Abstract P210: Lipoprotein Profiles in Patients With and Without Psoriasis

Circulation ◽  
2015 ◽  
Vol 131 (suppl_1) ◽  
Author(s):  
Paulo A Lotufo ◽  
Steven Jones ◽  
Michael Blaha ◽  
Cid Sabbag ◽  
Raul Dias-Santos ◽  
...  
Keyword(s):  
Waist Circumference ◽  
Lipid Profile ◽  
Lipid Lowering ◽  
Resonance Spectroscopy ◽  
Lipid Lowering Drugs ◽  
Increased Risk ◽  
Enhanced Secretion ◽  
Mean Size ◽  
The Mean ◽  
Disease Free

Introduction: Psoriasis is associated with chronically heightened systemic inflammatory tone and increased risk for cardiovascular disease. It remains to be established if the psoriatic state itself associates with dyslipidemia. Hypothesis: The lipid profile of patients with psoriasis is more atherogenic compared to disease-free control patients. Methods: The concentration and size of lipoprotein particles were measured using nuclear magnetic resonance spectroscopy in 221 patients with a diagnosis of psoriasis (53.6% men; mean age=56.6 years; mild cases=31%; moderate/severe only skin=27%; arthritis=27%)) and 689 disease-free persons matched by sex and age. We compared means of lipoprotein particle concentration and size using a univariate general linear model and adjusting for body-mass index, waist circumference, diabetes, use of lipid lowering-drugs, as well as duration/severity of psoriasis. Results: Patients with psoriasis were more overweight, had larger waist circumference, and a higher frequency of diabetes and use of lipid-lowering drugs. Total LDL particle means (nmol/L) for the psoriasis and control groups were 1436 (1378-1494) vs. 1420 (1388-1452) (P=0.4), respectively. The mean concentration of IDL was higher in patients with psoriasis compared to controls: 143.6 (130.7-156.5) vs. 106.1 (99.1-113.2), P<0.01. Large and small LDL particle concentrations were similar between groups. Large VLDL/chylomicron particle concentrations (nmol/L) were higher in psoriasis patients compared to controls 6.1 (5.2-7.0) vs. 4.0 (3.6-4.5) (P<0.01). Total HDL particle and subfractions were not statistically different between groups. The mean size (nm) of VLDL was higher in psoriasis patients: 50.2 (49.2-51.2) vs. 46.2 (45.6-46.7) (P<0.001) for psoriasis and controls, respectively. In contrast, mean sizes of LDL and HDL particles were similar (P=0.3). Adjustment for covariates above mentioned did not change these findings. The absence/presence of arthritis did not change the results. Conclusion: Patients with psoriasis have a more atherogenic lipid profile compared to controls with higher levels of IDL and VLDL of large and small size. In addition, the greater mean size of VLDL particles in psoriasis compared to controls suggests enhanced secretion of triglyceride loaded VLDL, impaired lipolysis and impaired clearance of remnant IDL.

scholarly journals Lipid Lowering Activity and Free Radical Scavenging Effect of Cinnamomum tamala (Fam: Lauraceae)

1970 ◽  
Vol 1 (4) ◽  
pp. 93-96
Author(s):  
R Al-Mamun ◽  
A Hamid ◽  
MK Islam ◽  
JA Chowdhury ◽  
ATM Zafrul Azam
Keyword(s):  
Free Radical ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Antioxidant Property ◽  
Free Radical Scavenging ◽  
Lipid Lowering ◽  
Increased Risk ◽  
Lowering Activity

Lipid profile is a blood test that measures the amount of lipids, or fats, in your blood. The lipids measured are usually total cholesterol, HDL-C, LDL-C and triglycerides. When levels of these lipids are abnormal, there is an increased risk of heart attack and stroke. In our study, we use methanol crude extract for lipid lowering activity on rabbit and found that lipid profile was reduced by 14.0, 1.0, 4.0 and 15.0 mg/dl for total cholesterol, HDL-C, LDL-C and triglyceride respectively after using the plant extract (dose 500mg/rabbit for 10 days); where atorvastatin (0.005mg/rabbit) was used as standard lipid lowering agent. We also focused on the antioxidant property of crude methanol extract. Here we also carried out free radical-scavenging activity study and found the IC50 value for C. tamala is 6.00 μg/ml where the standard antioxidant (ascorbic acid) gave the value of 3.21μg/ml. DOI: http://dx.doi.org/10.3329/ijns.v1i4.9735 IJNS 2011 1(4): 93-96

