scholarly journals Serum Osteocalcin, P1NP, Alkaline Phosphase, and CrossLaps in Humans.The relationship with body mass index

2019 ◽  
Vol 70 (5) ◽  
pp. 1615-1618
Author(s):  
Mara Carsote ◽  
Smaranda Adelina Preda ◽  
Mihaela Mitroi ◽  
Adrian Camen ◽  
Lucretiu Radu
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Biochemical Markers ◽  
Mean Value ◽  
Normal Weight ◽  
P Value ◽  
Biochemical Bone Marker ◽  
Vitamin D Levels ◽  
Significant Difference ◽  
Coefficient Of Regression

This is a clinical study on 56 subjects included in normal weight (NW) group (N=17), overweight (OW) group (N=19) and grade I obese (O) group (N=20), based on BMI (Body Mass Index) values: NW group had a mean BMI of 22.2 � 2.14 kg/sqm, OW group had a BMI of 25.89 � 1.04 kg/sqm, and O group had an average BMI of 32.2 � 2.09 kg/sqm (p-value NW-OW, NW-O, respective OW-O groups was p[0.0005). The 3 groups were similar as age (p-value NW-OW groups = 0.7, between NW- O groups = 0.8, respective between OW - O group = 0.7). The circulating bone formation (osteocalcin, P1NP alkaline phosphatase) and resorption profile (CrossLaps) indicated no statistical significant difference between groups while the coefficient of regression r between each biochemical bone marker and BMI in every BMI group exceeded the value of p]0.05. All the 3 groups had a mean value of 25-hydroxycholecalciferol in deficiency ranges ([ 30 ng/mL, normal recommended values are above 30 ng/mL) without significant differences regarding BMI groups, except for obese group when compare to the other two groups. No secondary hyperparathyroidism was associated in any group despite low vitamin D levels. Based on our observation, bone turnover biochemical markers are not influenced by BMI.

The Relationship between Body Mass Index and Dental Caries in Children Aged 6 to 10 Years Old in Rafsanjan

2021 ◽  
Author(s):  
Atefeh Pourfatahi ◽  
Hajar Atarzadeh ◽  
Forouzan Vahidi
Keyword(s):  
Body Mass Index ◽  
Dental Caries ◽  
Body Mass ◽  
Simple Random Sampling ◽  
Normal Weight ◽  
P Value ◽  
Cross Sectional ◽  
Significant Difference ◽  
Dmft Index ◽  
The Relationship

Introduction: Dental caries is one of the most common chronic childhood diseases that have a profound impact on the health of both the individual and community health. The present study aimed to assess the relationship between Body Mass Index (BMI) and dental caries in Rafsanjan children aged 6-10 years in 2019. Materials & Methods: This study is a cross-sectional study that investigated the relationship between body mass index and dental caries in 215 male and female students (6-10 years old), selected by simple random sampling in four groups: slim, normal BMI, overweight, and obese the relationship between BMI and DMFT / dmft had been determined by Mann-Whitney and Kruskal-Wallis tests and Spearman correlation coefficient. Results: There was a significant inverse relationship between dmft index and children's body mass index (p value < 0.001, r = -0.315). There was no significant difference between the mean DMFT index between lean, normal weight, overweight and obese children (p value = 0.205) Conclusion: The dmft index decreased with increasing BMI, and there was no significant relationship between DMFT index and BMI. 

scholarly journals OP0220 ASSESSING THE EFFECT OF INCREASED BODY MASS INDEX ON RESPONSE TO TNF INHIBITORS IN ESTABLISHED RHEUMATOID ARTHRITIS: RESULTS FROM THE METEOR DATABASE

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 137.1-137
Author(s):  
M. Dey ◽  
S. S. Zhao ◽  
R. J. Moots ◽  
R. B. M. Landewé ◽  
N. Goodson
Keyword(s):  
Rheumatoid Arthritis ◽  
Body Mass Index ◽  
Body Mass ◽  
Personalised Medicine ◽  
Normal Weight ◽  
Sensitivity Analyses ◽  
Established Rheumatoid Arthritis ◽  
Eular Response ◽  
Significant Difference ◽  
Das28 Remission

