Supportive Effects of Online Hemodiafiltration Therapy on the Nutritional State and Lipid Profile in Very Elderly Dialysis Patients

2021 ◽  
pp. 1-8
Author(s):  
Masanori Shibata ◽  
Hisae Tawada ◽  
Kojiro Nagai ◽  
Shinkichi Taniguchi

<b><i>Introduction:</i></b> Online hemodiafiltration (HDF) therapy has been recognized as one of the potential dialysis modalities. However, the long-term effects of online HDF therapy on very elderly dialysis patients older than 75 years have yet to be fully elucidated. <b><i>Methods:</i></b> Seventy-four very elderly patients older than 75 years undergoing maintenance dialysis therapy were studied retrospectively. Twenty-four (mean ± SE, 81.5 ± 1.0 years) were treated by predilution online HDF, and fifty (81.2 ± 0.6 years) were treated by conventional hemodialysis (HD) for 3 years. Laboratory data related to the nutritional state and lipid profile were collected. Body composition was measured by a bioelectrical impedance method. <b><i>Results:</i></b> Dry weight and body mass index decreased in HD patients (2.9%, <i>p</i> = 0.003 and 3.1%, <i>p</i> = 0.001, respectively), while no significant changes were found in online HDF patients. Serum albumin levels reduced in both HD and online HDF groups (3.5%, <i>p</i> = 0.003 and 2.9%, <i>p</i> = 0.026, respectively). The geriatric nutritional risk index decreased in HD patients (3.0%, <i>p</i> &#x3c; 0.001), while no significant change was shown in online HDF patients. Body composition analysis demonstrated a significant decrease in intracellular water and increases in extracellular water and edema ratio in both groups. Fat mass and %fat showed significant decreases in HD patients (8.1%, <i>p</i> = 0.003 and 7.3%, <i>p</i> = 0.003, respectively), but no significant changes in online HDF patients. Among laboratory data, serum high-density lipoprotein cholesterol levels did not change in HD patients. However, the levels elevated significantly (10.6%, <i>p</i> = 0.03) in online HDF patients. <b><i>Discussion/Conclusion:</i></b> These results indicated that the time-dependent deterioration of the nutritional state in very elderly dialysis patients was inevitable; however, such deterioration was not prominent in online HDF patients. Moreover, the lipid profile showed unique changes in online HDF patients. In order to treat very elderly dialysis patients, online HDF should preferentially be taken into consideration because the maintenance of general condition seems to be a practical goal against the natural time-dependent deterioration.

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. A296-A297
Author(s):  
Olivia Carla Bomfim Boaventura ◽  
Alina Coutinho Rodrigues Feitosa

Abstract The impact of maternal dyslipidemia (DLP) on fetal injury development occurs even in situations of transient DLP during pregnancy. Some authors define gestational DLP when the CT, LDL and TG concentrations are above the 95th percentile (P95%) and HDL, below the 5th percentile (P5%) for gestational age, but there is no consensus. OBJECTIVE: To compare the prevalence of DLP in pregnant women using percentiles criteria with the V Brazilian Guidelines on Dyslipidemia and to evaluate the association of lipid profile with body composition, physical activity(PA) practice and dietary pattern. Methods: A unicentric cross-sectional study that evaluated low-risk pregnant women between 18 and 45 years old in two maternity hospitals in the city of Salvador-BA. Using a standardized questionnaire, sociodemographic data and clinical and health characteristics, nutritional status and PA practice were evaluated, as well as lipid profile measurement in any trimester of pregnancy, classifying pregnant women according to presence of DLP by two criteria. The food intake was quantified through the 24-hour food survey, obtaining the nutritional composition of the food with the aid of the NutWin® program and the intensity of the PA was assessed by means of the PA questionnaire for pregnant women (PAQP). Bioimpedance was used for body composition analysis. Statistical analysis was performed and a p value &lt;0.05 was considered. Results: 165 pregnant women aged 28.6 ± 6.3 years were studied, with 57.6% in the 3rd trimester. Although only 13.9% of pregnant women were obese, with an average PGC of 36.2 ± 5.6%, there was distortion of self body image. Dairy and carbohydrate intake was out of the international recommendation range. The prevalence of any lipid alterations, according to the National Guideline criteria, was 84.7%:TC ≥ 200 mg / dL was found in 62.9%; LDL ≥ 160 mg / dL in 15.3%, HDL ≤ 50 mg / dL in 12.6% and TG ≥ 150 mg / dL in 59.6%. The prevalence of dyslipidemia by the percentile criterion was found in only 4%, with an increase higher than P95% for TC was found in 0.7%; for LDL, in 0.7%; for TG in 2.6% and below P5% for HDL in 2%. About 99.4% of the pregnant women had energy expenditure above 6.0 metabolic equivalents (METs). There was a positive correlation (p = 0.035, r=0.276) between body fat percentage and LDL values, between VLDL concentration and amount of carbohydrates ingested (p = 0.047, r 0.168) and an inversely proportional association between HDL analyzes and cervical circumference (p = 0.010, r= -0.227). There was no association of lipid profile with perception of body self-image, physical activity or eating pattern. Conclusion: The prevalence of dyslipidemia assessed by the criterion of the V Brazilian Dyslipidemia Guideline for adults was significantly higher than the prevalence identified by the criterion of specific pregnancy percentiles.


