The Anti-Malarial Action of Changshan (Febrifugine): A Review

2005 ◽  
Vol 1 (2) ◽  
pp. 421-431 ◽  
Author(s):  
Anthony Butler ◽  
John Moffett
Keyword(s):  
Side Effects ◽  
Chemical Structure ◽  
Malarial Parasite ◽  
Synthetic Material ◽  
Pharmaceutical Factory ◽  
Adverse Side Effects ◽  
Chinese Origin ◽  
The World ◽  
The One

The plant qinghao 青蒿 (Artemesia annua) has provided the world with a valuable anti-malarial drug (qinghaosu 青蒿素). Another useful anti-malarial drug (febrifugine) of Chinese origin can be extracted from the shrub Dichroa febrifuga (changshan) but, unlike qinghaosu, its chemical structure is relatively simple and it could be easily synthesised in a pharmaceutical factory. However, the presence of two chiral centres in the molecule makes this unsuitable for pharmacological use as only one of the four isomers (the one found naturally) kills the malarial parasite, but all four isomers (as in the synthetic material) have serious adverse side effects. Encouraging African governments to consider growing Dichroa febrifuga as an alternative to the expensive and scarce qinghaosu should be considered.

The Significance of Dopamine for the Mode of Action of Neuroleptics and the Pathogenesis of Schizophrenia

1977 ◽  
Vol 130 (5) ◽  
pp. 463-474 ◽  
Author(s):  
H. M. van Praag
Keyword(s):  
Side Effects ◽  
Clinical Research ◽  
Mode Of Action ◽  
Chemical Structure ◽  
Animal Experiments ◽  
The Other ◽  
Therapeutic Effects ◽  
Supporting Evidence ◽  
Pathogenetic Mechanism ◽  
The One

SummaryAnimal experiments have demonstrated the likelihood that all known neuroleptics inhibit transmission in central CA-ergic systems, regardless of their chemical structure and via different mechanisms. For clinical psychiatry this fact prompts a number of questions: (1) is this phenomenon also to be found in human individuals; (2) if so, is it of importance for the clinical (side) effects of neuroleptics; (3) do patients with (schizophrenic) psychoses show signs of central CA-ergic hyperactivity ? This article presents a survey of clinical research focused on these questions which, for the sake of brevity, is confined to DA metabolism. The available data indicate the plausibility of a correlation between inhibition of DA-ergic transmission on the one hand, and on the other hand the therapeutic effects of neuroleptics and the occurrence of hypokinetic-rigid symptoms. The hypothesis that DA-ergic hyperactivity is an important pathogenetic mechanism in schizophrenic psychoses can be based only on indirect arguments; direct studies of the DA metabolism have so far failed to reveal supporting evidence. The possible causes of this failure are discussed.

scholarly journals An Overview of Vaccines against SARS-CoV-2 in the COVID-19 Pandemic Era

Pathogens ◽  
2021 ◽  
Vol 10 (8) ◽  
pp. 1030
Author(s):  
Alejandro Pascual-Iglesias ◽  
Javier Canton ◽  
Ana Maria Ortega-Prieto ◽  
Jose M. Jimenez-Guardeño ◽  
Jose Angel Regla-Nava
Keyword(s):  
Side Effects ◽  
Vaccine Development ◽  
Current Knowledge ◽  
Severe Disease ◽  
S Protein ◽  
Adverse Side Effects ◽  
The World ◽  
Main Target

The emergence of SARS-CoV-2 in late 2019 led to the COVID-19 pandemic all over the world. When the virus was first isolated and its genome was sequenced in the early months of 2020, the efforts to develop a vaccine began. Based on prior well-known knowledge about coronavirus, the SARS-CoV-2 spike (S) protein was selected as the main target. Currently, more than one hundred vaccines are being investigated and several of them are already authorized by medical agencies. This review summarizes and compares the current knowledge about main approaches for vaccine development, focusing on those authorized and specifically their immunogenicity, efficacy preventing severe disease, adverse side effects, protection, and ability to cope with emergent SARS-CoV-2 variants.

Psychology from Egyptian, Arab, and Islamic Perspectives

1997 ◽  
Vol 2 (4) ◽  
pp. 356-365 ◽  
Author(s):  
Fouad A-L.H. Abou-Hatab
Keyword(s):  
Professional Identity ◽  
21St Century ◽  
The West ◽  
Islamic Perspective ◽  
National Heritage ◽  
Western Psychology ◽  
The World ◽  
The One

This paper presents the case of psychology from a perspective not widely recognized by the West, namely, the Egyptian, Arab, and Islamic perspective. It discusses the introduction and development of psychology in this part of the world. Whenever such efforts are evaluated, six problems become apparent: (1) the one-way interaction with Western psychology; (2) the intellectual dependency; (3) the remote relationship with national heritage; (4) its irrelevance to cultural and social realities; (5) the inhibition of creativity; and (6) the loss of professional identity. Nevertheless, some major achievements are emphasized, and a four-facet look into the 21st century is proposed.

