Influence of Visceral Fat in the Outcomes of Colorectal Cancer

Aim: To determine the relationship of visceral fat (VF) with the surgical outcome of the patients with colorectal cancer (CRC) submitted to curative surgery. Methods: Retrospective analysis of all patients submitted to CRC surgery during 3 years with a minimum of 5 years of follow-up. We assessed the length of hospital stay, complications, pathologic reports, surgical re-interventions and hospital re-admissions, relapses, survival time and disease-free time. VF was calculated based on patients’ pre-operative CT-scan. The patients were divided into quartiles according to the VF area. Linear regression models and logistic regression models were used to establish a relationship between VF and all data collected. Results: The study included 199 patients (129 with colon cancer [CC] and 70 with rectal cancer). The average area of VF was 115.7 cm2. Patients with CRC revealed a direct relationship between VF and postoperative complications (p = 0.043), anastomotic leakage (p = 0.009) and re-operation (p = 0.005). The subgroup of patients with CC had an inverse association between VF and lymph nodes harvested (p = 0.027). Survival analyses did not reveal significant differences. Conclusion: VF has an influence on postoperative complications, anastomotic leakage and re-operation. A negative influence of VF on lymph nodes harvested was observed on CC patients.

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Starchy Vegetables and Metabolic Syndrome in Costa Rica

Nutrients ◽

10.3390/nu13051639 ◽

2021 ◽

Vol 13 (5) ◽

pp. 1639

Author(s):

Zhongyao Li ◽

Dongqing Wang ◽

Edward A. Ruiz-Narváez ◽

Karen E. Peterson ◽

Hannia Campos ◽

...

Keyword(s):

Metabolic Syndrome ◽

Regression Models ◽

Fasting Blood Glucose ◽

Population Based ◽

Cross Sectional Study ◽

Costa Rican ◽

Least Square ◽

Inverse Association ◽

Linear Regression Models ◽

Cross Sectional

Only a few studies primarily examined the associations between starchy vegetables (other than potatoes) and metabolic syndrome (MetS). We aimed to evaluate the association between starchy vegetables consumption and MetS in a population-based sample of Costa Rican adults. We hypothesized that a higher overall intake of starchy vegetables would not be associated with higher MetS prevalence. In this cross-sectional study, log-binomial regression models were used to estimate prevalence ratios (PRs) of MetS across quintiles of total, unhealthy, healthy starchy vegetables, and individual starchy vegetables (potatoes, purple sweet potatoes, etc.), among 1881 Costa Rican adults. Least square means and 95% confidence intervals (CIs) from linear regression models were estimated for each MetS component by categories of starchy vegetable variables. Higher intakes of starchy vegetables were associated with a higher prevalence of MetS in crude models, but no significant trends were observed after adjusting for confounders. A significant inverse association was observed between total starchy and healthy starchy vegetables consumption and fasting blood glucose. In this population, starchy vegetables might be part of a healthy dietary pattern.

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The Clinical Utility of the Geriatric Nutritional Risk Index in Predicting Postoperative Complications and Long-Term Survival in Elderly Patients with Colorectal Cancer after Curative Surgery

Cancers ◽

10.3390/cancers13225852 ◽

2021 ◽

Vol 13 (22) ◽

pp. 5852

Author(s):

Chun-Kai Liao ◽

Yih-Jong Chern ◽

Yu-Jen Hsu ◽

Yueh-Chen Lin ◽

Yen-Lin Yu ◽

...

Keyword(s):

Colorectal Cancer ◽

Postoperative Complications ◽

Independent Risk Factor ◽

Risk Index ◽

Nutritional Risk ◽

Geriatric Nutritional Risk Index ◽

Curative Surgery ◽

Term Survival ◽

Nutritional Risk Index

Research on the relationship between the geriatric nutritional risk index (GNRI) and postoperative complications/oncological outcomes in elderly colorectal cancer (CRC) patients is limited. This study investigated the prognostic value of the GNRI in aged CRC patients. We retrospectively analyzed 1206 consecutive CRC patients aged over 75 years who underwent curative-intent surgery from January 2008 to December 2015 and categorized them into high GNRI (≥98) and low GNRI (<98) groups according to a receiver operating characteristic (ROC) curve analysis. Uni- and multivariate logistic regression analysis were used to explore the association of the GNRI with postoperative complications. Kaplan–Meier survival analyses and the Cox proportional hazard model were used to explore the association between GNRI and survival. We discovered that GNRI is an independent risk factor for postoperative complications (HR: 1.774, p = 0.037). Surgical site infection, wound dehiscence and pneumonia were more common in patients with GNRI < 98. Survival analysis showed significantly worse overall survival and disease-free survival in the low GNRI group (both p < 0.001). In the multivariate analysis, GNRI < 98 was an independent risk factor for OS (HR: 1.329, p = 0.031) and DFS (HR: 1.312, p = 0.034). Thus, preoperative GNRI can be effectively used to predict postoperative complications and long-term survival in elderly CRC patients after curative surgery.

