Study on the clinical effect of ranitidine combined with omeprazole in the treatment of peptic ulcers

The clinical safety and efficacy of a novel pharmaceutical material (ranitidine combined with omeprazole) for treating peptic ulcers was analyzed using gastroscopy. The subjects were from the Department of Gastroenterology, Nankai hospital, Tianjin, China. Gastroscopy was performed from March 2017 to March 2018. A 100 eligible patients with gastric ulcers were selected. The patients with peptic ulcers were randomly divided into two groups with 50 patients each. For the control group, 150 mg ranitidine was administered orally, twice a day before meals, for four weeks. For the combined group, 150 mg ranitidine was administered orally, twice a day before meals, along with 20 mg omeprazole once a day, for four weeks. The clinical efficacy of the therapy, disease recurrence, and adverse reactions were compared between the two groups. The antacid effect of combined therapy was stronger and longer lasting when compared with the control group (P < 0.05). After six months of follow-up, the Helicobacter pylori (HP) clearance in the combined treatment group was more efficient than in the control group (P < 0.05). Serious adverse reactions were not found in both the groups. Ranitidine combined with omeprazole is effective and safe in the treatment of peptic ulcers and worthy of clinical application.

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Observation of the effect on immediate mandibular implant-supported overdenture of micro implant system of Italy

Bioscience Journal ◽

10.14393/bj-v36n6a2020-54610 ◽

2020 ◽

Vol 36 (6) ◽

Author(s):

Yin Xuemeng ◽

Dai Shasha

Keyword(s):

Adverse Events ◽

Adverse Reactions ◽

Clinical Effect ◽

Alveolar Bone ◽

Control Group ◽

Observation Group ◽

Curative Effect ◽

Low Incidence ◽

Implant System

The study was design to investigate the clinical effect of Micro implant system in Italy on immediate mandibular implant-supported overdenture. A total of 192 patients with mandibular edentulous treated in our hospital were randomly divided into 2 groups in which the control group consisted of 96 patients treated with immediate mandibular implant-supported overdenture by Xive implant system, while the observation group included 96 cases treated with the overdenture by Italy Micro implant system. Patients were followed up for 1 year and then the states of implant-borne overdentures, marginal bone resorption around alveolar bone, the compatibility of implant restorations with adjacent teeth, adverse events and satisfaction degree were compared between the groups. According to the results of 1-year follow-up, the resorption around alveolar bone of the observation group was significantly higher than that of the control group (p<0.05). In the observation group the differences in labial gingival margin position, gingival color and texture were significantly better (p<0.05) as compared to control group. The incidence of adverse events was notably lower (p<0.05). The Italy Micro implant system has significant curative effect on mandibular implant-supported overdentures with good compatibility of the implant restorations with adjacent teeth and low incidence rate of adverse reactions, so it is worthy of clinical application and spreading.

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Polypoidal choroidal vasculopathy in pachychoroid: combined treatment with photodynamic therapy and Aflibercept

10.21203/rs.3.rs-307308/v1 ◽

2021 ◽

Author(s):

Maria Vadalà ◽

Massimo Castellucci ◽

Giulia Guarrasi ◽

Giovanni Cillino ◽

Vincenza Maria Elena Bonfiglio ◽

...

Keyword(s):