Background:Rheumatoid arthritis (RA) is associated with increased body mass index (BMI)- 60% of patients are either overweight or obese. Obesity in RA has been shown to predict reduced response to biologic therapy including tumour-necrosis-factor inhibitors (TNFi) [1]. However, it is not clear whether increased BMI influences response to all TNFi drugs in RA.Objectives:1.To explore whether BMI is associated with response to TNFi in patients with established rheumatoid arthritis (estRA), including those newly-starting on these drugs.Methods:Participants with estRA (>1year since diagnosis) taking biologic medications, registered on METEOR (international database of RA patients), 2008-2013, were included. EULAR response, DAS28 remission (including components), and treatment regimens were recorded at baseline, 6, and 12 months. WHO definitions of overweight (BMI≥ 25) and obese (BMI≥30) were explored as predictors of TNFi response (good EULAR response and DAS28 remission) using normal BMI as comparator. Logistic and linear regression models (controlling for age, gender, smoking, and baseline outcomes) and sensitivity analyses were performed. Subgroup analyses were performed for grouped TNFi and individual TNFi (infliximab, IFX; adalimumab, ADA; etanercept, ETN).Results:247 patients with estRA were taking a biologic at 6 months, and 231 patients were taking a biologic at 12 months. Obese patients taking any biologic were significantly less likely to achieve DAS28 remission (OR 0.33 [95%CI 0.12-0.80]) or good EULAR response (OR 0.37 [95%CI 0.16-0.81]) after 6 months, compared to those of normal BMI; this was also demonstrated in those co-prescribed methotrexate (DAS28 remission: OR 0.23 [95%CI 0.07-0.62]; good EULAR response: OR 0.39 [95%CI 0.15-0.92]). These associations did not remain statistically significant at the 12 months assessment.Regarding specific anti-TNF therapies, RA patients treated with monoclonal antibody (-mab) TNFis (IFX/ADA/ GOL) were significantly less likely to achieve good EULAR response at 6 months if they were obese RA (n=38), compared to those of normal weight (n=44) (OR 0.17 [95%CI 0.03-0.59]). A similar non-significant difference was demonstrated for DAS28 remission, and 12-month remission. Specifically, obese individuals were significantly less likely to achieve good EULAR response at 6 months with IFX (OR 0.09 [95%CI 0.00-0.61]; n=20), and significantly less likely to achieve DAS28 remission at 6 months when newly-starting ADA (OR 0.14 [95%CI 0.01-0.96]; n=17), compared to those of normal weight. There were no significant differences in remission outcomes between individuals of different BMI taking ETN. A small number of individuals stopped taking their respective biologic after 6months; reason for cessation was not recorded.Similar outcomes were seen in patients already established on anti-TNF therapy, with overweight and obese individuals less likely overall to be in DAS28 remission at all time points.Conclusion:In established RA, obesity is associated with reduced treatment response to -mab TNFi. No association between increased BMI and response to ETA was observed. Using BMI to direct biologic drug choice could prove to be a simple and cost-effective personalised-medicine approach to prescribing.References:[1]Schäfer M, Meißner Y, Kekow J, Berger S, Remstedt S, Manger B, et al. Obesity reduces the real-world effectiveness of cytokine-targeted but not cell-targeted disease-modifying agents in rheumatoid arthritis. Rheumatology. 2019 Nov 20.Disclosure of Interests:Mrinalini Dey: None declared, Sizheng Steven Zhao: None declared, Robert J Moots: None declared, Robert B.M. Landewé Consultant of: AbbVie; AstraZeneca; Bristol-Myers Squibb; Eli Lilly & Co.; Galapagos NV; Novartis; Pfizer; UCB Pharma, Nicola Goodson: None declared

scholarly journals Body mass index and clinical outcomes in patients with intracerebral haemorrhage: results from the China Stroke Center Alliance