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Infectious Postoperative Complications Decrease Long-term Survival in Patients Undergoing Curative Surgery for Colorectal Cancer

Annals of Surgery ◽

10.1097/sla.0000000000000854 ◽

2015 ◽

Vol 261 (3) ◽

pp. 497-505 ◽

Cited By ~ 138

Author(s):

Avo Artinyan ◽

Sonia T. Orcutt ◽

Daniel A. Anaya ◽

Peter Richardson ◽

G. John Chen ◽

...

Keyword(s):

Colorectal Cancer ◽

Postoperative Complications ◽

Curative Surgery ◽

Term Survival ◽

Long Term Survival

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Low Socioeconomic Status Is Associated with Worse Outcomes After Curative Surgery for Colorectal Cancer: Results from a Large, Multicenter Study

Journal of Gastrointestinal Surgery ◽

10.1007/s11605-019-04435-2 ◽

2019 ◽

Vol 24 (11) ◽

pp. 2628-2636 ◽

Cited By ~ 2

Author(s):

I. van den Berg ◽

S. Buettner ◽

R. R. J. Coebergh van den Braak ◽

K. H. J. Ultee ◽

H. F. Lingsma ◽

...

Keyword(s):

Colorectal Cancer ◽

Socioeconomic Status ◽

Postoperative Complications ◽

Cancer Patients ◽

Household Income ◽

Stage I ◽

Curative Surgery ◽

Cancer Specific Survival ◽

Increased Risk ◽

Percent Increase

Abstract Background Socioeconomic status (SES) has been associated with early mortality in cancer patients. However, the association between SES and outcome in colorectal cancer patients is largely unknown. The aim of this study was to investigate whether SES is associated with short- and long-term outcome in patients undergoing curative surgery for colorectal cancer. Methods Patients who underwent curative surgery in the region of Rotterdam for stage I–III colorectal cancer between January 2007 and July 2014 were included. Gross household income and survival status were obtained from a national registry provided by Statistics Netherlands Centraal Bureau voor de Statistiek. Patients were assigned percentiles according to the national income distribution. Logistic regression and Cox proportional hazard regression were performed to assess the association of SES with 30-day postoperative complications, overall survival and cancer-specific survival, adjusted for known prognosticators. Results For 965 of the 975 eligible patients (99%), gross household income could be retrieved. Patients with a lower SES more often had diabetes, more often underwent an open surgical procedure, and had more comorbidities. In addition, patients with a lower SES were less likely to receive (neo) adjuvant treatment. Lower SES was independently associated with an increased risk of postoperative complications (Odds ratio per percent increase 0.99, 95%CI 0.99–0.998, p = 0.004) and lower cancer-specific mortality (Hazard ratio per percent increase 0.99, 95%CI 0.98–0.99, p = 0.009). Conclusion This study shows that lower SES is associated with increased risk of postoperative complications, and poor cancer-specific survival in patients undergoing surgery for stage I–III colorectal cancer after correcting for known prognosticators.

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The impact of preoperative dexamethasone on the postoperative systemic inflammatory response and complications following surgery for colorectal cancer.

Journal of Clinical Oncology ◽

10.1200/jco.2016.34.4_suppl.692 ◽

2016 ◽

Vol 34 (4_suppl) ◽

pp. 692-692

Author(s):

Stephen Thomas McSorley ◽

Paul G. Horgan ◽

Donald C McMillan

Keyword(s):

Colorectal Cancer ◽

Postoperative Complications ◽

Inflammatory Response ◽

Elective Surgery ◽

Systemic Inflammatory Response ◽

Curative Surgery ◽

Association Table ◽

L 14 ◽

Induction Of Anaesthesia ◽

The Impact

692 Background: It is now clear that there is a significant association between the magnitude of the systemic inflammatory response and postoperative complications (Adamina et al. Br J Surg 2015;102(6):590-8). The present study examined the impact of preoperative steroids on the postoperative systemic inflammatory response and complications, following elective surgery for colorectal cancer. Methods: The administration of dexamethasone at induction of anaesthesia was prospectively audited from a cohort of patients who underwent elective, potentially curative surgery for colorectal cancer at a single centre between 2008 and 2013. Results: 286 patients were included, of which the majority were male (161, 57%), over 65 (190, 66%) with colonic (183, 64%) and node negative disease (192, 67%). 114 (40%) received dexamethasone at induction of anaesthesia. There was a significant association (Table 1) between preoperative dexamethasone administration and the proportion of patients breaching established CRP thresholds on postoperative days 2 (190mg/L, 14% vs. 50%, p<0.001), and 3 (170mg/L, 27% vs. 49%, p<0.001) but not 4 (145mg/L, 50% vs. 36%, p=0.658). There was no significant association between preoperative dexamethasone and postoperative complications. Conclusions: The present study suggests that the systemic inflammatory response following surgery for colorectal cancer may be attenuated by preoperative steroids. It remains to be determined whether this will lead to a reduction in postoperative complications. [Table: see text]

