Eosinophils may serve as CEA-secreting cells for allergic bronchopulmonary aspergillosis (ABPA) patients

AbstractAllergic bronchopulmonary aspergillosis (ABPA) is a condition characterized by an exaggerated response of the immune system to the fungus Aspergillus. This study aimed to assess the relationship between carcinoembryonic antigen (CEA) and eosinophils in ABPA patients. We describes a case of a 50-year-old patient who was diagnosed with ABPA presenting with high level of CEA and eosinophils. Besides,we used immunohistochemistry and immunofluorescence to identify eosinophils and CEA in sections which were obtained by Endobronchial ultrasound-guided transbronchial lung biopsy aspiration (EBUS-TBLB). The sections were then visualized using confocal microscopy. We also retrospectively analyzed a cohort of 37 ABPA patients between January 2013 and December 2019 in our hospital. We found the patient whose serum CEA levels were consistent with eosinophils during the follow-up (r = 0.929, P = 0.022). The positive expression of CEA and abnormal expression of eosinophils was higher in the ABPA tissue compared to the normal lung tissue. The co-localization was represented as pixels containing both red and green color in the image (with various shades of orange and yellow) which signified that eosinophils were immunohistochemically positive for CEA. Patients with higher levels of eosinophils had higher levels of CEA in the serum (P < 0.001). The results of Pearson correlation analysis showed that the levels of eosinophils were positively correlated with serum CEA levels (r = 0.459 and r = 0.506, P = 0.004 and P = 0.001). Serum CEA level is elevated in ABPA patients. The elevated serum CEA level was shown to be normalized after treatment. Increased CEA levels in ABPA patients may be positively correlated with eosinophil levels, and eosinophils may be served as CEA-secreting cells in patients with ABPA.

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Eosinophils May Serve as CEA-Secreting Cells for ABPA Patients

10.21203/rs.3.rs-73116/v1 ◽

2020 ◽

Author(s):

Yang yanfei ◽

Gao qiqi ◽

Jin yangyi ◽

Qi mengdie ◽

Lu guohua ◽

...

Keyword(s):

Pearson Correlation ◽

Allergic Bronchopulmonary Aspergillosis ◽

Elevated Serum ◽

Endobronchial Ultrasound ◽

Normal Lung ◽

Serum Cea ◽

Pearson Correlation Analysis ◽

High Level ◽

The Relationship

Abstract Background Allergic bronchopulmonary aspergillosis (ABPA) is a condition characterized by an exaggerated response of the immune system to the fungus Aspergillus. This study aimed to assess the relationship between carcinoembryonic antigen (CEA) and eosinophils in ABPA patients.Methods: We describes a case of a 50-year-old patient who was diagnosed with ABPA presenting with high level of CEA and eosinophils. Besides,we used immunohistochemistry and immunofluorescence to identify eosinophils and CEA in sections which were obtained by Endobronchial ultrasound-guided transbronchial lung biopsy aspiration (EBUS-TBLB). The sections were then visualized using confocal microscopy. We also retrospectively analyzed a cohort of 37 ABPA patients between January 2013 and December 2019 in our hospital.Results: We found the patient whose serum CEA levels were consistent with eosinophils during the follow-up(r=0.929,P=0.022). The positive expression of CEA and abnormal expression of eosinophils was higher in the ABPA tissue compared to the normal lung tissue. The co-localization was represented as pixels containing both red and green color in the image (with various shades of orange and yellow) which signified that eosinophils were immunohistochemically positive for CEA. Patients with higher levels of eosinophils had higher levels of CEA in the serum (P<0.001). The results of Pearson correlation analysis showed that the levels of eosinophils were positively correlated with serum CEA levels(r=0.459 and r=0.506，P=0.004 and P=0.001). Conclusion: Serum CEA level is elevated in ABPA patients. The elevated serum CEA level was shown to be normalized after treatment. Increased CEA levels in ABPA patients may be positively correlated with eosinophil levels, and eosinophils may be served as CEA-secreting cells in patients with ABPA.

