scholarly journals Phytochemical Constituents, Biological Activities, Therapeutic Potentials and Nutritional Values of <i>Moringa oleifera</i> (Zogale): A Review

2017 ◽  
Vol 3 (4) ◽  
pp. 60 ◽  
Author(s):  
Adamu Idris Maizuwo
Keyword(s):  
Moringa Oleifera ◽  
Biological Activities ◽  
Nutritional Values ◽  
Phytochemical Constituents

A Gift of Good Health from Mother Nature: Presenting Moringa oleifera, a Plant with Multiple Anticancer Activities

2021 ◽  
Vol 6 (4) ◽  
pp. 284-291
Author(s):  
Madhushree Das Sarma
Keyword(s):  
Moringa Oleifera ◽  
Biological Activities ◽  
Good Health ◽  
Anticancer Activities ◽  
Nutritional Values ◽  
Low Concentrations ◽  
The World ◽  
Low Toxicity ◽  
Different Parts ◽  
Moringa Oleifera Lam

Moringa oleifera Lam. (Moringaceae) is a multifarious beneficial tree and widely cultivated in the tropical and subtropical regions all over the world. All parts of this plants are edible and used as a plentiful source of phytochemicals with high nutritional values. Since antiquity, this plant was recognized as a panacea for the treatment of several ailments in ethnomedicinal system. In last few decades, this fact is further reconfirmed by various scientific research works in which the plant was found to show broad spectrum of biological activities including antioxidant, anti-inammatory, antiurolithic, antimicrobial, anangesic, antidiabetic, antihypertensive, antiproliferative, hepatoprotective, cardioprotective, etc. Different parts of this plant exhibited significant inhibitory activity against a variety of cancer cells at moderate to low concentrations and also possess low toxicity in normal cells. This review mainly focuses a brief overview on the anticancer profile of this wonderful tree.

Evaluation of the In Vivo Acute Toxicity and In Vitro Hemolytic and Immunomodulatory Activities of the Moringa oleifera Flower Trypsin Inhibitor (MoFTI)

2020 ◽  
Vol 27 ◽  
Author(s):  
Leydianne Leite de Siqueira Patriota ◽  
Dayane Kelly Dias do Nascimento Santos ◽  
Bárbara Rafaela da Silva Barros ◽  
Lethícia Maria de Souza Aguiar ◽  
Yasmym Araújo Silva ◽  
...  
Keyword(s):  
Acute Toxicity ◽  
Trypsin Inhibitor ◽  
Hemolytic Activity ◽  
Moringa Oleifera ◽  
Biological Activities ◽  
Hematological Parameters ◽  
Behavioral Alterations ◽  
Female Mice

Background: Protease inhibitors have been isolated from plants and present several biological activities, including immunomod-ulatory action. Objective: This work aimed to evaluate a Moringa oleifera flower trypsin inhibitor (MoFTI) for acute toxicity in mice, hemolytic activity on mice erythrocytes and immunomodulatory effects on mice splenocytes. Methods: The acute toxicity was evaluated using Swiss female mice that received a single dose of the vehicle control or MoFTI (300 mg/kg, i.p.). Behavioral alterations were observed 15–240 min after administration, and survival, weight gain, and water and food consumption were analyzed daily. Organ weights and hematological parameters were analyzed after 14 days. Hemolytic activity of MoFTI was tested using Swiss female mice erythrocytes. Splenocytes obtained from BALB/c mice were cultured in the absence or presence of MoFTI for the evaluation of cell viability and proliferation. Mitochondrial membrane potential (ΔΨm) and reactive oxygen species (ROS) levels were also determined. Furthermore, the culture supernatants were analyzed for the presence of cytokines and nitric oxide (NO). Results: MoFTI did not cause death or any adverse effects on the mice except for abdominal contortions at 15–30 min after administration. MoFTI did not exhibit a significant hemolytic effect. In addition, MoFTI did not induce apoptosis or necrosis in splenocytes and had no effect on cell proliferation. Increases in cytosolic and mitochondrial ROS release, as well as ΔΨm reduction, were observed in MoFTI-treated cells. MoFTI was observed to induce TNF-α, IFN-γ, IL-6, IL-10, and NO release. Conclusion: These results contribute to the ongoing evaluation of the antitumor potential of MoFTI and its effects on other immunological targets.