2021 ◽  
pp. svn-2020-000534
Author(s):  
Zhentang Cao ◽  
Xinmin Liu ◽  
Zixiao Li ◽  
Hongqiu Gu ◽  
Yingyu Jiang ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Hospital Mortality ◽  
Body Mass ◽  
Intracerebral Haemorrhage ◽  
Final Analysis ◽  
Normal Weight ◽  
Discharge Disposition ◽  
Increased Risk ◽  
Significant Difference ◽  
Stroke Center

Background and aimObesity paradox has aroused increasing concern in recent years. However, impact of obesity on outcomes in intracerebral haemorrhage (ICH) remains unclear. This study aimed to evaluate association of body mass index (BMI) with in-hospital mortality, complications and discharge disposition in ICH.MethodsData were from 85 705 ICH enrolled in the China Stroke Center Alliance study. Patients were divided into four groups: underweight, normal weight, overweight and obese according to Asian-Pacific criteria. The primary outcome was in-hospital mortality. The secondary outcomes included non-routine discharge disposition and in-hospital complications. Discharge to graded II or III hospital, community hospital or rehabilitation facilities was considered non-routine disposition. Multivariable logistic regression analysed association of BMI with outcomes.Results82 789 patients with ICH were included in the final analysis. Underweight (OR=2.057, 95% CI 1.193 to 3.550) patients had higher odds of in-hospital mortality than those with normal weight after adjusting for covariates, but no significant difference was observed for patients who were overweight or obese. No significant association was found between BMI and non-disposition. Underweight was associated with increased odds of several complications, including pneumonia (OR 1.343, 95% CI 1.138 to 1.584), poor swallow function (OR 1.351, 95% CI 1.122 to 1.628) and urinary tract infection (OR 1.532, 95% CI 1.064 to 2.204). Moreover, obese patients had higher odds of haematoma expansion (OR 1.326, 95% CI 1.168 to 1.504), deep vein thrombosis (OR 1.506, 95% CI 1.165 to 1.947) and gastrointestinal bleeding (OR 1.257, 95% CI 1.027 to 1.539).ConclusionsIn patients with ICH, being underweight was associated with increased in-hospital mortality. Being underweight and obese can both increased risk of in-hospital complications compared with having normal weight.

scholarly journals Correlation of Body Mass Index with Oncologic Outcomes in Colorectal Cancer Patients: A Large Population-Based Study

Cancers ◽  
2021 ◽  
Vol 13 (14) ◽  
pp. 3592
Author(s):  
Chong-Chi Chiu ◽  
Chung-Han Ho ◽  
Chao-Ming Hung ◽  
Chien-Ming Chao ◽  
Chih-Cheng Lai ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Body Mass Index ◽  
Body Weight ◽  
Body Mass ◽  
Survival Rates ◽  
Normal Weight ◽  
P Value ◽  
Administrative Claims ◽  
The Impact

It has been acknowledged that excess body weight increases the risk of colorectal cancer (CRC); however, there is little evidence on the impact of body mass index (BMI) on CRC patients’ long-term oncologic results in Asian populations. We studied the influence of BMI on overall survival (OS), disease-free survival (DFS), and CRC-specific survival rates in CRC patients from the administrative claims datasets of Taiwan using the Kaplan–Meier survival curves and the log-rank test to estimate the statistical differences among BMI groups. Underweight patients (<18.50 kg/m2) presented higher mortality (56.40%) and recurrence (5.34%) rates. Besides this, they had worse OS (aHR:1.61; 95% CI: 1.53–1.70; p-value: < 0.0001) and CRC-specific survival (aHR:1.52; 95% CI: 1.43–1.62; p-value: < 0.0001) rates compared with those of normal weight patients (18.50–24.99 kg/m2). On the contrary, CRC patients belonging to the overweight (25.00–29.99 kg/m2), class I obesity (30.00–34.99 kg/m2), and class II obesity (≥35.00 kg/m2) categories had better OS, DFS, and CRC-specific survival rates in the analysis than the patients in the normal weight category. Overweight patients consistently had the lowest mortality rate after a CRC diagnosis. The associations with being underweight may reflect a reverse causation. CRC patients should maintain a long-term healthy body weight.

