scholarly journals Serum Galectin-3 as a Potential Predictive Biomarker Is Associated with Poststroke Cognitive Impairment

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Qian Wang ◽  
Kai Wang ◽  
Yihong Ma ◽  
Simin Li ◽  
Yuzhen Xu

Objective. Galectin-3, an inflammatory mediator derived from microglia, participates in the pathophysiological process of various neurological diseases. However, the relationship between galectin-3 and poststroke cognitive impairment (PSCI) remains ambiguous. This research purposed to prove whether serum galectin-3 can predict PSCI. Methods. In the end, an aggregate of 416 patients with the first acute ischemic stroke (AIS) were continuously and prospectively enrolled in the study. Upon admission, the baseline data of AIS patients were collected, and their serum galectin-3 levels were measured. Three months after the stroke, the Montreal Cognitive Scale (MoCA) was utilized to measure the cognitive function of AIS patients, and PSCI was defined as a MoCA score less than 26 points. Results. Premised on the MoCA scores, patients were categorized into PSCI cohort and non-PSCI cohort. The two AIS patient cohorts did not exhibit any statistical difference in their baseline characteristics ( p > 0.05 ). However, the serum galectin-3 level of AIS patients in the PSCI cohort was considerably elevated ( p < 0.001 ). Pearson correlation analysis illustrated that serum galectin-3 level was negatively linked to MoCA score ( r = − 0.396 , p < 0.05 ). The findings from the receiver-operating curve (ROC) illustrated that the sensitivity of serum galectin-3 as a possible biomarker for diagnosing PSCI was 66%, and the specificity was 94%. The cut-off value of serum galectin-3 to diagnose PSCI is 6.3 ng/mL ( OR = 5.49 , p < 0.001 ). Upon controlling for different variables, serum galectin-3 level remained to be an independent predictor of PSCI ( p < 0.001 ). Conclusions. Elevated serum galectin-3 levels are linked to a higher risk of PSCI. Serum galectin-3 could be a prospective biomarker for predicting PSCI.

2020 ◽  
Author(s):  
Yang yanfei ◽  
Gao qiqi ◽  
Jin yangyi ◽  
Qi mengdie ◽  
Lu guohua ◽  
...  

Abstract Background Allergic bronchopulmonary aspergillosis (ABPA) is a condition characterized by an exaggerated response of the immune system to the fungus Aspergillus. This study aimed to assess the relationship between carcinoembryonic antigen (CEA) and eosinophils in ABPA patients.Methods: We describes a case of a 50-year-old patient who was diagnosed with ABPA presenting with high level of CEA and eosinophils. Besides,we used immunohistochemistry and immunofluorescence to identify eosinophils and CEA in sections which were obtained by Endobronchial ultrasound-guided transbronchial lung biopsy aspiration (EBUS-TBLB). The sections were then visualized using confocal microscopy. We also retrospectively analyzed a cohort of 37 ABPA patients between January 2013 and December 2019 in our hospital.Results: We found the patient whose serum CEA levels were consistent with eosinophils during the follow-up(r=0.929,P=0.022). The positive expression of CEA and abnormal expression of eosinophils was higher in the ABPA tissue compared to the normal lung tissue. The co-localization was represented as pixels containing both red and green color in the image (with various shades of orange and yellow) which signified that eosinophils were immunohistochemically positive for CEA. Patients with higher levels of eosinophils had higher levels of CEA in the serum (P<0.001). The results of Pearson correlation analysis showed that the levels of eosinophils were positively correlated with serum CEA levels(r=0.459 and r=0.506,P=0.004 and P=0.001). Conclusion: Serum CEA level is elevated in ABPA patients. The elevated serum CEA level was shown to be normalized after treatment. Increased CEA levels in ABPA patients may be positively correlated with eosinophil levels, and eosinophils may be served as CEA-secreting cells in patients with ABPA.


2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Yanfei Yang ◽  
qiqi Gao ◽  
Yangyi Jin ◽  
Mengdie Qi ◽  
Guohua Lu ◽  
...  

