scholarly journals Using Tertiary Sulci to Map the “Cognitive Globe” of Prefrontal Cortex

2021 ◽  
pp. 1-18
Author(s):  
Jacob A. Miller ◽  
Mark D'Esposito ◽  
Kevin S. Weiner
Keyword(s):  
Prefrontal Cortex ◽  
Frontal Lobe ◽  
Spatial Scales ◽  
Structure And Function ◽  
Future Research ◽  
Functional Relationships ◽  
Theoretical Perspectives ◽  
Individual Participant ◽  
And Function

Stuss considered the human prefrontal cortex (pFC) as a “cognitive globe” [Stuss, D. T., & Benson, D. F. Neuropsychological studies of the frontal lobes. Psychological Bulletin, 95, 3–28, 1984] on which functions of the frontal lobe could be mapped. Here, we discuss classic and recent findings regarding the evolution, development, function, and cognitive role of shallow indentations or tertiary sulci in pFC, with the goal of using tertiary sulci to map the “cognitive globe” of pFC. First, we discuss lateral pFC (LPFC) tertiary sulci in classical anatomy and modern neuroimaging, as well as their development, with a focus on those within the middle frontal gyrus. Second, we discuss tertiary sulci in comparative neuroanatomy, focusing on primates. Third, we summarize recent findings showing the utility of tertiary sulci for understanding structural–functional relationships with functional network insights in ventromedial pFC and LPFC. Fourth, we revisit and update unresolved theoretical perspectives considered by C. Vogt and O. Vogt (Allgemeinere ergebnisse unserer hirnforschung. Journal für Psychologie und Neurologie, 25, 279–462, 1919) and F. Sanides (Structure and function of the human frontal lobe. Neuropsychologia, 2, 209–219, 1964) that tertiary sulci serve as landmarks for cortical gradients. Together, the consideration of these classic and recent findings indicate that tertiary sulci are situated in a unique position within the complexity of the “cognitive globe” of pFC: They are the smallest and shallowest of sulci in pFC, yet can offer insights that bridge spatial scales (microns to networks), modalities (functional connectivity to behavior), and species. As such, the map of tertiary sulci within each individual participant serves as a coordinate system specific to that individual on which functions may be further mapped. We conclude with new theoretical and methodological questions that, if answered in future research, will likely lead to mechanistic insight regarding the structure and function of human LPFC.

scholarly journals Using tertiary sulci to map the “cognitive globe” of prefrontal cortex

2020 ◽  
Author(s):  
Jacob Miller ◽  
Mark D'Esposito ◽  
kevin weiner
Keyword(s):  
Prefrontal Cortex ◽  
Spatial Scales ◽  
Future Research ◽  
Comparative Neuroanatomy ◽  
Functional Relationships ◽  
Mechanistic Insight ◽  
Theoretical Perspectives ◽  
Individual Participant ◽  
And Function

Stuss (1984) considered the human prefrontal cortex (PFC) as a “cognitive globe” on which functions of the frontal lobe could be mapped. Here, we discuss classic and recent findings regarding the evolution, development, function, and cognitive role of shallow indentations, or tertiary sulci, in PFC with the goal of using tertiary sulci to map the “cognitive globe” of PFC. First, we discuss lateral PFC (LPFC) tertiary sulci in classical anatomy and modern neuroimaging, as well as their development, with a focus on those within the middle frontal gyrus (MFG). Second, we discuss tertiary sulci in comparative neuroanatomy, focusing on primates. Third, we summarize recent findings showing the utility of tertiary sulci for understanding structural-functional relationships with functional network insights in ventromedial and LPFC. Fourth, we revisit and update unresolved theoretical perspectives considered by Vogt and Vogt (1919) and Sanides (1964) that tertiary sulci serve as landmarks for cortical gradients. Together, the consideration of these classic and recent findings indicate that tertiary sulci are situated in a unique position within the complexity of the “cognitive globe” of PFC: they are the smallest and shallowest of sulci in PFC, yet can offer insights that bridge spatial scales (microns to networks), modalities (functional connectivity to behavior), and species. As such, the map of tertiary sulci within each individual participant serves as a coordinate system specific to that individual on which functions may be further mapped. We conclude with new theoretical and methodological questions that if answered in future research, will likely lead to mechanistic insight regarding the structure and function of human LPFC.

scholarly journals The key role of prefrontal cortex structure and function

2006 ◽  
Vol 29 (1) ◽  
pp. 22-22
Author(s):  
Antonino Raffone ◽  
Gary L. Brase
Keyword(s):  
Prefrontal Cortex ◽  
Species Differences ◽  
Structure And Function ◽  
Primary Role ◽  
Neural Connectivity ◽  
Neuronal Connectivity ◽  
Connectivity Patterns ◽  
Brain Expansion ◽  
And Function

The tension between focusing on species similarities versus species differences (phylogenetic versus adaptationist approaches) recurs in discussions about the nature of neural connectivity and organization following brain expansion. Whereas Striedter suggests a primary role for response inhibition, other possibilities include dense recurrent connectivity loops. Computer simulations and brain imaging technologies are crucial in better understanding actual neuronal connectivity patterns.