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Physiological Aldosterone Concentrations Are Associated with Alterations of Lipid Metabolism: Observations from the General Population

International Journal of Endocrinology ◽

10.1155/2018/4128174 ◽

2018 ◽

Vol 2018 ◽

pp. 1-6 ◽

Cited By ~ 6

Author(s):

M. Hannich ◽

H. Wallaschofski ◽

M. Nauck ◽

M. Reincke ◽

C. Adolf ◽

...

Keyword(s):

Lipid Metabolism ◽

General Population ◽

Linear Regression ◽

Standard Error ◽

Regression Models ◽

Adult Population ◽

Density Lipoprotein ◽

Lipoprotein Cholesterol ◽

Inverse Association ◽

Linear Regression Models

Objective. Aldosterone and high-density lipoprotein cholesterol (HDL-C) are involved in many pathophysiological processes that contribute to the development of cardiovascular diseases. Previously, associations between the concentrations of aldosterone and certain components of the lipid metabolism in the peripheral circulation were suggested, but data from the general population is sparse. We therefore aimed to assess the associations between aldosterone and HDL-C, low-density lipoprotein cholesterol (LDL-C), total cholesterol, triglycerides, or non-HDL-C in the general adult population. Methods. Data from 793 men and 938 women aged 25–85 years who participated in the first follow-up of the Study of Health in Pomerania were obtained. The associations of aldosterone with serum lipid concentrations were assessed in multivariable linear regression models adjusted for sex, age, body mass index (BMI), estimated glomerular filtration rate (eGFR), and HbA1c. Results. The linear regression models showed statistically significant positive associations of aldosterone with LDL-C (β-coefficient = 0.022, standard error = 0.010, p=0.03) and non-HDL-C (β-coefficient = 0.023, standard error = 0.009, p=0.01) as well as an inverse association of aldosterone with HDL-C (β-coefficient = −0.022, standard error = 0.011, p=0.04). Conclusions. The present data show that plasma aldosterone is positively associated with LDL-C and non-HDL-C and inversely associated with HDL-C in the general population. Our data thus suggests that aldosterone concentrations within the physiological range may be related to alterations of lipid metabolism.

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Does a laparoscopic approach affect the number of lymph nodes harvested during curative surgery for colorectal cancer?

Surgical Endoscopy ◽

10.1007/s00464-009-0534-z ◽

2009 ◽

Vol 24 (1) ◽

pp. 113-118 ◽

Cited By ~ 20

Author(s):

Galal El-Gazzaz ◽

Tracy Hull ◽

Jeffery Hammel ◽

Daniel Geisler

Keyword(s):

Colorectal Cancer ◽

Lymph Nodes ◽

Laparoscopic Approach ◽

Curative Surgery

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Bioelectrical Impedance Analysis Versus Quantitative Computer Tomography and Anthropometry for The Assessment of Body Composition Parameters in China

10.21203/rs.3.rs-109288/v1 ◽

2020 ◽

Author(s):

Qian Qin ◽

Yang Yang ◽

Jingfeng Chen ◽

Yaojun Jiang ◽

Ang Li ◽

...

Keyword(s):

Body Composition ◽

Linear Regression ◽

Computer Tomography ◽

Visceral Fat ◽

Regression Models ◽

Bioelectrical Impedance Analysis ◽

Bioelectrical Impedance ◽

Impedance Analysis ◽

Linear Regression Models ◽

Quantitative Computer Tomography

Abstract Objectives: The study evaluated the bioelectrical impedance analysis (BIA) device against the body composition parameters measured by anthropometry and quantitative computer tomography (QCT) to assess its reliability and accuracy among Chinese adults.Methods: Body composition parameters (waist circumstance [WC], body weight, body mass index [BMI] and visceral fat area [VFA]) were measured in 1,379 subjects (20-81 years old), both manually and by BIA, and in 1,317 of 1,379 subjects by QCT. The correlation coefficients were calculated between these measurements. Linear regression models were used to estimate each parameter based on the BIA measurements. Multivariate linear regression models were applied to calculate the correlation among VFA, WC and BMI. The concordance correlation coefficient from the Bland-Altman plots were calculated for VFA between QCT and BIA. Results: High correlation was observed for WC, weight and BMI (adjusted R2=0.78, 0.99 and 0.99) between BIA and anthropometry, and for VFA between BIA and QCT in both sex (adjusted R2=0.549 and 0.462). The multivariate regression models were established for the accurate prediction of QCT-VFA using WC and BMI (adjusted R2=0.603). In addition, a strong consistency of VFA measurement was found between BIA and QCT.Conclusion: Body composition parameters could be accurately determined in clinic using simple measurements of BIA. WC is more reliable as a predictor of visceral fat in the metabolic syndrome. Being non-invasive, accurate and free of radiation, BIA can be used as a safe and convenient tool in scientific research and clinical practice for the quick measurement of anthropometric parameters.