AbstractAllergic bronchopulmonary aspergillosis (ABPA) is a condition characterized by an exaggerated response of the immune system to the fungus Aspergillus. This study aimed to assess the relationship between carcinoembryonic antigen (CEA) and eosinophils in ABPA patients. We describes a case of a 50-year-old patient who was diagnosed with ABPA presenting with high level of CEA and eosinophils. Besides,we used immunohistochemistry and immunofluorescence to identify eosinophils and CEA in sections which were obtained by Endobronchial ultrasound-guided transbronchial lung biopsy aspiration (EBUS-TBLB). The sections were then visualized using confocal microscopy. We also retrospectively analyzed a cohort of 37 ABPA patients between January 2013 and December 2019 in our hospital. We found the patient whose serum CEA levels were consistent with eosinophils during the follow-up (r = 0.929, P = 0.022). The positive expression of CEA and abnormal expression of eosinophils was higher in the ABPA tissue compared to the normal lung tissue. The co-localization was represented as pixels containing both red and green color in the image (with various shades of orange and yellow) which signified that eosinophils were immunohistochemically positive for CEA. Patients with higher levels of eosinophils had higher levels of CEA in the serum (P < 0.001). The results of Pearson correlation analysis showed that the levels of eosinophils were positively correlated with serum CEA levels (r = 0.459 and r = 0.506, P = 0.004 and P = 0.001). Serum CEA level is elevated in ABPA patients. The elevated serum CEA level was shown to be normalized after treatment. Increased CEA levels in ABPA patients may be positively correlated with eosinophil levels, and eosinophils may be served as CEA-secreting cells in patients with ABPA.


2016 ◽  
Vol 1 (1) ◽  
pp. 27-42
Author(s):  
Hazlin Kadir @ Shahar ◽  
Razaleigh Muhamat @ Kawangit ◽  
Rosmawati Mohamad Rasit ◽  
Badlihisham Mohd Nasir

This article examines the relationship between learning and behavioural evaluation among religious officers in Malaysia after attending the Manual on HIV/AIDS in Islam Training Programmes organized by the Islamic Development Department of Malaysia (JAKIM). The training programmes were implemented to deliver the most accurate and the latest information on HIV / AIDS as well as to train religious officers in Malaysia to address the issues among Muslims. The training programmes apply the theoretical and practical activities where participants had the opportunity to carry out outreach activities with People Living with HIV / AIDS (ODHA). Quantitative methods through questionnaires were used to obtain data. A total of 350 religious officers who had attended the training programmes were selected as respondents by simple random sampling technique. Pearson correlation analysis was conducted to determine the relationship between the learning and behavioural evaluation. The results of the Pearson correlation analysis found that there was a significant relationship between learning evaluation in terms of the information obtained from programmes’ contents and behaviour evaluation with r = 0.489 and sig = 0.000 (p <0.05) at the medium positive range.. While the relationship between learning evaluation in terms of the information obtained from outreach activities with behavioural evaluation showed a strong positive correlation with the strength values obtained were r = 0.539 and sig = 0.000 (p <0.05). This analysis shows that the information acquired through the training program Manual Islam and HIV / AIDS has been successful in changing the behaviour of religious officers’ awareness in terms of the role of dakwah to ODHA. ABSTRAK Artikel ini bertujuan melihat hubungan antara penilaian pembelajaran dengan penilaian tingkah laku dalam kalangan Pegawai Agama di Malaysia setelah mengikuti Program Latihan Manual Islam dan HIV/AIDS anjuran Jabatan Kemajuan Islam Malaysia (JAKIM). Program latihan ini dilaksanakan untuk menyampaikan maklumat yang tepat serta informasi terkini isu HIV/AIDS di samping melatih Pegawai-pegawai Agama di Malaysia untuk menangani isu tersebut dalam kalangan umat Islam. Program latihan ini berbentuk teori dan praktikal di mana peserta program berpeluang melaksanakan dakwah secara temu seru (outreach) dengan Orang Yang Hidup dengan HIV/AIDS (ODHA) secara langsung. Kaedah kuantitatif melalui soal selidik telah digunakan untuk memperoleh data. Seramai 350 orang Pegawai Agama yang telah mengikuti program latihan ini dipilih sebagai responden melalui teknik pensampelan rawak mudah. Analisis korelasi Pearson dijalankan bagi mengenal pasti hubungan di antara penilaian pembelajaran dengan penilaian tingkah laku peserta yang mengikuti Program Latihan Manual Islam dan HIV/AIDS. Hasil analisis ujian korelasi Pearson tersebut mendapati bahawa terdapat hubungan yang signifikan di antara penilaian pembelajaran dari segi maklumat yang diperoleh daripada kandungan program dengan penilaian tingkah laku dengan nilai r = 0.489 dan sig = 0.000 (p<0.05). Kekuatan hubungan ialah positif sederhana. Manakala hubungan antara penilaian pembelajaran dari segi maklumat yang diperoleh daripada program temu seru dengan penilaian tingkah laku pula menunjukkan kekuatan hubungan positif kuat dengan nilai yang diperoleh ialah r = 0.539 dan sig = 0.000 (p<0.05). Analisis ini menunjukkan bahawa pembelajaran yang diperoleh melalui program latihan Manual Islam dan HIV/AIDS ini telah berjaya mengubah tingkah laku Pegawai Agama dari segi kesedaran peranan berdakwah kepada ODHA.