Update on Phytochemical and Biological Studies on Rocaglate Derivatives from Aglaia Species

Planta Medica ◽  
2021 ◽  
Author(s):  
Garima Agarwal ◽  
Long-Sheng Chang ◽  
Djaja Doel Soejarto ◽  
A. Douglas Kinghorn
Keyword(s):  
Biological Activities ◽  
Chemical Constituents ◽  
Protein Translation ◽  
Biological Properties ◽  
Translation Initiation Factor ◽  
Initiation Factor ◽  
Eukaryotic Translation ◽  
Ability To Act ◽  
Biological Studies ◽  
Phytochemical Constituents

AbstractWith about 120 species, Aglaia is one of the largest genera of the plant family Meliaceae (the mahogany plants). It is native to the tropical rainforests of the Indo-Australian region, ranging from India and Sri Lanka eastward to Polynesia and Micronesia. Various Aglaia species have been investigated since the 1960s for their phytochemical constituents and biological properties, with the cyclopenta[b]benzofurans (rocaglates or flavaglines) being of particular interest. Phytochemists, medicinal chemists, and biologists have conducted extensive research in establishing these secondary metabolites as potential lead compounds with antineoplastic and antiviral effects, among others. The varied biological properties of rocaglates can be attributed to their unusual structures and their ability to act as inhibitors of the eukaryotic translation initiation factor 4A (eIF4A), affecting protein translation. The present review provides an update on the recently reported phytochemical constituents of Aglaia species, focusing on rocaglate derivatives. Furthermore, laboratory work performed on investigating the biological activities of these chemical constituents is also covered.

scholarly journals The Phytochemistry of Cherokee Aromatic Medicinal Plants

Medicines ◽  
2018 ◽  
Vol 5 (4) ◽  
pp. 121 ◽  
Author(s):  
William Setzer
Keyword(s):  
Native Americans ◽  
Medicinal Plants ◽  
Biological Activities ◽  
Herbal Medicines ◽  
Black Cohosh ◽  
Cimicifuga Racemosa ◽  
Traditional Uses ◽  
Aromatic And Medicinal Plants ◽  
Phytochemical Investigation ◽  
Phytochemical Constituents

Background: Native Americans have had a rich ethnobotanical heritage for treating diseases, ailments, and injuries. Cherokee traditional medicine has provided numerous aromatic and medicinal plants that not only were used by the Cherokee people, but were also adopted for use by European settlers in North America. Methods: The aim of this review was to examine the Cherokee ethnobotanical literature and the published phytochemical investigations on Cherokee medicinal plants and to correlate phytochemical constituents with traditional uses and biological activities. Results: Several Cherokee medicinal plants are still in use today as herbal medicines, including, for example, yarrow (Achillea millefolium), black cohosh (Cimicifuga racemosa), American ginseng (Panax quinquefolius), and blue skullcap (Scutellaria lateriflora). This review presents a summary of the traditional uses, phytochemical constituents, and biological activities of Cherokee aromatic and medicinal plants. Conclusions: The list is not complete, however, as there is still much work needed in phytochemical investigation and pharmacological evaluation of many traditional herbal medicines.

scholarly journals Harnessing the medicinal properties of Cussonia barteri Seem. (Araliaceae) in drug development. A review

2018 ◽  
Vol 64 (3) ◽  
pp. 50-61 ◽  
Author(s):  
Ighodaro Igbe ◽  
Osaze Edosuyi ◽  
Agbonlahor Okhuarobo
Keyword(s):  
Drug Development ◽  
Antioxidant Activities ◽  
Biological Activities ◽  
Stem Bark ◽  
Deciduous Tree ◽  
Drug Candidates ◽  
Medicinal Properties ◽  
Phytochemical Constituents ◽  
Anti Inflammatory ◽  
Novel Drug

Summary Cussonia barteri Seem (Araliaceae) is a deciduous tree growing in savannah of Africa. Ethnomedicinally, it is used in Africa as an analgesic, anti-malarial, anti-inflammatory, anti-anaemic, anti-diarhoea, anti-poison, ani-pyschotic and anti-epileptic agent. This review provides a brief summary on the phytochemical screenings, ethnomedicinal and pharmacological applications of various parts of C. barteri. Leaves, stem bark and seed of C. barteri have been shown to be rich in saponins, flavonoids, phenols, sugars and alkaloids. Some of these constituents have been isolated and elucidated from C. barteri. Several compounds isolated from plant include triterpenes, saponins, polyenyne and quinic esters. Phytochemical constituents are also partly responsible for biological activities of C. barteri. Extracts and components isolated from the plant have demonstrated neuropharmacological, anti-larvicidal, anti-microbial, anti-inflammatory and antioxidant activities. Overall, the insights provided by this review reinforce the potential of C. barteri for drug development and create the need for further scientific probe of constituents of the plant with the aim of developing novel drug candidates.