scholarly journals New methods of spatial analysis in urban gardens inform future vegetation surveying

2020 ◽  
Vol 35 (3) ◽  
pp. 761-778
Author(s):  
Monika H. Egerer ◽  
Benjamin Wagner ◽  
Brenda B. Lin ◽  
Dave Kendal ◽  
Kai Zhu
Keyword(s):  
Spatial Scale ◽  
Vegetation Structure ◽  
New Technologies ◽  
Spatial Scales ◽  
Community Gardens ◽  
Structure And Function ◽  
Future Application ◽  
Future Research ◽  
Traditional Methods ◽  
And Function

Abstract Context Land use change requires measuring shifting patterns in biodiversity at various spatial scales to inform landscape management. Assessing vegetation change at different scales is challenging in urban ecosystems managed by many individuals. Thus, we do not know much about the structure and function of green spaces that support biodiversity. Objective We aim to understand how vegetation structure and function indicators in urban community gardens vary with spatial scale, applying new and traditional methods in landscape ecology to inform future research and application. Methods We performed two methods to assess garden vegetation structure (height) and function (species diversity, cover) at the garden- and garden plot scale. First, we used traditional field sampling to estimate garden vegetation at the garden scale (1 m2 quadrats along transects) and at the plot scale (estimated within entire plot) to measure height, diversity and cover. Second, we used UAV aerial imagery to derive measures of garden and plot vegetation using canopy height models (CHMs). We evaluated differences in CHMs at each scale across the gardens, and compared field and UAV-derived measures. Results Garden vegetation characteristics vary with spatial scale. Plant species richness and vegetation cover, but not height, related to UAV-derived imagery. Conclusions New technologies paired with traditional field methods can together inform how vegetation structure and function vary with spatial scale in urban landscapes. Spatial scale is key to accurate and meaningful urban vegetation analyses. New and traditional methods in urban ecology research should develop together to improve and streamline their future application.

Physiology of Nucleoside Transporters: Back to the Future. . . .

Physiology ◽  
2008 ◽  
Vol 23 (1) ◽  
pp. 41-48 ◽  
Author(s):  
Jennifer B. Rose ◽  
Imogen R. Coe
Keyword(s):  
Viral Infections ◽  
Drug Efficacy ◽  
Structure And Function ◽  
Nucleoside Transporters ◽  
Integral Membrane Proteins ◽  
Future Research ◽  
The Everyday ◽  
And Function ◽  
The Relationship

Nucleoside transporters (NTs) are integral membrane proteins responsible for mediating and facilitating the flux of nucleosides and nucleobases across cellular membranes. NTs are also responsible for the uptake of nucleoside analog drugs used in the treatment of cancer and viral infections, and they are the target of certain compounds used in the treatment of some types of cardiovascular disease. The important role of NTs as drug transporters and therapeutic targets has necessarily led to intense interest into their structure and function and the relationship between these proteins and drug efficacy. In contrast, we still know relatively little about the fundamental physiology of NTs. In this review, we discuss various aspects of the physiology of NTs in mammalian systems, particularly noting tissues and cells where there has been little recent research. Our central thesis is reference back to some of the older literature, combined with current findings, will provide direction for future research into NT physiology that will lead to a fuller understanding of the role of these intriguing proteins in the everyday lives of cells, tissues, organs, and whole animals.

scholarly journals Microglia: sculptors of neuropathic pain?

2020 ◽  
Vol 7 (6) ◽  
pp. 200260 ◽  
Author(s):  
Harry Ward ◽  
Steven J. West
Keyword(s):  
Nervous System ◽  
Neuropathic Pain ◽  
Structure And Function ◽  
System Structure ◽  
Future Research ◽  
Important Target ◽  
Underlying Mechanisms ◽  
And Function ◽  
Future Therapy

Neuropathic pain presents a huge societal and individual burden. The limited efficacy of current analgesics, diagnostic markers and clinical trial outcome measures arises from an incomplete understanding of the underlying mechanisms. A large and growing body of evidence has established the important role of microglia in the onset and possible maintenance of neuropathic pain, and these cells may represent an important target for future therapy. Microglial research has further revealed their important role in structural remodelling of the nervous system. In this review, we aim to explore the evidence for microglia in sculpting nervous system structure and function, as well as their important role in neuropathic pain, and finally integrate these studies to synthesize a new model for microglia in somatosensory circuit remodelling, composed of six key and inter-related mechanisms. Summarizing the mechanisms through which microglia modulate nervous system structure and function helps to frame a better understanding of neuropathic pain, and provide a clear roadmap for future research.

scholarly journals Essential Role of Septin 7 in Skeletal Muscle Structure and Function