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THE RELATIONSHIP BETWEEN IMPACT OF ZAKAT DISTRIBUTION AND RELIGIOUS PRACTICE AMONG MUALLAF IN SELANGOR

Humanities & Social Sciences Reviews ◽

10.18510/hssr.2019.7448 ◽

2019 ◽

Vol 7 (4) ◽

pp. 371-376

Author(s):

Syarul Azman Shaharuddin ◽

Muhammad Yusuf Marlon ◽

Mariam Abd Majid ◽

Abur Hamdi Usman ◽

Fakhri Sungit ◽

...

Keyword(s):

Islamic Law ◽

Pearson Correlation ◽

Descriptive Analysis ◽

Religious Practice ◽

Mean Value ◽

Quantitative Methodology ◽

Pearson Correlation Analysis ◽

High Level ◽

The Impact ◽

The Relationship

Purpose and problem of the study: This study to identify the level of impact of zakat distribution and the level of religious practice among the mualaf (convert) in Selangor. The aim is also to analyse the relationship between the level of impact of zakat distribution and the level of religious practice of mualaf in Selangor. The problem of the study is issues which related to the granting of zakat rights to Muslims and its impact on strengthening the faith of these groups and their appreciation of Islamic teachings. Methodology: This study applies quantitative methodology which involves 454 Muslim converts as respondents and they were randomly selected to get the data of this study. Main Findings: The descriptive analysis findings demonstrate that the level of impact of zakat distribution and the level of religious practice of mualaf in Selangor is at high level, where each has a mean value (4.20 and 4.63). The result of the Pearson correlation analysis proves that there is a significant relationship between the impact of the distribution (r = 0.643, p < 0.01) and religious practice (r = 0.677, p < 0.01). Applications of this study: This study involves respondents from the mualaf group in Selangor. Selangor has chosen to be the area of study as the total number of muallaf registered in this state is greater than those in other states in Malaysia. Novelty/Originality of this study: The implementation of zakat distribution based on the principals and concepts dictated by Islamic law will give a great impact to the group of mualaf (convert).

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Serum Galectin-3 as a Potential Predictive Biomarker Is Associated with Poststroke Cognitive Impairment

Oxidative Medicine and Cellular Longevity ◽

10.1155/2021/5827812 ◽

2021 ◽

Vol 2021 ◽

pp. 1-7

Author(s):

Qian Wang ◽

Kai Wang ◽

Yihong Ma ◽

Simin Li ◽

Yuzhen Xu

Keyword(s):

Cognitive Impairment ◽

Neurological Diseases ◽

Pearson Correlation ◽

Elevated Serum ◽

Predictive Biomarker ◽

Receiver Operating Curve ◽

Galectin 3 ◽

Pearson Correlation Analysis ◽

The Relationship ◽

Moca Score

Objective. Galectin-3, an inflammatory mediator derived from microglia, participates in the pathophysiological process of various neurological diseases. However, the relationship between galectin-3 and poststroke cognitive impairment (PSCI) remains ambiguous. This research purposed to prove whether serum galectin-3 can predict PSCI. Methods. In the end, an aggregate of 416 patients with the first acute ischemic stroke (AIS) were continuously and prospectively enrolled in the study. Upon admission, the baseline data of AIS patients were collected, and their serum galectin-3 levels were measured. Three months after the stroke, the Montreal Cognitive Scale (MoCA) was utilized to measure the cognitive function of AIS patients, and PSCI was defined as a MoCA score less than 26 points. Results. Premised on the MoCA scores, patients were categorized into PSCI cohort and non-PSCI cohort. The two AIS patient cohorts did not exhibit any statistical difference in their baseline characteristics ( p > 0.05 ). However, the serum galectin-3 level of AIS patients in the PSCI cohort was considerably elevated ( p < 0.001 ). Pearson correlation analysis illustrated that serum galectin-3 level was negatively linked to MoCA score ( r = − 0.396 , p < 0.05 ). The findings from the receiver-operating curve (ROC) illustrated that the sensitivity of serum galectin-3 as a possible biomarker for diagnosing PSCI was 66%, and the specificity was 94%. The cut-off value of serum galectin-3 to diagnose PSCI is 6.3 ng/mL ( OR = 5.49 , p < 0.001 ). Upon controlling for different variables, serum galectin-3 level remained to be an independent predictor of PSCI ( p < 0.001 ). Conclusions. Elevated serum galectin-3 levels are linked to a higher risk of PSCI. Serum galectin-3 could be a prospective biomarker for predicting PSCI.