The Effect of Micronized Fenofibrate on Lipid Profiles of Patients Converted from Gemfibrozil

2002 ◽  
Vol 37 (9) ◽  
pp. 953-956 ◽  
Author(s):  
Jim M. Backes ◽  
Patrick M. Moriarty ◽  
Cheryl A. Gibson
Keyword(s):  
Randomized Trial ◽  
Lipid Profile ◽  
Lipid Profiles ◽  
Comparative Data ◽  
Lipid Lowering ◽  
Lipid Lowering Therapy ◽  
Two Agents ◽  
Lowering Therapy ◽  
Micronized Fenofibrate ◽  
The Mean

Although numerous studies have established the efficacy of micronized fenofibrate (MF) and gemfibrozil in improving lipid profiles, there are limited comparative data on the lipid-lowering effects of these two agents. The objective of this study was to evaluate the mean changes in lipid values of hypertriglyceridemic patients crossed over from gemfibrozil to MF. The Medical charts of 21 patients were analyzed retrospectively. Patients were maintained on gemfibrozil 600 mg twice daily for a minimum of 3 months. The patient's last fasting lipid profile on gemfibrozil was compared to the first lipid profile after crossover to MF 200 to 201 mg/day. Patients were excluded if there were alterations in other lipid-lowering therapy during the cross-over or documented non-adherence. The lipid profiles after the crossover showed a significant reduction in triglycerides (56%; P < 0.05) and TC/HDL ratio (38%; P < 0.05) and a significant increase in HDL (22%; P < 0.05). There were nonsignificant changes in other lipid values: TC (-22%; P = 0.058), LDL (+5%; P = 0.866) and LDL/HDL ratio (+6; P = 1.0). The results show that MF had additional favorable effects on triglycerides, HDL, and TC/HDL ratio compared with gemfibrozil. A larger, randomized trial to confirm these effects is warranted.

Are users of lipid-lowering drugs at increased risk of peripheral neuropathy?

2001 ◽  
Vol 56 (12) ◽  
pp. 931-933 ◽  
Author(s):  
David Gaist ◽  
Luis Alberto García Rodríguez ◽  
Consuelo Huerta ◽  
Jesper Hallas ◽  
Søren H. Sindrup
Keyword(s):  
Peripheral Neuropathy ◽  
Lipid Lowering ◽  
Lipid Lowering Drugs ◽  
Increased Risk

scholarly journals Water-Soluble Chitosan Nanoparticles Inhibit Hypercholesterolemia Induced by Feeding a High-Fat Diet in Male Sprague-Dawley Rats

2011 ◽  
Vol 2011 ◽  
pp. 1-5 ◽  
Author(s):  
Yi Tao ◽  
Hongliang Zhang ◽  
Bing Gao ◽  
Jiao Guo ◽  
Yinming Hu ◽  
...  
Keyword(s):  
High Fat Diet ◽  
Chitosan Nanoparticles ◽  
Plasma Viscosity ◽  
Water Soluble ◽  
Lipid Lowering ◽  
Sprague Dawley ◽  
High Fat ◽  
Sprague Dawley Rats ◽  
Mean Size ◽  
The Mean

Chitosan, a deacetylated product of chitin, has been demonstrated to lower cholesterol in humans and animals. However, chitosan is not fully soluble in water which would influence absorption in the human intestine. In addition, water-soluble chitosan (WSC) has higher reactivity compared to chitosan. The present study was designed to clarify the effects of WSC and water-soluble chitosan nanoparticles (WSC-NPs) on hypercholesterolemia induced by feeding a high-fat diet in male Sprague-Dawley rats. WSC-NPs were prepared by the ionic gelation method and the spray-drying technique. The nanoparticles were spherical in shape and had a smooth surface. The mean size of WSC-NPs was 650 nm variing from 500 to 800 nm. Results showed that WSC-NPs reduced the blood lipids and plasma viscosity significantly and increased the serum superoxide dismutase (SOD) activities significantly. This paper is the first report of the lipid-lowering effects of WSC-NPs suggesting that the WSC-NPs could be used for the treatment of hypercholesterolemia.