2020 ◽  
Vol 118 (3) ◽  
pp. 258a
Author(s):  
Laszlo Csernoch ◽  
Mónika Gönczi ◽  
Zsolt Ráduly ◽  
László Szabó ◽  
Nóra Dobrosi ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Essential Role ◽  
Structure And Function ◽  
Muscle Structure ◽  
And Function

scholarly journals Effects of Dysbiosis and Dietary Manipulation on the Digestive Microbiota of a Detritivorous Arthropod

2021 ◽  
Vol 9 (1) ◽  
pp. 148
Author(s):  
Marius Bredon ◽  
Elisabeth Depuydt ◽  
Lucas Brisson ◽  
Laurent Moulin ◽  
Ciriac Charles ◽  
...  
Keyword(s):  
Crucial Role ◽  
Structure And Function ◽  
Ecological Interactions ◽  
Dietary Manipulation ◽  
Biotic Factors ◽  
Abiotic And Biotic Factors ◽  
And Function ◽  
Multicellular Organisms ◽  
Over Time

The crucial role of microbes in the evolution, development, health, and ecological interactions of multicellular organisms is now widely recognized in the holobiont concept. However, the structure and stability of microbiota are highly dependent on abiotic and biotic factors, especially in the gut, which can be colonized by transient bacteria depending on the host’s diet. We studied these impacts by manipulating the digestive microbiota of the detritivore Armadillidium vulgare and analyzing the consequences on its structure and function. Hosts were exposed to initial starvation and then were fed diets that varied the different components of lignocellulose. A total of 72 digestive microbiota were analyzed according to the type of the diet (standard or enriched in cellulose, lignin, or hemicellulose) and the period following dysbiosis. The results showed that microbiota from the hepatopancreas were very stable and resilient, while the most diverse and labile over time were found in the hindgut. Dysbiosis and selective diets may have affected the host fitness by altering the structure of the microbiota and its predicted functions. Overall, these modifications can therefore have effects not only on the holobiont, but also on the “eco-holobiont” conceptualization of macroorganisms.

scholarly journals Neuroplacentology in congenital heart disease: placental connections to neurodevelopmental outcomes

2021 ◽  
Author(s):  
Rachel L. Leon ◽  
Imran N. Mir ◽  
Christina L. Herrera ◽  
Kavita Sharma ◽  
Catherine Y. Spong ◽  
...  
Keyword(s):  
Brain Development ◽  
Congenital Heart ◽  
Fetal Brain ◽  
In Utero ◽  
Structure And Function ◽  
Brain Growth ◽  
Neurodevelopmental Outcomes ◽  
Fetal Brain Development ◽  
And Function

Abstract Children with congenital heart disease (CHD) are living longer due to effective medical and surgical management. However, the majority have neurodevelopmental delays or disorders. The role of the placenta in fetal brain development is unclear and is the focus of an emerging field known as neuroplacentology. In this review, we summarize neurodevelopmental outcomes in CHD and their brain imaging correlates both in utero and postnatally. We review differences in the structure and function of the placenta in pregnancies complicated by fetal CHD and introduce the concept of a placental inefficiency phenotype that occurs in severe forms of fetal CHD, characterized by a myriad of pathologies. We propose that in CHD placental dysfunction contributes to decreased fetal cerebral oxygen delivery resulting in poor brain growth, brain abnormalities, and impaired neurodevelopment. We conclude the review with key areas for future research in neuroplacentology in the fetal CHD population, including (1) differences in structure and function of the CHD placenta, (2) modifiable and nonmodifiable factors that impact the hemodynamic balance between placental and cerebral circulations, (3) interventions to improve placental function and protect brain development in utero, and (4) the role of genetic and epigenetic influences on the placenta–heart–brain connection. Impact Neuroplacentology seeks to understand placental connections to fetal brain development. In fetuses with CHD, brain growth abnormalities begin in utero. Placental microstructure as well as perfusion and function are abnormal in fetal CHD.

scholarly journals Endogenous Mammalian Cardiotonic Steroids—A New Cardiovascular Risk Factor?—A Mini-Review

Life ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 727
Author(s):  
Natalia Słabiak-Błaż ◽  
Grzegorz Piecha
Keyword(s):  
Adenosine Triphosphatase ◽  
Therapeutic Strategies ◽  
Structure And Function ◽  
Sodium Potassium ◽  
Sodium Homeostasis ◽  
Cardiovascular Tissue ◽  
Ancient Times ◽  
And Function ◽  
Regulation Of Blood Pressure

The role of endogenous mammalian cardiotonic steroids (CTS) in the physiology and pathophysiology of the cardiovascular system and the kidneys has interested researchers for more than 20 years. Cardiotonic steroids extracted from toads or plants, such as digitalis, have been used to treat heart disease since ancient times. CTS, also called endogenous digitalis-like factors, take part in the regulation of blood pressure and sodium homeostasis through their effects on the transport enzyme called sodium–potassium adenosine triphosphatase (Na/K-ATPase) in renal and cardiovascular tissue. In recent years, there has been increasing evidence showing deleterious effects of CTS on the structure and function of the heart, vasculature and kidneys. Understanding the role of CTS may be useful in the development of potential new therapeutic strategies.

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