A Matrix Metalloproteinase-2-Based Nomogram to Assess the Risk of Encapsulating Peritoneal Sclerosis in Peritoneal Dialysis Patients

Background. Encapsulating peritoneal sclerosis (EPS) is a rare but serious complication of peritoneal dialysis (PD). So far, there is no biomarker-based prediction tool available for EPS. Matrix metalloproteinase-2 (MMP-2) is a protein involved in the breakdown of the extracellular matrix, and the effluent MMP-2 can be a potential biomarker of EPS. This study is aimed at developing a nomogram for EPS based on effluent MMP-2 levels. Patients and Methods. We enrolled 18 EPS patients and 90 gender-matched PD patients without EPS in this cross-sectional case-controlled study. The effluent MMP-2 levels and possible risk factors for EPS were analyzed using multivariable logistic regression, and a nomogram was developed. The nomogram was validated using 200 bootstrap resamples to reduce overfit bias. Results. The effluent MMP-2 levels in EPS patients were significantly higher than those in normal PD patients ( p < 0.001 , Manny-Whitney U test). Effluent MMP-2 levels and PD duration were independently associated with EPS risks ( p < 0.001 and p = 0.001 ) in multivariate logistic regression. A nomogram based on MMP-2 levels and PD duration was proposed. The AUC of MMP-2 was 0.824, and the AUC of the nomogram was 0.907 ( p = 0.05 ). Conclusion. A nomogram based on effluent MMP-2 levels and PD duration may predict EPS with high accuracy.

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HLA-DR Expression and Apoptosis: A Cross-Sectional Controlled Study in Hemodialysis and Peritoneal Dialysis Patients

Blood Purification ◽

10.1159/000122110 ◽

2008 ◽

Vol 26 (3) ◽

pp. 249-254 ◽

Cited By ~ 10

Author(s):

Massimo de Cal ◽

Dinna N. Cruz ◽

Valentina Corradi ◽

Federico Nalesso ◽

Natalia Polanco ◽

...

Keyword(s):

Peritoneal Dialysis ◽

Controlled Study ◽

Dialysis Patients ◽

Cross Sectional ◽

Hla Dr

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The second pregnancy has no effect in the incidence of macrosomia: a cross-sectional survey in two western Chinese regions

Journal of Health Population and Nutrition ◽

10.1186/s41043-021-00244-z ◽

2021 ◽

Vol 40 (1) ◽

Author(s):

Li Luo ◽

Huan Zeng ◽

Mao Zeng ◽

Xueqing Liu ◽

Xianglong Xu ◽

...

Keyword(s):

Logistic Regression ◽

Western China ◽

Fetal Macrosomia ◽

Multivariate Logistic Regression Model ◽

Multivariate Logistic Regression ◽

Cross Sectional ◽

Second Child ◽

Child Policy ◽

Significant Difference ◽

The Impact

Abstract Background After the implementation of the universal two-child policy in China, the increase in parity has led to an increase in adverse pregnancy outcomes. The impact of one and two fetuses on the incidence of fetal macrosomia has not been fully confirmed in China. This study aimed to explore the differences in the incidence of fetal macrosomia in first and second pregnancies in Western China after the implementation of the universal two-child policy. Methods A total of 1598 pregnant women from three hospitals were investigated by means of a cross-sectional study from August 2017 to January 2018. Participants were recruited by convenience and divided into first and second pregnancy groups. These groups included 1094 primiparas and 504 women giving birth to their second child. Univariate and multivariate logistic regression analyses were performed to discuss the differences in the incidence of fetal macrosomia in first and second pregnancies. Results No significant difference was found in the incidence of macrosomia in the first pregnancy group (7.2%) and the second pregnancy group (7.1%). In the second-time pregnant mothers, no significant association was found between the macrosomia of the second child (5.5%) and that of the first child (4.7%). The multivariate logistic regression model showed that mothers older than 30 years are not likely to give birth to children with macrosomia (odds ratio (OR) 0.6, 95% confidence interval (CI) 0.4,0.9). Conclusions The incidence of macrosomia in Western China is might not be affected by the birth of the second child and is not increased by low parity.

