scholarly journals Relevance of Physical Activities, Sedentary Behaviors, and Genetic Predisposition in Body Fatness: Population-Based Study on Chinese Adults

Obesity Facts ◽  
2021 ◽  
pp. 1-11
Author(s):  
Hongmei Xue ◽  
Xiao Zhang ◽  
Danting Li ◽  
Mengxue Chen ◽  
Jiao Luo ◽  
...  
Keyword(s):  
Body Composition ◽  
Genetic Predisposition ◽  
Genetic Risk ◽  
Protective Factor ◽  
Vigorous Physical Activity ◽  
Physical Activities ◽  
Sedentary Behaviors ◽  
Chinese Adults ◽  
Television Watching ◽  
High Bmi

<b><i>Introduction:</i></b> Little attention has been paid to the interacting effect of specific intensities of physical activities (PAs) and sedentary lifestyle, like television watching, and genetic predisposition on body composition indices among Chinese adults. Herein, we aimed to examine whether specific types of PAs and sedentary behaviors (SBs) were associated with body composition indices among Chinese adults and to further explore whether these associations interacted with the genetic predisposition to high BMI. <b><i>Methods:</i></b> Cross-sectional data regarding PAs and time spent on SBs and dietary intake of 3,976 Chinese adults (54.9% women) aged 25–65 years in Southwest China were obtained via questionnaires in 2013–2015. Weight, height, and waist circumference (WC) were measured, and BMI, percentage of body fat (%BF), fat mass index (FMI), and fat-free mass index (FFMI) of the participants were calculated. Genetic risk score (GRS) was calculated on 9 established BMI-associated SNPs among Chinese adults. <b><i>Results:</i></b> When the participants were stratified by GRS for BMI, significant associations were only found for adults with high GRS for BMI: moderate-to-vigorous physical activity (MVPA) was negatively associated with WC and %BF and positively related to FFMI. The adjusted positive relationship of time spent watching television with BMI, WC, %BF, and FMI were also just found between adults with high weighted GRS for high BMI: for every 1 h increment in television watching, the BMI, WC, %BF, and FMI of the participants increased by 0.2 kg/m<sup>2</sup>, 0.9 cm, 0.3%, and 0.1 kg/m<sup>2</sup>, respectively (<i>p</i> &#x3c; 0.02). <b><i>Conclusion:</i></b> MVPA may be a protective factor against obesity, and prolonged television watching may accentuate adiposity. These putative effects may be more pronounced among individuals with a high genetic risk of a high BMI.

scholarly journals Replacement of Sedentary Behavior by Various Daily-Life Physical Activities and Structured Exercises: Genetic Risk and Incident Type 2 Diabetes

2021 ◽  
Author(s):  
Xiang Li ◽  
Tao Zhou ◽  
Hao Ma ◽  
Zhaoxia Liang ◽  
Vivian A Fonseca ◽  
...  
Keyword(s):  
Sedentary Behavior ◽  
Genetic Predisposition ◽  
Genetic Risk ◽  
Daily Life ◽  
Physical Activities ◽  
Sedentary Behaviors ◽  
Equal Time ◽  
Increased Risk ◽  
Different Types ◽  
Sedentary Behavior Time

<b>Objective: </b>To prospectively analyze the association of sedentary behavior time with T2D risk and perform the iso-temporal substitution analyses to estimate the effect of substituting sedentary behaviors by equal time of different types of daily-life physical activities and structured exercise. We also examined modifications by the genetic predisposition to T2D. <p><b>Research Design and Methods: </b>We included 475,502 participants free of T2D in the UK Biobank. Sedentary time was quantified by summing up the time spent on television watching, computer using, and driving.</p> <p><b>Results: </b>During a median follow-up of 11 years, we documented 18,169 incident T2D. Comparing the extreme categories (≥6 vs. <2 hours/day), the hazard ratio (HR) for T2D was 1.58 (95% CI, 1.47-1.71), after adjustment for age, race, sex, lifestyle factors, and other covariates. Replacing 30 minutes of sedentary behavior per day with an equal time of different types of daily-life activities and structured exercise were significantly associated with a 6-31% risk reduction of T2D, with strenuous sports showing the strongest (31%, 95% CI, 24%-37%) benefit. Moreover, we found a significant interaction between sedentary behavior and genetic predisposition on the risk of T2D (p-interaction=0.0008). The association was more profound among participants with a lower genetic risk of T2D.</p> <p><b>Conclusions: </b>Our study indicates that sedentary behavior time is associated with an increased risk of T2D; replacing sedentary behavior with a short-duration (30 minutes/day) daily-life physical activities or structured exercise is related to a significant reduction in T2D risk. Furthermore, such association was stronger among those with a lower genetic risk of T2D.</p>

scholarly journals Replacement of Sedentary Behavior by Various Daily-Life Physical Activities and Structured Exercises: Genetic Risk and Incident Type 2 Diabetes