Visual Acuity ◽

Photodynamic Therapy ◽

Polypoidal Choroidal Vasculopathy ◽

Combined Therapy ◽

Combined Treatment ◽

Subretinal Fluid ◽

Clinical Activity ◽

Monthly Basis ◽

Choroidal Vasculopathy

Abstract Introduction To evaluate the effects of combined therapy using intravitreal Aflibercept (IVA) and photodynamic therapy (PDT) on polypoidal choroidal vasculopathy related to pachychoroid disease (PPCV).Methods Patients with PPCV were treated with PDT combined with 3 IVA injections on a monthly basis, followed by pro re nata criteria. The 12-month follow-up consisted of multiple revaluations of visual acuity and SSOCT parameters of clinical activity.Results Nineteen eyes were included in the study; mean age was 65.5 years. Visual acuity improved after 12 months (0.35 ± 0.25 to 0.2 ± 0.20 logMAR, p = 0.005). Percentage of eyes with intraretinal and subretinal fluid reduced from baseline to the 12-month follow-up (from 52.6–10.5%, p = 0.12, and from 89.5–5.3% p = 0.0009, respectively). Central retinal and mean macular thicknesses reduced (258 ± 39.6 to 204.8 ± 38.8 µm p = 0.04 and 293.8 ± 32.1 to 248.1 ± 29.6 µm p = 0.017 respectively). Central choroidal and mean choroidal thicknesses also displayed a reduction (328.6 ± 54.9 to 289.8 ± 44.6 µm p = 0.001 and 314.5 ± 55.3 to 287.9 ± 47.6 µm p = 0.015 respectively). The mean number of injections was 4.6/year.Conclusion The results support the use of a combined therapy with Aflibercept and PDT in PPCV. This treatment would act in synergy, with anti-VEGF controlling exudation and PDT closing the aneurysmal vessel and reducing choroidal congestion.

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Combined treatment for acromegaly with long-acting somatostatin analogs and pegvisomant: long-term safety for up to 4.5 years (median 2.2 years) of follow-up in 86 patients

Acta Endocrinologica ◽

10.1530/eje-08-0843 ◽

2009 ◽

Vol 160 (4) ◽

pp. 529-533 ◽

Cited By ~ 81

Author(s):

SJCMM Neggers ◽

WW de Herder ◽

JAMJL Janssen ◽

RA Feelders ◽

AJ van der Lely

Keyword(s):

Combined Therapy ◽

Combined Treatment ◽

Somatostatin Analogs ◽

Pituitary Surgery ◽

Median Dosage ◽

Previously Treated ◽

Long Acting

BackgroundWe previously reported on the efficacy, safety, and quality of life (QoL) of long-acting somatostatin analogs (SSA) and (twice) weekly pegvisomant (PEG-V) in acromegaly and improvement after the addition of PEG-V to long-acting SSA.ObjectiveTo assess the long-term safety in a larger group of acromegalic patients over a larger period of time: 29.2 (1.2–57.4) months (mean (range)).DesignPegvisomant was added to SSA monotherapy in 86 subjects (37 females), to normalize serum IGF1 concentrations (n=63) or to increase the QoL. The median dosage was 60.0 (20–200) mg weekly.ResultsAfter a mean treatment period of 29.2 months, 23 patients showed dose-independent PEG-V related transient liver enzyme elevations (TLEE). TLEE occurred only once during the continuation of combination therapy, but discontinuation and re-challenge induced a second episode of TLEE. Ten of these patients with TLEE also suffered from diabetes mellitus (DM). In our present series, DM had a 2.28 odds ratio (CI 1.16–9.22; p=0.03) higher risk for developing TLEE. During the combined therapy, a clinical significant decrease in tumor size by more than 20% was observed in 14 patients. Two of these patients were previously treated by pituitary surgery, 1 with additional radiotherapy and all other patients received primary medical treatment.ConclusionLong-term combined treatment with SSA and twice weekly PEG-V up to more than 4 years seems to be safe. Patients with both acromegaly and DM have a 2.28 higher risk of developing TLEE. Clinical significant tumor shrinkage was observed in 14 patients during combined treatment.