2021 ◽  
Vol 8 (7) ◽  
pp. 14-27
Author(s):  
Anwar Sholeh ◽  
Alwi Thamrin Nasution ◽  
Radar Radius Tarigan

Background: Chronic kidney disease (CKD) is characterized by structural and functional disorder of the kidney with irreversible and gradual characteristics with one of the modalities of renal replacement therapy such as hemodialysis (HD). The role of inflammation in HD patients by uremic toxin and dialysis can be assessed by the marker of High Sensitive C Reactive Protein (HsCRP). Several studies have examined the relationship between HsCRP and red cell distribution width (RDW) in regular HD patients which leads to increase patient morbidity and mortality, but until now, there has been no study in Indonesia regarding the correlation between HsCRP and RDW in regular HD patients. This study aims to determine the correlation HsCRP as a marker of inflammation and RDW values in regular HD patients. Methods: This is a cross-sectional study in Regular HD patients at Dialysis Unit-H. Adam Malik General Hospital. A total of 20 subjects were included. Bivariate and multivariate analysis was conducted to analyze the relationship of HsCRP, ureum, creatinin, hemoglobin, and eGFR to RDW. Results: There were 20 Regular HD patients analyzed. The proportion of patients with increased RDW was 80%. In pearson correlation test, there is a strong correlation between HsCRP and RDW (r= 0.667, p<0.001). Discussion: Majority of regular HD patients at H. Adam Malik General Hospital were assessed with increased RDW. Pearson correlation analysis revealed HsCRP was significantly associated with RDW. Conclusion: Increased RDW was found in 80% of regular HD patients at H. Adam malik General Hospital. From pearson correlation analysis, we found HsCRP was significantly associated with RDW. Keywords: inflammation, high sensitive c reactive protein, red blood cell distribution width, regular hemodialysis.


2019 ◽  
Vol 7 (4) ◽  
pp. 371-376
Author(s):  
Syarul Azman Shaharuddin ◽  
Muhammad Yusuf Marlon ◽  
Mariam Abd Majid ◽  
Abur Hamdi Usman ◽  
Fakhri Sungit ◽  
...  

Purpose and problem of the study: This study to identify the level of impact of zakat distribution and the level of religious practice among the mualaf (convert) in Selangor. The aim is also to analyse the relationship between the level of impact of zakat distribution and the level of religious practice of mualaf in Selangor. The problem of the study is issues which related to the granting of zakat rights to Muslims and its impact on strengthening the faith of these groups and their appreciation of Islamic teachings. Methodology: This study applies quantitative methodology which involves 454 Muslim converts as respondents and they were randomly selected to get the data of this study. Main Findings: The descriptive analysis findings demonstrate that the level of impact of zakat distribution and the level of religious practice of mualaf in Selangor is at high level, where each has a mean value (4.20 and 4.63). The result of the Pearson correlation analysis proves that there is a significant relationship between the impact of the distribution (r = 0.643, p < 0.01) and religious practice (r = 0.677, p < 0.01).       Applications of this study: This study involves respondents from the mualaf group in Selangor. Selangor has chosen to be the area of study as the total number of muallaf registered in this state is greater than those in other states in Malaysia. Novelty/Originality of this study: The implementation of zakat distribution based on the principals and concepts dictated by Islamic law will give a great impact to the group of mualaf (convert). 


2018 ◽  
Vol 6 (2) ◽  
pp. 121-126
Author(s):  
Zawiah Mat ◽  
Nooraini Sulaiman ◽  
Sazelin Arif ◽  
Safiah Sidek ◽  
Norain Ismail ◽  
...  