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Relationship between Vascular Calcification, Protein-Energy Wasting Syndrome, and Sarcopenia in Maintenance Automated Peritoneal Dialysis

Life ◽

10.3390/life11070666 ◽

2021 ◽

Vol 11 (7) ◽

pp. 666

Author(s):

Gustavo Leal-Alegre ◽

Claudia Lerma ◽

Gabriela Leal-Escobar ◽

Bernardo Moguel-González ◽

Karen Belén Martínez-Vázquez ◽

...

Keyword(s):

Logistic Regression ◽

Regression Analysis ◽

Peritoneal Dialysis ◽

Vascular Calcification ◽

Automated Peritoneal Dialysis ◽

Dialysis Patients ◽

Protein Energy Wasting ◽

Wasting Syndrome ◽

Protein Energy ◽

Inflammation Score

Vascular calcifications affect 80% to 90% of chronic kidney disease patients and are a predictive factor of cardiovascular mortality. Sarcopenia and protein-energy wasting syndrome are also associated with mortality. The aim was to assess the relationship between vascular calcification, sarcopenia, and protein-energy wasting syndrome (PEW) in automated peritoneal dialysis patients. Fifty-one maintenance automated peritoneal dialysis patients were included (27 were male, mean age 39 ± 14 years). Vascular calcification was assessed based on abdomen, pelvis, and hand radiographs. Sarcopenia was assessed with bioimpedance analysis and a hand grip strength test. The Malnutrition–Inflammation Score and the presence of PEW were also assessed. Vascular calcification was present in 21 patients (41.2%). Univariate logistic regression analysis showed that age (p = 0.001), Malnutrition–Inflammation Score (p = 0.022), PEW (p = 0.049), sarcopenia (p = 0.048), and diabetes (p = 0.010) were associated with vascular calcification. Multivariate logistic regression analysis showed that age (p = 0.006) was the only variable associated independently with vascular calcification. In conclusion, there is association between vascular calcification, PEW, and sarcopenia in patients with maintenance automated peritoneal dialysis. These associations are not independent of age. This demonstrates the importance of nutritional status in the prevention of vascular calcification.

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Malnutrition-inflammation is a risk factor for cerebral small vessel diseases and cognitive decline in peritoneal dialysis patients: a cross-sectional observational study

BMC Nephrology ◽

10.1186/s12882-017-0777-1 ◽

2017 ◽

Vol 18 (1) ◽

Cited By ~ 10

Author(s):

Ke Zheng ◽

Haiyun Wang ◽

Bo Hou ◽

Hui You ◽

Jing Yuan ◽

...

Keyword(s):

Risk Factor ◽

Peritoneal Dialysis ◽

Observational Study ◽

Cognitive Decline ◽

Small Vessel ◽

Dialysis Patients ◽

Cross Sectional ◽

Cerebral Small Vessel Diseases

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Serum matrix metalloproteinase-2: A potential biomarker for diagnosis of epilepsy

Epilepsy Research ◽

10.1016/j.eplepsyres.2016.02.009 ◽

2016 ◽

Vol 122 ◽

pp. 114-119 ◽

Cited By ~ 4

Author(s):

Rui Wang ◽

Guang Qun Zeng ◽

Rui Zhan Tong ◽

Dong Zhou ◽

Zhen Hong

Keyword(s):

Matrix Metalloproteinase ◽

Matrix Metalloproteinase 2 ◽

Potential Biomarker

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Cinacalcet lowering of serum fibroblast growth factor-23 concentration may be independent from serum Ca, P, PTH and dose of active vitamin D in peritoneal dialysis patients: a randomized controlled study

BMC Nephrology ◽

10.1186/1471-2369-14-112 ◽

2013 ◽

Vol 14 (1) ◽

Cited By ~ 25

Author(s):

Hyo Jin Kim ◽

◽

Hyunsuk Kim ◽

Nara Shin ◽

Ki Young Na ◽

...