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Tahap Kemahiran dan Sikap Guru Terhadap Penggunaan Multimedia dalam Pengajaran dan Pembelajaran al-Quran Murid Autisme

Journal of Quran Sunnah Education & Special Needs ◽

10.33102/jqss.vol5no2.125 ◽

2021 ◽

Vol 5 (2) ◽

pp. 80-92

Author(s):

Norhisham Muhamad ◽

Muhammad Zulazizi Mohd Nawi ◽

Norhasniza Daud

Keyword(s):

Teaching And Learning ◽

Pearson Correlation ◽

Teacher Attitude ◽

Skill Level ◽

Teaching Process ◽

Special Education Program ◽

Pearson Correlation Analysis ◽

Spss Software ◽

High Level ◽

The Relationship

This study was conducted to identify the teacher skill level and attitude towards the use of multimedia in the teaching and learning of the Holy Koran for Autism students. This study was conducted using a set of questionnaires that were completed by 40 teachers who teach in the Integrated Special Education Program (PPKI) class selected by random. These quantitative data from the questionnaire were analyzed descriptively through SPSS software, version 22 to obtain the frequency, percentage, mean and standard deviation. Pearson correlation analysis was used to determine the relationship between skill level and teacher attitude towards using multimedia in the teaching and learning of the Holy Koran for Autism students. The results of the analysis of the study found that the teacher skill level (M=3.63, SD.=0.82) and teacher attitude (M=3.80, SD.=0.71) were at a moderate and high level. Meanwhile, this study also shows that there is a significant relationship between skill level and teacher attitude. Indeed, the teacher skill level and attitude towards using multimedia in teaching is positive but has weaknesses in terms of the application of multimedia items. Thus, while conducting the teaching process, a teacher must take into account the skill level to be applied and the readiness of the teacher attitude to build a multimedia-based teaching process to be more effective. AbstrakKajian ini dijalankan bagi mengenal pasti tahap kemahiran dan sikap guru terhadap penggunaan multimedia dalam pengajaran dan pembelajaran al-Quran untuk murid Autisme. Kajian ini dilakukan menggunakan set soal selidik yang telah dilengkapkan oleh 40 orang guru yang mengajar di kelas Program Pendidikan Khas Integrasi (PPKI) yang dipilih secara rawak. Data kuantitatif daripada soal selidik ini dianalisis secara deskriptif menggunakan SPSS versi 22 bagi mendapatkan kekerapan (frekuensi), peratusan, min dan sisihan piawai. Analisis korelasi Pearson digunakan untuk menentukan hubungan antara tahap kemahiran dengan sikap guru menggunakan multimedia dalam pengajaran dan pembelajaran al-Quran murid Autisme. Hasil analisis kajian mendapati, tahap kemahiran guru (M=3.63, SP.=0.82) dan sikap guru (M=3.80, SP.=0.71) berada pada aras sederhana tinggi. Sementara itu, kajian ini juga menunjukkan wujud hubungan yang signifikan antara tahap kemahiran dengan sikap guru. Sememangnya tahap kemahiran dan sikap guru ke arah menggunakan multimedia dalam pengajaran adalah positif tetapi mempunyai kelemahan dari aspek pengaplikasian item-item multimedia. Justeru, semasa menjalankan proses pengajaran, seseorang guru mesti mengambil kira mengenai tahap kemahiran untuk diaplikasikan dan kebersediaan sikap guru untuk membina proses pengajaran berasaskan multimedia agar menjadi lebih efektif.

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THE RELATIONSHIP BETWEEN SOCIAL SUPPORT AND ACADEMIC STRESS AMONG FIRST YEAR STUDENTS AT SYIAH KUALA UNIVERSITY

Psikoislamedia Jurnal Psikologi ◽

10.22373/psikoislamedia.v1i1.1487 ◽

2017 ◽

Vol 1 (1) ◽

Cited By ~ 2

Author(s):

Fauzah Marhamah ◽

Hazalizah Binti Hamzah

Keyword(s):

Social Support ◽

Life Stress ◽

Pearson Correlation ◽

Academic Stress ◽

First Year ◽

First Year Students ◽

Pearson Correlation Analysis ◽

Stress Inventory ◽

High Level ◽

The Relationship

The purpose of this study was to examine the relationship between social support and academic stress among first year students at Syiah Kuala University (UNSYIAH). Data was collected through questionnaires. The respondents were first year students at UNSYIAH (n = 364) with ranging age from 16 to 21. Respondents completed the Multi Dimensional Scale of Perceived Social Support (MSPSS) and Student Life Stress Inventory (SLSI). Pearson Correlation Analysis was used to analyze the relationship between social support and academic stress among first year students. The results revealed that the sample reported moderate levels of social support and academic stress. Students with high level of social support, reported low level of academic stress.