scholarly journals Anemia in relation to body mass index among female students of North Kerala: a pilot study

2018 ◽  
Vol 6 (11) ◽  
pp. 3607
Author(s):  
Veena Thamban ◽  
Kavana G. Venkatappa ◽  
Swarnalatha P. K. ◽  
Sparshadeep E. M.
Keyword(s):  
Body Mass Index ◽  
Pilot Study ◽  
Body Mass ◽  
Growth And Development ◽  
Mean Value ◽  
Normal Weight ◽  
Female Students ◽  
First Year ◽  
Nutrition And Health ◽  
Larger Sample

Background: Anemia among women causes many serious health problems and is pervasive in developing country. Many research studies have documented that malnutrition affects body growth and development, especially during the crucial period of adolescence. The association between anemia and body mass index (BMI) is a measure of nutrition and health status of adults. Aim was to study the association between anemia and BMI among female students.Methods: An observational study was conducted among first year medical and dental female students (n=109) aged 18-20years. Hemoglobin (Hb) levels (g/dL) by Sahli’s hemoglobinometer and BMI (kg/m2) were estimated. Anemia was defined as Hb content <12g/dL. Subjects were classified by BMI categories as underweight (BMI <18.5kg/m2), normal weight (BMI:18.5-24.99kg/m2), overweight (BMI ≥25kg/m2) and obesity (BMI ≥30kg/m2) according to WHO. Then the relation between anemia and BMI were statistically analyzed.Results: Overall, 48.62% female students were anemic. Of which 43.4% were underweight, 22.6% normal weight and 34.5% were above normal weight (over weight and obese). Mean value of hemoglobin was significantly decreased in underweight and overweight compared to normal weight (p<0.001). Anemia was significantly associated with BMI (χ2 =46.48, p=0.000).Conclusions: The study concludes the occurrence of anemia in both undernourished and over-nourished individuals which were significantly associated. Further studies are needed with larger sample size to document the factors that may be associated with anemia in females.

scholarly journals Association between Acne and Body Mass Index: A Hospital Based Cross Sectional Study

2018 ◽  
Vol 16 (1) ◽  
pp. 53-56
Author(s):  
Saraswoti Neupane ◽  
Binamra Basnet ◽  
Tara Devi Sharma
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Acne Vulgaris ◽  
Cross Sectional Study ◽  
Normal Weight ◽  
P Value ◽  
Cross Sectional ◽  
Middle Income ◽  
Medical College ◽  
Middle Income Countries

Introduction: Acne vulgaris is a common and chronic inflammatory skin disease of pilosebaceous unit. Obesity is one of the biggest problems in western life style but nowadays, the problem is increasing even in low and middle-income countries. Body Mass Index (BMI) is used to accurately measure obesity.Objective: To find out the association between different categories of BMI and severity of acne.Materials and methods: This was a cross sectional prospective study conducted in the outpatient department of Gandaki Medical College from January to July, 2017. All the newly diagnosed patients with acne were included in the study. Height and weight of the patients was recorded and BMI was calculated. BMI was categorized as underweight, normal weight, overweight and obese. Type of lesions were noted and severity of acne was graded from 1 to 4.Statistical analysis was performed using SPSS version 17.0 for windows. One-way Analysis of Variance between groups (ANOVA) test was applied. P value of less than 0.05 was considered significant.Results: There were altogether 249 patients with acne. Age of the patients ranged from 10 to 44 years with mean age of 20.82 ±5.9 years. Most of the patients were in the age group of 11-20 years. Female: male ratio was 1:1.4. Majority of patients (65.5%) had normal BMI. Most of the patients had Grade 2 acne (52.6%). There was no significant association between the BMI and severity of acne (p=0.129).Conclusion: There was no significant association between BMI and severity of acne.

scholarly journals Is body mass index associated with irregular menstruation: A questionnaire study?

