Oral Administration of Liposomal Insulin

2006 ◽  
Vol 6 (9) ◽  
pp. 2945-2949 ◽  
Author(s):  
I. Tuncer Değim ◽  
Bülent Gümüşel ◽  
Zelihagül Değim ◽  
Tanju Özçelikay ◽  
Aydin Tay ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Methyl Cellulose ◽  
Application Site ◽  
Dipalmitoyl Phosphatidylcholine ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Effective Components ◽  
Reduce Blood Glucose ◽  
Reduce Blood Glucose Level ◽  
Tablet Formulations

There have been several attempts published in the literature related with orally effective insulin formulations, which are increasing in popularity. Some of the results indicate that it is possible to reduce blood glucose level by orally administered liposomal insulin formulations, but there is general need to understand the mechanism and effective components of the liposome formulations. In our study, liposomal insulin formulations were prepared using insulin (Humulin R) or protaminecontaining insulin (Humulin N) with cholesterol, dipalmitoyl phosphatidylcholine (egg) (DPPC)-cholesterol mixture, and mucoadhesive agent (methyl cellulose, MC)-added DPPC-cholesterol mixture. A tablet formulation of insulin was also prepared. Formulations of liposomal insulin were introduced to mice and rats orally and reduced blood glucose levels were observed. The composition of phospholipid (DPPC, cholesterol and MC mixture) was found to be quite effective in reducing blood glucose levels. The pH of the solution and the presence of the protamine sulfate were found to be important. The application site was also found to be important because liposomal insulin formulations administered through the mouth or esophagus resulted in reduced blood glucose levels. Reduced blood glucose levels were also observed when tablet formulations of insulin were administered to rats orally.

scholarly journals Pengaruh Ekstrak Rebusan Daun Tithonia diversifolia (Hemsl.) A. Gray Terhadap Kadar Glukosa Darah

2019 ◽  
Vol 7 (1) ◽  
pp. 41
Author(s):  
Rinawati Rinawati ◽  
E Suharyanto ◽  
Nastiti Wijayanti
Keyword(s):  
Blood Glucose ◽  
Young Leaf ◽  
Tithonia Diversifolia ◽  
Treatment Groups ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Randomized Design ◽  
Adult Leaf ◽  
Reduce Blood Glucose ◽  
Completely Randomized Design

Tithonia diversifolia is a plant that has the potential to reduce blood glucose levels that is crucial in Diabetes Mellitus therapy. This study aims to determine the active compounds contained in the extract of T. diversifolia leaves decoction, the effect of decoction extract on the reduction of blood glucose, and the most effective decoction extract to reduce blood glucose levels as well. The study used a Completely Randomized Design (CRD) with the research treatment groups, namely: Kn = normal control (normal mice and not given leaves decoction extract), Ka = STZ control (DM mice, which are normal mice induced by 65mg/Kg of STZ), Kp = treatment control (normal mice given leaf decoction extract) , P1 = DM + mice were given young leaf decoction extract, P2 = DM + mice were given a mixture of young leaf and adult leaf decoction extract, P3 = DM + mice were given adult leaf decoction extract. The leaves used for decoction were 1-6 leaves from the shoots. The analysis of T. diversifolia leaves decoction compounds is using the visible spectrophotometers for tannins, phenols and flavonoids and GC-MS for terpenoid analysis. The result found that Tithonia diversifolia leaves decoction extracts contain tannins, flavonoids and phenols, while terpenoids are not detected. The leaves decoction extracts of T. diversifolia influenced the decreases in blood glucose levels of DM mice, especially the decoction extract of adult leaves which reduced blood glucose levels to 71.16%.

scholarly journals Levels of Blood Glucose in Animals Try Wistar White Mix (Rattus Norvegicus) Dined by Green Beans of Sari Bean Packaging

2019 ◽  
Vol 4 (2) ◽  
pp. 17
Author(s):  
Maruni Wiwin Diarti ◽  
Siti Zaetun ◽  
Urip . ◽  
Yunan Jiwintarum ◽  
Baiq Anies Trisnasanti
Keyword(s):  
Blood Glucose ◽  
Functional Food ◽  
Green Bean ◽  
Green Beans ◽  
Experimental Animals ◽  
High Fiber ◽  
Glucose Levels ◽  
White Rats ◽  
Blood Glucose Levels ◽  
Reduce Blood Glucose