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The risk of venous thromboembolism and physical activity level, especially high level: a systematic review

Journal of Thrombosis and Thrombolysis ◽

10.1007/s11239-020-02372-5 ◽

2021 ◽

Author(s):

H. Danin-Mankowitz ◽

A. Ugarph-Morawski ◽

F. Braunschweig ◽

P. Wändell

Keyword(s):

Physical Activity ◽

Systematic Review ◽

Venous Thromboembolism ◽

Activity Level ◽

Case Control Studies ◽

The Third ◽

Area Of Interest ◽

High Level ◽

The Relationship

AbstractVenous thromboembolism (VTE) is the third most common cause of cardiovascular disease. Connection between high level of physical activity (PA) and the onset of VTE is unknown. We searched the literature on the possible association between PA level, especially high levels, and the risk of VTE. A systematic review was carried out to identify relevant articles on the relation between PA level and VTE. The initial search was conducted together with the Karolinska Institutet University Library in February 2018, with follow-up searches after that. In total, 4383 records were found and then screened for exclusion of duplicates and articles outside the area of interest. In total, 16 articles with data on 3 or more levels of PA were included. Of these, 12 were cohort and 4 were case-control studies. Totally 13 studies aimed at investigating VTE cases primarily, while three studies had other primary outcomes. Of the 16 studies, five found a U-shaped association between PA level and VTE risk, although non-significant in three of them. Two articles described an association between a more intense physical activity and a higher risk of VTE, which was significant in one. Nine studies found associations between increasing PA levels and a decreasing VTE risk. Available literature provides diverging results as to the association between high levels of PA and the risk of venous thromboembolism, but with several studies showing an association. Further research is warranted to clarify the relationship between high level PA and VTE.

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Hubungan antara Penilaian Pembelajaran dengan Tingkah Laku Pegawai Agama dalam Usaha Dakwah kepada Odha di Malaysia

al-Irsyad: Journal of Islamic and Contemporary Issues ◽

10.53840/alirsyad.v1i1.33 ◽

2016 ◽

Vol 1 (1) ◽

pp. 27-42

Author(s):

Hazlin Kadir @ Shahar ◽

Razaleigh Muhamat @ Kawangit ◽

Rosmawati Mohamad Rasit ◽

Badlihisham Mohd Nasir

Keyword(s):

