 5,027,183 and 248,467,363 confirmed cases have been reported so far as per the data published by WHO (World Health Organization) till 5th November 2021. Scientific communities all over the world are toiling to find a suitable therapeutic drug for this deadly disease. Although till date no promising drug has been discovered for this COVID-19. However, as per the WHO, over 102 COVID-19 vaccines are in clinical development and 185 in pre-clinical development. Naturally occurring phytoconstituents possess considerable chemical richness in the form of anti-viral and anti-parasitic potential and have been extensively exploited for the same globally. Still, phytomedicine-based therapies are considered as the best available treatment option to minimize and treat the symptoms of COVID-19 because of the least possible side effects compared to synthetic drugs recommended by the physicians/clinicians. In this review, the use of plant chemicals as a possible therapeutic agent for severe acute respiratory syndrome coronavirus 2 (SARS CoV2) is highlighted with their proposed mechanism of action, which will prove fruitful and effective in finding a cure for this deadly disease.

scholarly journals Prenatal Hyperglycemia Exposure and Cellular Stress, a Sugar-Coated View of Early Programming of Metabolic Diseases

Biomolecules ◽  
2020 ◽  
Vol 10 (10) ◽  
pp. 1359
Author(s):  
Jessica Tozour ◽  
Francine Hughes ◽  
Arnaud Carrier ◽  
Didier Vieau ◽  
Fabien Delahaye
Keyword(s):  
Molecular Mechanisms ◽  
Metabolic Diseases ◽  
Cellular Stress ◽  
World Health ◽  
Metabolic Dysfunction ◽  
Early Programming ◽  
Established Risk Factor ◽  
Glucose Exposure ◽  
Glycemic Memory ◽  
Health Organization

Worldwide, the number of people with diabetes has quadrupled since 1980 reaching 422 million in 2014 (World Health Organization). This distressing rise in diabetes also affects pregnant women and thus, in regard to early programming of adult diseases, creates a vicious cycle of metabolic dysfunction passed from one generation to another. Metabolic diseases are complex and caused by the interplay between genetic and environmental factors. High-glucose exposure during in utero development, as observed with gestational diabetes mellitus (GDM), is an established risk factor for metabolic diseases. Despite intense efforts to better understand this phenomenon of early memory little is known about the molecular mechanisms associating early exposure to long-term diseases risk. However, evidence promotes glucose associated oxidative stress as one of the molecular mechanisms able to influence susceptibility to metabolic diseases. Thus, we decided here to further explore the relationship between early glucose exposure and cellular stress in the context of early development, and focus on the concept of glycemic memory, its consequences, and sexual dimorphic and epigenetic aspects.

Becoming a Faithful Defender: Traditional Chinese Medicine against Coronavirus Disease 2019 (COVID-19)

2020 ◽  
Vol 48 (04) ◽  
pp. 763-777 ◽  
Author(s):  
Leyin Zhang ◽  
Jieru Yu ◽  
Yiwen Zhou ◽  
Minhe Shen ◽  
Leitao Sun
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Viral Entry ◽  
Meta Analysis ◽  
Chinese Herb ◽  
Chinese Herbs ◽  
World Health ◽  
Symptom Improvement ◽  
Novel Coronavirus ◽  
Health Organization

The outbreak caused by COVID-19 is causing a major challenge to clinical management and a worldwide threat to public health. So far, there is no specific anti-coronavirus therapy approved for the treatment of COVID-19. Recently, as the efficacy and safety of traditional Chinese medicine (TCM) is widely acknowledged, it has been brought to a crucial status by the public, governments, and World Health Organization (WHO). For a better popularization of TCM, governments have made several advances in regulations and policies for treatment and measures of novel coronavirus pneumonia (NCP). Therefore, on the basis of epidemiology and virology information, we reviewed relevant meta-analysis and clinical studies of anti-coronavirus therapeutics by TCM, in the aspect of mortality, symptom improvement, duration and dosage of corticosteroid, incidence of complications and the like. In addition, we also summarized preclinical rationale for anti-coronavirus activity by TCM in terms of virion assembly and release, as well as viral entry and replication, which could be a useful contribution for figuring out effective Chinese herbal medicine (CHM) for coronavirus, including ingredients from single monomeric compounds, Chinese herbs, Chinese herb extracts and Chinese herb formulas, or potential targets for medicine. We would like to see these relevant studies, ranging from basic researches to clinical application, could provide some idea on effects of CHM to combat COVID-19 or other coronaviruses, and also offer new thinking for the exploration of therapeutic strategies under the guidance of TCM.

