scholarly journals Improving hemoglobin estimation accuracy through standardizing of light-emitting diode power

2022 ◽  
Vol 12 (1) ◽  
pp. 219
Author(s):  
Caje Francis Pinto ◽  
Jivan Shrikrishna Parab ◽  
Marlon Darius Sequeira ◽  
Gourish Naik
Keyword(s):  
Light Emitting Diode ◽  
Estimation Accuracy ◽  
Coefficient Of Determination ◽  
Altman Analysis ◽  
Light Emitting ◽  
Non Invasive ◽  
Transmitted Signal ◽  
On Chip ◽  
Embedded Development ◽  
Good Agreement

Nowadays, hemoglobin monitoring is essential during surgeries, blood donations, and dialysis. Which are normally done using invasive methods. To monitor hemoglobin, a non-invasive hemoglobin meter was developed with five fixed light-emitting diode (LED) wavelengths at 670 nm, 770 nm, 810 nm, 850 nm, 950 nm and controlled using an Arduino Uno embedded development board. A photodetector with an on-chip trans-impedance amplifier was utilized to acquire the transmitted signal through the finger using the photoplethysmography (PPG) principle. Before the standardization of LED power, we had tested the designed system on fifteen subjects for the five wavelengths and estimated the hemoglobin with an accuracy of 96.51% and root mean square error (RMSE) of 0.57 gm/dL. To further improve the accuracy, the LED power was standardized and the PPG signal was reacquired on the same subjects. With this, the accuracy improved to 98.29% and also reduced the RMSE to 0.36 gm/dL. The designed system with LED power standardization showed a good agreement with pathology results with the coefficient of determination R<sup>2</sup>=0.981. Also, Bland–Altman analysis was used to evaluate the designed system and it showed good agreement between the two measurements.

On-chip cavity-enhanced absorption spectroscopy using a white light-emitting diode and polymer mirrors

Lab on a Chip ◽  
2015 ◽  
Vol 15 (3) ◽  
pp. 711-717 ◽  
Author(s):  
Cathy M. Rushworth ◽  
Gareth Jones ◽  
Martin Fischlechner ◽  
Emma Walton ◽  
Hywel Morgan
Keyword(s):  
Absorption Spectroscopy ◽  
White Light ◽  
Microfluidic Chip ◽  
Path Length ◽  
Light Emitting Diode ◽  
Absorption Path Length ◽  
Light Emitting ◽  
Enhanced Absorption ◽  
Cavity Enhanced Absorption Spectroscopy ◽  
On Chip

We have integrated disposable polymer mirrors within a microfluidic chip to form a multi-pass cell, which increases the absorption path length by a maximum of 28 times, providing micromolar detection limits in a probed volume of 10 nL.

scholarly journals Pinhole microLED Array as Point Source Illumination for Miniaturized Lensless Cell Monitoring Systems

Proceedings ◽  
2018 ◽  
Vol 2 (13) ◽  
pp. 866 ◽  
Author(s):  
Shinta Mariana ◽  
Gregor Scholz ◽  
Feng Yu ◽  
Agus Budi Dharmawan ◽  
Iqbal Syamsu ◽  
...  
Keyword(s):  
Image Quality ◽  
Light Emitting Diode ◽  
Free Cell ◽  
Monitoring Systems ◽  
Label Free ◽  
Light Emitting ◽  
Non Invasive ◽  
Cell Monitoring ◽  
Blue Spectral Region ◽  
Led Arrays

Pinhole‐shaped light‐emitting diode (LED) arrays with dimension ranging from 100 μm down to 5 μm have been developed as point illumination sources. The proposed microLED arrays, which are based on gallium nitride (GaN) technology and emitting in the blue spectral region (λ = 465 nm), are integrated into a compact lensless holographic microscope for a non‐invasive, label‐free cell sensing and imaging. From the experimental results using single pinhole LEDs having a diameter of 90 μm, the reconstructed images display better resolution and enhanced image quality compared to those captured using a commercial surface‐mount device (SMD)‐based LED.

scholarly journals Non-invasive Autonomic Neuromodulation Is Opening New Landscapes for Cardiovascular Diseases