Indonesian Literature’s Position in World Literature

TEKNOSASTIK ◽  
2018 ◽  
Vol 14 (2) ◽  
pp. 1
Author(s):  
Dina Amelia
Keyword(s):  
World Literature ◽  
The Other ◽  
National Literature ◽  
Western World ◽  
The World ◽  
The One ◽  
The Voice

There are two most inevitable issues on national literature, in this case Indonesian literature. First is the translation and the second is the standard of world literature. Can one speak for the other as a representative? Why is this representation matter? Does translation embody the voice of the represented? Without translation Indonesian literature cannot gain its recognition in world literature, yet, translation conveys the voice of other. In the case of production, publication, or distribution of Indonesian Literature to the world, translation works can be very beneficial. The position of Indonesian literature is as a part of world literature. The concept that the Western world should be the one who represent the subaltern can be overcome as long as the subaltern performs as the active speaker. If the subaltern remains silent then it means it allows the “representation” by the Western.

CRYPTOCURRENCY PHENOMENON IN THE INTERNATIONAL MONETARY SYSTEM

2017 ◽  
pp. 95-100
Author(s):  
Артур Анатолійович Василенко
Keyword(s):  
World Economy ◽  
International Monetary System ◽  
State University ◽  
Electronic Money ◽  
Monetary System ◽  
Current Trends ◽  
The World ◽  
Post Graduate Student ◽  
The One ◽  
Xix Century

UDC 336.74   Vasylenko Artur, post-graduate student. Mariupol State University. Cryptocurrency Phenomenon in the International Monetary System. The main prerequisites of cryptocurrency emergence in the international monetary system in terms of regionalization of the world economy are defined in the article. Determination of «cryptocurrency» category was analysed from the point of two main approaches to its treatment: on the one hand cryptocurrency is admitted to be the currency equally to the sovereign currency, and on the other hand it is considered as an unrecognized virtual asset. The main consequences which arise in case of widespread use of crypto currency for the country and for the parties that agreed to use cryptocurrency were analysed and systematized. On the basis of the research, given the current trends in the world economy, the author put forward and substantiated the hypothesis to classify the phenomenon of cryptocurrency as the effects of a famous philosophical «Negation of negation law» formulated by G. Hegel at the beginning of the XIX century.   Keywords: cryptocurrency, material money, electronic money, digital currency, regional currency integration, blockchain, mining, capitalization, «Negation of negation law».

Embracing multiculturalism of Canada: the roots & the present-day realities

2017 ◽  
pp. 32-41
Author(s):  
Valentyna Bohatyrets
Keyword(s):  
National Identity ◽  
Human Dignity ◽  
Public Support ◽  
Immigrant Integration ◽  
Mutual Understanding ◽  
Positive Outcomes ◽  
The World ◽  
The One ◽  
Digital Diplomacy ◽  
Equality And Diversity

The paper provides the framework for embracing multiculturalism as a source of national identity, a political ‘profession de foi’, and an engine for a government to gain positive outcomes, leading to better immigrant integration and economic advantages for any country in the world. Noteworthy, Canadian federal policy of multiculturalism, since its official adoption in 1971, is witnessed to work stunningly and in contrast to developments elsewhere – in Canada, public support for multiculturalism is seeing unprecedented growth. Currently, the diversity of the Canadian populace is increasing faster than at any time in its history; Canada’s ethnic makeup has notably altered over the time due to changing immigration patterns. According to the latest poll findings, 84% of Canadians agree with the statement that ‘Canada’s multicultural makeup is one of the best things about this country’; 61% of Canadians believe multiculturalism ‘strengthens national identity’. Moreover, released data from Environics reveals that 27% of Canadians believe ‘multiculturalism is the one characteristic about Canada that most deserves to be celebrated on its upcoming 150thanniversary. Undeniably, people around the world tend to view Canada as “good”. Importantly, the election of Justin Trudeau is viewed as an excellent opportunity to invigorate brand Canada. Noteworthy, brand Justin Trudeau is currently composed of his belief in and promotion of the values of tolerance, equality and diversity. While recognizing the value for society of the human dignity inherent in each individual, Trudeau’s government aims to push beyond mere tolerance to mutual understanding and respect. Keywords: Multiculturalism of Canada, immigration, digital diplomacy, brand, national identity, poll, ethnic groups

PERSUASIVE STRATEGIES USED IN BURGER KING’S INSTAGRAM POSTS CAPTION

2020 ◽  
Vol 8 (1) ◽  
pp. 96-104
Author(s):  
Yeremia Yori Rudito ◽  
Anita
Keyword(s):  
Fast Food ◽  
Research Method ◽  
Qualitative Method ◽  
Fast Food Restaurant ◽  
Rhetorical Question ◽  
Persuasive Strategies ◽  
Inclusive Language ◽  
Colloquial Language ◽  
The World ◽  
The One

Burger King is the one of the most successful fast food restaurant in the world. According to Wikipedia, there are 17,796 locations of Burger King all over the world in 2018. Burger King also has its Instagram account. Now this account has been followed by 1,6 million people and has posted 938 posts. That statistic shows that Burger King is active in social media especially in Instagram platform. The writer see the indication of the using of Persuasive Strategies because in promoting their product. In this research the writer wants to know the persuasive strategies that applied in Burger King’s Instagram post caption and the most used strategy. This research applied Qualitative Method as research method. This research has two findings, first, there are 13 strategies that appear in Burger King’s Instagram post caption they are, Anecdote, Assonance, Cliché, Connotation, Evidence, Everyday/Colloquial Language, Hyperbole, Imagery, Inclusive Language, Pun, Repetition, Rhetorical Question, and Simile. Second, the most used strategy is Everyday/Colloquial Language.

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