Correlation Analysis ◽

Quantitative Methods ◽

Pearson Correlation ◽

People Living With Hiv ◽

Strong Positive Correlation ◽

Learning Evaluation ◽

Pearson Correlation Analysis ◽

Training Programmes ◽

The Relationship ◽

Hiv Aids

This article examines the relationship between learning and behavioural evaluation among religious officers in Malaysia after attending the Manual on HIV/AIDS in Islam Training Programmes organized by the Islamic Development Department of Malaysia (JAKIM). The training programmes were implemented to deliver the most accurate and the latest information on HIV / AIDS as well as to train religious officers in Malaysia to address the issues among Muslims. The training programmes apply the theoretical and practical activities where participants had the opportunity to carry out outreach activities with People Living with HIV / AIDS (ODHA). Quantitative methods through questionnaires were used to obtain data. A total of 350 religious officers who had attended the training programmes were selected as respondents by simple random sampling technique. Pearson correlation analysis was conducted to determine the relationship between the learning and behavioural evaluation. The results of the Pearson correlation analysis found that there was a significant relationship between learning evaluation in terms of the information obtained from programmes’ contents and behaviour evaluation with r = 0.489 and sig = 0.000 (p <0.05) at the medium positive range.. While the relationship between learning evaluation in terms of the information obtained from outreach activities with behavioural evaluation showed a strong positive correlation with the strength values obtained were r = 0.539 and sig = 0.000 (p <0.05). This analysis shows that the information acquired through the training program Manual Islam and HIV / AIDS has been successful in changing the behaviour of religious officers’ awareness in terms of the role of dakwah to ODHA. ABSTRAK Artikel ini bertujuan melihat hubungan antara penilaian pembelajaran dengan penilaian tingkah laku dalam kalangan Pegawai Agama di Malaysia setelah mengikuti Program Latihan Manual Islam dan HIV/AIDS anjuran Jabatan Kemajuan Islam Malaysia (JAKIM). Program latihan ini dilaksanakan untuk menyampaikan maklumat yang tepat serta informasi terkini isu HIV/AIDS di samping melatih Pegawai-pegawai Agama di Malaysia untuk menangani isu tersebut dalam kalangan umat Islam. Program latihan ini berbentuk teori dan praktikal di mana peserta program berpeluang melaksanakan dakwah secara temu seru (outreach) dengan Orang Yang Hidup dengan HIV/AIDS (ODHA) secara langsung. Kaedah kuantitatif melalui soal selidik telah digunakan untuk memperoleh data. Seramai 350 orang Pegawai Agama yang telah mengikuti program latihan ini dipilih sebagai responden melalui teknik pensampelan rawak mudah. Analisis korelasi Pearson dijalankan bagi mengenal pasti hubungan di antara penilaian pembelajaran dengan penilaian tingkah laku peserta yang mengikuti Program Latihan Manual Islam dan HIV/AIDS. Hasil analisis ujian korelasi Pearson tersebut mendapati bahawa terdapat hubungan yang signifikan di antara penilaian pembelajaran dari segi maklumat yang diperoleh daripada kandungan program dengan penilaian tingkah laku dengan nilai r = 0.489 dan sig = 0.000 (p<0.05). Kekuatan hubungan ialah positif sederhana. Manakala hubungan antara penilaian pembelajaran dari segi maklumat yang diperoleh daripada program temu seru dengan penilaian tingkah laku pula menunjukkan kekuatan hubungan positif kuat dengan nilai yang diperoleh ialah r = 0.539 dan sig = 0.000 (p<0.05). Analisis ini menunjukkan bahawa pembelajaran yang diperoleh melalui program latihan Manual Islam dan HIV/AIDS ini telah berjaya mengubah tingkah laku Pegawai Agama dari segi kesedaran peranan berdakwah kepada ODHA.

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Correlation of High Sensitive C Reactive Protein Levels as Inflammation Marker with Red Blood Cell Distribution Width Value in Regular Hemodialysis Patients at H. Adam Malik General Hospital

International Journal of Research and Review ◽

10.52403/ijrr.20210703 ◽

2021 ◽

Vol 8 (7) ◽

pp. 14-27

Author(s):

Anwar Sholeh ◽

Alwi Thamrin Nasution ◽

Radar Radius Tarigan

Keyword(s):

General Hospital ◽

Pearson Correlation ◽

Cell Distribution ◽

C Reactive Protein ◽

Distribution Width ◽

Reactive Protein ◽

Pearson Correlation Analysis ◽

The Relationship ◽

Red Blood Cell Distribution ◽

Regular Hemodialysis

Background: Chronic kidney disease (CKD) is characterized by structural and functional disorder of the kidney with irreversible and gradual characteristics with one of the modalities of renal replacement therapy such as hemodialysis (HD). The role of inflammation in HD patients by uremic toxin and dialysis can be assessed by the marker of High Sensitive C Reactive Protein (HsCRP). Several studies have examined the relationship between HsCRP and red cell distribution width (RDW) in regular HD patients which leads to increase patient morbidity and mortality, but until now, there has been no study in Indonesia regarding the correlation between HsCRP and RDW in regular HD patients. This study aims to determine the correlation HsCRP as a marker of inflammation and RDW values in regular HD patients. Methods: This is a cross-sectional study in Regular HD patients at Dialysis Unit-H. Adam Malik General Hospital. A total of 20 subjects were included. Bivariate and multivariate analysis was conducted to analyze the relationship of HsCRP, ureum, creatinin, hemoglobin, and eGFR to RDW. Results: There were 20 Regular HD patients analyzed. The proportion of patients with increased RDW was 80%. In pearson correlation test, there is a strong correlation between HsCRP and RDW (r= 0.667, p<0.001). Discussion: Majority of regular HD patients at H. Adam Malik General Hospital were assessed with increased RDW. Pearson correlation analysis revealed HsCRP was significantly associated with RDW. Conclusion: Increased RDW was found in 80% of regular HD patients at H. Adam malik General Hospital. From pearson correlation analysis, we found HsCRP was significantly associated with RDW. Keywords: inflammation, high sensitive c reactive protein, red blood cell distribution width, regular hemodialysis.

