scholarly journals A change of IL-2 and IL-4 production in patients withHelicobactor pyloriinfection

1995 ◽  
Vol 4 (4) ◽  
pp. 289-292 ◽  
Author(s):  
X. G. Fan ◽  
J. Yakoob ◽  
X. J. Fan ◽  
P. W. N. Keeling
Keyword(s):  
Chronic Infection ◽  
Cytokine Production ◽  
Interleukin 2 ◽  
Peripheral Blood Lymphocytes ◽  
Immunological Mechanism ◽  
Common Cause ◽  
Helicobactor Pylori ◽  
Gastric Biopsies ◽  
H Pylori

Helicobactor pyloriis the most common cause of gastroduodenal inflammation. However, the exact immune pathogenesis is not fully understood. To look for evidence of the immunological mechanism inH. pyloriassociated disease, we measured cytokine interleukin-2 (IL-2) and IL-4 levels produced by peripheral blood lymphocytes (PBL) and gastric biopsies in 20 subjects with or withoutH. pyloriinfection.H. pylorican stimulate IL-2 and IL-4 production from PBL inH. pylorinegative as well asH. pyloripositive individuals. The spontaneous IL-2 production by PBL and gastric biopsies was greater (p < 0.0025, <0.001)inH. pylorinegative individuals than that inH. pyloriinfected patients. Increased IL-4 levels from PBL inH. pyloriinfected patients were found in the presence ofH. pylori(p < 0.0025). An increased spontaneous production of IL-4 from gastric biopsies was also observed inH. pyloriinfected patients (p < 0.025). In conclusion, an enhanced type 2 cytokine production was observed inH. pyloriinfected patients, which may be responsible forH. pylorichronic infection.

scholarly journals Human immunodeficiency virus (HIV) phenotype and interleukin-2/ interleukin-10 ratio are associated markers of protection and progression in HIV infection

Blood ◽  
1996 ◽  
Vol 88 (2) ◽  
pp. 574-579 ◽  
Author(s):  
M Clerici ◽  
C Balotta ◽  
A Salvaggio ◽  
C Riva ◽  
D Trabattoni ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Hiv Infection ◽  
Cytokine Production ◽  
Interleukin 2 ◽  
Interleukin 10 ◽  
Cd4 Counts ◽  
Immunodeficiency Virus ◽  
Type 1 Cytokine

Human immunodeficiency virus (HIV) isolability, rate of viral replication, HIV phenotype, type 1 and type 2 cytokine production, and CD4 counts were cross sectionally analyzed in 63 HIV seropositive (HIV+) individuals to establish possible correlations between virologic and immunologic markers of protection and progression. We observed that these markers are tightly correlated. Thus, lack or low prevalence of HIV isolability and the presence of nonsyncitium inducing strains are associated with the strongest type 1 cytokine production, the weakest type 2 cytokine production, and highest CD4 counts. Conversely, the isolation of highly replicating, syncitium-inducing HIV strains is associated with the weakest type 1 cytokine production, the strongest type 2 cytokine production, and lowest CD4 counts. Additionally, it was determined that the interleukin (IL)-10/IL-2 ratio best discriminates among different virologic scenarios. These data suggest that the virologic and immunologic correlates of disease protection and progression might be associated variables that define two different subsets of HIV+ individuals and lend support to a viro-immunologic hypothesis of HIV infection.

scholarly journals GASTRIC ADENOCARCINOMA AND HELICOBACTER PYLORI INFECTION

2003 ◽  
Vol 41 (144) ◽  
pp. 457-462
Author(s):  
Ram Chandra Adhikari ◽  
B M Pokharel ◽  
H G Shrestha
Keyword(s):  
Helicobacter Pylori ◽  
Gastric Adenocarcinoma ◽  
Serological Test ◽  
Signet Ring Cell ◽  
Gastric Adenocarcinomas ◽  
Signet Ring ◽  
Gastric Biopsies ◽  
Ring Cell ◽  
H Pylori

Gastric adenocarcinoma is of major importance worldwide as a cause of death frommalignant disease. It is the commonest malignant tumor in T.U. Teaching Hospital.Helicobacter pylori infection is an important risk factor for the development of gastriccancer. This prospective study was carried out to correlate H. pylori infection withgastric adenocarcinoma. This study was done from January 1999 to January 2000;included 38 cases of gastric adenocarcinomas of which 28 (73.69%) cases were tubulartype; 6 (15.79%) cases were signet-ring cell type; 2 (5.26%) cases were papillary typeand 2 (5.26%) cases were mucinous type. Gastric adenocarcinomas were more commonin male (73.68%) and after the age of 50 years. Giemsa staining revealed H. pylori in30 cases (78.95%) of adenocarcinomas; whereas H. pylori seropositivity (IgG) wasfound in 29 (76.31%) cases. H. pylori were histologically detected in 88.3% cases ofresected specimens and in 71.4% cases of endoscopic gastric biopsies. Both histologicalmethod and serological test showed positivity for H. pylori in 65.78% cases. Thus, H.pylori infection is associated with gastric carcinognesisKey Words: Gastric adenocarcinoma, Helicobacter pylori, Giemsa stain. 