2020 ◽  
Vol 11 ◽  
Author(s):  
Mingxian Chen ◽  
Songyun Wang ◽  
Xuping Li ◽  
Lilei Yu ◽  
Hui Yang ◽  
...  
Keyword(s):  
Cardiovascular Diseases ◽  
Vagus Nerve ◽  
Nerve Stimulation ◽  
Vagus Nerve Stimulation ◽  
Light Emitting Diode ◽  
Heart Diseases ◽  
Bipolar Electrode ◽  
Light Emitting ◽  
Non Invasive ◽  
Emerging Therapies

Autonomic imbalance plays a crucial role in the genesis and maintenance of cardiac disorders. Approaches to maintain sympatho-vagal balance in heart diseases have gained great interest in recent years. Emerging therapies However, certain types of emerging therapies including direct electrical stimulation and nerve denervation require invasive implantation of a generator and a bipolar electrode subcutaneously or result in autonomic nervous system (ANS) damage, inevitably increasing the risk of complications. More recently, non-invasive neuromodulation approaches have received great interest in ANS modulation. Non-invasive approaches have opened new fields in the treatment of cardiovascular diseases. Herein, we will review the protective roles of non-invasive neuromodulation techniques in heart diseases, including transcutaneous auricular vagus nerve stimulation, electromagnetic field stimulation, ultrasound stimulation, autonomic modulation in optogenetics, and light-emitting diode and transcutaneous cervical vagus nerve stimulation (gammaCore).

Near-Infrared Light Emitting Diode Based Non-Invasive Glucose Detection System

2019 ◽  
Vol 19 (10) ◽  
pp. 6187-6191 ◽  
Author(s):  
Seung Ho Lee ◽  
Min Seok Kim ◽  
Ok-Kyun Kim ◽  
Hyung-Hwan Baik ◽  
Ji-Hye Kim
Keyword(s):  
Near Infrared ◽  
Detection System ◽  
Light Emitting Diode ◽  
Infrared Light ◽  
Glucose Detection ◽  
Near Infrared Light ◽  
Light Emitting ◽  
Non Invasive

scholarly journals Light-Emitting Diode Based Photoacoustic Imaging System

2020 ◽  
Author(s):  
Ebrahim Najafzadeh ◽  
Parastoo Farnia ◽  
Alireza Ahmadian ◽  
Hossein Ghadiri
Keyword(s):  
Imaging System ◽  
Photoacoustic Imaging ◽  
Light Emitting Diode ◽  
Imaging Modality ◽  
Optical Excitation ◽  
Poly Vinyl Alcohol ◽  
Ultrasound Images ◽  
Light Emitting ◽  
Non Invasive ◽  
Wide Range

Purpose: A Photoacoustic Imaging (PAI) as a non-invasive hybrid imaging modality has the potential to be used in a wide range of pre-clinical and clinical applications. There are different optical excitation sources that affect the performance of PAI systems. Our goal is proving the capability of the Light-Emitting Diode (LED) based PAI system for imaging of objects in different depths. Materials and Methods: In this study the Full Width of Half Maximum (FWHM) and Contrast to Noise Ratio (CNR) of LED-based PAI system is evaluated using agar, and Poly-Vinyl Alcohol Cryogel (PVA-C) phantoms. Results: The results show that axial and lateral FWHM of the photoacoustic image in agar phantom 1%, are 0.59 and 1.16 mm, respectively. It is capable of distinguishing objects about 250 µm. Furthermore, one of the main improvements of photoacoustic images is achieved by proposed LED-based system that is a 26% higher CNR versus the ultrasound images. Conclusion: Therefore, the provided technical characteristics in this study have made designed LED-based PAI system as a suitable tool for preclinical and clinical imaging.

scholarly journals Organic optoelectronics for lab-on-chip fluorescence detection

2017 ◽  
Vol 84 (s1) ◽  
Author(s):  
Sabrina Jahns ◽  
Andre F.K. Iwers ◽  
Jan Balke ◽  
Martina Gerken
Keyword(s):  
Fluorescence Detection ◽  
Light Emitting Diode ◽  
Light Emitting ◽  
Lab On Chip ◽  
Organic Light Emitting Diode ◽  
Photo Diode ◽  
Organic Optoelectronics ◽  
Organic Light ◽  
On Chip

AbstractWe present two designs of organic optoelectronics for compact lab-on-chip fluorescence detection. In the first configuration, organic light emitting diode (OLED) and organic photo diode (OPD) are fabricated

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