Purpose: The aim of this study is to identify the relationship between professional and universal ethics of engineers. Methodology:This study used quantitative methods to distribute the questionnaire by using random sampling to get data from 248 respondents of engineers from government and private sectors in Melaka. Respondents were required to valuate agreement to statement about work ethics that used a five-point Likert scale. Meanwhile, the scales used for measuring correlation were given as 0.000-0.2000 “negligible”, 0.201-0.400 “low”, 0.401-0.600, “moderate”, 0.601-0.800 “high”, and 0.801-1.000 “very high”. The Pearson correlation analysis was used to obtain these correlation results. In this research, we analysed the data collected using SPSS Ver.22 to identify the relationship between professional and universal ethics of engineers in Melaka. Main Findings:The findings showed that all variables of professional of engineers correlated significantly with universal ethics. The significant level (p-value) was found to be less than 0.05, the study findings indicate a significant relationship between independent variables and dependent variable. Results obtained in this study confirmed that there were significant positive relationships between all variables that could influence professional and universal ethics. Implications:This study contributes towards the improvement of Board of Engineers Malaysia (BEM’S) existing policy. Based on the study’s findings, the policy implication of this study includes: responsible bodies such as the governing institutions of engineers need to ensure that ethical practices are made as the main core in their profession by increasing knowledge and awareness about ethical practices in the engineering profession. Originality:This study only focus on the relationship between professional and universal ethics of engineers and the results will be useful towards the improvement of Board of Engineers Malaysia (BEM’S) existing policy.


Author(s):  
Siti Fatimah ◽  
Maya Masyita Suherman ◽  
Euis Eti Rohaeti ◽  
Ragil Amida Army Duntari ◽  
Riska Hidayat

Academic stress in students will arise when there is pressure for achievement both in the learning process and the interaction process in school. Academic stress is caused by the inability of students to process perceptions so that the achievement of the learning process is considered as academic demands that exceed the limits of their abilities and also the students' uncertainty about events in their lives can be controlled by themselves. This study aims to determine the relationship of internal locus of control and academic stress of students of SMAN 2 Cimahi. The subject of this research is the students of SMAN 2 Cimahi in the academic year 2018/2019. Measuring instruments in this study were academic stress scale (49 items; α = 0.875) and internal locus of control scale (30 items; α = 0.618). The method of data analysis in this study is Pearson correlation analysis. The results of Pearson correlation analysis based on the significance value p = 0.00 <0.05, which means that there is a relationship between internal locus of control and academic stress. The results of a simple correlation analysis (r) obtained a correlation between internal locus of control and academic stress of 0.610. This means that there is a strong relationship between internal locus of control and academic stress, while the direction of the relationship is positively significant, which means that the higher the internal locus of control, the academic stress will be lower. Internal locus of control effectively contributed 37.2% to academic stress, while 62.8% was determined by other variables not examined in this study.


2019 ◽  
Vol 3 ◽  
Author(s):  
Mardzelah binti Makhsin ◽  
Noriana Binti Abdullah

This article aims to review and identify the characteristics of Ulul Amri's personality and    leadership among Islamic Education teachers. A total of 109 students from 4 secondary schools in Kota Bharu district were randomly selected as respondents for the study. This study was conducted through a quantitative approach. The data were collected through a questionnaire translated from The Big Five Inventory (BFI) by John (1990) and Ulul Amri's Leadership following the Qur'an. The degree of reliability of the BFI instrument ranges from 0.62 to 0.77 while the Ulul Amri Leadership instrument is between 0.61 and 0.71. Descriptive analysis of frequencies and mins used for distribution analysis. Inference statistics that pearson correlation analysis is used to analyze the relationship between teacher personality and Ulul Amri Leadership. The significant level used is 0.05. The findings show that the most dominant personality dimensions of teachers are Openness, Conscientiousness, Extraversion, Agreeableness and Neuroticism. The results of the correlation test showed that there was no significant relationship between the personality of the Islamic Education Teacher and the leadership of the Ulul Amri teacher except the personality of the agreeableness. The findings show that Islamic Education teachers have positive personalities such as Openness, Agreeableness, Extraversion and Conscientiousness. Meanwhile, Neuroticism with a negative personality teacher of Islamic Education has recorded the lowest mean. This finding shows that Islamic Education teachers in Kota Bharu have a good and positive perception among students. This is also a reflection of the expectation and dependence of the students on the Islamic Education teacher is very high. As Al-Qabisi's theory emphasizes the four qualities of a quality teacher in educating morals, ie by example, qudwah, unity, demonstration and understanding. Teachers through a qudwah approach or exemplary example can become themselves as followers or model roles to students by means of interaction inside and outside the classroom.