2021 ◽  
Author(s):  
Xiang Li ◽  
Tao Zhou ◽  
Hao Ma ◽  
Zhaoxia Liang ◽  
Vivian A Fonseca ◽  
...  
Keyword(s):  
Sedentary Behavior ◽  
Genetic Predisposition ◽  
Genetic Risk ◽  
Daily Life ◽  
Physical Activities ◽  
Sedentary Behaviors ◽  
Equal Time ◽  
Increased Risk ◽  
Different Types ◽  
Sedentary Behavior Time

<b>Objective: </b>To prospectively analyze the association of sedentary behavior time with T2D risk and perform the iso-temporal substitution analyses to estimate the effect of substituting sedentary behaviors by equal time of different types of daily-life physical activities and structured exercise. We also examined modifications by the genetic predisposition to T2D. <p><b>Research Design and Methods: </b>We included 475,502 participants free of T2D in the UK Biobank. Sedentary time was quantified by summing up the time spent on television watching, computer using, and driving.</p> <p><b>Results: </b>During a median follow-up of 11 years, we documented 18,169 incident T2D. Comparing the extreme categories (≥6 vs. <2 hours/day), the hazard ratio (HR) for T2D was 1.58 (95% CI, 1.47-1.71), after adjustment for age, race, sex, lifestyle factors, and other covariates. Replacing 30 minutes of sedentary behavior per day with an equal time of different types of daily-life activities and structured exercise were significantly associated with a 6-31% risk reduction of T2D, with strenuous sports showing the strongest (31%, 95% CI, 24%-37%) benefit. Moreover, we found a significant interaction between sedentary behavior and genetic predisposition on the risk of T2D (p-interaction=0.0008). The association was more profound among participants with a lower genetic risk of T2D.</p> <p><b>Conclusions: </b>Our study indicates that sedentary behavior time is associated with an increased risk of T2D; replacing sedentary behavior with a short-duration (30 minutes/day) daily-life physical activities or structured exercise is related to a significant reduction in T2D risk. Furthermore, such association was stronger among those with a lower genetic risk of T2D.</p>

scholarly journals Temporal Trends and Recent Correlates in Sedentary Behaviors among Chinese Adults from 2002 to 2010–2012

2019 ◽  
Vol 17 (1) ◽  
pp. 158 ◽  
Author(s):  
Caicui Ding ◽  
Ganyu Feng ◽  
Fan Yuan ◽  
Weiyan Gong ◽  
Yecheng Yao ◽  
...  
Keyword(s):  
Urban Areas ◽  
Leisure Time ◽  
Sedentary Time ◽  
Temporal Trends ◽  
Physical Activities ◽  
Sedentary Behaviors ◽  
Chinese Adults ◽  
Nutrition And Health ◽  
Sociodemographic Correlates ◽  
Using Data

Evidence suggests that more time spent in sedentary behaviors (SB) increases health risk independent of physical activities. Trends in SB among adults have not been fully described in China, and the sociodemographic correlates of SB have not been systematically evaluated either. This study examined the temporal trends of SB among 184,257 adults (2002: n = 52,697, 2010–2012: n = 131,560) using data from the China National Nutrition and Health Survey in 2002 and 2010–2012, and analyzed the recent correlates of SB in Chinese adults. Overall, an increase (+0.29 h/d) was seen in total SB across the survey years, and there was a slight increase (+0.14 h/d) in leisure time SB and a decrease (−0.39 h/d) in occupational SB. From 2002 to 2012, the proportion of Chinese adults whose total SB time over 4 h/d increased from 35.4% to 43.0%, and the proportion of leisure SB time over 3 h/d increased from 42.0% to 48.0%, and the proportion of occupational SB time over 4 h/d decreased from 63.4% to 53.0%. Male, urban areas, employed, unmarried, and with higher educational and family economic level were all positively associated with high sedentary time (HST) in 2010–2012. These trends and correlates are important for health policy in China and other countries that are facing similar challenges.

scholarly journals Association between Compliance with Movement Behavior Guidelines and Obesity among Malaysian Preschoolers