scholarly journals Fasting lipid profile in acute ischemic stroke patients who are already on lipid-lowering drugs: An observational study

2020 ◽  
Vol 19 (4) ◽  
pp. 286-291
Author(s):  
Muhammad Sohaib Asghar ◽  
◽  
Muhammad Nadeem Ahsan ◽  
Zara Saeed ◽  
Faran Khalid ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Observational Study ◽  
Acute Ischemic Stroke ◽  
Lipid Profile ◽  
Lipid Lowering ◽  
Stroke Patients ◽  
Lipid Lowering Drugs

scholarly journals Effect of Peanut (Arachis Hypogaea L.) on Dyslipidemia in Young Adult

2015 ◽  
Vol 10 (1) ◽  
pp. 11-16
Author(s):  
Hasina Akter ◽  
Nasim Jahan ◽  
Nayma Sultana
Keyword(s):  
Lipid Profile ◽  
Arachis Hypogaea ◽  
Modern Medicine ◽  
Lipid Lowering ◽  
Enzymatic Method ◽  
Active Components ◽  
Interventional Study ◽  
Medical College ◽  
Arachis Hypogaea L ◽  
The Mean

Background: Dyslipidemia is a major risk factor for cardiovascular disease. Lipid lowering drugs are available in modern medicine but prolong use of these drugs may produce some side effects. Peanut due to some of its active component can improve lipid profile.Objective: To observe the effects of peanut (Arachis hypogaea L.) on dyslipidemia in young adults.Methods: This prospective interventional study was carried out in the Department of Physiology, Sir Salimullah Medical College (SSMC), Dhaka between 1st July 2013 and 30th June 2014. For this purpose 30 dyslipidemic young adults of both sexes with aged 30 to 40 years were included in this study and they were selected from Out Patient Department of Medicine of Sir Salimullah Medical College and Mitford Hospital, Dhaka. They were studied three times i,e before supplementation with peanut (BSP), after 4 weeks supplementation with peanut (4 wks AP) and after 8 weeks supplementation with peanut (8 wks AP). For assessing lipid profile TAG, LDL-C, TC and HDL-C of all subjects were estimated by enzymatic method. The statistical analysis was done by using paired sample‘t’ test as applicable.Results: In this study, the mean serum TAG, LDL-C and TC levels were significantly decreased after 8 weeks supplementation with peanut in comparison to those of after 4 weeks and before supplementation with peanut. However, these levels were also decreased after 4 weeks supplementation than those of before supplementation but it was significant only for TC (p<0.05) and LDL-C (p<0.001). Whereas, the mean serum HDL-C level was significantly (p<0.001) increased after 8 weeks supplementation when compared to those of after 4 weeks and before supplementation of peanut.Conclusion: The present study revealed that, peanut (Arachis hypogaea L.) has effect on improvement of lipid profile by lowering serum TAG, LDL-C, TC levels and by increasing serum HDL-C level. This lipid lowering effects of peanut may be due to its high Mg+2 content and other active components of peanut.Bangladesh Soc Physiol. 2015, June; 10(1): 11-16

scholarly journals Criteria for Excision of Suspicious Calcifications Using the Breast Lesion Excision System (BLES)

2021 ◽  
pp. 100-108
Author(s):  
Alexandra Christou ◽  
Vassilis Koutoulidis ◽  
Dimitra Koulocheri ◽  
Afrodite Nonni ◽  
Constantinos George Zografos ◽  
...  
Keyword(s):  
Breast Lesion ◽  
Success Rates ◽  
Molecular Type ◽  
Mean Size ◽  
Size Grade ◽  
The Mean ◽  
Underestimation Rate ◽  
Disease Free ◽  
Stereotactic Biopsies ◽  
Cell Atypia