Functional food is food that is naturally or through a process that is beneficial to health. One functional food is a green bean juice packaging beverage that can reduce blood glucose levels. High fiber content, low glycemic index and flavonoids, and polyphenols in green beans (Phaseolus radiatus L) can reduce glucose levels in the blood. This study used experimental animals 7 tails. All experimental animals were given packaged mung bean juice 2 times a day for 9 days by means of a round. The mean results of an examination of blood glucose levels in white rat experimental animals before giving packaged green bean juice drinks was 85 mg dl, while the average results of an examination of blood glucose levels in experimental rats after administration of packaged green bean juice were 75 mg/dl. The results of the Paired T-test statistical test obtained p = 0,000 <α = 0.05. Packaged green bean juice can reduce blood glucose levels in animals testing white rats.

scholarly journals The Potential of Noni (Moringa citrifolia) in Lowering Blood Glucose Levels in Diabetes Mellitus Patients

BIOEDUSCIENCE ◽  
2020 ◽  
Vol 4 (2) ◽  
pp. 120-123
Author(s):  
Putri Dafriani ◽  
Mutiara Karamika ◽  
Siska Sakti Anggraini ◽  
Roza Marlinda
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Intervention Group ◽  
Control Group ◽  
Diabetic Patients ◽  
Test Results ◽  
Glucose Levels ◽  
Glucose Testing ◽  
Blood Glucose Levels ◽  
Reduce Blood Glucose

Background: Diabetes Mellitus is a chronic metabolic disorder caused by insulin resistance. Noni juice has the potential as herbal medicine which believed to reduce blood glucose levels. This study aims to determine the effect of noni juice on blood sugar levels on diabetic patients. Methods: This study used 16 respondents. They divided two groups, a control group and a treatment group. Each group consists of 8 respondents. The intervention group received 150 ml of noni juice which was given once a day for ten days. Glucose testing was carried out by the glucose-check method. The blood was taken from the respondent's fingertips capillary. The blood glucose levels between the control group and the intervention group were analyzed using independent t-test. Results: The average blood glucose level in the intervention group was 199.88 mg/dl, while the control group was 326.25 mg/dl. The test results of the mean blood glucose levels between the control group and the intervention group had a significant difference with a value of p = 0.003 (p ≤ 0.05). This indicates a significant effect between blood glucose levels in the control group and the intervention group. Conclusion: Noni can reduce blood glucose levels because it contains flavonoid. It has a hypoglycemic effect. Health workers can suggest consuming noni juice to decrease blood glucose in diabetic patients.    

scholarly journals Self Instructional Training Methods to Reduce Blood Glucose Levels Type 2 Diabetes Mellitus

2017 ◽  
Vol 4 (1) ◽  
pp. 006-011
Author(s):  
Nian Afrian Nuari
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
T Test ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Number Of Patients ◽  
Patients With Diabetes ◽  
Reduce Blood Glucose ◽  
Instructional Training ◽  
Paired T Test

Blood glucose levels  uncontrolled is a problem that is often found in patients with Diabetes Mellitus. This has an impact on the health of the patient as it would appear some macrovascular and microvascular complications. Number of patients with DM in Indonesia has increased every year and only 50% of patients suffering from diabetes who are aware of, and around 30% of them take medication regularly. The purpose of this study to determine the effect of Self Instructional Training method on blood glucose levels of patients. The method used is pre experiment with purposive sampling technique and the sample size of 16 respondents. Measuring instrument used glucometers to measure blood glucose levels and analyzed with Paired T Test. Based on the results, the entire blood glucose levels before the intervention above 200 mg /dl. After Self Instructional Training Intervention average blood glucose level was 35.75 mg /dl. Blood glucose levels are highest when the post test was 253 mg /dl and the lowest is 197 mg /dl. Based on Paired T Test  analysis obtained Self Instructional Training interventions can reduce blood glucose levels of patients with Diabetes Mellitus Type II (p value = 0.000). Diabetes Mellitus patients expected to be able to apply the  SIT method to perform self-care so that the patient's blood glucose levels can be controlled. Patient can do this methods  at home and needed support from their  family and health professionals to treat the diseases.Keywords : Self, Instructional, Training, level, glucose, blood, DM

scholarly journals PENGARUH EKSTRAK BAWANG HITAM TERHADAP PENURUNAN KADAR GLUKOSA DARAH PADA MENCIT

2021 ◽  
Vol 4 (1) ◽  
pp. 49
Author(s):  
Pipit Festi W
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Mus Musculus ◽  
T Test ◽  
Control Group ◽  
Control Group Design ◽  
Significance Level ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Reduce Blood Glucose