2021 ◽  
Vol 18 (9) ◽  
pp. 4611
Author(s):  
Shoo Thien Lee ◽  
Jyh Eiin Wong ◽  
Geraldine K. L. Chan ◽  
Bee Koon Poh
Keyword(s):  
Physical Activity ◽  
Screen Time ◽  
Weight Status ◽  
Vigorous Physical Activity ◽  
Overweight And Obesity ◽  
Physical Activities ◽  
Movement Behavior ◽  
Sedentary Behaviors ◽  
Kuala Lumpur ◽  
Overweight Or Obesity

A daily balance of physical activities, sedentary behaviors and sleep are important for maintaining the health of young children. The aim of this study is to explore the association between 24-h movement behavior of Malaysian children aged 4 to 6 years with weight status. A total of 230 preschoolers were recruited from 22 kindergartens in Kuala Lumpur. Physical activity was assessed by Actical accelerometer while screen time and sleep duration were proxy-reported by parents. Children spent on average 5.5 ± 1.3 h on total physical activity (including 1.0 ± 0.4 h of moderate- vigorous physical activity), 3.0 ± 1.6 h on screen activities and 9.5 ± 1.3 h sleeping daily. The proportion of children who complied with physical activity and sleep guidelines were 48.7% and 55.2%, respectively. About 25.2% of children met screen time recommendation. Only 6.5% of children met all three age-specific physical activity, screen time and sleep guidelines. Children who met any two guidelines were less likely to be overweight or obesity compared to those who did not meet any of the guidelines (OR: 0.276; 95% CI: 0.080–0.950). In conclusion, Malaysian preschoolers have low compliance to movement behavior guidelines, especially in meeting screen time recommendations. Compliance to movement behavior guidelines was associated with lower odds of overweight and obesity.

scholarly journals Genetic predisposition to television watching increases the risk of type 2 diabetes: a bidirectional and multivariable Mendelian randomization study

2020 ◽  
Author(s):  
Songzan Chen ◽  
Fangkun Yang ◽  
Tian Xu ◽  
Yao Wang ◽  
Kaijie Zhang ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Genetic Predisposition ◽  
Computer Use ◽  
Mendelian Randomization ◽  
Driving Behavior ◽  
Sensitivity Analyses ◽  
Sedentary Behaviors ◽  
Television Watching ◽  
Increased Risk

Abstract Background: Excessive sedentary behaviors have been reported to be associated with increased risk of type 2 diabetes, but whether this association is causal remains unclear. In current study, we aimed to investigate the causal association between domain-specific sedentary behaviors and the risk of type 2 diabetes using a two-sample Mendelian randomization (MR) study. Methods: We identified 165 single nucleotide polymorphisms as instrumental variables for television watching, 43 for computer use and 5 for driving behavior from a recently published genome-wide association study (n = 408,815). Genetic association estimates for type 2 diabetes were obtained from the DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) consortium (74,124 cases and 824,006 controls). The inverse variance-weighted method was used to estimate the effect of genetically predicted sedentary behaviors on the risk of type 2 diabetes. Reverse MR analysis was performed to investigate the reverse causation. The weighted median method, MR-Egger method, and MR Pleiotropy Residual Sum and Outlier method were employed in the sensitivity analyses. In addition, multivariable MR analysis and mediation analysis were conducted to explore the potential mechanistic elements.Results: Genetic predisposition to excessive television watching was associated with increased risk of type 2 diabetes. The OR (95% CI) per 1.5h (1 standard deviation) increment in television watching time was 1.82 (1.61, 2.07) for type 2 diabetes. This association was substantially attenuated after adjustment for anthropometric traits (adjusting BMI: OR = 1.35, 95% CI = 1.17 – 1.57, P = 4.1 × 10-5; adjusting WHR: OR = 1.26, 95% CI = 1.09 – 1.45, P = 1.4 × 10-3) and educational attainment (OR = 1.49, 95% CI = 1.16 – 1.91, P = 1.7 × 10-3). There was limited evidence of associations of computer use and driving behavior with the risk of type 2 diabetes. Conclusions: Our study clarifies the causal effect of excessive television watching on the increased risk of type 2 diabetes from a genetic perspective, which may be partly mediated via anthropometric and educational traits. Television watching may serve as a behavioral target to prevent incident diabetes.