2019 ◽  
Vol 73 ◽  
pp. 572-580
Author(s):  
Katarzyna Banach ◽  
Paweł Glibowski ◽  
Paulina Skorek

Aim: Body composition, especially the mass of adipose tissue, affects the risk of developing the metabolic and cardiovascular diseases as well as some cancers. The aim of this study was to determine the relationship between the body composition of adults and their Body Mass Index. Material/Methods: The study involved 120 subjects (69 women and 51 men) aged 19 – 66 (30.55 ± 10.41). The recruited subjects were assigned to three subgroups: with normal body weight, overweight and obesity, depending on the BMI value. There were 40 subjects in each subgroup, including 23 women and 17 men. Besides the measurements of height and body mass, the SECA mBCA515 analyser was applied for the body composition analysis using the bioelectric impedance method. Results: A significant association was found between the BMI index and fat mass, lean mass and muscle mass, both in the whole group and after taking into account the sex. The correlation coefficient R range was from –0.88 to 0.97. The incidence of obesity in the studied group according to body fat content criteria (>25% for men and >30% for women) was 57%, while according to BMI criteria –33%. BMI cut-off points for obesity were 27.8, 26.4 and 26.4 kg/m2 for men, women and for all, respectively. Conclusions: In epidemiological studies, to identify obese people, body fat should also be taken into account in addition to BMI. If obesity is understood as excess fat, and not excess weight, the cut-off points for BMI-based obesity should be lowered.


PLoS ONE ◽  
2018 ◽  
Vol 13 (8) ◽  
pp. e0200775 ◽  
Author(s):  
Vineetha K. Ramdas Nayak ◽  
Kirtana Raghurama Nayak ◽  
Sudha Vidyasagar ◽  
Asha Kamath

2021 ◽  
pp. 1-6
Author(s):  
Kazuaki Asai ◽  
Masanori Shibata ◽  
Isao Ito ◽  
Hisae Tawada ◽  
Shinkichi Taniguchi

<b><i>Background/Aims:</i></b> Malnutrition is a serious complication in dialysis patients that develops slowly but steadily. Cross-sectional studies may not adequately characterize this complication because not only the intensity but longitudinally cumulative effect should also be taken into consideration. Relationship between time-dependent changes in a nutritional marker, Geriatric Nutritional Risk Index (GNRI), and cumulative C-reactive protein (CRP) values was examined whether both intensity and duration of inflammation correlated with time-dependent progression and severity of malnutrition over 3 years, retrospectively. <b><i>Methods:</i></b> One hundred and sixty-four dialysis patients were examined over 3 years retrospectively. Based on analysis of clinical and laboratory findings over a period of 3 years, patients were divided into 2 groups: those with a &#x3e;3.0 decrease in GNRI after 3 years (<i>n</i> = 84) and those in whom GNRI was unchanged (<i>n</i> = 80). <b><i>Results:</i></b> When comparing the 2 groups at 3 years, the GNRI-decreased group had 12% lower serum albumin (<i>p</i> &#x3c; 0.001) and lower levels of creatinine (9%, <i>p</i> &#x3c; 0.001), BUN (6%, <i>p</i> &#x3c; 0.05), total cholesterol (6%, <i>p</i> &#x3c; 0.05), and low-density lipoprotein cholesterol (10%, <i>p</i> &#x3c; 0.01), which suggest onset of malnutrition. CRP levels, routinely measured twice a month in all patients, were summed to calculate the cumulative CRP. Cumulative CRP after 3 years was 57.6 ± 7.8 (mg/dL/3 years) in the GNRI-decreased group, which was significantly higher than that in the GNRI-unchanged group (38.6 ± 3.9; <i>p</i> &#x3c; 0.05). Over 3 years, the GNRI-decreased group showed a time-dependent increase in cumulative CRP alongside a time-dependent decrease in the GNRI, producing an obvious mirror image; however, such inverse correlation was absent in the GNRI-unchanged group. <b><i>Conclusion:</i></b> A long-term perspective is needed in the management of malnutrition in dialysis patients because this complication develops progressively and is often irreversible when diagnosed. Cumulative CRP values may be useful in evaluating the degree of the progression of malnutrition in following up individual patients longitudinally.