scholarly journals The Role of Micronutrients to Support Immunity for COVID-19 Prevention

2021 ◽  
Author(s):  
Mukhtar H. Ahmed ◽  
Arez Hassan ◽  
Judit Molnár
Keyword(s):  
Immune System ◽  
Healing Process ◽  
Strong Relationship ◽  
The Body ◽  
World Health ◽  
Disease Spread ◽  
Food Sources ◽  
Novel Coronavirus ◽  
Health Organization ◽  
The Impact

AbstractThe World Health Organization declared the novel coronavirus, named as SARS-CoV-2, as a global pandemic in early 2020 after the disease spread to more than 180 countries leading to tens of thousands of cases and many deaths within a couple of months. Consequently, this paper aims to summarize the evidence for the relationships between nutrition and the boosting of the immune system in the fight against the disease caused by SARS-CoV-2. This review, in particular, assesses the impact of vitamin and mineral supplements on the body’s defence mechanisms against SARS-CoV-2. The results revealed that there is a strong relationship between the ingestion of biological ingredients like vitamins C–E, and minerals such as zinc, and a reduction in the effects of coronavirus infection. These can be received from either nutrition rich food sources or from vitamin supplements. Furthermore, these macromolecules might have roles to play in boosting the immune response, in the healing process and the recovery time. Hence, we recommend that eating healthy foods rich in vitamins C–E with zinc and flavonoids could boost the immune system and consequently protect the body from serious infections. Graphical Abstract

scholarly journals Pelatihan Teknik Suntik Insulin Pada Keluarga Penderita Diabetes Mellitus Di Dusun Pattiro Desa Paccelekang Kec.Pattalassang Kab.Gowa

2021 ◽  
Vol 4 (5) ◽  
pp. 1109-1116
Author(s):  
Sriwahyuni Sriwahyuni ◽  
Sri Darmawan
Keyword(s):  
Diabetes Mellitus ◽  
Health Education ◽  
World Health Organization ◽  
Health Workers ◽  
Insulin Injection ◽  
World Health ◽  
Injection Technique ◽  
Sugar Levels ◽  
Health Organization ◽  
The Right