 Administration of oral hypoglycemic drugs and insulin is one of the most common pharmacological treatments given to people with diabetes mellitus. This treatment is carried out in the long term so that it causes side effects and is carried out continuously so that it will affect the financial condition of the diabetes mellitus patient. The purpose of this study was to determine the effect of black garlic extract on decreasing blood glucose levels in mice (mus musculus). This study uses the design of True Experimental design (pretest-posttest with control group design). The population is mice in Pusvetma Surabaya. Sampling method uses Non Probability Sampling Purposive Sampling type. Samples taken were 30 mice consisting of 15 intervention groups and 15 control groups. Data was collected using observation sheets, then analyzed using Independent sample t test and Dependent sample t test with a significance level of 5 0.05. The results showed: Using the test Independent sample T test obtained a significance value ρ = 0,000  It can be concluded that there is an effect of black onion extract to reduce blood glucose levels in mice. In the paired t-test test in the treatment group showed ρ = 0,000  that there were differences in blood glucose levels before being given extracts of garlic and after being given intervention. It is expected that black garlic can be used as an alternative medicine to reduce blood glucose levels.Keyword : Ekstrak of black garlic, Blood sugar levels, mus musculus

scholarly journals Eurotium Cristatum Fermented Okara as a Potential Food Ingredient to Combat Diabetes

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Li Yan Chan ◽  
Masaki Takahashi ◽  
Pei Jean Lim ◽  
Shinya Aoyama ◽  
Saneyuki Makino ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Postprandial Blood Glucose ◽  
Food Ingredient ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Reduce Blood Glucose ◽  
Good Nutrition ◽  
Physical Attributes

AbstractType 2 diabetes mellitus (T2DM) is a chronic disease, and dietary modification is a crucial part of disease management. Okara is a sustainable source of fibre-rich food. Most of the valorization research on okara focused more on the physical attributes instead of the possible health attributes. The fermentation of okara using microbes originated from food source, such as tea, sake, sufu and yoghurt, were explored here. The aim of this study is to investigate fermented okara as a functional food ingredient to reduce blood glucose levels. Fermented and non-fermented okara extracts were analyzed using the metabolomic approach with UHPLC-QTof-MSE. Statistical analysis demonstrated that the anthraquinones, emodin and physcion, served as potential markers and differentiated Eurotium cristatum fermented okara (ECO) over other choices of microbes. The in-vitro α-glucosidase activity assays and in-vivo mice studies showed that ECO can reduce postprandial blood glucose levels. A 20% ECO loading crispy snack prototype revealed a good nutrition composition and could serve as a fundamental formulation for future antidiabetes recipe development, strengthening the hypothesis that ECO can be used as a novel food ingredient for diabetic management.

scholarly journals PENINGKATAN KERJA INSULIN DENGAN ACTIVE STRETCHING EXERCISE PADA DMT2 DI KABUPATEN PEKALONGAN

2019 ◽  
Vol 10 (2) ◽  
pp. 369
Author(s):  
Nurul Aktifah ◽  
Firman Faradisi
Keyword(s):  
Blood Glucose ◽  
Controlled Trial ◽  
Blood Glucose Control ◽  
Sampling Technique ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
A Value ◽  
Significant Difference ◽  
Before And After ◽  
Reduce Blood Glucose

Physical exercise can significantly reduce weight and insulin sensitivity; hence, it can reduce blood glucose levels and improve blood glucose control. The main objective of this study was to determine the effectiveness of active stretching exercise to increase the function of insulin on Diabetes Mellitus Type 2(DMT2) at Pekalongan Regency. The design of this study was a randomized controlled trial (RCT) with one-group pretest-posttest design. 20 respondents were chosen by using total sampling technique on  August 3 - October 27, 2018. The data collection tools were a questionnaire, GlucoDrTM, and Autocheck®. The Shapiro-Wilk test was implemented as a normality test.To determine the effect of the treatment, a paireddependent T-Test was used. This study found out that there was no significant difference of the work of insulin, before and after the respondents did the active exercise, with a value of ρ 0.315. Therefore, it is strongly recommended that further research applies active stretching exercise combined with 7 self-management of diabetes. 

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