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Psychoeducation and cognitive-behavioral therapy for patients with refractory bipolar disorder: A 5-year controlled clinical trial

European Psychiatry ◽

10.1016/j.eurpsy.2012.11.002 ◽

2014 ◽

Vol 29 (3) ◽

pp. 134-141 ◽

Cited By ~ 36

Author(s):

A. González Isasi ◽

E. Echeburúa ◽

J.M. Limiñana ◽

A. González-Pinto

Keyword(s):

Bipolar Disorder ◽

Cognitive Behavioral Therapy ◽

Pharmacological Treatment ◽

Behavioral Therapy ◽

Combined Treatment ◽

Control Group ◽

Time Points ◽

Evaluation Time ◽

Experimental Group

AbstractObjective:The aim of this research, which represents an additional and longer follow-up to a previous trial, was to evaluate a 5-year follow-up study of a combined treatment (pharmacological + psychoeducational and cognitive-behavioral therapy) as compared with a standard pharmacological treatment in patients with refractory bipolar disorder.Method:Forty patients were randomly assigned to either an Experimental group–under combined treatment — or a Control group — under pharmacological treatment. Data were analyzed by analysis of variance (ANOVA), with repeated measures at different evaluation time points.Results:Between-group differences were significant at all evaluation time points after treatment. Experimental group had less hospitalization events than Control group in the 12-month evaluation (P = 0.015). The Experimental group showed lower depression and anxiety in the 6-month (P = 0.006; P = 0.019), 12-month (P = 0.001; P < 0.001) and 5-year (P < 0.001, P < 0.001) evaluation time points. Significant differences emerged in mania and misadjustment already in the post-treatment evaluation (P = 0.009; P < 0.001) and were sustained throughout the study (6-month: P = 0.006, P < 0.001; 12-month: P < 0.001, P < 0.001; 5-year: P = 0.004, P < 0.001). After 5-year follow-up, 88.9% of patients in the Control group and 20% of patients in the Experimental group showed persistent affective symptoms and/or difficulties in social-occupational functioning.Conclusions:A combined therapy is long-term effective for patients with refractory bipolar disorder. Suggestions for future research are commented.

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Four Years' Follow-up Results of Three Different Percutaneous Treatments for Male Varicocele

Phlebology The Journal of Venous Disease ◽

10.1177/026835559901400203 ◽

1999 ◽

Vol 14 (2) ◽

pp. 48-53

Author(s):

M. Pocek ◽

M. R. Guazzaroni ◽

G. Sodani ◽

M. N. Guazzaroni ◽

R. Cancellieri ◽

...

Keyword(s):

Combined Therapy ◽

Combined Treatment ◽

Duplex Ultrasound ◽

Fourth Degree ◽

The Third ◽

University Of Rome ◽

Radiological Procedures ◽

Gianturco Coils

Objective: To evaluate the efficacy of three different interventional radiological procedures for the treatment of venous reflux in symptomatic male varicocele. Design: Prospective study with a 48-month colour duplex ultrasound (CD) follow-up. Setting: Department of Radiology, Tor Vergata University of Rome. Patients: From January 1991 to December 1993, 45 symptomatic patients with third- to fourth-degree varicocele, according to Sarteschi's CD classification, were randomly divided into three equal groups (15 patients each). Interventions: The first group received sclerotherapy (Athoxysclerol), the second underwent embolisation (Gianturco coils), while the third group received combined sclero–embolisation therapy (Athoxysclerol and Gianturco coils). Main outcomes measures: The frequency of recurrence for each procedure. Results: Two recurrences (13%) after 1 and 2 years occurred in patients who underwent sclerotherapy. In the embolisation group, two patients showed residual varices (13%). Neither recurrence nor residue was seen in the third group, who received combined therapy. Conclusions: Sclerotherapy provides good immediate results but drug dilution may cause a relapse shortly after treatment. Embolisation has a lower immediate success but better long-term success. Combined treatment provides the highest long-term success rate.