ABSTRAK Penyakit Diabetes merupakan salah satu penyakit degeneratif yang terkait langsung dengan gaya hidup atau life style, Menurut World Health Organization (WHO), pada tahun 2014, 8,5% dari orang dewasa berusia 18 tahun dan lebih tua menderita diabetes. Indonesia berdasarkan wawancara yang terdiagnosis dokter sebesar 1,5%, dan Provinsi Sulawesi Selatan pada tahun 2014, jumlah Kasus Diabetes Mellitus (282 penderita) terdiri atas Diabetes mellitus yang terlapor (207 penderita), Diabetes mellitus yang tidak terlapor (160 penderita) dan Diabetes mellitus bergantung insulin (72 penderita) Peran dari tenaga kesehatan dan orang terdekat yang sangat dianggap penting oleh penderita juga sangat mempengaruhi perilaku dalam mengontrol kadar gula darah penderita DM Tipe II, karena jika tidak ada dukungan dan motivasi dan health edukasi dari tenaga kesehatan  serta orang terdekat maka penderita cenderung tidak memperhatikan status kesehatannya. Kegiatan ini sasaran utama adalah keluarga penderita Diabetes Mellitus yang aktif melakukan suntik insulin yang ada di Dusun Pattiro Desa Paccelekang Kec.Pattalassang Kab.Gowa . Salah satu cara yang ditempuh sebelum dilakukan pelatihan adalah dengan melakukan pertemuan dan pendataan terlebih dahulu tentang warga yang memiliki riwayat aktif melakukan suntik insulin. Pelatihan teknik dan keterampilan melakukan suntik insulin yang tepat Daya serap para peserta terhadap materi kegiatan cukup baik, hal ini terlihat dari kemampuan masyarakat menjawab dan mempraktikan Teknik Suntik Insulin..Kata kunci : Health Edukasi, Pelatihan, Suntik Insulin, Diabetes Mellitus  ABSTRACT Diabetes is a degenerative disease that is directly related to lifestyle, according to the World Health Organization (WHO), in 2014, 8.5% of adults aged 18 years and older suffered from diabetes. Indonesia based on interviews with diagnosed doctors by 1.5%, and South Sulawesi Province in 2014, the number of Diabetes Mellitus Cases (282 patients) consisted of reported Diabetes Mellitus (207 cases), Unreported Diabetes Mellitus (160 cases), and Diabetes Insulin-dependent Mellitus (72 patients) The role of health workers and loved ones who are very important to sufferers also greatly affects behavior in controlling blood sugar levels for people with Type II diabetes, because if there is no support and motivation and health education from health workers and those closest to them then sufferers tend not to pay attention to their health status. This activity is the main target for families with Diabetes Mellitus who actively inject insulin in the Pattiro Hamlet, Paccelekang Village, Pattalassang District, Gowa Regency. One of the methods taken before training is to conduct meetings and collect data in advance about residents who have a history of actively injecting insulin. Training on techniques and skills for performing the right insulin injection The participants' absorption of the activity material was quite good, this can be seen from the community's ability to answer and practice the Insulin Injection Technique. Keywords: Health Education, Training, Insulin Injection, Diabetes                   Mellitus

scholarly journals Arsenic in drinking water: not just a problem for Bangladesh

2009 ◽  
Vol 2 (1) ◽  
pp. 51-64 ◽  
Author(s):  
D. van Halem ◽  
S. A. Bakker ◽  
G. L. Amy ◽  
J. C. van Dijk
Keyword(s):  
Drinking Water ◽  
World Health ◽  
Drinking Water Standard ◽  
Naturally Occurring ◽  
Arsenic In Groundwater ◽  
Tube Wells ◽  
The Usa ◽  
Health Organization ◽  
Near Future ◽  
High Arsenic

Abstract. For more than a decade it has been known that shallow tube wells in Bangladesh are frequently contaminated with arsenic concentrations at a level that is harmful to human health. By now it is becoming clear that a disaster of an unheard magnitude is going on: the World Health Organization fears that in the near future 1 in every 10 adult deaths in Bangladesh will be caused by arsenic-related cancers. Other studies show that problems with arsenic in groundwater/drinking water occur in many more countries worldwide, such as in the USA and China. In Europe the focus on arsenic problems is confined to countries with high arsenic levels in their groundwater, such as Romania, Hungary and Italy. In most other European countries, the naturally occurring arsenic concentrations are lower than the drinking water standard of 10 μg L−1. However, from the literature review presented in this paper, it may also be concluded that using the European standard, health risks cannot be excluded. It is therefore recommended that the current arsenic standard be reconsidered.

scholarly journals Anti-malaria and hypoglycaemic activities of Diosgenin on alloxan-induced, diabetic Wistar rats

2021 ◽  
Vol 15 (3) ◽  
pp. 073-079
Author(s):  
Omoirri Moses Aziakpono ◽  
Madubogwu Ngozi Ukamaka ◽  
Oraekei Daniel Ikechukwu ◽  
Ataihire Johnson Uyovwiesevwa ◽  
Chukwuemeka Charles Ofili ◽  
...  
Keyword(s):  
Body Weight ◽  
Blood Sugar ◽  
Wistar Rats ◽  
World Health ◽  
Treatment Groups ◽  
Male Wistar Rats ◽  
Normal Rat ◽  
Sugar Levels ◽  
Health Organization ◽  
Alloxan Monohydrate