2019 ◽  
Vol 121 (10) ◽  
pp. 2296-2308
Author(s):  
Anna Katarzyna Mazurek-Kusiak ◽  
Agata Kobyłka ◽  
Bogusław Sawicki

Purpose The purpose of this paper is to assess nutritional habits and body composition parameters in the group of Polish pupils and students. Design/methodology/approach The study was conducted by the body composition analysis using the biological impedance method applying TANITA analyzer and diagnostic survey method using standardized direct interview with selected elements of the Sarzynska test. The research was carried out in various regions of Poland on a group of 1,000 pupils and students, using a targeted sample selection in the following subgroups: 250 middle school pupils, 250 high school students, 250 students living in a family home and 250 students living in an academic home. Findings Significantly the worst nutritional habits according to the Sarzynska test are shown by students living in academic home. As many as 21.6 percent of them eat very badly, while only 10.4 percent of students living in a family home eat very badly. This may indicate a lack of conditions, skills and time to prepare healthy meals, but also the lack of parental control in relation to what their child eats. The middle school pupils eat the healthiest meals (64.4 percent). It can be seen the regularity that the older the child is, the smaller the percentage of people in the healthy group. Research limitations/implications A research limitation was the little sample size of the study (1,000 person) and participants might have felt uncomfortable during research. Practical implications People planning class schedules should also plan breaks for a full-value meal. It is necessary to organize affordable courses that would teach simple and fast food preparation that does not require a lot of equipment and little popular ingredients. It would also be necessary to draw parents’ attention to excessive care and the fact that not allowing children to “experiment” in the kitchen may arouse in them the reluctance and fear of cooking. Social implications Among students, one should conduct universal education regarding a healthy lifestyle, which should focus on the subject of proper nutrition and physical activity, because there are no systemic solutions that would include adults. In order to improve nutritional habits, social rooms in academic homes should be adjusted so that students have the conditions to prepare nutritious meals, as well as provide access to canteens, where students would receive a reasonable meal at a reasonable price. The qualifications of the staff working there should also be improved. Originality/value The present study adds to the existing body of literature nutritional habits and body composition parameters in the group of Polish pupils and students. The results are the foundation for providing recommendations to policy makers, universitets, schools, food organizations and parents.


2021 ◽  
Vol 0 (0) ◽  
pp. 0-0
Author(s):  
Ayşe Serra ARTAN ◽  
Meltem GÜRSU ◽  
Ömer Celal ELÇİOĞLU ◽  
Ayşegül YABACI ◽  
Rümeyza KAZANCIOĞLU

2015 ◽  
Vol 85 (5-6) ◽  
pp. 348-355 ◽  
Author(s):  
Masamitsu Ubukata ◽  
Nobuyuki Amemiya ◽  
Kosaku Nitta ◽  
Takashi Takei

Abstract. Objective: Hemodialysis patients are prone to malnutrition because of diet or many uremic complications. The objective of this study is to determine whether thiamine deficiency is associated with regular dialysis patients. Methods: To determine whether thiamine deficiency is associated with regular dialysis patients, we measured thiamine in 100 patients undergoing consecutive dialysis. Results: Average thiamine levels were not low in both pre-hemodialysis (50.1 ± 75.9 ng/mL; normal range 24 - 66 ng/mL) and post-hemodialysis (56.4 ± 61.7 ng/mL). In 18 patients, post-hemodialysis levels of thiamine were lower than pre-hemodialysis levels. We divided the patients into two groups, the decrease (Δthiamine/pre thiamine < 0; - 0.13 ± 0.11) group (n = 18) and the increase (Δthiamine/pre thiamine> 0; 0.32 ± 0.21)) group (n = 82). However, there was no significance between the two groups in Kt/V or type of dialyzer. Patients were dichotomized according to median serum thiamine level in pre-hemodialysis into a high-thiamine group (≥ 35.5 ng/mL) and a low-thiamine group (< 35.4 ng/mL), and clinical characteristics were compared between the two groups. The low-thiamine value group (< 35.4 ng/ml; 26.8 ± 5.3 ng/ml) exhibited lower levels of serum aspartate aminotransferase and alanine aminotransferase than the high-thiamine value group (≥ 35.4 ng/ml; 73.5 ± 102.5 ng/ml) although there was no significance in nutritional marker, Alb, geriatric nutritional risk index , protein catabolic rate and creatinine generation rate. Conclusion: In our regular dialysis patients, excluding a few patients, we did not recognize thiamine deficiency and no significant difference in thiamine value between pre and post hemodialysis.


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