Keyword(s):

Vitamin D ◽

Peritoneal Dialysis ◽

Growth Factor ◽

Fibroblast Growth Factor ◽

Fibroblast Growth Factor 23 ◽

Controlled Study ◽

Fibroblast Growth ◽

Dialysis Patients ◽

Active Vitamin ◽

Randomized Controlled

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FACTORS AFFECTING NURSE ANXIETY IN ROLE AS A CAREGIVER DURING THE COVID-19 PANDEMIC

Nurse and Health: Jurnal Keperawatan ◽

10.36720/nhjk.v10i1.233 ◽

2021 ◽

Vol 10 (1) ◽

pp. 108-115

Author(s):

Yurike Septianingrum ◽

Andikawati Fitriasari ◽

Erika Martining Wardani

Keyword(s):

Logistic Regression ◽

Personal Protective Equipment ◽

Health Workers ◽

Psychological Symptoms ◽

Cross Sectional Study ◽

Protective Equipment ◽

Multivariate Logistic Regression ◽

Chi Square ◽

Cross Sectional ◽

Chi Square Test

Background: During the Covid-19 outbreak, health workers, especially nurses, are vulnerable to potential psychological symptoms such as anxiety, which can prevent nurses from carrying out their role as caregivers in health services (Lai et al., 2020; Shanafelt et al., 2020). Objectives: The purpose of this study is to analyze the factors that can influence the anxiety of nurses in playing the role of caregiver during the Covid-19 pandemic. Methods: This is a cross-sectional study with a population of all nurses who met the inclusion criteria as much as 105 nurses. The research sample was selected through stratified random sampling and obtained 84 nurses. This research was conducted at RSI Jemursari Surabaya from June until September 2020. The research instruments used in this study were the demographic observation sheet, knowledge questionnaire, and the Hamilton Anxiety Rank Scale (HARS). Data analysis used Pearson chi-square test and multivariate logistic regression. Results: The results of the Pearson Chi-square test showed that of all the factors studied, only age (p = 0.004), availability of personal protective equipment (p = 0.002), and knowledge (p = 0.017) influenced nurses' anxiety. The results of the analysis using multivariate logistic regression test showed that the factor that most influenced nurses' anxiety was the availability of personal protective equipment (p = 0.001; OR = -3.062). Conclusion: Younger nurses, inadequate personal protective equipment, and less knowledgeable nurses were at high risk for more severe anxiety. Regular observation of the psychological condition of nurses and the fulfillment of the need for personal protective equipment is needed to prevent increased anxiety in nurses. Keywords: Nurse, anxiety, Covid-19, caregiver.

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Unmet Healthcare Needs and Associated Factors in Rural and Suburban Vietnam: A Cross-Sectional Study

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph17176320 ◽

2020 ◽

Vol 17 (17) ◽

pp. 6320

Author(s):

Ju Young Kim ◽

Dae In Kim ◽

Hwa Yeon Park ◽

Yuliya Pak ◽

Phap Ngoc Hoang Tran ◽

...

Keyword(s):

Logistic Regression ◽

Associated Factors ◽

Healthcare Providers ◽

Healthcare Services ◽

Cross Sectional Study ◽

Sectional Study ◽

Multivariate Logistic Regression ◽

Cross Sectional ◽

Healthcare Needs ◽

Unmet Healthcare Needs

The purpose of this study was to examine the current utilization of healthcare services, exploring unmet healthcare needs and the associated factors among people living in rural Vietnam. This cross-sectional study was conducted with 233 participants in a rural area. The methods included face-to-face interviews using a structured questionnaire, and anthropometric and blood pressure measurements. We considered participants to have unmet health needs if they had any kind of health problem during the past 12 months for which they were unable to see a healthcare provider. Multivariate logistic regression analysis was performed to determine the factors associated with unmet healthcare needs. Of the participants, 18% (n = 43) had unmet healthcare needs, for reasons like transportation (30%), a lack of available doctors or medicine (47%), and communication issues with healthcare providers (16%). The multivariate logistic regression showed that living in a rural area, having stage 2 hypertension, and having insurance were associated with unmet healthcare needs. To better meet the healthcare needs in rural or suburban areas of Vietnam, allocation of adequate healthcare resources should be distributed in rural areas and insurance coverage for personalized healthcare needs might be required. Efforts should focus on availability of medicine, improvement of transportation systems, and communication skills of healthcare providers to improve access to healthcare services.

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