Olfactory Function, Genetic Predisposition, and Cognitive Performance in Chinese adults

2021 ◽  
Vol 19 ◽  
Author(s):  
Xianyi Yang ◽  
Jing Si ◽  
Shuchun Lin ◽  
Xiaofeng Zhou ◽  
Hui Zhang ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Performance ◽  
Genetic Predisposition ◽  
Genetic Risk ◽  
Genetic Risk Score ◽  
Olfactory Function ◽  
Central China ◽  
Nucleotide Polymorphisms ◽  
Chinese Adults

Objective: The objective of this study is to examine the association of olfactory function and genetic predisposition of Alzheimer’s disease (AD) with cognitive performance in adults. Methods: A total of 2049 Chinese adults from Rugao Longevity and Ageing Study (RuLAS, n=1460, mean age 78 years) and Central China Cohort (CCC, n=589, mean age 48 years) were included in this study. A standard interview-based survey, clinical information, and blood samples were collected in both cohorts. Olfactory function in terms of olfactory identification was measured by the brief version of the Chinese Smell Identification Test consisted of 18 full points. Cognitive performance was measured by the Chinese version of the Mini-mental State Examination. A genetic risk score (GRS) was calculated from 5 single nucleotide polymorphisms, which were robustly related to Alzheimer’s disease in Caucasians and cognitive performance in our Chinese population. Results: In the pooled analyses, participants at the lowest quartile of olfactory function had significantly higher odds of cognitive impairment (adjusted odds ratio [95% CI] =1.45 [1.00 to 2.09], Ptrend =0.005), and such association was stronger among participants with a stronger genetic predisposition of Alzheimer’s disease (β coefficient±SE, -0.06±0.03 in participants with a lower GRS vs. -0.19±0.05 in those with a higher GRS, respectively, Pinteraction=0.01). Similar associations were observed in RuLAS (P-trend=0.06) and in CCC (P-trend<0.001). Conclusion: In this study, a decreased olfactory function was associated with worse cognitive performance in adults, especially among participants with a higher genetic risk of Alzheimer’s disease. Further studies are warranted to evaluate the causal relationship between olfaction and cognitive performance.

scholarly journals Impact of Work and Recreational Physical Activity on Prediabetes Condition among U.S. Adults: NHANES 2015–2016

2021 ◽  
Vol 18 (4) ◽  
pp. 1378
Author(s):  
Lenin Pazmino ◽  
Wilmer Esparza ◽  
Arian Ramón Aladro-Gonzalvo ◽  
Edgar León
Keyword(s):  
Physical Activity ◽  
Protective Factor ◽  
Hemoglobin A1c ◽  
Physical Activities ◽  
Recreational Physical Activity ◽  
Physically Active ◽  
Hba1c Test ◽  
Health And Nutrition ◽  
The Impact

More minutes of physical activity (PA) accumulated during a day are associated with a lower risk of diabetes mellitus type 2. However, it is less known if distinct dimensions of PA can produce a different protective effect in the prevention of prediabetes. The aim of this study was to analyze the impact of work and recreational PA on prediabetes among U.S. adults during the period 2015–2016 using the National Health and Nutrition Examination Survey (NHANES) database. Individuals (n = 4481) with hemoglobin A1c (HbA1c) test values of 5.7% to 6.4% were included. A logistic regression multivariate-adjusted analysis was conducted to estimate the association between the odds ratios (ORs) and 95% confidence intervals (CIs) of prediabetes, with work and recreational PA. The prevalence of prediabetes among U.S. adults was lower in physically active individuals both at work (~24%) and recreational (~21%) physical activities compared to individuals who were not physically active (27 to 30%). Individuals lacking practice of recreational PA had a high risk of prediabetes (OR = 1.26, 95% CI: 1.080 to 1.466). PA may be a protective factor for prediabetes conditions depending on gender, age, ethnic group, waist circumference, and thyroid disease.

scholarly journals Interaction between dietary branched-chain amino acids and genetic risk score on the risk of type 2 diabetes in Chinese

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Weiqi Wang ◽  
Haiyang Jiang ◽  
Ziwei Zhang ◽  
Wei Duan ◽  
Tianshu Han ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Genetic Predisposition ◽  
Genetic Risk ◽  
Odds Ratio ◽  
Regression Models ◽  
Fasting Glucose ◽  
Genetic Risk Score ◽  
Branched Chain Amino Acids ◽  
Branched Chain