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Analysis of Clinical Effect of Treating Arrhythmia with Stable Heart Granules

Advanced Emergency Medicine ◽

10.18686/aem.v2i1.3 ◽

2013 ◽

Vol 2 ◽

pp. 7

Author(s):

Li Liu

Keyword(s):

Clinical Practice ◽

Adverse Reactions ◽

Clinical Effect ◽

Total Effective Rate ◽

Effective Rate ◽

Control Group ◽

Observation Group ◽

The Difference ◽

And Control ◽

Group Observation

Objective: To study the clinical effect on the treatment of cardiac arrhythmia, and further guide the clinical treatment. Method: From January 2011 to January 2013, 100 patients with arrhythmia were randomly divided into observation group and control group with 50 cases in each group. Observation group patients given oral Stable heart granule treatment, while control group was treated with oral propafenone treatment. The therapeutic effect and adverse reactions of the two groups were observed and compared. Results: The total effective rate of the observation group was higher than control group and incidence of adverse reactions was lower than control group, the difference was statistically significant, p < 0.05. The use of stable heart particles in the treatment of arrhythmia produce significant effect. Conclusion: Clinical effect for Stable heart granule on arrhythmia was significant and should widely entrenched in clinical practice.

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Docetaxel HIPEC Combined with Endostar versus Docetaxel HIPEC Alone in Treatment of Malignant Ascites：A Retrospective Study

10.21203/rs.3.rs-306501/v1 ◽

2021 ◽

Author(s):

Jing Wu ◽

Hao Jiang ◽

Liting Chen ◽

Bingqi Yu ◽

Zhibing Wu

Keyword(s):

Qualitative Data ◽

Adverse Reactions ◽

Clinical Effect ◽

Objective Response ◽

Malignant Ascites ◽

Control Group ◽

Observation Group ◽

Improvement Rate ◽

Significant Difference

Abstract Objective：The purpose of this study is to retrospectively observe the clinical efficacy and adverse reactions of docetaxel hyperthermic intraperitoneal chemotherapy (HIPEC) combined with endostar in treatment of malignant ascites. Methods：56 cases of malignant ascites admitted to Zhejiang Hospital from July 2019 and October 2020 had received no less than second-line chemotherapy. The observation group (n = 29) was treated with endostar 60mg d1,4,7 Q3W intraperitoneal injection combined with docetaxel 60mg/m2 d4 HIPEC Q3W for 2 cycles. The control group (n = 27) was just treated with docetaxel 60mg/m2 d1 HIPEC Q3W for 2 cycles. The general clinical data and qualitative data of the treatment results were processed by SPSS26.0 using χ2 test, and quantitative data were processed by t test. When P < 0.05, statistical data can be considered statistically significant.Results：There were significant differences between the observation group and the control group in objective response rate (ORR) (65.5% vs 37.0%，P=0.033)，in the improvement rate of KPS (48.3% vs 22.2%, P=0.042)，also in the median control time (57dvs 45d，P=0.027). The incidence of III to IV adverse reactions was low, and no treatment-related death was observed. There was no significant difference in the incidence of adverse reactions between the two groups.Conclusion：Endostar combined with docetaxel HIPEC has good clinical effect on malignant ascites and can improve patients’ quality of life, and the adverse reactions can be tolerated.

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Effect of Ketoprofenphonophoresis and Femoral Nerve Block in Knee Osteoarthritis

Journal of Clinical and Nursing Research ◽

10.26689/jcnr.v5i6.2710 ◽

2021 ◽

Vol 5 (6) ◽

pp. 72-78

Author(s):

Fan Fan ◽

Wei Wei ◽

Binyan He ◽

Chaonan Li ◽

Qing Yang ◽

...