Background: The aim of the study was to retrospectively evaluate possible imaging and histopathology criteria that can be used in a clinical basis to assess the success of excision of suspicious calcifications using the breast lesion excision system (BLES).Methods: We investigated 400 BLES stereotactic biopsies of suspicious calcifications with the mean size of 15.38 mm (st. dev.= 13.579 mm, range 3-78 mm) using a 20 mm probe performed in our department between January 2014 and 2016. The mean age of our population was 58.5 years old (range 39-78 years). The pathology results of BLES specimens were compared with the final surgical results to assess excision success rates. Possible imaging and histopathology criteria for removal were statistically analyzed (mammographic size, disease free margins, grade, comedo phenotype, molecular type).Results: The results showed that 90/400 (22.5%) biopsies were cancers (80% DCIS) and 38/400 were lesions with cell atypia (9.5%) of which 29/38 had subsequent surgery and were included in the study. Excision was achieved in 31/90 cancers (34.4%) and in 23/29 lesions with cell atypia (76.3%). The imaging and histopathology criteria for BLES excision that could be potentially clinically assessed were the initial mammographic size (p<0.001), the distance of the lesion from the specimen margins (p<0.001), the presence of comedo necrosis (p=0.014) and the grade of the cancers (p=0.021). The underestimation rate was 15.5%. Conclusion: the mammographic size, grade, comedo presence and disease-free margins, were the main criteria for BLES success rate of excision of suspicious calcifications.

scholarly journals Altered Lipid Profile is a Risk Factor for the Progression Andrecurrenceof COVID-19: From Two Retrospective Cohorts

2020 ◽  
Author(s):  
Hui Jin ◽  
Junji He ◽  
Chuan Dong ◽  
Luhong Cao ◽  
Xing Qi ◽  
...  
Keyword(s):  
Risk Factor ◽  
Lipid Profile ◽  
Cox Regression ◽  
Lipid Lowering ◽  
Hospital Death ◽  
Lipid Lowering Therapy ◽  
Clinical Endpoints ◽  
Increased Risk ◽  
The Impact ◽  
The Relationship

Abstract Background The COVID-19 pandemic has spread worldwide. However, the impact of lipid profile and lipid-lowering treatment on clinical endpoints in COVID-19 have not previously been investigated. Methods In this retrospective, multicenter cohort study, we consecutively enrolled 430 adult COVID-19 patients from two Chinese hospitals (one each in Chengdu and Wuhan) admitted during February 2020 and followed-up until April 30. Demographic, metabolic profile, laboratory, treatment and clinical endpoint data including in-hospital death and recurrence of COVID-19, were collected. Results In Chengdu patients, univariable and multivariable Cox regression showed that the low-density lipoprotein cholesterol (LDL-C) dyslipidemia on admission was associated with the recurrence of COVID-19 during the follow-up period. In Wuhan cohort, the patients with triglycerides hyperlipemia had an increased risk of in-hospital death. However, in both cohorts, statin therapy during COVID-19 course did not affect these clinical endpoints. Compared to the Chengdu cohort, the Wuhan patients tended to have more severe COVID-19 but, unexpectedly, had lower levels of serum lipid. It is of interesting to notice that the relationship between the observed biomarkers of inflammation and lipid do not match the relationship between the organ function measures and this lipid. Conclusions The baseline dyslipidemia should be considered as a risk factor for poor prognosis and recurrence of COVID-19. The lipid level may be altered during COVID-19 course, since lipidology may be distinctly affected by both inflammation and organic damage for SARS-CoV-2. Further investigation is needed on the role of use of lipid-lowering therapy among patients with COVID-19 infections.

scholarly journals The −256T>C Polymorphism in the Apolipoprotein A-II Gene Promoter Is Associated with Body Mass Index and Food Intake in the Genetics of Lipid Lowering Drugs and Diet Network Study

2007 ◽  
Vol 53 (6) ◽  
pp. 1144-1152 ◽  
Author(s):  
Dolores Corella ◽  
Donna K Arnett ◽  
Michael Y Tsai ◽  
Edmond K Kabagambe ◽  
James M Peacock ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Food Intake ◽  
Dietary Intake ◽  
Body Mass ◽  
Proton Nuclear Magnetic Resonance ◽  
Lipid Lowering ◽  
Resonance Spectroscopy ◽  
Lipid Lowering Drugs ◽  
Apolipoprotein A ◽  
Validated Questionnaire