Abstract Background and objectives Previous studies have found the important gene-diet interactions on type 2 diabetes (T2D) incident but have not followed branched-chain amino acids (BCAAs), even though they have shown heterogeneous effectiveness in diabetes-related factors. So in this study, we aim to investigate whether dietary BCAAs interact with the genetic predisposition in relation to T2D risk and fasting glucose in Chinese adults. Methods In a case-control study nested in the Harbin Cohort Study on Diet, Nutrition and Chronic Non-Communicable Diseases, we obtained data for 434 incident T2D cases and 434 controls matched by age and sex. An unweighted genetic risk score (GRS) was calculated for 25 T2D-related single nucleotide polymorphisms by summation of the number of risk alleles for T2D. Multivariate logistic regression models and general linear regression models were used to assess the interaction between dietary BCAAs and GRS on T2D risk and fasting glucose. Results Significant interactions were found between GRS and dietary BCAAs on T2D risk and fasting glucose (p for interaction = 0.001 and 0.004, respectively). Comparing with low GRS, the odds ratio of T2D in high GRS were 2.98 (95% CI 1.54–5.76) among those with the highest tertile of total BCAA intake but were non-significant among those with the lowest intake, corresponding to 0.39 (0.12) mmol/L versus − 0.07 (0.10) mmol/L fasting glucose elevation per tertile. Viewed differently, comparing extreme tertiles of dietary BCAAs, the odds ratio (95% CIs) of T2D risk were 0.46 (0.22–0.95), 2.22 (1.15–4.31), and 2.90 (1.54–5.47) (fasting glucose elevation per tertile: − 0.23 (0.10), 0.18 (0.10), and 0.26 (0.13) mmol/L) among participants with low, intermediate, and high genetic risk, respectively. Conclusions This study indicated that dietary BCAAs could amplify the genetic association with T2D risk and fasting glucose. Moreover, higher BCAA intake showed positive association with T2D when genetic predisposition was also high but changed to negative when genetic predisposition was low.

Association of BMI, body composition and outcomes in Chinese patients with metastatic renal cell carcinoma treated with immunotherapy: A retrospective, multicohort analysis.

2021 ◽  
Vol 39 (15_suppl) ◽  
pp. e16563-e16563
Author(s):  
Jun Wang ◽  
Yuanyuan Qu ◽  
Wenhao Xu ◽  
Chunping Yu ◽  
Zhiling Zhang ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Overall Survival ◽  
Body Composition ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Normal Weight ◽  
Chinese Patients ◽  
Tissue Area ◽  
Subcutaneous Adipose ◽  
High Bmi

e16563 Association of BMI, body composition and outcomes in Chinese patients with metastatic renal cell carcinoma treated with immunotherapy: a retrospective, multicohort analysis. Background: Obesity (body-mass index [BMI] ≥30 kg/m) is associated with a higher risk of developing clear cell renal cell carcinoma (RCC) but, paradoxically, obesity is also associated with better outcome in renal cell carcinoma (RCC) patients treated with immunotherapy. Whether BMI associate outcomes in Chinese RCC patients treated with immunotherapy considering Asian population has a lower BMI? In this study, we aimed to investigate the relationship between BMI, body composition and outcomes of Chinese patients with RCC treated with immunotherapy. Methods: We evaluated clinical data of metastatic RCC patients treated with immunotherapy from five major centers in China. Despite using the Chinese standard, only 6 people met the obese standard (BMI ≥28 kg/m, as per WHO's BMI categories), so we divided the patients into high BMI gourps (BMI ≥24.0 kg/m), and normal weight groups (BMI 18.5-23·9 kg/m). We assessed overall survival, defined as the time from treatment initiation to the date of any-cause death or of censoring on the day of the last follow-up, in high BMI patients and in patients with a normal weight. We also investigative the relationship between body composition (skeletal muscle index (SMI = skeletal muscle area/height2), skeletal muscle density (SMD), and subcutaneous adipose distribution index (SADI = subcutaneous adipose tissue area / subcutaneous adipose tissue area + visceral adipose tissue area) of each patient at the third lumbar vertebrae) and overall survival using CT or MRI scan at the treatment initiation. Results: Out of a total of 222 patients, 203 had evaluable CT or MRI radiographs, pretreatment BMI measurements, and overall survival data for analyses, and we excluded 4 (1.7%) underwetight patients, leaving a final cohort of 199 patients from this study for our analyses. There were 79 (39.7%) high BMI patients and 120 (65.3%) normal weight patients. There was no difference in overall survival between the high BMI and normal weight groups (HR:1.36, CI 0.83-2.21). In addition, SMI and SMD were not associated with outcome of patients. Interestingly, although there was no statistical difference, subcutaneous fat was associated with better outcomes, while visceral fat was associated with poor outcomes. Thus, the combination of the two indicators, SADI, showed a significant prognostic correlation after adjustment for International Metastatic RCC Database risk score (aHR:0.314, CI 0.19-0.51). Conclusions: BMI is not a good predictor of the outcome of immunotherapy in Chinese patients with RCC. Evaluation of body composition may be a better tool for predicting prognosis in RCC patients treated with immunotherapy.

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