The rising threat of Plasmodium falciparum resistance to Monotherapies has prompted the world health organization (WHO) 2006 guidelines to recommend the use of different anti-malarias. In this study, the anti-malaria and hypoglycaemic activities of Diosgenin, a potent, yet poorly reported saponin was investigated on P. falciparum inoculated and Alloxan-Induced, Diabetic Wistar Rats. Fort two (42) adult male wistar rats of between 100g and 150g were procured, acclimatized (for two weeks), and grouped into seven of six (6) rats per group. While Group 1 (Normal control) received normal rat chow and water ad libitum, groups 2 – 4 received no treatment (untreated), 10 mg/kg body weight of anti-diabetic Metformin and 25 mg/kg body weight of diosgenin respectively after inducing diabetes mellitus (DM) with alloxan monohydrate; whereas, groups 5-7 (all malaria infected) were untreated (negative malaria control), 25 mg/kg body weight of diosgenin and 56 mg/kg body weight of anti-malaria coartem respectively. Following treatment period, blood samples were obtained and assayed for fasting blood sugar, packed cell volume (PCV) and total white blood cell count (TWBCC). From the result, P. falciparum exposed rats showed lowered PCV values than control with observed improvements in coartem (significant at p < 0.05) and diosgenin (insignificant) treatment groups. Also, diabetic, diosgenin treated rats showed an insignificant reduction in blood sugar levels compared to control, even though this change was apparently improved compared to diabetic, untreated group. Again, TWBCC caused notable decrease in diosgenin treated, though this decrease signified a huge recovery compared to untreated rats. Corroborative studies on diosgenin with other systems is recommended.

scholarly journals Free Sugars Intake, Sources and Determinants of High Consumption among Australian 2-Year-Olds in the SMILE Cohort

Nutrients ◽  
2019 ◽  
Vol 11 (1) ◽  
pp. 161 ◽  
Author(s):  
Gemma Devenish ◽  
Rebecca Golley ◽  
Aqif Mukhtar ◽  
Andrea Begley ◽  
Diep Ha ◽  
...  
Keyword(s):  
Fruit Juice ◽  
Energy Requirement ◽  
Prevalence Ratio ◽  
World Health ◽  
Food Sources ◽  
Eating Patterns ◽  
Free Sugars ◽  
High Consumption ◽  
Health Organization ◽  
Dairy Milk

In the first 2 years of life, it is important to limit exposure to foods high in free sugars, in order to lay foundations for lifelong eating patterns associated with a reduced risk of chronic disease. Intake data at this age is limited, so compliance with recommendations is not known. This analysis describes free sugars intakes, food sources and determinants of high consumption among Australian children at 2 years of age. Free sugars intakes were estimated using a customized Food Frequency Questionnaire, and median usual free sugars intake at 2 years was 22.5 (Interquartile Range (IQR) 12.8–37.7) g/day, contributing a median 8% of the estimated energy requirement (EER). Based on the EER, most children (71.1%) exceeded the World Health Organization recommendation that <5% of energy should come from free sugars, with 38% of participants exceeding the <10% recommendation. Children from households with the greatest socioeconomic disadvantage were more likely to exceed the 10% recommendation (Prevalence Ratio (PR) 1.44, 95% Confidence Interval (95% CI) 1.13–1.84), and be in the top tertile for free sugars intake (PR 1.58, 95% CI 1.19–2.10) than the least disadvantaged. Main sources of free sugars were non-core foods, such as fruit juice, biscuits, cakes, desserts and confectionery; with yogurt and non-dairy milk alternatives the two notable exceptions. Improved efforts to reduce free sugars are needed from the introduction of solid food, with a particular focus on fruit juice and non-core foods.

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