2020 ◽  
Author(s):  
Yunhui Tang ◽  
Yan Chen ◽  
Hua Feng ◽  
Chen Zhu ◽  
Mancy Tong ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Menstrual Cycle ◽  
Blood Loss ◽  
Body Mass ◽  
Odds Ratio ◽  
Normal Weight ◽  
Menstrual Blood ◽  
Menstrual Blood Loss ◽  
Menstrual Cycles ◽  
Significant Difference

Abstract Background: Irregular menstrual cycles including the length of cycles and menses, and heavy menstrual blood loss are linked to many gynaecological diseases. Obesity has been reported to be associated with irregular menstrual cycles. However, to date, most studies investigating this association are focused on adolescence or university students. Whether this association is also seen in adult women, especially women who had a history of birth has not been fully investigated. Methods: Questionnaire data were collected from 1012 women aged 17 to 53 years. Data on age, weight and height, gravida, the length of menstrual cycles and menses, and the number of pads used during menses were collected. Factors associated with menstrual cycle according to BMI categories were analysed.Results: There were no differences in the length of menstrual cycles and menses in women of different body mass index (BMI) groups. However, there was a significant difference in menstrual blood loss in women of different BMI categories. The odds ratio of having heavy menstrual blood loss in obese women was 2.28 (95% CL: 1.244, 4.193), compared to women with normal weight, while there was no difference in the odds ratio of having heavy menstrual blood loss in overweight, compared to normal weight, women. In contrast, the odds ratio of having heavy menstrual blood loss in underweight women was 0.4034 (95% CL: 0.224, 0.725), compared to women with normal weight. Conclusion: Although BMI was not correlated with the length of menstrual cycle and menses, BMI is positively associated with menstrual blood loss. Our data suggest that BMI influences menstrual blood loss in women of reproductive age and weight control is important in women’s reproductive years.

scholarly journals Evaluation of Ocular Anterior Chamber Depth and Body Mass Index in Normal Blacks in a Nigerian City

2019 ◽  
pp. 1-8
Author(s):  
I. N. Aprioku ◽  
C. S. Ejimadu
Keyword(s):  
Body Mass Index ◽  
Anterior Chamber ◽  
Body Mass ◽  
Normal Population ◽  
Anterior Chamber Depth ◽  
Angle Closure ◽  
P Value ◽  
Multi Stage ◽  
Significant Difference ◽  
Lens Power

Aim: To evaluate ocular anterior chamber depth (ACD) and body mass index (BMI) in a normal population in Port Harcourt City Local Government Area (LGA), with a view to determine formulae in estimating intraocular lens power for cataract surgeries and possible association with angle closure glaucoma and other ocular pathological conditions.            Methods: This is a multi-stage study with inclusion criteria of Visual Acuity > 6/18, age greater than 18 years with no history of past ocular surgeries or trauma. Data obtained through a structured proforma included age, sex, tribe, occupation and level of education. Body Mass Index (BMI) was measured using a standard height and weight automated scale (SECA 769,220). Comprehensive ocular examination done and Anterior Chamber Depth (ACD) measured using Amplitude (A) scan ultrasonography (SONOMED PACSCAN 300AP). Data was analyzed using SPSS (Version 17), and p value was set at ≤ 0.05. Results: Four hundred and sixty six (466) subjects participated in the study made up of two hundred and twelve (212) males (45.5%) and two hundred and fifty four (254) females (54.5%) with M: F ratio of 1:1.2. The age range was 18-92 years and mean age of the subjects studied 43.0±14.2 years. Findings revealed mean ACD and Body Mass Index to be 3.1±0.5 mm and 26.9±6.2 kg/m2 respectively. The mean ACD was greater in males than females. There was a statistically significant relationship between age and ACD. Obesity was found to be higher in females (n=97; 78.2%) compared to the males among those with BMI >30Kg/m2 and this was found to be statistically significant (p=0.0001). A larger proportion of subjects with normal BMI and overweight BMI 25-29.5 Kg/m2 were males. There was a statistically significant difference in the ACD values between genders among those overweight (BMI 25- 29.5 Kg/m2) and the obese (BMI >30 Kg/m2). Conclusion: There was a statistically significant difference in the ACD values between genders among those overweight.

