Abstract P161: Blood Pressure And Vascular Stiffness With Increased Body Weight In Young People In The Aspect Of The Obesity Paradox

Background: The relationship of arterial stiffness, which is marker of vascular age, with the main risk factors (RF) was studied mainly in adults and elderly. Purpose - to evaluate associations of various body mass (BM) with vascular stiffness, blood pressure (BP) and some other RF in young people. Material and Methods: Within the framework of the National Preventive Project "University Territory of Health", 264 students (93 boys and 171 girls) aged 18-25 years were evaluated for BP and profile of metabolic RF - total cholesterol (TC), low-density lipoproteins (LDL), triglycerides (TG), high-density lipoproteins (HDL) and glucose. Vascular stiffness was determined using cardio-ankle vascular index (CAVI), which was measured using diagnostic complex VaSera-1500 (Fucuda Denshi, Japan). Students were divided into groups according to BM-index: 1group - insufficient BM; 2 group - normal BM and 3 group - overweight. Data processing was performed using software package "Statistica 10.0" (StatSoft Inc, USA). Results: It turned out CAVI values in three observation groups, formed by BM indicator, in boys averaged 6.8 ±0.2, 5.9 ± 0.1 and 5.4 ± 0.1, and in girls - 6,1 ± 0,11, 5,9 ± 0,05 and 5,7 ±0,13. In boys, differences between groups on this indicator reached significant level (p = 0,032). At same time, systolic and diastolic BP from first to third group rose in boys by 9 and 2, and in girls - by 11 and 4 mm Hg. TC, LDL and TG also increased from first to third group in boys by 0.5, 0.4 and 0.5, and in girls - by 0.6, 0.7 and 0.65 mmol/l. HDL decreased in these groups in boys by 0.07, and in girls - by 0.37 mmol/l. The glucose level from first to third group increased by 0.12 in boys and 0.14 mmol/l in girls. Conclusion: A decrease in the vascular stiffness index CAVI was found among young people as their BM increased. It is noteworthy that in young people with an increased BM, positive changes in vascular rigidity occur in the presence of negative changes in hemodynamic and metabolic parameters, which are more significantly represented among girls. Further in-depth research is needed to clarify the mechanisms that regulate the relationship between metabolic status of young people and peculiarities of their vascular remodeling.