PHYTOCHEMICAL, PHARMACOLOGICAL SCREENING AND IMPORTANCE OF MARSDENIA TENACISSIMA: A REVIEW

INDIAN DRUGS ◽  
2021 ◽  
Vol 58 (4) ◽  
pp. 7-22
Author(s):  
Mayur Porwal ◽  
◽  
Arvind Kumar ◽  
Kamal K. Maheshwari ◽  
Najam A. Khan ◽  
...  
Keyword(s):  
Heart Disease ◽  
Skin Disease ◽  
Recent Literature ◽  
Biological Activities ◽  
Intermittent Fever ◽  
Pharmacological Activities ◽  
Phytochemical Constituents ◽  
Pharmacological Screening ◽  
Anti Hiv ◽  
Marsdenia Tenacissima

In conventional methods of medication, Marsdenia tenacissima (family: Apocynaceae) is used in the treatment of scurvy, urinary diseases, arthritis, heart disease, skin disease, pruritus, vomiting and intermittent fever. Estimation of biological activities confirmed that M. tenacissima plant shows antipyretic, antioxidant, anticancer and anti-HIV activities. This assessment presents the phytochemical constituents, traditional importance and pharmacological activities accounted for the plant in recent literature and it will be supportive to explore incisive information about M. tenacissima for the researchers.

scholarly journals Effects of Harvest Time on Phytochemical Constituents and Biological Activities of Panax ginseng Berry Extracts

Molecules ◽  
2019 ◽  
Vol 24 (18) ◽  
pp. 3343 ◽  
Author(s):  
Seung-Yeap Song ◽  
Dae-Hun Park ◽  
Seong-Wook Seo ◽  
Kyung-Mok Park ◽  
Chun-Sik Bae ◽  
...  
Keyword(s):  
Panax Ginseng ◽  
Biological Activities ◽  
Mass Spectrometry Analysis ◽  
Harvest Time ◽  
Medicinal Products ◽  
Spectrometry Analysis ◽  
Liquid Chromatography Tandem Mass ◽  
Phytochemical Constituents ◽  
Ethanol Extracts ◽  
Berry Extracts

Ginseng (Panax ginseng) has long been used as a traditional medicine for the prevention and treatment of various diseases. Generally, the harvest time and age of ginseng have been regarded as important factors determining the efficacy of ginseng. However, most studies have mainly focused on the root of ginseng, while studies on other parts of ginseng such as its berry have been relatively limited. Thus, the aim of this study iss to determine effects of harvest time on yields, phenolics/ginsenosides contents, and the antioxidant/anti-elastase activities of ethanol extracts of three- and four-year-old ginseng berry. In both three- and fourfour-year-old ginseng berry extracts, antioxidant and anti-elastase activities tended to increase as berries ripen from the first week to the last week of July. Liquid chromatography-tandem mass spectrometry analysis has revealed that contents of ginsenosides except Rg1 tend to be the highest in fourfour-year-old ginseng berries harvested in early July. These results indicate that biological activities and ginsenoside profiles of ginseng berry extracts depend on their age and harvest time in July, suggesting the importance of harvest time in the development of functional foods and medicinal products containing ginseng berry extracts. To the best of our knowledge, this is the first report on the influence of harvest time on the biological activity and ginsenoside contents of ginseng berry extracts.

scholarly journals PHYTOCHEMICAL CONSTITUENTS AND PHARMACOLOGICAL ACTIVITIES OF Kigelia africana AND Mansoa alliacea - A COMPREHENSIVE REVIEW

2018 ◽  
Vol 11 ◽  
Author(s):  
Sowmyalakshmi Venkataraman ◽  
Gunda Srilakshmi
Keyword(s):  
Rural Areas ◽  
Biological Activities ◽  
Chemical Constituents ◽  
Reproductive Organ ◽  
Human Beings ◽  
Pharmacological Activities ◽  
Phytochemical Constituents ◽  
Athlete’S Foot ◽  
Collective Information

Context: The focus of the present review is to compile the different phytochemical constituents and pharmacological activities of bignoniaceous plants, namely Kigelia africana and Mansoa alliacea. Objective: Medicinal plants are routinely used in clinical practice for the treatment of various diseases of human beings over thousands of years across the world. In rural areas of the developing countries, they are still used in practice due to the easy availability of the medication. The main objective of this work is to explore the phytochemical studies and biological activities of plants belonging to Bignoniaceae family. Methods: The present study also discusses about the different phytochemical constituents of K. africana and M. alliacea that were isolated and characterized using various analytical methods. Different extracts of these plants were subjected to different in vitro anticancer, analgesic, antimicrobial, and antimalarial activities using earlier reported methods were also discussed. Results: K. africana is commonly referred to as sausage or cucumber tree due to its huge sausage or cucumber-like fruit. These plants find application as traditional medicine for treating several ailments such as malignant tumor, ulcer, aging, and malaria among others. It is conjointly used for the treatment of reproductive organ infections, renal ailments, dizziness, epilepsy, sickle cell disease, depression, metabolism disorders, skin grievance, leprosy, impetigo, helminthic infections, athlete’s foot, tumors, etc. These plant extracts have also been used as a cosmetic by enhancing the collagen action and thus exhibit antiaging properties. Conclusion: The present study attempts to provide collective information on various phytochemical constituents and pharmacological actions of K. africana and M. alliacea belonging to Bignoniaceae. This review in its present form is believed to help the researchers to provide adequate information about the chemical constituents and biological uses of these plants.

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