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Trunk Fat Volume Can Be a Predictor of Short-Term Surgical Outcomes After Gastrectomy: A Retrospective Cohort Study

10.21203/rs.3.rs-156566/v1 ◽

2021 ◽

Author(s):

Shinichiro Shiomi ◽

Tetsuro Toriumi ◽

Koichi Yagi ◽

Raito Asaoka ◽

Yasuhiro Okumura ◽

...

Keyword(s):

Body Mass Index ◽

Postoperative Complications ◽

Lymph Nodes ◽

Visceral Fat ◽

Surgical Outcomes ◽

Operative Time ◽

Proximal Gastrectomy ◽

Short Term ◽

Visceral Fat Area ◽

Fat Volume

Abstract Background Obesity can affect postoperative outcomes of gastrectomy. Visceral fat area is superior to body mass index in predicting postoperative complications. However, visceral fat area measurement is time-consuming and is not optimum for clinical use. Meanwhile, trunk fat volume (TFV) can be easily measured via bioelectrical impedance analysis. Hence, this current study aimed to determine the association of trunk fat volume in predicting the occurrence of complications after gastrectomy. Methods We retrospectively reviewed patients who underwent curative gastrectomy for gastric cancer between November 2016 and November 2019. The trunk fat volume-to-the ideal amount (%TFV) ratio was obtained using InBody 770 before surgery. The patients were classified into the obese and nonobese groups according to %TFV (TFV-H group, ≥ 150 %; TFV-L group, < 150 %) and body mass index (BMI-H group, ≥ 25 kg/m2; BMI-L group, < 25 kg/m2). We compared the short-term postoperative outcomes (e.g., operative time, blood loss volume, number of resected lymph nodes, and duration of hospital stay) between the obese and nonobese patients. Risk factors for complications were assessed using logistic regression analysis. Results In total, 232 patients were included in this study. The TFV-H and BMI-H groups had a significantly longer operative time than the TFV-L (p = 0.022) and BMI-L groups (p = 0.006). Moreover, the TFV-H group had a significantly higher complication rate (p = 0.004) and a lower number of resected lymph nodes (p < 0.001) than the TFV-L group. In univariate analysis, %TFV ≥ 150, total or proximal gastrectomy, and open gastrectomy were found to be potentially associated with higher complication rates with p values < 0.1. Meanwhile, multivariate analysis revealed that %TFV ≥ 150 (OR: 2.73; 95%CI: 1.37–5.46; p = 0.005) and total or proximal gastrectomy (OR: 3.57; 95%CI: 1.79–7.12; p < 0.001) were independently correlated with postoperative morbidity. Conclusions %TFV independently affected postoperative complications. Hence, it may be a useful parameter for the evaluation of obesity and a predictor of short-term surgical outcomes after gastrectomy.

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Seasonal Polymorphism in Elytral Coloration Pattern of Anomala flavipennis Burmeister (Coleoptera: Scarabaeidae) in Mexico

Journal of Entomological Science ◽

10.18474/0749-8004-39.4.545 ◽

2004 ◽

Vol 39 (4) ◽

pp. 545-550 ◽

Cited By ~ 1

Author(s):

Luis A. Rodríguez-del-Bosque

Keyword(s):

Linear Regression ◽

Significant Interaction ◽

Regression Models ◽

Inverse Association ◽

Linear Regression Models ◽

Weighted Mean ◽

Coloration Pattern ◽

Northeastern Mexico ◽

Coloration Patterns

Elytral polychromatism in Anomala flavipennis Burmeister was detected in both spring and fall generations in northeastern Mexico from 2000 to 2002. Four distinctive coloration patterns were observed: (a) immaculated, (b) one-spotted, (c) two-spotted, and (d) striped. These categories were represented by 0, 1.4, 7.8, and 28.0% respective levels of melanization of elytral area. A significant interaction was detected between elytral pattern and generation, with melanized forms occurring more commonly during the spring and clearer forms during the fall. Weighted mean of elytral melanized area in the population ranged from 1.46% for fall to 7.80% for spring generations. Linear regression models suggested (R2 ≥ 0.93) an inverse association between temperature during pupation-adult ecdysis and elytral melanized area. The rationale and advantage for A. flavipennis responding to temperature by elytral melanization remain unknown, particularly because of the crepuscular-nocturnal habits of adults.

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