Abstract Background: Apolipoprotein A-II (APOA2) plays an ambiguous role in lipid metabolism, obesity, and atherosclerosis. Methods: We studied the association between a functional APOA2 promoter polymorphism (−265T&gt;C) and plasma lipids (fasting and postprandial), anthropometric variables, and food intake in 514 men and 564 women who participated in the Genetics of Lipid Lowering Drugs and Diet Network (GOLDN) study. We obtained fasting and postprandial (after consuming a high-fat meal) measures. We measured lipoprotein particle concentrations by proton nuclear magnetic resonance spectroscopy and estimated dietary intake by use of a validated questionnaire. Results: We observed recessive effects for this polymorphism that were homogeneous by sex. Individuals homozygous for the −265C allele had statistically higher body mass index (BMI) than did carriers of the T allele. Consistently, after multivariate adjustment, the odds ratio for obesity in CC individuals compared with T allele carriers was 1.70 (95% CI 1.02–2.80, P = 0.039). Interestingly, total energy intake in CC individuals was statistically higher [mean (SE) 9371 (497) vs 8456 (413) kJ/d, P = 0.005] than in T allele carriers. Likewise, total fat and protein intakes (expressed in grams per day) were statistically higher in CC individuals (P = 0.002 and P = 0.005, respectively). After adjustment for energy, percentage of carbohydrate intake was statistically lower in CC individuals. These associations remained statistically significant even after adjustment for BMI. We found no associations with fasting lipids and only some associations with HDL subfraction distribution in the postprandial state. Conclusions: The −265T&gt;C polymorphism is consistently associated with food consumption and obesity, suggesting a new role for APOA2 in regulating dietary intake.

scholarly journals Study of Lipid Profile in Newly Diagnosed Hypertensive Patients

2014 ◽  
Vol 6 (2) ◽  
pp. 112-115
Author(s):  
MAK Akanda ◽  
KN Choudhury ◽  
MZ Ali ◽  
LA Sayami ◽  
RM Huda
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Waist Circumference ◽  
Lipid Profile ◽  
Density Lipoprotein ◽  
Newly Diagnosed ◽  
Hypertensive Patients ◽  
Significant Difference ◽  
The Mean ◽  
Lipid Parameters

Back ground: Hypertension is one of the most important modifiable risk factors for cardiovascular disease (CVD) and stroke. Dyslipidemia is closely associated with hypertension. Dyslipidemia and hypertension are the commonest risk factors for CVD. The aim of the present study was to compare different lipid parameters among newly diagnosed hypertensive patients with normotensive subjects in Bangladesh and find out the relationship. Methods: This study was a cross sectional study in which 42 newly diagnosed hypertensive patients who were on no antihypertensive medication and 42 subjects with normal blood pressure (normotensive) were enrolled for compare. Lipid parameters total cholesterol (TC), triglyceride (TG), low density lipoprotein ( LDLc) and high density lipoprotein (HDLc) were estimated by Enzymatic colorimetric test. Results: The mean systolic blood pressure of hypertensive and normotensive were 154.6±22.5 vs111.50±3.42 mmof.Hg and mean diastolic blood pressure were 93.2±5.20 vs 71.44± 3.21mm of Hg. The mean of SBP and DBP of hypertensive patients was found to be higher than normotensive (p< 0.05). There was significant increase in different lipid levels namely TC 199.4±44.5 vs188.7±37.9 mg/dl, TG155.9±88.8 vs 121.9±73.2 mg/dl and LDLc 119.8±35.6 vs112.7±28.6 mg/dl in hypertensive patients as compared to normotensive (p<0.05). However there was no significant difference in HDLc level. BMI and waist circumference showed significant association in hypertensive patients (p<0.001). Conclusion: Analytical results of the study revealed that hypertensive patients have been found to have close association with dyslipidemia, BMI and waist circumference. Hypertension and dyslipidemia can be modified either by proper life style changes or medical management or by the combination of the both. This study suggests that hypertensive patients need measurement of blood pressure and lipid profile at regular interval to prevent heart diseases and stroke. DOI: http://dx.doi.org/10.3329/cardio.v6i2.18350 Cardiovasc. j. 2014; 6(2): 112-115

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