Keyword(s):

Knee Osteoarthritis ◽

Nerve Block ◽

Femoral Nerve Block ◽

Combined Treatment ◽

Femoral Nerve ◽

Control Group ◽

Before And After ◽

Effective Efficiency ◽

Experimental Group

Objective: To evaluate the effect of ketoprofenphonophoresis and femoral nerve block in knee osteoarthritis. Methods: One hundred and fourteen patients with knee osteoarthritis were randomly divided into two groups. The control group consisted of 57 patients who were treated with only ketoprofenphonophoresis. The experimental group consisted of patients were treated with ketoprofenphonophoresis and femoral nerve block. The patients were followed for more than one month. The treatment effect assessed by observing their WOMAC index before and after therapy. Results: All the patients finished the follow-up. Their WOMAC indexes were reduced after therapy and one month after treatment, especially in the experimental group (P < 0.05). The effective efficiency of ketoprofenphonophoresis and femoral nerve block were higher than that in the control group after treatment and after one month of follow-up (P < 0.05). Conclusion: Compared with only ketoprofenphonophoresis, the combined treatment of ketoprofenphonophoresis and femoral nerve block was more appropriate in knee osteoarthritis.

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EFFECT OF SELECTED YOGA TECHNIQUES ALONG WITH ASHWAGANDHA AND VACHA IN DEPRESSION IN THE AGE GROUP 65–75 YEARS

Asian Journal of Pharmaceutical and Clinical Research ◽

10.22159/ajpcr.2021.v14i11.42259 ◽

2021 ◽

pp. 65-68

Author(s):

SOUMYA MELEPPURAKKAL ◽

SUNITHA K ◽

JAYAN D

Keyword(s):

Combined Therapy ◽

Holistic Approach ◽

Study Groups ◽

Warm Water ◽

Treatment Modalities ◽

Control Group ◽

Study Group ◽

Age Group ◽

Study Population

Objective: The study was done to compare the effect of selected yoga techniques, drugs, and combined therapy in depression in geriatrics. Methods: 75 patients between 65 and 75 years of age with depression were included in the study which was assessed by HAM D Score. The study population was randomly allocated to one control group and two study groups. The control group was given Aswangandha and Vacha churna with warm water as anupana after food, selected yoga techniques in the first study group, and combined yoga and the drug were given to the second study group. Outcome variables were assessed for the groups after the 30th day and follow-up after 45 days. Results: The results obtained in the study were analyzed using the ANOVA test. Yoga along with drug experienced a comparatively greater reduction in HAM-D score after treatment and follow-up (p<0.05) than other groups. Conclusion: Holistic approach can bring a better and static result than applying the treatment modalities alone.

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Clinical Effect of Auricular Point Sticking in Patients with Lung Cancer Receiving Chemotherapy

Proceedings of Anticancer Research ◽

10.26689/par.v5i6.2810 ◽

2021 ◽

Vol 5 (6) ◽

pp. 73-77

Author(s):

Xiaorui Zhu

Keyword(s):

Lung Cancer ◽

Stress Response ◽

Adverse Reactions ◽

Clinical Effect ◽

Clinical Symptoms ◽

Auricular Point Sticking ◽

Jiangxi Province ◽

Control Group ◽

Study Group ◽

Auricular Point

Objective: To discuss and analyze the clinical effect of auricular point sticking in lung cancer chemotherapy. Methods: Sixty-two patients with lung cancer treated with chemotherapy in Suqian Traditional Chinese Medicine Hospital of Jiangxi Province were selected for case evaluation and analysis. The time span of the research was from June 2020 to June 2021. The patients were divided into two groups: a study group (n = 31) and a control group (n = 31) based on their medical record numbers. All the patients were treated with conventional western medicine before and after chemotherapy to prevent adverse reactions; however, the patients in the study group were also treated with auricular point sticking in addition to the former. The relevant indexes of the two groups were compared. Results: The incidence of adverse reactions was significantly lower in the study group compared to the control group (P < 0.05); the rate of symptomatic relief of the patients in the study group was higher than that of the control group (P < 0.05); the stress response indexes toward chemotherapy of the study group were better than those of the control group (P < 0.05). Conclusion: Auricular point sticking for patients with lung cancer who are receiving chemotherapy can reduce the incidence of adverse reactions, alleviate clinical symptoms, such as chest distress, asthma, and poor appetite, significantly alleviate stress response caused by chemotherapy, as well as promote the treatment effect; thus, it is worthy of promotion.

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