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Investigation of Burnout Levels of Anaesthesiologists and Technicians in Covid-19 Pandemic Period

Acta Medica ◽

10.32552/2021.actamedica.578 ◽

2021 ◽

pp. 1-5

Author(s):

Gülsüm Kavalci ◽

Selvi Ceran Kayipmaz

Keyword(s):

Pearson Correlation ◽

Categorical Variables ◽

Continuous Variables ◽

Research Hospital ◽

Pearson Correlation Test ◽

Training And Research ◽

The Mean ◽

Questionnaire Method ◽

High Level ◽

The Relationship

Objective: The ongoing Covid-19 pandemic further increased this stress of employees. This disease, which did not have a cure and a vaccine at the beginning, increased the anxiety of the employees and forced them to live separately due to the risk of infecting family members. This study aimed to investigate the burnout levels of doctors and technicians working in Yenimahalle Training and Research Hospital Anaesthesiology and Reanimation Clinic. Materials and Methods: This study was conducted prospectively by using a questionnaire method in the Yenimahalle Training and Research Hospital. Maslach Burnout questionnaire applied to the participants. Quantitative data were expressed as %, the number of subjects as (n). The distribution of continuous variables was evaluated with the Kolmogorov-Smirnow test. Qualitative data were expressed in mean±SD (standard deviation). X2 test was used for comparison of categorical variables. Independent Student T-test was used for comparison of continuous variables. The relationship between burnout level and variables was determined by Pearson Correlation Test. The value of p<0.05 was considered statistically significant. Results: A total of 52 volunteers participated in the study. The average emotional exhaustion score of the volunteers participating in the study was 31.13±4.6, the average depersonalization score was 15.06±3.3, and the mean personal achievement score was 23.60±3.7. There was no statistically significant relationship between any of the variables and the burnout level (p>0.05). Conclusion: The high level of burnout in a clinic that is at the forefront of the fight against Covid-19, such as anesthesiology and reanimation, is important in terms of determining the situation.

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Clinical Prognosis of Pericardial Effusion in COVID 19

10.21203/rs.3.rs-857221/v1 ◽

2021 ◽

Author(s):

İbrahim Saraç ◽

Gökhan Tonkaz ◽

Emrah Aksakal ◽

Faruk Aydınyılmaz ◽

Kaan Alişar ◽

...

Keyword(s):

Intensive Care ◽

Mortality Rate ◽

Pericardial Effusion ◽

Hospital Mortality ◽

Elevated Serum ◽

Clinical Prognosis ◽

Pneumonia Severity ◽

Polymerase Chain ◽

The Relationship

Abstract Purpose In our study, we investigated the relationship between pneumonia severity and pericardial effusion, predisposing factors and the effect of pericardial effusion on clinical prognosis and mortality in COVID-19 patients. Methods A total of 3794 patients who were diagnosed with COVID- 19 by polymerase chain reaction (PCR), were hospitalized between March 21 and November 30, 2020 were included in the study. For each of the 3794 patients, the initial chest CT images, pericardial efusion (PE), pleural efusion and pneumonia severity were evaluated. Results The mean age of patients with PE was higher and it was more common in males. Patients with PE had more comorbid diseases and significantly elevated serum cardiac and inflammatory biomarkers. In addition, the need for intensive care and mortality rates were higher in these patients. While the in-hospital mortality rate was 56.9% in patients with PE and AC involvement above 50%, in-hospital mortality rate was 34.4% in patients with AC involvement above 50% and without PE (p < 0.001). Conclusions In patients presenting with severe AC involvement on CT or being followed up with COVID-19 pneumonia, PE often accompanies the deterioration in the laboratories and clinics of the patients. The clinical prognosis in patients presenting with PE was quite poor, and the frequency of intensive care admissions and mortality were significantly higher. In conclusion, in our study, PE emerged as an important finding in the follow-up and management of patients with COVID-19 and reflects the clinical prognosis.

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