scholarly journals The Effects of Cardiovascular Exercises on Body Mass Index and Vital Capacity among Students of Sargodha University

2020 ◽  
Vol V (III) ◽  
pp. 358-364
Author(s):  
Yassar Iqbal ◽  
Zubia Savila ◽  
Muhammad Badar Habib
Keyword(s):  
Body Mass Index ◽  
University Students ◽  
Body Mass ◽  
Vital Capacity ◽  
Control Group ◽  
P Value ◽  
Daily Routine ◽  
Cardiovascular Exercise ◽  
Significant Difference ◽  
Experimental Group

This research was designed to evaluate the effect of cardiovascular exercises on body mass index (BMI) and vital capacity (VC) among student aged between 21-27 years (M � SD 22.3� 3.05). The experimental research study was applied to 54 University students of Sargodha. Data were analyzed by using SPSS version 24.0. P-value ? 0.05 was considered significant. The result showed that the average BMI of the control group and experimental groups was 20.73�3.02 vs 21.51�3.21. The effectiveness of cardiovascular exercise on Vital capacity on Pre and post-test of the experimental group was -56.91272 � 22.03192 with a pvalue of 0.000, which was showed there was a highly significant improvement in vital capacity of students and compare with the control group. It was concluded that body masses index and vital capacity is significantly improved in university students of the experimental group as a result of 10 weeks of the cardiovascular exercise training program. Conclude that there is a significant difference between the effects of cardiovascular exercise and daily routine sports activities on BMI.

scholarly journals Body mass index in relation to dental maturation of 10 to 14 years old school children in Erbil city. A cross-sectional prospective study.

2020 ◽  
Vol 3 (2) ◽  
pp. 145-150
Author(s):  
Omar Chawshli ◽  
Yara Ameen
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
School Children ◽  
P Value ◽  
Dental Age ◽  
Chi Square ◽  
Cross Sectional ◽  
Dental Maturation ◽  
Significant Difference ◽  
Chi Square Test

Background and Objectives: Estimation of dental age is based upon the rate of development and calcification of tooth buds and their progressive sequence of eruption in the oral cavity. The tooth calcification provides a valuable indicator of dental age and serves as an index of the maturation of the child. The aim of this study is to determine whether Body Mass Index (BMI) has association with dental maturation. Materials and Methods: A cross sectional study design was applied for the present study, 383 school children were participated in this study which nominated from Erbil city. For the sample to be representative the city was divided in to six geographic areas according to the municipalities, the samples randomly selected school children of 10 to 14 years old from both genders. The height and the weight of each participant had been recorded in the college of dentistry / Hawler Medical University in order to calculate the body mass index of the following the guidelines of centers of disease control (CDC) , at the same time an orthopantomography radiograph had been used to investigate the stage of the dental maturation using the Demirjian method, finally, the relationship between BMI and dental maturation were investigated using chi square test with P value of ≤ 0.05 was considered significant difference. Result: there was a statistically significant relationship between dental maturation and BMI. The majority (93.6%) of samples with under-mature dentition were under-weight at the same time. The vast majority (96%) of samples with mature dentition had normal BMI. In the same manner, majority (91.7%) of samples with over mature dentition were over-weight too. Chi square test was used to find out the association and P-value was 0.001 Conclusion: In conclusion, normal weight students have normal dental maturation, underweight students have under dental maturation and overweight or obese students have over dental maturation. Keywords: body mass index, Demirjian, Orthopantomography.

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