PRE CANCER LESION H. pylori CHRONIC INFECTION

2000 ◽  
Vol 15 (12) ◽  
pp. H29-H29
Author(s):  
Vera D. Yoewono ◽  
E. Krinuhoni ◽  
W Marwoto ◽  
S.O. Sri Widodo
Keyword(s):  
Chronic Infection ◽  
H Pylori ◽  
Cancer Lesion

Analysis of babA, cagE and cagA Genes in Helicobacter pylori from Upper Gastric Patients in the North of Iran

2019 ◽  
Vol 19 (3) ◽  
pp. 274-278 ◽  
Author(s):  
Saba Fakhrieh Asl ◽  
Mehrnaz Pourvahedi ◽  
Ali Mojtahedi ◽  
Mohammad Shenagari
Keyword(s):  
Helicobacter Pylori ◽  
Gastric Diseases ◽  
Specific Primers ◽  
The North ◽  
Different Types ◽  
North Of Iran ◽  
Gastric Biopsies ◽  
Pcr Method ◽  
Non Ulcer Dyspepsia ◽  
H Pylori

Objective:Helicobacter pylori is a Gram-negative bacterium which has a serious effect on up to half of the world’s population and has been related to different gastric diseases. The goal of this study was to assess the frequency of babA, cagE and cagA genotypes among H. pylori strains isolated from gastric biopsies of endoscopic patients in the north of Iran.Methods:The present study was performed on 90 strains of H. pylori isolated from patients with gastric diseases (Gastric ulcer (GU), Duodenal ulcer (DU), Gastritis (G), Non-ulcer dyspepsia (NUD) and Gastric adenocarcinoma (GC)). DNA was extracted from all isolated strains and PCR method was performed to detect the prevalence of babA2, cagE and cagA genes using specific primers.Results:Among 90 samples of H. pylori, babA2, cagE, and cagA genes were detected in 42.2%, 30% and 82.2% of strains respectively. The statistical analysis showed that the prevalence of cagA gene in GU, G, DU, and NUD was significantly higher than other genes. Moreover, cagA, and babA2 genes were significantly more prevalent in GC patients compared to cagE gene. Our isolates exhibited 8 distinct arrangements of virulence patterns. The occurrence of cagA (35.6%) was the most prevalent pattern followed by cagA/babA2 (20%) and cagA/babA2/cagE (14.4%).Conclusion:In summary, as first report from Guilan province in the north of Iran, we showed significant association between the presence of babA2, cagE, and cagA genes in different types of gastric disorders.

scholarly journals Helicobacter pylori eradication in patients with type 2 diabetes mellitus: Multicenter prospective observational study

2019 ◽  
Vol 7 ◽  
pp. 205031211983209 ◽  
Author(s):  
Seung-Joo Nam ◽  
Sung Chul Park ◽  
Sang Hoon Lee ◽  
Dong Wook Choi ◽  
Sung Joon Lee ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Observational Study ◽  
Prospective Observational Study ◽  
Eradication Rate ◽  
Laboratory Data ◽  
P Value ◽  
Diabetic Patients ◽  
Multicenter Prospective Observational Study ◽  
H Pylori

Objective: To compare Helicobacter pylori ( H. pylori) eradication rate of type 2 diabetic patients with non-diabetic subjects. Methods: In this multicenter prospective observational study, H. pylori-infected subjects were enrolled from three university-affiliated hospitals. Eradication regimen was triple therapy with standard dose of proton pump inhibitors (b.i.d), amoxicillin (1.0 g b.i.d), and clarithromycin (500 mg b.i.d) for 7 days. Urea breath test was performed 4 weeks after treatment. Various clinical and laboratory data were collected for identification of factors associated with successful eradication. Results: Totally, 144 subjects were enrolled and 119 (85 non-diabetic and 34 diabetic patients) were finally analyzed. Eradication rate was 75.6% and there was no difference between diabetic patients and non-diabetic subjects (73.5% vs 76.5%, p value: 0.814). Adverse drug reactions were reported in 44.5% of patients. In multivariate analysis for predicting H. pylori eradication in diabetic patients, HbA1c (⩾7.5%) was a significant factor affecting eradication rate (adjusted odds ratio: 0.100, 95% confidence interval: 0.011–0.909, p value: 0.041). Conclusion: Diabetes itself is not a major factor affecting H. pylori eradication. However, poor glucose control may harmfully affect H. pylori eradication.

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