2021 ◽  
Vol 5 (2) ◽  
pp. 80-92
Author(s):  
Norhisham Muhamad ◽  
Muhammad Zulazizi Mohd Nawi ◽  
Norhasniza Daud

This study was conducted to identify the teacher skill level and attitude towards the use of multimedia in the teaching and learning of the Holy Koran for Autism students. This study was conducted using a set of questionnaires that were completed by 40 teachers who teach in the Integrated Special Education Program (PPKI) class selected by random. These quantitative data from the questionnaire were analyzed descriptively through SPSS software, version 22 to obtain the frequency, percentage, mean and standard deviation. Pearson correlation analysis was used to determine the relationship between skill level and teacher attitude towards using multimedia in the teaching and learning of the Holy Koran for Autism students. The results of the analysis of the study found that the teacher skill level (M=3.63, SD.=0.82) and teacher attitude (M=3.80, SD.=0.71) were at a moderate and high level. Meanwhile, this study also shows that there is a significant relationship between skill level and teacher attitude. Indeed, the teacher skill level and attitude towards using multimedia in teaching is positive but has weaknesses in terms of the application of multimedia items. Thus, while conducting the teaching process, a teacher must take into account the skill level to be applied and the readiness of the teacher attitude to build a multimedia-based teaching process to be more effective. AbstrakKajian ini dijalankan bagi mengenal pasti tahap kemahiran dan sikap guru terhadap penggunaan multimedia dalam pengajaran dan pembelajaran al-Quran untuk murid Autisme. Kajian ini dilakukan menggunakan set soal selidik yang telah dilengkapkan oleh 40 orang guru yang mengajar di kelas Program Pendidikan Khas Integrasi (PPKI) yang dipilih secara rawak. Data kuantitatif daripada soal selidik ini dianalisis secara deskriptif menggunakan SPSS versi 22 bagi mendapatkan kekerapan (frekuensi), peratusan, min dan sisihan piawai. Analisis korelasi Pearson digunakan untuk menentukan hubungan antara tahap kemahiran dengan sikap guru menggunakan multimedia dalam pengajaran dan pembelajaran al-Quran murid Autisme. Hasil analisis kajian mendapati, tahap kemahiran guru (M=3.63, SP.=0.82) dan sikap guru (M=3.80, SP.=0.71) berada pada aras sederhana tinggi. Sementara itu, kajian ini juga menunjukkan wujud hubungan yang signifikan antara tahap kemahiran dengan sikap guru. Sememangnya tahap kemahiran dan sikap guru ke arah menggunakan multimedia dalam pengajaran adalah positif tetapi mempunyai kelemahan dari aspek pengaplikasian item-item multimedia. Justeru, semasa menjalankan proses pengajaran, seseorang guru mesti mengambil kira mengenai tahap kemahiran untuk diaplikasikan dan kebersediaan sikap guru untuk membina proses pengajaran berasaskan multimedia agar menjadi lebih efektif.


2019 ◽  
Vol 7 (7) ◽  
pp. 118
Author(s):  
Burcu Güvendi ◽  
Ayşe Türksoy Işım

The goal of this study is to investigate the moral disengagement and aggression levels of fight sport athletes according to several independent variables and reveal the relationship among them. The study group consisted of totally 207 fight sport athletes, 88 females and 119 males with age  = 21,99 ± 4,92 and year of sport  = 6,14 ± 5,42. “The Scale of Moral Disengagement in Sport” and “The Questionnaire of Buss-Perry Aggression” were used as data collection tools. Descriptive statistics, t test, ANOVA and Pearson Correlation analysis were used in the analysis of data. While the mean of physical aggression of athletes was found as the highest, verbal aggression had the lowest mean value within the sub-dimensions of aggression, and they stated that they somewhat disagreed with the moral disengagement. It was found that there was a moderate positive significant correlation between moral disengagement and sub-dimensions of anger, hostility, physical and verbal aggressions of aggression scale. Significant difference was observed in the dimension of moral disengagement in accordance with age and year of sport. Physical and verbal aggression scores of males are significantly higher according to gender. The aggression and moral disengagement scores of kickboxers are significantly higher than those of taekwondo athletes in line with the branch. To conclude, it was determined that fight sport athletes did not approve moral disengagement in sport, however, the case of moral disengagement of athletes, who were younger and started the sport recently, was higher and they mostly showed the behaviour of aggression physically.


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